Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | NETPATH_EGFR1_PATHWAY_UP |
| Enrichment Score (ES) | -0.50950927 |
| Normalized Enrichment Score (NES) | -1.7712994 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.041237738 |
| FWER p-Value | 0.997 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GJB2 | GJB2 Entrez, Source | gap junction protein, beta 2, 26kDa (connexin 26) | 115 | 0.397 | 0.0216 | No |
| 2 | SLC20A1 | SLC20A1 Entrez, Source | solute carrier family 20 (phosphate transporter), member 1 | 345 | 0.251 | 0.0235 | No |
| 3 | EGR1 | EGR1 Entrez, Source | early growth response 1 | 437 | 0.219 | 0.0333 | No |
| 4 | TMEM97 | TMEM97 Entrez, Source | transmembrane protein 97 | 532 | 0.196 | 0.0412 | No |
| 5 | MGLL | MGLL Entrez, Source | monoglyceride lipase | 754 | 0.167 | 0.0372 | No |
| 6 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 901 | 0.153 | 0.0379 | No |
| 7 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 986 | 0.146 | 0.0427 | No |
| 8 | SAA4 | SAA4 Entrez, Source | serum amyloid A4, constitutive | 1024 | 0.143 | 0.0508 | No |
| 9 | FKBP4 | FKBP4 Entrez, Source | FK506 binding protein 4, 59kDa | 1164 | 0.132 | 0.0504 | No |
| 10 | FGFBP1 | FGFBP1 Entrez, Source | fibroblast growth factor binding protein 1 | 1310 | 0.124 | 0.0489 | No |
| 11 | LIF | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 1372 | 0.121 | 0.0535 | No |
| 12 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1609 | 0.108 | 0.0439 | No |
| 13 | IL4R | IL4R Entrez, Source | interleukin 4 receptor | 1697 | 0.105 | 0.0454 | No |
| 14 | PHLDA1 | PHLDA1 Entrez, Source | pleckstrin homology-like domain, family A, member 1 | 1708 | 0.105 | 0.0526 | No |
| 15 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 1781 | 0.102 | 0.0550 | No |
| 16 | AREG | AREG Entrez, Source | amphiregulin (schwannoma-derived growth factor) | 1999 | 0.094 | 0.0458 | No |
| 17 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 2125 | 0.090 | 0.0432 | No |
| 18 | NOL5A | NOL5A Entrez, Source | nucleolar protein 5A (56kDa with KKE/D repeat) | 2257 | 0.086 | 0.0399 | No |
| 19 | AMD1 | AMD1 Entrez, Source | adenosylmethionine decarboxylase 1 | 2566 | 0.078 | 0.0226 | No |
| 20 | PPAT | PPAT Entrez, Source | phosphoribosyl pyrophosphate amidotransferase | 2613 | 0.076 | 0.0249 | No |
| 21 | SOX9 | SOX9 Entrez, Source | SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal) | 2781 | 0.072 | 0.0178 | No |
| 22 | NOS1 | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 2908 | 0.069 | 0.0135 | No |
| 23 | UBE2N | UBE2N Entrez, Source | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 2977 | 0.067 | 0.0135 | No |
| 24 | ACOT7 | ACOT7 Entrez, Source | acyl-CoA thioesterase 7 | 3055 | 0.065 | 0.0127 | No |
| 25 | HS3ST1 | HS3ST1 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 3289 | 0.060 | -0.0003 | No |
| 26 | SDC4 | SDC4 Entrez, Source | syndecan 4 (amphiglycan, ryudocan) | 3350 | 0.059 | -0.0003 | No |
| 27 | EHD1 | EHD1 Entrez, Source | EH-domain containing 1 | 3447 | 0.057 | -0.0033 | No |
| 28 | PPP1R10 | PPP1R10 Entrez, Source | protein phosphatase 1, regulatory subunit 10 | 4035 | 0.046 | -0.0441 | No |
| 29 | CYP27B1 | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 4218 | 0.043 | -0.0546 | No |
| 30 | SPP1 | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 4327 | 0.041 | -0.0596 | No |
