Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | V$COUP_01 |
| Enrichment Score (ES) | 0.47295424 |
| Normalized Enrichment Score (NES) | 1.8449188 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.010778993 |
| FWER p-Value | 0.725 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PKLR | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 31 | 0.561 | 0.0408 | Yes |
| 2 | LTB | LTB Entrez, Source | lymphotoxin beta (TNF superfamily, member 3) | 35 | 0.539 | 0.0821 | Yes |
| 3 | G0S2 | G0S2 Entrez, Source | G0/G1switch 2 | 66 | 0.461 | 0.1152 | Yes |
| 4 | ASGR2 | ASGR2 Entrez, Source | asialoglycoprotein receptor 2 | 80 | 0.434 | 0.1476 | Yes |
| 5 | SERPIND1 | SERPIND1 Entrez, Source | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 92 | 0.424 | 0.1794 | Yes |
| 6 | APOM | APOM Entrez, Source | apolipoprotein M | 113 | 0.401 | 0.2087 | Yes |
| 7 | GJB2 | GJB2 Entrez, Source | gap junction protein, beta 2, 26kDa (connexin 26) | 115 | 0.397 | 0.2392 | Yes |
| 8 | G6PC | G6PC Entrez, Source | glucose-6-phosphatase, catalytic subunit | 129 | 0.383 | 0.2677 | Yes |
| 9 | PON1 | PON1 Entrez, Source | paraoxonase 1 | 159 | 0.345 | 0.2921 | Yes |
| 10 | HPN | HPN Entrez, Source | hepsin (transmembrane protease, serine 1) | 254 | 0.286 | 0.3070 | Yes |
| 11 | GYS2 | GYS2 Entrez, Source | glycogen synthase 2 (liver) | 314 | 0.263 | 0.3227 | Yes |
| 12 | SLC7A7 | SLC7A7 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 | 320 | 0.260 | 0.3424 | Yes |
| 13 | SLC11A2 | SLC11A2 Entrez, Source | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 322 | 0.259 | 0.3622 | Yes |
| 14 | FOXA3 | FOXA3 Entrez, Source | forkhead box A3 | 340 | 0.252 | 0.3804 | Yes |
| 15 | FKBP5 | FKBP5 Entrez, Source | FK506 binding protein 5 | 406 | 0.229 | 0.3931 | Yes |
| 16 | ALDH6A1 | ALDH6A1 Entrez, Source | aldehyde dehydrogenase 6 family, member A1 | 445 | 0.217 | 0.4069 | Yes |
| 17 | ADRB2 | ADRB2 Entrez, Source | adrenergic, beta-2-, receptor, surface | 617 | 0.184 | 0.4081 | Yes |
| 18 | DMD | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 686 | 0.175 | 0.4165 | Yes |
| 19 | SERPINC1 | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 690 | 0.175 | 0.4297 | Yes |
| 20 | KYNU | KYNU Entrez, Source | kynureninase (L-kynurenine hydrolase) | 695 | 0.174 | 0.4428 | Yes |
| 21 | ARFGEF2 | ARFGEF2 Entrez, Source | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 702 | 0.173 | 0.4556 | Yes |
| 22 | CREB3L3 | CREB3L3 Entrez, Source | cAMP responsive element binding protein 3-like 3 | 745 | 0.168 | 0.4653 | Yes |
| 23 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 901 | 0.153 | 0.4654 | Yes |
| 24 | ZPBP2 | ZPBP2 Entrez, Source | zona pellucida binding protein 2 | 953 | 0.149 | 0.4730 | Yes |
| 25 | FGFR3 | FGFR3 Entrez, Source | fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) | 1450 | 0.116 | 0.4444 | No |
| 26 | NDUFS1 | NDUFS1 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 1817 | 0.101 | 0.4245 | No |
| 27 | SLC9A3 | SLC9A3 Entrez, Source | solute carrier family 9 (sodium/hydrogen exchanger), member 3 | 1860 | 0.099 | 0.4289 | No |
