Details for gene set ORGANIC_ACID_METABOLIC

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos
Phenotype	class.cls#double_gel_72h_versus_single_gel_72h_repos
Upregulated in class	double_gel_72h
GeneSet	ORGANIC_ACID_METABOLIC_PROCESS
Enrichment Score (ES)	0.63714945
Normalized Enrichment Score (NES)	2.5360432
Nominal p-value	0.0
FDR q-value	0.0
FWER p-Value	0.0

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SLC27A5	SLC27A5 Entrez, Source	solute carrier family 27 (fatty acid transporter), member 5	9	0.779	0.0355	Yes
2	BBOX1	BBOX1 Entrez, Source	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	13	0.740	0.0696	Yes
3	FTCD	FTCD Entrez, Source	formiminotransferase cyclodeaminase	15	0.731	0.1035	Yes
4	GLYAT	GLYAT Entrez, Source	glycine-N-acyltransferase	33	0.554	0.1280	Yes
5	HACL1	HACL1 Entrez, Source	2-hydroxyacyl-CoA lyase 1	54	0.488	0.1492	Yes
6	CDO1	CDO1 Entrez, Source	cysteine dioxygenase, type I	58	0.484	0.1714	Yes
7	ACOX2	ACOX2 Entrez, Source	acyl-Coenzyme A oxidase 2, branched chain	95	0.419	0.1882	Yes
8	GOT1	GOT1 Entrez, Source	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	110	0.403	0.2058	Yes
9	HGD	HGD Entrez, Source	homogentisate 1,2-dioxygenase (homogentisate oxidase)	126	0.385	0.2226	Yes
10	AGXT	AGXT Entrez, Source	alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)	128	0.384	0.2403	Yes
11	GCK	GCK Entrez, Source	glucokinase (hexokinase 4, maturity onset diabetes of the young 2)	140	0.368	0.2566	Yes
12	ARG1	ARG1 Entrez, Source	arginase, liver	145	0.358	0.2729	Yes
13	FADS2	FADS2 Entrez, Source	fatty acid desaturase 2	182	0.324	0.2852	Yes
14	ASL	ASL Entrez, Source	argininosuccinate lyase	183	0.323	0.3003	Yes
15	ACLY	ACLY Entrez, Source	ATP citrate lyase	212	0.305	0.3123	Yes
16	FAH	FAH Entrez, Source	fumarylacetoacetate hydrolase (fumarylacetoacetase)	219	0.299	0.3258	Yes
17	PFKFB1	PFKFB1 Entrez, Source	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	230	0.293	0.3386	Yes
18	AS3MT	AS3MT Entrez, Source	arsenic (+3 oxidation state) methyltransferase	242	0.289	0.3512	Yes
19	NR1H4	NR1H4 Entrez, Source	nuclear receptor subfamily 1, group H, member 4	246	0.288	0.3644	Yes
20	ACN9	ACN9 Entrez, Source	ACN9 homolog (S. cerevisiae)	284	0.273	0.3742	Yes
21	GAMT	GAMT Entrez, Source	guanidinoacetate N-methyltransferase	295	0.267	0.3859	Yes
22	MAT1A	MAT1A Entrez, Source	methionine adenosyltransferase I, alpha	315	0.262	0.3966	Yes
23	SLC7A7	SLC7A7 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	320	0.260	0.4084	Yes
24	GLS2	GLS2 Entrez, Source	glutaminase 2 (liver, mitochondrial)	341	0.252	0.4186	Yes
25	SLC25A10	SLC25A10 Entrez, Source	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	378	0.240	0.4270	Yes
26	TST	TST Entrez, Source	thiosulfate sulfurtransferase (rhodanese)	388	0.235	0.4372	Yes
27	MSRA	MSRA Entrez, Source	methionine sulfoxide reductase A	428	0.222	0.4446	Yes
28	SC4MOL	SC4MOL Entrez, Source	sterol-C4-methyl oxidase-like	444	0.218	0.4536	Yes
29	ALDH6A1	ALDH6A1 Entrez, Source	aldehyde dehydrogenase 6 family, member A1	445	0.217	0.4637	Yes
30	SCLY	SCLY Entrez, Source	selenocysteine lyase	454	0.214	0.4730	Yes
