Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | SERUM_FIBROBLAST_CORE_UP |
| Enrichment Score (ES) | -0.50424755 |
| Normalized Enrichment Score (NES) | -1.7898588 |
| Nominal p-value | 0.0016528926 |
| FDR q-value | 0.038961045 |
| FWER p-Value | 0.984 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | DHFR | DHFR Entrez, Source | dihydrofolate reductase | 291 | 0.268 | 0.0015 | No |
| 2 | MTHFD1 | MTHFD1 Entrez, Source | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 405 | 0.229 | 0.0130 | No |
| 3 | MAP3K8 | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 950 | 0.149 | -0.0151 | No |
| 4 | SAR1B | SAR1B Entrez, Source | SAR1 gene homolog B (S. cerevisiae) | 968 | 0.148 | -0.0035 | No |
| 5 | FLNC | FLNC Entrez, Source | filamin C, gamma (actin binding protein 280) | 1014 | 0.144 | 0.0057 | No |
| 6 | PDIA4 | PDIA4 Entrez, Source | protein disulfide isomerase family A, member 4 | 1197 | 0.130 | 0.0033 | No |
| 7 | MCTS1 | MCTS1 Entrez, Source | malignant T cell amplified sequence 1 | 1519 | 0.112 | -0.0111 | No |
| 8 | MRPL12 | MRPL12 Entrez, Source | mitochondrial ribosomal protein L12 | 1652 | 0.107 | -0.0118 | No |
| 9 | SNRPA | SNRPA Entrez, Source | small nuclear ribonucleoprotein polypeptide A | 2182 | 0.089 | -0.0440 | No |
| 10 | EBNA1BP2 | EBNA1BP2 Entrez, Source | EBNA1 binding protein 2 | 2276 | 0.086 | -0.0435 | No |
| 11 | FARSLB | FARSLB Entrez, Source | phenylalanine-tRNA synthetase-like, beta subunit | 2367 | 0.084 | -0.0430 | No |
| 12 | PTS | PTS Entrez, Source | 6-pyruvoyltetrahydropterin synthase | 2407 | 0.082 | -0.0387 | No |
| 13 | HNRPA3 | HNRPA3 Entrez, Source | heterogeneous nuclear ribonucleoprotein A3 | 2440 | 0.081 | -0.0341 | No |
| 14 | SSR3 | SSR3 Entrez, Source | signal sequence receptor, gamma (translocon-associated protein gamma) | 2461 | 0.081 | -0.0285 | No |
| 15 | MKKS | MKKS Entrez, Source | McKusick-Kaufman syndrome | 2769 | 0.072 | -0.0454 | No |
| 16 | HMGN2 | HMGN2 Entrez, Source | high-mobility group nucleosomal binding domain 2 | 2936 | 0.068 | -0.0520 | No |
| 17 | UMPS | UMPS Entrez, Source | uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) | 3035 | 0.066 | -0.0536 | No |
| 18 | NCLN | NCLN Entrez, Source | nicalin homolog (zebrafish) | 3156 | 0.063 | -0.0572 | No |
| 19 | MRPL37 | MRPL37 Entrez, Source | mitochondrial ribosomal protein L37 | 3397 | 0.058 | -0.0702 | No |
| 20 | SLC25A5 | SLC25A5 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 3418 | 0.058 | -0.0667 | No |
| 21 | COPB2 | COPB2 Entrez, Source | coatomer protein complex, subunit beta 2 (beta prime) | 3627 | 0.053 | -0.0777 | No |
| 22 | RUVBL1 | RUVBL1 Entrez, Source | RuvB-like 1 (E. coli) | 3647 | 0.053 | -0.0745 | No |
| 23 | NUP35 | NUP35 Entrez, Source | nucleoporin 35kDa | 3698 | 0.052 | -0.0738 | No |
| 24 | CENPJ | CENPJ Entrez, Source | centromere protein J | 3740 | 0.051 | -0.0724 | No |
| 25 | RAB3B | RAB3B Entrez, Source | RAB3B, member RAS oncogene family | 3815 | 0.050 | -0.0737 | No |
| 26 | RPN1 | RPN1 Entrez, Source | ribophorin I | 4101 | 0.045 | -0.0913 | No |
| 27 | CEP78 | CEP78 Entrez, Source | centrosomal protein 78kDa | 4186 | 0.043 | -0.0939 | No |
| 28 | TDP1 | TDP1 Entrez, Source | tyrosyl-DNA phosphodiesterase 1 | 4272 | 0.042 | -0.0967 | No |
| 29 | LYAR | LYAR Entrez, Source | - | 4619 | 0.036 | -0.1197 | No |
| 30 | GPLD1 | GPLD1 Entrez, Source | glycosylphosphatidylinositol specific phospholipase D1 | 4695 | 0.034 | -0.1223 | No |
| 31 | TOMM40 | TOMM40 Entrez, Source | translocase of outer mitochondrial membrane 40 homolog (yeast) | 5228 | 0.026 | -0.1603 | No |
| 32 | PCSK7 | PCSK7 Entrez, Source | proprotein convertase subtilisin/kexin type 7 | 5310 | 0.025 | -0.1642 | No |