| 31 | PDLIM4 | PDLIM4 Entrez, Source | PDZ and LIM domain 4 | 4357 | 0.040 | -0.0588 | No |
| 32 | DUSP4 | DUSP4 Entrez, Source | dual specificity phosphatase 4 | 4576 | 0.037 | -0.0724 | No |
| 33 | PTHLH | PTHLH Entrez, Source | parathyroid hormone-like hormone | 5115 | 0.027 | -0.1110 | No |
| 34 | AKAP12 | AKAP12 Entrez, Source | A kinase (PRKA) anchor protein (gravin) 12 | 5319 | 0.024 | -0.1244 | No |
| 35 | TFPI2 | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 5729 | 0.018 | -0.1539 | No |
| 36 | FASLG | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 6273 | 0.010 | -0.1941 | No |
| 37 | LCN2 | LCN2 Entrez, Source | lipocalin 2 (oncogene 24p3) | 6284 | 0.010 | -0.1941 | No |
| 38 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 6332 | 0.009 | -0.1970 | No |
| 39 | MSLN | MSLN Entrez, Source | mesothelin | 6411 | 0.008 | -0.2023 | No |
| 40 | ZFP36L2 | ZFP36L2 Entrez, Source | zinc finger protein 36, C3H type-like 2 | 6635 | 0.005 | -0.2187 | No |
| 41 | DUSP1 | DUSP1 Entrez, Source | dual specificity phosphatase 1 | 6673 | 0.004 | -0.2212 | No |
| 42 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 6707 | 0.004 | -0.2234 | No |
| 43 | PRPS1 | PRPS1 Entrez, Source | phosphoribosyl pyrophosphate synthetase 1 | 6821 | 0.002 | -0.2318 | No |
| 44 | CA2 | CA2 Entrez, Source | carbonic anhydrase II | 7159 | -0.002 | -0.2570 | No |
| 45 | COMMD10 | COMMD10 Entrez, Source | COMM domain containing 10 | 7320 | -0.005 | -0.2687 | No |
| 46 | RPL15 | RPL15 Entrez, Source | ribosomal protein L15 | 7353 | -0.005 | -0.2708 | No |
| 47 | UBE2A | UBE2A Entrez, Source | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 7458 | -0.007 | -0.2781 | No |
| 48 | HNRPAB | HNRPAB Entrez, Source | heterogeneous nuclear ribonucleoprotein A/B | 7472 | -0.007 | -0.2785 | No |
| 49 | MT3 | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 7492 | -0.007 | -0.2794 | No |
| 50 | NR4A3 | NR4A3 Entrez, Source | nuclear receptor subfamily 4, group A, member 3 | 7647 | -0.010 | -0.2903 | No |
| 51 | CCNC | CCNC Entrez, Source | cyclin C | 7782 | -0.012 | -0.2995 | No |
| 52 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 8308 | -0.020 | -0.3376 | No |
| 53 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 8319 | -0.020 | -0.3368 | No |
| 54 | CDK9 | CDK9 Entrez, Source | cyclin-dependent kinase 9 (CDC2-related kinase) | 8367 | -0.021 | -0.3388 | No |
| 55 | CORO1A | CORO1A Entrez, Source | coronin, actin binding protein, 1A | 8440 | -0.022 | -0.3426 | No |
| 56 | MMP3 | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 8953 | -0.031 | -0.3788 | No |
| 57 | IER3 | IER3 Entrez, Source | immediate early response 3 | 9311 | -0.038 | -0.4029 | No |
| 58 | EREG | EREG Entrez, Source | epiregulin | 9343 | -0.039 | -0.4023 | No |
| 59 | TUBG1 | TUBG1 Entrez, Source | tubulin, gamma 1 | 9358 | -0.039 | -0.4004 | No |
| 60 | SERPINB2 | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 9372 | -0.039 | -0.3984 | No |
| 61 | SNAI1 | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 9442 | -0.040 | -0.4005 | No |
| 62 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 9556 | -0.043 | -0.4058 | No |
| 63 | PPP2R1A | PPP2R1A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform | 9862 | -0.049 | -0.4250 | No |