31	ALDH1L1	ALDH1L1 Entrez, Source	aldehyde dehydrogenase 1 family, member L1	465	0.211	0.4821	Yes
32	ACADVL	ACADVL Entrez, Source	acyl-Coenzyme A dehydrogenase, very long chain	482	0.207	0.4905	Yes
33	HAO2	HAO2 Entrez, Source	hydroxyacid oxidase 2 (long chain)	536	0.195	0.4955	Yes
34	FAAH	FAAH Entrez, Source	fatty acid amide hydrolase	553	0.192	0.5032	Yes
35	SLC25A15	SLC25A15 Entrez, Source	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	595	0.186	0.5088	Yes
36	BAAT	BAAT Entrez, Source	bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	597	0.186	0.5174	Yes
37	GNE	GNE Entrez, Source	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	599	0.186	0.5259	Yes
38	ALDH5A1	ALDH5A1 Entrez, Source	aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)	612	0.184	0.5336	Yes
39	ACOT12	ACOT12 Entrez, Source	acyl-CoA thioesterase 12	619	0.184	0.5417	Yes
40	PAH	PAH Entrez, Source	phenylalanine hydroxylase	628	0.182	0.5496	Yes
41	ECHS1	ECHS1 Entrez, Source	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	633	0.182	0.5577	Yes
42	BCKDHB	BCKDHB Entrez, Source	branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)	651	0.179	0.5647	Yes
43	BCKDHA	BCKDHA Entrez, Source	branched chain keto acid dehydrogenase E1, alpha polypeptide	662	0.178	0.5723	Yes
44	SLC7A2	SLC7A2 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	776	0.165	0.5713	Yes
45	ME1	ME1 Entrez, Source	malic enzyme 1, NADP(+)-dependent, cytosolic	800	0.163	0.5772	Yes
46	GCSH	GCSH Entrez, Source	glycine cleavage system protein H (aminomethyl carrier)	816	0.161	0.5835	Yes
47	GCLC	GCLC Entrez, Source	glutamate-cysteine ligase, catalytic subunit	823	0.160	0.5905	Yes
48	BCKDK	BCKDK Entrez, Source	branched chain ketoacid dehydrogenase kinase	868	0.156	0.5944	Yes
49	CYP4F2	CYP4F2 Entrez, Source	cytochrome P450, family 4, subfamily F, polypeptide 2	933	0.150	0.5965	Yes
50	UGDH	UGDH Entrez, Source	UDP-glucose dehydrogenase	951	0.149	0.6022	Yes
51	YARS	YARS Entrez, Source	tyrosyl-tRNA synthetase	984	0.146	0.6065	Yes
52	CPT1A	CPT1A Entrez, Source	carnitine palmitoyltransferase 1A (liver)	1046	0.140	0.6084	Yes
53	PECI	PECI Entrez, Source	peroxisomal D3,D2-enoyl-CoA isomerase	1151	0.133	0.6068	Yes
54	PPARA	PPARA Entrez, Source	peroxisome proliferative activated receptor, alpha	1252	0.127	0.6051	Yes
55	PPARD	PPARD Entrez, Source	peroxisome proliferative activated receptor, delta	1387	0.119	0.6005	Yes
56	AMT	AMT Entrez, Source	aminomethyltransferase	1397	0.119	0.6053	Yes
57	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	1471	0.115	0.6051	Yes
58	ACADSB	ACADSB Entrez, Source	acyl-Coenzyme A dehydrogenase, short/branched chain	1480	0.114	0.6098	Yes
59	IDH1	IDH1 Entrez, Source	isocitrate dehydrogenase 1 (NADP+), soluble	1494	0.114	0.6141	Yes
60	FADS1	FADS1 Entrez, Source	fatty acid desaturase 1	1495	0.114	0.6194	Yes
61	CD74	CD74 Entrez, Source	CD74 molecule, major histocompatibility complex, class II invariant chain	1524	0.112	0.6225	Yes
62	HDC	HDC Entrez, Source	histidine decarboxylase	1527	0.112	0.6275	Yes
63	QDPR	QDPR Entrez, Source	quinoid dihydropteridine reductase	1560	0.110	0.6302	Yes
