Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | TGFBETA_ALL_UP |
| Enrichment Score (ES) | -0.6457988 |
| Normalized Enrichment Score (NES) | -2.008891 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.005872251 |
| FWER p-Value | 0.14 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 391 | 0.235 | 0.0003 | No |
| 2 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 473 | 0.209 | 0.0207 | No |
| 3 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 1644 | 0.107 | -0.0537 | No |
| 4 | LRP1 | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 2212 | 0.088 | -0.0853 | No |
| 5 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 2800 | 0.071 | -0.1204 | No |
| 6 | DVL1 | DVL1 Entrez, Source | dishevelled, dsh homolog 1 (Drosophila) | 2814 | 0.071 | -0.1123 | No |
| 7 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 3018 | 0.066 | -0.1192 | No |
| 8 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 3063 | 0.065 | -0.1143 | No |
| 9 | COL16A1 | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 3121 | 0.064 | -0.1105 | No |
| 10 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 3728 | 0.051 | -0.1496 | No |
| 11 | NOTCH2 | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 3989 | 0.047 | -0.1632 | No |
| 12 | IGFBP5 | IGFBP5 Entrez, Source | insulin-like growth factor binding protein 5 | 4057 | 0.045 | -0.1626 | No |
| 13 | WNT2B | WNT2B Entrez, Source | wingless-type MMTV integration site family, member 2B | 4771 | 0.033 | -0.2120 | No |
| 14 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 5548 | 0.021 | -0.2677 | No |
| 15 | THBS2 | THBS2 Entrez, Source | thrombospondin 2 | 6709 | 0.004 | -0.3545 | No |
| 16 | NID1 | NID1 Entrez, Source | nidogen 1 | 7761 | -0.011 | -0.4322 | No |
| 17 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 8051 | -0.016 | -0.4520 | No |
| 18 | ITGB2 | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 8281 | -0.020 | -0.4667 | No |
| 19 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 8308 | -0.020 | -0.4661 | No |
| 20 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 8312 | -0.020 | -0.4638 | No |
| 21 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 8576 | -0.024 | -0.4805 | No |
| 22 | ARHGDIA | ARHGDIA Entrez, Source | Rho GDP dissociation inhibitor (GDI) alpha | 8656 | -0.026 | -0.4832 | No |
| 23 | EFNA5 | EFNA5 Entrez, Source | ephrin-A5 | 8800 | -0.028 | -0.4904 | No |
| 24 | LRRC17 | LRRC17 Entrez, Source | leucine rich repeat containing 17 | 8928 | -0.031 | -0.4961 | No |
| 25 | MMP3 | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 8953 | -0.031 | -0.4939 | No |
| 26 | BSG | BSG Entrez, Source | basigin (Ok blood group) | 9146 | -0.035 | -0.5039 | No |
| 27 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 9287 | -0.038 | -0.5097 | No |
| 28 | RHOG | RHOG Entrez, Source | ras homolog gene family, member G (rho G) | 9303 | -0.038 | -0.5060 | No |
| 29 | CDH6 | CDH6 Entrez, Source | cadherin 6, type 2, K-cadherin (fetal kidney) | 9721 | -0.046 | -0.5316 | No |
| 30 | FN1 | FN1 Entrez, Source | fibronectin 1 | 10062 | -0.053 | -0.5504 | No |
| 31 | MTA1 | MTA1 Entrez, Source | metastasis associated 1 | 10549 | -0.065 | -0.5787 | No |
| 32 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10733 | -0.071 | -0.5835 | No |
| 33 | PAK2 | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 11000 | -0.079 | -0.5935 | No |
| 34 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11466 | -0.098 | -0.6161 | No |
| 35 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 11527 | -0.101 | -0.6078 | No |
| 36 | NEO1 | NEO1 Entrez, Source | neogenin homolog 1 (chicken) | 11629 | -0.106 | -0.6020 | No |
| 37 | JUP | JUP Entrez, Source | junction plakoglobin | 12003 | -0.125 | -0.6142 | No |
| 38 | SMO | SMO Entrez, Source | smoothened homolog (Drosophila) | 12424 | -0.161 | -0.6254 | Yes |
| 39 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 12491 | -0.169 | -0.6089 | Yes |
| 40 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 12492 | -0.169 | -0.5875 | Yes |
| 41 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 12541 | -0.177 | -0.5686 | Yes |
| 42 | MMP2 | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 12615 | -0.187 | -0.5504 | Yes |
| 43 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 12629 | -0.189 | -0.5273 | Yes |
| 44 | DSP | DSP Entrez, Source | desmoplakin | 12648 | -0.194 | -0.5041 | Yes |
| 45 | PXN | PXN Entrez, Source | paxillin | 12740 | -0.211 | -0.4841 | Yes |
| 46 | ZYX | ZYX Entrez, Source | zyxin | 12928 | -0.262 | -0.4650 | Yes |
| 47 | RHOQ | RHOQ Entrez, Source | ras homolog gene family, member Q | 13120 | -0.369 | -0.4327 | Yes |
| 48 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 13125 | -0.378 | -0.3851 | Yes |
| 49 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 13174 | -0.431 | -0.3340 | Yes |
| 50 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 13193 | -0.458 | -0.2773 | Yes |
| 51 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 13198 | -0.463 | -0.2189 | Yes |
| 52 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 13271 | -0.644 | -0.1427 | Yes |
| 53 | MARCKSL1 | MARCKSL1 Entrez, Source | MARCKS-like 1 | 13330 | -1.167 | 0.0009 | Yes |