| 28 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 1997 | 0.094 | 0.4259 | No |
| 29 | STOML2 | STOML2 Entrez, Source | stomatin (EPB72)-like 2 | 2106 | 0.091 | 0.4247 | No |
| 30 | TOMM70A | TOMM70A Entrez, Source | translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) | 2268 | 0.086 | 0.4191 | No |
| 31 | TBX5 | TBX5 Entrez, Source | T-box 5 | 2299 | 0.085 | 0.4234 | No |
| 32 | OTP | OTP Entrez, Source | orthopedia homolog (Drosophila) | 2326 | 0.084 | 0.4279 | No |
| 33 | DHRS3 | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 2353 | 0.084 | 0.4324 | No |
| 34 | RNF103 | RNF103 Entrez, Source | ring finger protein 103 | 2728 | 0.073 | 0.4097 | No |
| 35 | MRPL2 | MRPL2 Entrez, Source | mitochondrial ribosomal protein L2 | 2738 | 0.073 | 0.4147 | No |
| 36 | FABP2 | FABP2 Entrez, Source | fatty acid binding protein 2, intestinal | 2972 | 0.067 | 0.4022 | No |
| 37 | ATF4 | ATF4 Entrez, Source | activating transcription factor 4 (tax-responsive enhancer element B67) | 3058 | 0.065 | 0.4008 | No |
| 38 | LZIC | LZIC Entrez, Source | leucine zipper and CTNNBIP1 domain containing | 3066 | 0.065 | 0.4053 | No |
| 39 | TNNI1 | TNNI1 Entrez, Source | troponin I type 1 (skeletal, slow) | 3145 | 0.063 | 0.4043 | No |
| 40 | LGI4 | LGI4 Entrez, Source | leucine-rich repeat LGI family, member 4 | 3512 | 0.056 | 0.3809 | No |
| 41 | TCF1 | TCF1 Entrez, Source | transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor | 3566 | 0.054 | 0.3811 | No |
| 42 | DAB2IP | DAB2IP Entrez, Source | DAB2 interacting protein | 4122 | 0.044 | 0.3425 | No |
| 43 | BMF | BMF Entrez, Source | Bcl2 modifying factor | 4128 | 0.044 | 0.3455 | No |
| 44 | PAX6 | PAX6 Entrez, Source | paired box gene 6 (aniridia, keratitis) | 4359 | 0.040 | 0.3312 | No |
| 45 | CRYGC | CRYGC Entrez, Source | crystallin, gamma C | 4877 | 0.031 | 0.2946 | No |
| 46 | HSD17B8 | HSD17B8 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 8 | 5000 | 0.029 | 0.2876 | No |
| 47 | GATA4 | GATA4 Entrez, Source | GATA binding protein 4 | 5021 | 0.029 | 0.2883 | No |
| 48 | EFNB1 | EFNB1 Entrez, Source | ephrin-B1 | 5440 | 0.023 | 0.2584 | No |
| 49 | ANGPT1 | ANGPT1 Entrez, Source | angiopoietin 1 | 5474 | 0.022 | 0.2576 | No |
| 50 | EXOSC7 | EXOSC7 Entrez, Source | exosome component 7 | 5539 | 0.021 | 0.2544 | No |
| 51 | DNAJA2 | DNAJA2 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 2 | 6068 | 0.013 | 0.2155 | No |
| 52 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 6072 | 0.013 | 0.2163 | No |
| 53 | AGPS | AGPS Entrez, Source | alkylglycerone phosphate synthase | 6079 | 0.013 | 0.2168 | No |
| 54 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6158 | 0.012 | 0.2119 | No |
| 55 | MLLT10 | MLLT10 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 6336 | 0.009 | 0.1992 | No |
| 56 | RBBP6 | RBBP6 Entrez, Source | retinoblastoma binding protein 6 | 6400 | 0.008 | 0.1950 | No |
| 57 | PABPN1 | PABPN1 Entrez, Source | poly(A) binding protein, nuclear 1 | 6488 | 0.007 | 0.1889 | No |