64	ASRGL1	ASRGL1 Entrez, Source	asparaginase like 1	1612	0.108	0.6314	Yes
65	NANP	NANP Entrez, Source	N-acetylneuraminic acid phosphatase	1648	0.107	0.6337	Yes
66	MLYCD	MLYCD Entrez, Source	malonyl-CoA decarboxylase	1678	0.106	0.6364	Yes
67	ASPA	ASPA Entrez, Source	aspartoacylase (Canavan disease)	1733	0.104	0.6371	Yes
68	GCLM	GCLM Entrez, Source	glutamate-cysteine ligase, modifier subunit	1840	0.100	0.6338	No
69	AKR1D1	AKR1D1 Entrez, Source	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	1859	0.099	0.6370	No
70	ABCD2	ABCD2 Entrez, Source	ATP-binding cassette, sub-family D (ALD), member 2	1926	0.096	0.6365	No
71	NFS1	NFS1 Entrez, Source	NFS1 nitrogen fixation 1 (S. cerevisiae)	2100	0.091	0.6276	No
72	ADI1	ADI1 Entrez, Source	acireductone dioxygenase 1	2159	0.089	0.6274	No
73	ACO1	ACO1 Entrez, Source	aconitase 1, soluble	2259	0.086	0.6239	No
74	PTS	PTS Entrez, Source	6-pyruvoyltetrahydropterin synthase	2407	0.082	0.6166	No
75	CPT1B	CPT1B Entrez, Source	carnitine palmitoyltransferase 1B (muscle)	2496	0.080	0.6136	No
76	ADIPOR2	ADIPOR2 Entrez, Source	adiponectin receptor 2	2598	0.076	0.6095	No
77	IDH3B	IDH3B Entrez, Source	isocitrate dehydrogenase 3 (NAD+) beta	2648	0.075	0.6093	No
78	ACOX3	ACOX3 Entrez, Source	acyl-Coenzyme A oxidase 3, pristanoyl	3046	0.066	0.5823	No
79	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	3058	0.065	0.5845	No
80	TNFRSF1A	TNFRSF1A Entrez, Source	tumor necrosis factor receptor superfamily, member 1A	3063	0.065	0.5872	No
81	ACO2	ACO2 Entrez, Source	aconitase 2, mitochondrial	3136	0.064	0.5847	No
82	GNPAT	GNPAT Entrez, Source	glyceronephosphate O-acyltransferase	3398	0.058	0.5676	No
83	MCCC2	MCCC2 Entrez, Source	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	3517	0.056	0.5613	No
84	ACOT2	ACOT2 Entrez, Source	acyl-CoA thioesterase 2	3642	0.053	0.5544	No
85	GGTLA1	GGTLA1 Entrez, Source	gamma-glutamyltransferase-like activity 1	3715	0.052	0.5513	No
86	MPST	MPST Entrez, Source	mercaptopyruvate sulfurtransferase	3883	0.049	0.5409	No
87	GSS	GSS Entrez, Source	glutathione synthetase	4011	0.046	0.5335	No
88	AGPAT1	AGPAT1 Entrez, Source	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)	4028	0.046	0.5344	No
89	GAD1	GAD1 Entrez, Source	glutamate decarboxylase 1 (brain, 67kDa)	4162	0.044	0.5263	No
90	AARS	AARS Entrez, Source	alanyl-tRNA synthetase	4275	0.042	0.5198	No
91	ACADM	ACADM Entrez, Source	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	4299	0.041	0.5200	No
92	BRCA1	BRCA1 Entrez, Source	breast cancer 1, early onset	4326	0.041	0.5199	No
93	HPD	HPD Entrez, Source	4-hydroxyphenylpyruvate dioxygenase	4383	0.040	0.5175	No
94	SLC7A5	SLC7A5 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	4470	0.038	0.5128	No
95	HADHB	HADHB Entrez, Source	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit	4675	0.035	0.4989	No
96	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	4803	0.032	0.4908	No
97	PTGS1	PTGS1 Entrez, Source	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	4887	0.031	0.4860	No
98	ARPP-19	ARPP-19 Entrez, Source	-	5020	0.029	0.4773	No
99	GLUD1	GLUD1 Entrez, Source	glutamate dehydrogenase 1	5087	0.028	0.4736	No
