Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | NETPATH_ALPHA6_BETA4_INTEGRIN_PATHWAY |
| Enrichment Score (ES) | -0.6722093 |
| Normalized Enrichment Score (NES) | -2.0802712 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0024173935 |
| FWER p-Value | 0.039 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 1001 | 0.144 | -0.0532 | No |
| 2 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 1997 | 0.094 | -0.1137 | No |
| 3 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 2329 | 0.084 | -0.1257 | No |
| 4 | NTN1 | NTN1 Entrez, Source | netrin 1 | 3284 | 0.060 | -0.1882 | No |
| 5 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 3374 | 0.059 | -0.1859 | No |
| 6 | PRKCA | PRKCA Entrez, Source | protein kinase C, alpha | 3999 | 0.046 | -0.2258 | No |
| 7 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 4079 | 0.045 | -0.2249 | No |
| 8 | METAP2 | METAP2 Entrez, Source | methionyl aminopeptidase 2 | 4125 | 0.044 | -0.2215 | No |
| 9 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 4760 | 0.033 | -0.2641 | No |
| 10 | RPSA | RPSA Entrez, Source | ribosomal protein SA | 5605 | 0.020 | -0.3245 | No |
| 11 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 6191 | 0.011 | -0.3668 | No |
| 12 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 6361 | 0.009 | -0.3782 | No |
| 13 | EIF4E | EIF4E Entrez, Source | eukaryotic translation initiation factor 4E | 6703 | 0.004 | -0.4033 | No |
| 14 | EIF4EBP1 | EIF4EBP1 Entrez, Source | eukaryotic translation initiation factor 4E binding protein 1 | 6950 | 0.000 | -0.4217 | No |
| 15 | PLEC1 | PLEC1 Entrez, Source | plectin 1, intermediate filament binding protein 500kDa | 7482 | -0.007 | -0.4606 | No |
| 16 | FRAP1 | FRAP1 Entrez, Source | FK506 binding protein 12-rapamycin associated protein 1 | 8101 | -0.016 | -0.5046 | No |
| 17 | YWHAE | YWHAE Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 8149 | -0.017 | -0.5055 | No |
| 18 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 8414 | -0.022 | -0.5221 | No |
| 19 | YWHAB | YWHAB Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 8834 | -0.029 | -0.5492 | No |
| 20 | CLCA2 | CLCA2 Entrez, Source | chloride channel, calcium activated, family member 2 | 9159 | -0.035 | -0.5682 | No |
| 21 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 9287 | -0.038 | -0.5720 | No |
| 22 | ITGB4BP | ITGB4BP Entrez, Source | integrin beta 4 binding protein | 9293 | -0.038 | -0.5666 | No |
| 23 | RTKN | RTKN Entrez, Source | rhotekin | 9437 | -0.040 | -0.5712 | No |
| 24 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 9459 | -0.041 | -0.5665 | No |
| 25 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10634 | -0.068 | -0.6445 | No |
| 26 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10733 | -0.071 | -0.6410 | No |
| 27 | AR | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 10940 | -0.077 | -0.6448 | No |
| 28 | YWHAH | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 10999 | -0.079 | -0.6372 | No |
| 29 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11466 | -0.098 | -0.6572 | Yes |
| 30 | SRC | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 11494 | -0.099 | -0.6441 | Yes |
| 31 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 11622 | -0.106 | -0.6375 | Yes |
| 32 | YWHAZ | YWHAZ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 11724 | -0.110 | -0.6282 | Yes |
| 33 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 11736 | -0.111 | -0.6121 | Yes |
| 34 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 11904 | -0.119 | -0.6065 | Yes |
| 35 | SMAD2 | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 11923 | -0.120 | -0.5895 | Yes |
| 36 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 12233 | -0.142 | -0.5910 | Yes |
| 37 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 12254 | -0.144 | -0.5705 | Yes |
| 38 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 12348 | -0.153 | -0.5541 | Yes |
| 39 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 12355 | -0.153 | -0.5311 | Yes |
| 40 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 12465 | -0.166 | -0.5140 | Yes |
| 41 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 12536 | -0.176 | -0.4923 | Yes |
| 42 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 12592 | -0.184 | -0.4683 | Yes |
| 43 | YWHAQ | YWHAQ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 12601 | -0.184 | -0.4407 | Yes |
| 44 | DSP | DSP Entrez, Source | desmoplakin | 12648 | -0.194 | -0.4145 | Yes |
| 45 | CD151 | CD151 Entrez, Source | CD151 molecule (Raph blood group) | 12732 | -0.210 | -0.3886 | Yes |
| 46 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12855 | -0.239 | -0.3612 | Yes |
| 47 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 13018 | -0.300 | -0.3276 | Yes |
| 48 | LAMB3 | LAMB3 Entrez, Source | laminin, beta 3 | 13195 | -0.458 | -0.2707 | Yes |
| 49 | VIM | VIM Entrez, Source | vimentin | 13227 | -0.506 | -0.1957 | Yes |
| 50 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 13264 | -0.594 | -0.1075 | Yes |
| 51 | LAMB2 | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 13299 | -0.740 | 0.0032 | Yes |