| 58 | RBP2 | RBP2 Entrez, Source | retinol binding protein 2, cellular | 6542 | 0.006 | 0.1854 | No |
| 59 | NEK6 | NEK6 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 6 | 6778 | 0.003 | 0.1678 | No |
| 60 | DOCK11 | DOCK11 Entrez, Source | dedicator of cytokinesis 11 | 6881 | 0.002 | 0.1603 | No |
| 61 | TPCN1 | TPCN1 Entrez, Source | two pore segment channel 1 | 6990 | -0.000 | 0.1521 | No |
| 62 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 7382 | -0.006 | 0.1230 | No |
| 63 | SLC26A3 | SLC26A3 Entrez, Source | solute carrier family 26, member 3 | 7421 | -0.006 | 0.1206 | No |
| 64 | GBL | GBL Entrez, Source | - | 7427 | -0.006 | 0.1207 | No |
| 65 | PLEC1 | PLEC1 Entrez, Source | plectin 1, intermediate filament binding protein 500kDa | 7482 | -0.007 | 0.1172 | No |
| 66 | CRABP2 | CRABP2 Entrez, Source | cellular retinoic acid binding protein 2 | 7542 | -0.008 | 0.1133 | No |
| 67 | NR4A3 | NR4A3 Entrez, Source | nuclear receptor subfamily 4, group A, member 3 | 7647 | -0.010 | 0.1062 | No |
| 68 | MYBPH | MYBPH Entrez, Source | myosin binding protein H | 7699 | -0.010 | 0.1032 | No |
| 69 | RQCD1 | RQCD1 Entrez, Source | RCD1 required for cell differentiation1 homolog (S. pombe) | 7860 | -0.013 | 0.0921 | No |
| 70 | PPARGC1A | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 8036 | -0.015 | 0.0800 | No |
| 71 | RTN2 | RTN2 Entrez, Source | reticulon 2 | 8156 | -0.017 | 0.0724 | No |
| 72 | NR2F1 | NR2F1 Entrez, Source | nuclear receptor subfamily 2, group F, member 1 | 8175 | -0.018 | 0.0723 | No |
| 73 | NET1 | NET1 Entrez, Source | neuroepithelial cell transforming gene 1 | 8186 | -0.018 | 0.0729 | No |
| 74 | PDE3B | PDE3B Entrez, Source | phosphodiesterase 3B, cGMP-inhibited | 8189 | -0.018 | 0.0742 | No |
| 75 | DLX5 | DLX5 Entrez, Source | distal-less homeobox 5 | 8422 | -0.022 | 0.0583 | No |
| 76 | PCTK1 | PCTK1 Entrez, Source | PCTAIRE protein kinase 1 | 8584 | -0.024 | 0.0480 | No |
| 77 | AP1B1 | AP1B1 Entrez, Source | adaptor-related protein complex 1, beta 1 subunit | 8657 | -0.026 | 0.0445 | No |
| 78 | WBP4 | WBP4 Entrez, Source | WW domain binding protein 4 (formin binding protein 21) | 8859 | -0.029 | 0.0316 | No |
| 79 | SYMPK | SYMPK Entrez, Source | symplekin | 8892 | -0.030 | 0.0315 | No |
| 80 | MAP3K11 | MAP3K11 Entrez, Source | mitogen-activated protein kinase kinase kinase 11 | 9043 | -0.033 | 0.0227 | No |
| 81 | SATB1 | SATB1 Entrez, Source | special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's) | 9100 | -0.034 | 0.0211 | No |
| 82 | DNMT3A | DNMT3A Entrez, Source | DNA (cytosine-5-)-methyltransferase 3 alpha | 9156 | -0.035 | 0.0196 | No |
| 83 | SMOC1 | SMOC1 Entrez, Source | SPARC related modular calcium binding 1 | 9480 | -0.041 | -0.0016 | No |
| 84 | ESRRG | ESRRG Entrez, Source | estrogen-related receptor gamma | 9512 | -0.042 | -0.0008 | No |
| 85 | DDB1 | DDB1 Entrez, Source | damage-specific DNA binding protein 1, 127kDa | 9544 | -0.042 | 0.0002 | No |
| 86 | LMO3 | LMO3 Entrez, Source | LIM domain only 3 (rhombotin-like 2) | 9664 | -0.045 | -0.0054 | No |
