Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | P53_SIGNALING |
| Enrichment Score (ES) | -0.5687662 |
| Normalized Enrichment Score (NES) | -1.8454393 |
| Nominal p-value | 0.0017006802 |
| FDR q-value | 0.028411856 |
| FWER p-Value | 0.84 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | NDRG2 | NDRG2 Entrez, Source | NDRG family member 2 | 610 | 0.185 | -0.0145 | No |
| 2 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1609 | 0.108 | -0.0712 | No |
| 3 | CCNH | CCNH Entrez, Source | cyclin H | 1938 | 0.096 | -0.0795 | No |
| 4 | PRKCB1 | PRKCB1 Entrez, Source | protein kinase C, beta 1 | 2401 | 0.082 | -0.1003 | No |
| 5 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2765 | 0.072 | -0.1153 | No |
| 6 | TEAD1 | TEAD1 Entrez, Source | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 3114 | 0.064 | -0.1307 | No |
| 7 | PRKCA | PRKCA Entrez, Source | protein kinase C, alpha | 3999 | 0.046 | -0.1893 | No |
| 8 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 4326 | 0.041 | -0.2069 | No |
| 9 | TBP | TBP Entrez, Source | TATA box binding protein | 4369 | 0.040 | -0.2033 | No |
| 10 | CSNK2B | CSNK2B Entrez, Source | casein kinase 2, beta polypeptide | 4466 | 0.038 | -0.2040 | No |
| 11 | THRA | THRA Entrez, Source | thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) | 4857 | 0.032 | -0.2280 | No |
| 12 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 5011 | 0.029 | -0.2346 | No |
| 13 | WT1 | WT1 Entrez, Source | Wilms tumor 1 | 5408 | 0.023 | -0.2605 | No |
| 14 | FAF1 | FAF1 Entrez, Source | Fas (TNFRSF6) associated factor 1 | 5927 | 0.015 | -0.2969 | No |
| 15 | APEX1 | APEX1 Entrez, Source | APEX nuclease (multifunctional DNA repair enzyme) 1 | 6037 | 0.014 | -0.3027 | No |
| 16 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6158 | 0.012 | -0.3097 | No |
| 17 | EI24 | EI24 Entrez, Source | etoposide induced 2.4 mRNA | 6663 | 0.004 | -0.3469 | No |
| 18 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 6739 | 0.003 | -0.3520 | No |
| 19 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 6755 | 0.003 | -0.3526 | No |
| 20 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 6861 | 0.002 | -0.3602 | No |
| 21 | MAP2K4 | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 7050 | -0.001 | -0.3741 | No |
| 22 | MAPK8IP2 | MAPK8IP2 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 2 | 7361 | -0.005 | -0.3965 | No |
| 23 | RPL13A | RPL13A Entrez, Source | ribosomal protein L13a | 7446 | -0.007 | -0.4017 | No |
| 24 | NUMB | NUMB Entrez, Source | numb homolog (Drosophila) | 7901 | -0.014 | -0.4336 | No |
| 25 | STAT5A | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 8113 | -0.016 | -0.4467 | No |
| 26 | SP1 | SP1 Entrez, Source | Sp1 transcription factor | 8115 | -0.016 | -0.4439 | No |
| 27 | PPIA | PPIA Entrez, Source | peptidylprolyl isomerase A (cyclophilin A) | 8225 | -0.018 | -0.4490 | No |
| 28 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 8319 | -0.020 | -0.4526 | No |
| 29 | CDK7 | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 8462 | -0.022 | -0.4595 | No |
| 30 | DAXX | DAXX Entrez, Source | death-associated protein 6 | 8480 | -0.023 | -0.4569 | No |
| 31 | PMP22 | PMP22 Entrez, Source | peripheral myelin protein 22 | 8539 | -0.024 | -0.4573 | No |
| 32 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 8561 | -0.024 | -0.4547 | No |
| 33 | CSNK2A1 | CSNK2A1 Entrez, Source | casein kinase 2, alpha 1 polypeptide | 8665 | -0.026 | -0.4581 | No |
| 34 | CTSD | CTSD Entrez, Source | cathepsin D (lysosomal aspartyl peptidase) | 8727 | -0.027 | -0.4581 | No |
| 35 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 8887 | -0.030 | -0.4651 | No |
| 36 | CSNK1A1 | CSNK1A1 Entrez, Source | casein kinase 1, alpha 1 | 9528 | -0.042 | -0.5061 | No |
| 37 | SERPINB5 | SERPINB5 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 9769 | -0.047 | -0.5161 | No |
| 38 | BAX | BAX Entrez, Source | BCL2-associated X protein | 9773 | -0.047 | -0.5083 | No |
| 39 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 9946 | -0.051 | -0.5126 | No |
| 40 | ESR1 | ESR1 Entrez, Source | estrogen receptor 1 | 9961 | -0.051 | -0.5049 | No |
| 41 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 10137 | -0.055 | -0.5087 | No |
| 42 | PCAF | PCAF Entrez, Source | p300/CBP-associated factor | 10191 | -0.056 | -0.5031 | No |
| 43 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 10518 | -0.065 | -0.5167 | No |
| 44 | PRKCQ | PRKCQ Entrez, Source | protein kinase C, theta | 10994 | -0.078 | -0.5391 | No |
| 45 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 11002 | -0.079 | -0.5263 | No |
| 46 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 11146 | -0.083 | -0.5229 | No |
| 47 | ACTB | ACTB Entrez, Source | actin, beta | 11552 | -0.102 | -0.5360 | No |
| 48 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 11988 | -0.124 | -0.5477 | Yes |
| 49 | NDRG4 | NDRG4 Entrez, Source | NDRG family member 4 | 12261 | -0.145 | -0.5436 | Yes |
| 50 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 12376 | -0.156 | -0.5257 | Yes |
| 51 | CHEK2 | CHEK2 Entrez, Source | CHK2 checkpoint homolog (S. pombe) | 12445 | -0.163 | -0.5031 | Yes |
| 52 | HIF1A | HIF1A Entrez, Source | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 12528 | -0.175 | -0.4794 | Yes |
| 53 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12725 | -0.209 | -0.4587 | Yes |
| 54 | HSPA4 | HSPA4 Entrez, Source | heat shock 70kDa protein 4 | 13114 | -0.366 | -0.4256 | Yes |
| 55 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 13156 | -0.411 | -0.3589 | Yes |
| 56 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 13266 | -0.607 | -0.2639 | Yes |
| 57 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13340 | -1.586 | 0.0002 | Yes |