| 33 | TPRKB | TPRKB Entrez, Source | TP53RK binding protein | 5505 | 0.022 | -0.1770 | No |
| 34 | RNF138 | RNF138 Entrez, Source | ring finger protein 138 | 5579 | 0.021 | -0.1807 | No |
| 35 | DCLRE1B | DCLRE1B Entrez, Source | DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) | 5698 | 0.019 | -0.1880 | No |
| 36 | TFPI2 | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 5729 | 0.018 | -0.1887 | No |
| 37 | ST3GAL6 | ST3GAL6 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 5745 | 0.018 | -0.1882 | No |
| 38 | NUPL1 | NUPL1 Entrez, Source | nucleoporin like 1 | 5833 | 0.017 | -0.1933 | No |
| 39 | NUP93 | NUP93 Entrez, Source | nucleoporin 93kDa | 5890 | 0.016 | -0.1961 | No |
| 40 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 5924 | 0.015 | -0.1973 | No |
| 41 | SFRS2 | SFRS2 Entrez, Source | splicing factor, arginine/serine-rich 2 | 5972 | 0.015 | -0.1996 | No |
| 42 | WDR77 | WDR77 Entrez, Source | WD repeat domain 77 | 6730 | 0.003 | -0.2565 | No |
| 43 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 6773 | 0.003 | -0.2594 | No |
| 44 | PSMA7 | PSMA7 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 7 | 6888 | 0.001 | -0.2679 | No |
| 45 | EIF4EBP1 | EIF4EBP1 Entrez, Source | eukaryotic translation initiation factor 4E binding protein 1 | 6950 | 0.000 | -0.2724 | No |
| 46 | DCK | DCK Entrez, Source | deoxycytidine kinase | 6967 | 0.000 | -0.2736 | No |
| 47 | CDCA4 | CDCA4 Entrez, Source | cell division cycle associated 4 | 6971 | 0.000 | -0.2738 | No |
| 48 | POLE3 | POLE3 Entrez, Source | polymerase (DNA directed), epsilon 3 (p17 subunit) | 6995 | -0.000 | -0.2756 | No |
| 49 | TXNL2 | TXNL2 Entrez, Source | thioredoxin-like 2 | 7061 | -0.001 | -0.2804 | No |
| 50 | PSMD12 | PSMD12 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 7153 | -0.002 | -0.2870 | No |
| 51 | EIF4G1 | EIF4G1 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 1 | 7196 | -0.003 | -0.2899 | No |
| 52 | RUVBL2 | RUVBL2 Entrez, Source | RuvB-like 2 (E. coli) | 7409 | -0.006 | -0.3054 | No |
| 53 | HNRPAB | HNRPAB Entrez, Source | heterogeneous nuclear ribonucleoprotein A/B | 7472 | -0.007 | -0.3095 | No |
| 54 | MT3 | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 7492 | -0.007 | -0.3103 | No |
| 55 | WSB2 | WSB2 Entrez, Source | WD repeat and SOCS box-containing 2 | 7925 | -0.014 | -0.3417 | No |
| 56 | NUP107 | NUP107 Entrez, Source | nucleoporin 107kDa | 8038 | -0.015 | -0.3488 | No |
| 57 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 8216 | -0.018 | -0.3606 | No |
| 58 | HMGB1 | HMGB1 Entrez, Source | high-mobility group box 1 | 8508 | -0.023 | -0.3806 | No |
| 59 | PSMD2 | PSMD2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 8545 | -0.024 | -0.3812 | No |
| 60 | EPHB1 | EPHB1 Entrez, Source | EPH receptor B1 | 8589 | -0.025 | -0.3823 | No |
| 61 | RPP40 | RPP40 Entrez, Source | ribonuclease P 40kDa subunit | 8631 | -0.025 | -0.3832 | No |
| 62 | NLN | NLN Entrez, Source | neurolysin (metallopeptidase M3 family) | 8790 | -0.028 | -0.3927 | No |
| 63 | CCT5 | CCT5 Entrez, Source | chaperonin containing TCP1, subunit 5 (epsilon) | 9022 | -0.033 | -0.4073 | No |
| 64 | LYPLA2 | LYPLA2 Entrez, Source | lysophospholipase II | 9600 | -0.043 | -0.4470 | No |
| 65 | RNASEH2A | RNASEH2A Entrez, Source | ribonuclease H2, subunit A | 9648 | -0.045 | -0.4467 | No |
| 66 | PSMC3 | PSMC3 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 9750 | -0.047 | -0.4502 | No |
| 67 | SFRS10 | SFRS10 Entrez, Source | splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) | 9770 | -0.047 | -0.4476 | No |
| 68 | FABP5 | FABP5 Entrez, Source | fatty acid binding protein 5 (psoriasis-associated) | 9829 | -0.048 | -0.4477 | No |