100	PTGES	PTGES Entrez, Source	prostaglandin E synthase	5602	0.020	0.4357	No
101	ECH1	ECH1 Entrez, Source	enoyl Coenzyme A hydratase 1, peroxisomal	5859	0.016	0.4170	No
102	ACADS	ACADS Entrez, Source	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain	5886	0.016	0.4158	No
103	GOT2	GOT2 Entrez, Source	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	5916	0.015	0.4143	No
104	SCYE1	SCYE1 Entrez, Source	small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)	6040	0.014	0.4057	No
105	DARS	DARS Entrez, Source	aspartyl-tRNA synthetase	6478	0.007	0.3729	No
106	GGT1	GGT1 Entrez, Source	gamma-glutamyltransferase 1	6489	0.007	0.3724	No
107	PTGDS	PTGDS Entrez, Source	prostaglandin D2 synthase 21kDa (brain)	6738	0.003	0.3538	No
108	KARS	KARS Entrez, Source	lysyl-tRNA synthetase	7266	-0.004	0.3141	No
109	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	7269	-0.004	0.3141	No
110	SLC3A1	SLC3A1 Entrez, Source	1	7374	-0.006	0.3065	No
111	PPARGC1A	PPARGC1A Entrez, Source	peroxisome proliferative activated receptor, gamma, coactivator 1, alpha	8036	-0.015	0.2572	No
112	HSD3B7	HSD3B7 Entrez, Source	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	8089	-0.016	0.2540	No
113	SLC7A8	SLC7A8 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	8292	-0.020	0.2396	No
114	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	8460	-0.022	0.2280	No
115	SDS	SDS Entrez, Source	serine dehydratase	8683	-0.026	0.2124	No
116	INDO	INDO Entrez, Source	indoleamine-pyrrole 2,3 dioxygenase	9012	-0.032	0.1891	No
117	CYP7B1	CYP7B1 Entrez, Source	cytochrome P450, family 7, subfamily B, polypeptide 1	9114	-0.034	0.1831	No
118	FARS2	FARS2 Entrez, Source	phenylalanine-tRNA synthetase 2 (mitochondrial)	9209	-0.036	0.1776	No
119	MIF	MIF Entrez, Source	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	9316	-0.038	0.1714	No
120	SLC7A9	SLC7A9 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	9816	-0.048	0.1358	No
121	LTA4H	LTA4H Entrez, Source	leukotriene A4 hydrolase	10430	-0.062	0.0923	No
122	GAD2	GAD2 Entrez, Source	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	10797	-0.072	0.0680	No
123	WARS	WARS Entrez, Source	tryptophanyl-tRNA synthetase	10801	-0.073	0.0711	No
124	DEGS1	DEGS1 Entrez, Source	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	11324	-0.092	0.0359	No
125	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	11580	-0.103	0.0214	No
126	CROT	CROT Entrez, Source	carnitine O-octanoyltransferase	11691	-0.109	0.0181	No
127	PLOD1	PLOD1 Entrez, Source	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	12626	-0.189	-0.0439	No
128	DDAH2	DDAH2 Entrez, Source	dimethylarginine dimethylaminohydrolase 2	12900	-0.253	-0.0528	No
129	LYPLA3	LYPLA3 Entrez, Source	lysophospholipase 3 (lysosomal phospholipase A2)	12939	-0.266	-0.0433	No
130	SLC6A6	SLC6A6 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	13097	-0.354	-0.0387	No
131	DDAH1	DDAH1 Entrez, Source	dimethylarginine dimethylaminohydrolase 1	13118	-0.367	-0.0232	No
132	SMS	SMS Entrez, Source	spermine synthase	13163	-0.420	-0.0070	No
133	BCAT1	BCAT1 Entrez, Source	branched chain aminotransferase 1, cytosolic	13181	-0.442	0.0122	No