| 87 | FGF12 | FGF12 Entrez, Source | fibroblast growth factor 12 | 9681 | -0.045 | -0.0031 | No |
| 88 | ALDOA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 9779 | -0.047 | -0.0068 | No |
| 89 | SLC7A9 | SLC7A9 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 | 9816 | -0.048 | -0.0058 | No |
| 90 | PPP2R5D | PPP2R5D Entrez, Source | protein phosphatase 2, regulatory subunit B (B56), delta isoform | 9902 | -0.050 | -0.0084 | No |
| 91 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 9909 | -0.050 | -0.0050 | No |
| 92 | MXI1 | MXI1 Entrez, Source | MAX interactor 1 | 9949 | -0.051 | -0.0040 | No |
| 93 | NCDN | NCDN Entrez, Source | neurochondrin | 10110 | -0.055 | -0.0119 | No |
| 94 | LGALS4 | LGALS4 Entrez, Source | lectin, galactoside-binding, soluble, 4 (galectin 4) | 10393 | -0.061 | -0.0285 | No |
| 95 | PTHR1 | PTHR1 Entrez, Source | parathyroid hormone receptor 1 | 10494 | -0.064 | -0.0311 | No |
| 96 | ADRA1A | ADRA1A Entrez, Source | adrenergic, alpha-1A-, receptor | 10505 | -0.064 | -0.0270 | No |
| 97 | ZDHHC3 | ZDHHC3 Entrez, Source | zinc finger, DHHC-type containing 3 | 10824 | -0.073 | -0.0454 | No |
| 98 | ID1 | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 10891 | -0.075 | -0.0446 | No |
| 99 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 10974 | -0.078 | -0.0448 | No |
| 100 | DCTN1 | DCTN1 Entrez, Source | dynactin 1 (p150, glued homolog, Drosophila) | 10978 | -0.078 | -0.0390 | No |
| 101 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 11218 | -0.087 | -0.0505 | No |
| 102 | PTMS | PTMS Entrez, Source | parathymosin | 11251 | -0.088 | -0.0461 | No |
| 103 | JMJD1C | JMJD1C Entrez, Source | jumonji domain containing 1C | 11508 | -0.100 | -0.0578 | No |
| 104 | PITX2 | PITX2 Entrez, Source | paired-like homeodomain transcription factor 2 | 11663 | -0.108 | -0.0611 | No |
| 105 | TNFRSF12A | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 11673 | -0.108 | -0.0535 | No |
| 106 | TCF2 | TCF2 Entrez, Source | transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor | 11711 | -0.110 | -0.0479 | No |
| 107 | ARHGEF7 | ARHGEF7 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 7 | 11790 | -0.113 | -0.0451 | No |
| 108 | LMNA | LMNA Entrez, Source | lamin A/C | 12083 | -0.130 | -0.0572 | No |
| 109 | FOXA1 | FOXA1 Entrez, Source | forkhead box A1 | 12239 | -0.143 | -0.0579 | No |
| 110 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 12254 | -0.144 | -0.0478 | No |
| 111 | MARK2 | MARK2 Entrez, Source | MAP/microtubule affinity-regulating kinase 2 | 12371 | -0.155 | -0.0447 | No |
| 112 | RBMS1 | RBMS1 Entrez, Source | RNA binding motif, single stranded interacting protein 1 | 12691 | -0.203 | -0.0532 | No |
| 113 | PRKRA | PRKRA Entrez, Source | protein kinase, interferon-inducible double stranded RNA dependent activator | 12753 | -0.214 | -0.0413 | No |
| 114 | TIMELESS | TIMELESS Entrez, Source | timeless homolog (Drosophila) | 12940 | -0.266 | -0.0349 | No |
| 115 | PPP2R3A | PPP2R3A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha | 13312 | -0.847 | 0.0023 | No |