| 69 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 9869 | -0.049 | -0.4464 | No |
| 70 | HNRPR | HNRPR Entrez, Source | heterogeneous nuclear ribonucleoprotein R | 10233 | -0.058 | -0.4687 | No |
| 71 | EMP2 | EMP2 Entrez, Source | epithelial membrane protein 2 | 10455 | -0.063 | -0.4799 | No |
| 72 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 10498 | -0.064 | -0.4775 | No |
| 73 | ACTL6A | ACTL6A Entrez, Source | actin-like 6A | 10539 | -0.065 | -0.4748 | No |
| 74 | SNRPB | SNRPB Entrez, Source | small nuclear ribonucleoprotein polypeptides B and B1 | 10738 | -0.071 | -0.4836 | No |
| 75 | DUT | DUT Entrez, Source | dUTP pyrophosphatase | 10990 | -0.078 | -0.4957 | No |
| 76 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 11071 | -0.081 | -0.4947 | No |
| 77 | GNG11 | GNG11 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 11 | 11199 | -0.086 | -0.4968 | Yes |
| 78 | HAS2 | HAS2 Entrez, Source | hyaluronan synthase 2 | 11211 | -0.086 | -0.4901 | Yes |
| 79 | NPTN | NPTN Entrez, Source | neuroplastin | 11383 | -0.094 | -0.4947 | Yes |
| 80 | SDC1 | SDC1 Entrez, Source | syndecan 1 | 11411 | -0.095 | -0.4885 | Yes |
| 81 | CLCF1 | CLCF1 Entrez, Source | cardiotrophin-like cytokine factor 1 | 11535 | -0.101 | -0.4889 | Yes |
| 82 | MNAT1 | MNAT1 Entrez, Source | menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) | 11555 | -0.102 | -0.4814 | Yes |
| 83 | STX3 | STX3 Entrez, Source | syntaxin 3 | 11595 | -0.104 | -0.4753 | Yes |
| 84 | TNFRSF12A | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 11673 | -0.108 | -0.4717 | Yes |
| 85 | PFN1 | PFN1 Entrez, Source | profilin 1 | 11762 | -0.112 | -0.4686 | Yes |
| 86 | CCDC5 | CCDC5 Entrez, Source | coiled-coil domain containing 5 (spindle associated) | 12034 | -0.127 | -0.4779 | Yes |
| 87 | MAPRE1 | MAPRE1 Entrez, Source | microtubule-associated protein, RP/EB family, member 1 | 12109 | -0.132 | -0.4720 | Yes |
| 88 | NUDT1 | NUDT1 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 12372 | -0.155 | -0.4782 | Yes |
| 89 | DCBLD2 | DCBLD2 Entrez, Source | discoidin, CUB and LCCL domain containing 2 | 12412 | -0.159 | -0.4672 | Yes |
| 90 | MCM7 | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 12413 | -0.160 | -0.4533 | Yes |
| 91 | GGH | GGH Entrez, Source | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 12437 | -0.162 | -0.4408 | Yes |
| 92 | MET | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 12449 | -0.164 | -0.4274 | Yes |
| 93 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 12464 | -0.165 | -0.4140 | Yes |
| 94 | RNF41 | RNF41 Entrez, Source | ring finger protein 41 | 12523 | -0.174 | -0.4031 | Yes |
| 95 | ACTC1 | ACTC1 Entrez, Source | actin, alpha, cardiac muscle 1 | 12692 | -0.203 | -0.3980 | Yes |
| 96 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12725 | -0.209 | -0.3822 | Yes |
| 97 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12855 | -0.239 | -0.3710 | Yes |
| 98 | PFKP | PFKP Entrez, Source | phosphofructokinase, platelet | 13129 | -0.381 | -0.3583 | Yes |
| 99 | SMS | SMS Entrez, Source | spermine synthase | 13163 | -0.420 | -0.3241 | Yes |
| 100 | PDLIM7 | PDLIM7 Entrez, Source | PDZ and LIM domain 7 (enigma) | 13173 | -0.431 | -0.2871 | Yes |
| 101 | VIL2 | VIL2 Entrez, Source | villin 2 (ezrin) | 13200 | -0.467 | -0.2482 | Yes |
| 102 | ID3 | ID3 Entrez, Source | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 13204 | -0.471 | -0.2073 | Yes |
| 103 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 13266 | -0.607 | -0.1588 | Yes |
| 104 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 13308 | -0.800 | -0.0920 | Yes |
| 105 | MSN | MSN Entrez, Source | moesin | 13329 | -1.080 | 0.0010 | Yes |