| 64 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 9946 | -0.051 | -0.4274 | No |
| 65 | ESR1 | ESR1 Entrez, Source | estrogen receptor 1 | 9961 | -0.051 | -0.4246 | No |
| 66 | BZW1 | BZW1 Entrez, Source | basic leucine zipper and W2 domains 1 | 10041 | -0.053 | -0.4265 | No |
| 67 | HNRPK | HNRPK Entrez, Source | heterogeneous nuclear ribonucleoprotein K | 10138 | -0.055 | -0.4295 | No |
| 68 | TGM2 | TGM2 Entrez, Source | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 10171 | -0.056 | -0.4277 | No |
| 69 | CLDN4 | CLDN4 Entrez, Source | claudin 4 | 10487 | -0.064 | -0.4466 | No |
| 70 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 10498 | -0.064 | -0.4424 | No |
| 71 | HPRT1 | HPRT1 Entrez, Source | hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) | 10730 | -0.071 | -0.4545 | No |
| 72 | MAPT | MAPT Entrez, Source | microtubule-associated protein tau | 10830 | -0.073 | -0.4564 | No |
| 73 | AR | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 10940 | -0.077 | -0.4587 | No |
| 74 | HAS2 | HAS2 Entrez, Source | hyaluronan synthase 2 | 11211 | -0.086 | -0.4726 | No |
| 75 | DKK3 | DKK3 Entrez, Source | dickkopf homolog 3 (Xenopus laevis) | 11419 | -0.096 | -0.4809 | No |
| 76 | HPCAL1 | HPCAL1 Entrez, Source | hippocalcin-like 1 | 11438 | -0.097 | -0.4749 | No |
| 77 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 11671 | -0.108 | -0.4842 | No |
| 78 | DUSP6 | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 11745 | -0.111 | -0.4812 | No |
| 79 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11886 | -0.118 | -0.4827 | No |
| 80 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 12112 | -0.132 | -0.4897 | No |
| 81 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 12376 | -0.156 | -0.4976 | Yes |
| 82 | MET | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 12449 | -0.164 | -0.4906 | Yes |
| 83 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 12465 | -0.166 | -0.4791 | Yes |
| 84 | SPRY2 | SPRY2 Entrez, Source | sprouty homolog 2 (Drosophila) | 12553 | -0.179 | -0.4720 | Yes |
| 85 | CAV2 | CAV2 Entrez, Source | caveolin 2 | 12694 | -0.203 | -0.4670 | Yes |
| 86 | BUB1B | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 12774 | -0.218 | -0.4564 | Yes |
| 87 | PLCG1 | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 12798 | -0.224 | -0.4410 | Yes |
| 88 | HBEGF | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 12819 | -0.229 | -0.4250 | Yes |
| 89 | ZYX | ZYX Entrez, Source | zyxin | 12928 | -0.262 | -0.4132 | Yes |
| 90 | CXCL5 | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 12997 | -0.289 | -0.3963 | Yes |
| 91 | TUBB | TUBB Entrez, Source | tubulin, beta | 13001 | -0.292 | -0.3743 | Yes |
| 92 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13085 | -0.343 | -0.3544 | Yes |
| 93 | EMP1 | EMP1 Entrez, Source | epithelial membrane protein 1 | 13109 | -0.363 | -0.3284 | Yes |
| 94 | VIM | VIM Entrez, Source | vimentin | 13227 | -0.506 | -0.2987 | Yes |
| 95 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 13260 | -0.571 | -0.2575 | Yes |
| 96 | GPRC5A | GPRC5A Entrez, Source | G protein-coupled receptor, family C, group 5, member A | 13289 | -0.705 | -0.2058 | Yes |
| 97 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13336 | -1.272 | -0.1122 | Yes |
| 98 | TAGLN | TAGLN Entrez, Source | transgelin | 13339 | -1.475 | 0.0002 | Yes |
