Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | V$HNF1_Q6 |
| Enrichment Score (ES) | 0.3753572 |
| Normalized Enrichment Score (NES) | 1.4713562 |
| Nominal p-value | 0.015424165 |
| FDR q-value | 0.13887054 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | AFM | AFM Entrez, Source | afamin | 28 | 0.567 | 0.0348 | Yes |
| 2 | AQP9 | AQP9 Entrez, Source | aquaporin 9 | 38 | 0.530 | 0.0686 | Yes |
| 3 | PLG | PLG Entrez, Source | plasminogen | 81 | 0.434 | 0.0937 | Yes |
| 4 | APOM | APOM Entrez, Source | apolipoprotein M | 113 | 0.401 | 0.1174 | Yes |
| 5 | G6PC | G6PC Entrez, Source | glucose-6-phosphatase, catalytic subunit | 129 | 0.383 | 0.1413 | Yes |
| 6 | SERPINA7 | SERPINA7 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | 162 | 0.343 | 0.1612 | Yes |
| 7 | PRODH2 | PRODH2 Entrez, Source | proline dehydrogenase (oxidase) 2 | 169 | 0.338 | 0.1827 | Yes |
| 8 | RARB | RARB Entrez, Source | retinoic acid receptor, beta | 214 | 0.304 | 0.1992 | Yes |
| 9 | NR1H4 | NR1H4 Entrez, Source | nuclear receptor subfamily 1, group H, member 4 | 246 | 0.288 | 0.2156 | Yes |
| 10 | SERPINA4 | SERPINA4 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 | 252 | 0.287 | 0.2339 | Yes |
| 11 | HPN | HPN Entrez, Source | hepsin (transmembrane protease, serine 1) | 254 | 0.286 | 0.2525 | Yes |
| 12 | AFP | AFP Entrez, Source | alpha-fetoprotein | 273 | 0.277 | 0.2692 | Yes |
| 13 | DPYD | DPYD Entrez, Source | dihydropyrimidine dehydrogenase | 303 | 0.265 | 0.2842 | Yes |
| 14 | FGFR4 | FGFR4 Entrez, Source | fibroblast growth factor receptor 4 | 402 | 0.230 | 0.2918 | Yes |
| 15 | EGR1 | EGR1 Entrez, Source | early growth response 1 | 437 | 0.219 | 0.3036 | Yes |
| 16 | FXYD2 | FXYD2 Entrez, Source | FXYD domain containing ion transport regulator 2 | 480 | 0.207 | 0.3139 | Yes |
| 17 | SGK2 | SGK2 Entrez, Source | serum/glucocorticoid regulated kinase 2 | 505 | 0.201 | 0.3252 | Yes |
| 18 | SPINK1 | SPINK1 Entrez, Source | serine peptidase inhibitor, Kazal type 1 | 590 | 0.187 | 0.3310 | Yes |
| 19 | HNF4A | HNF4A Entrez, Source | hepatocyte nuclear factor 4, alpha | 626 | 0.183 | 0.3403 | Yes |
| 20 | DMD | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 686 | 0.175 | 0.3472 | Yes |
| 21 | IGFBP1 | IGFBP1 Entrez, Source | insulin-like growth factor binding protein 1 | 703 | 0.173 | 0.3572 | Yes |
| 22 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 932 | 0.150 | 0.3498 | Yes |
| 23 | FGB | FGB Entrez, Source | fibrinogen beta chain | 1040 | 0.141 | 0.3509 | Yes |
| 24 | SLC5A1 | SLC5A1 Entrez, Source | solute carrier family 5 (sodium/glucose cotransporter), member 1 | 1139 | 0.134 | 0.3523 | Yes |
| 25 | CART1 | CART1 Entrez, Source | cartilage paired-class homeoprotein 1 | 1198 | 0.130 | 0.3563 | Yes |
| 26 | SLC12A2 | SLC12A2 Entrez, Source | solute carrier family 12 (sodium/potassium/chloride transporters), member 2 | 1216 | 0.129 | 0.3634 | Yes |
| 27 | GJB1 | GJB1 Entrez, Source | gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) | 1293 | 0.124 | 0.3658 | Yes |
| 28 | CYP2E1 | CYP2E1 Entrez, Source | cytochrome P450, family 2, subfamily E, polypeptide 1 | 1369 | 0.121 | 0.3680 | Yes |
| 29 | NAPSA | NAPSA Entrez, Source | napsin A aspartic peptidase | 1408 | 0.118 | 0.3728 | Yes |
| 30 | FGA | FGA Entrez, Source | fibrinogen alpha chain | 1474 | 0.115 | 0.3754 | Yes |
| 31 | ASPA | ASPA Entrez, Source | aspartoacylase (Canavan disease) | 1733 | 0.104 | 0.3626 | No |
| 32 | POU2F1 | POU2F1 Entrez, Source | POU domain, class 2, transcription factor 1 | 1790 | 0.102 | 0.3650 | No |
| 33 | RAB3IP | RAB3IP Entrez, Source | RAB3A interacting protein (rabin3) | 1896 | 0.098 | 0.3634 | No |
| 34 | HGFAC | HGFAC Entrez, Source | HGF activator | 2074 | 0.092 | 0.3560 | No |
| 35 | NOG | NOG Entrez, Source | noggin | 2077 | 0.091 | 0.3618 | No |
| 36 | TBXAS1 | TBXAS1 Entrez, Source | thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) | 2199 | 0.088 | 0.3584 | No |
| 37 | SFRS7 | SFRS7 Entrez, Source | splicing factor, arginine/serine-rich 7, 35kDa | 2205 | 0.088 | 0.3638 | No |
| 38 | F2 | F2 Entrez, Source | coagulation factor II (thrombin) | 2335 | 0.084 | 0.3595 | No |
| 39 | GC | GC Entrez, Source | group-specific component (vitamin D binding protein) | 2397 | 0.082 | 0.3602 | No |
| 40 | OPRM1 | OPRM1 Entrez, Source | opioid receptor, mu 1 | 2556 | 0.078 | 0.3534 | No |
| 41 | BPHL | BPHL Entrez, Source | biphenyl hydrolase-like (serine hydrolase; breast epithelial mucin-associated antigen) | 2720 | 0.073 | 0.3458 | No |
| 42 | USP3 | USP3 Entrez, Source | ubiquitin specific peptidase 3 | 2804 | 0.071 | 0.3442 | No |
| 43 | ZFHX1B | ZFHX1B Entrez, Source | zinc finger homeobox 1b | 2854 | 0.070 | 0.3451 | No |
| 44 | CRB3 | CRB3 Entrez, Source | crumbs homolog 3 (Drosophila) | 3038 | 0.066 | 0.3355 | No |
| 45 | PNMA1 | PNMA1 Entrez, Source | paraneoplastic antigen MA1 | 3062 | 0.065 | 0.3380 | No |
| 46 | SI | SI Entrez, Source | sucrase-isomaltase (alpha-glucosidase) | 3180 | 0.063 | 0.3333 | No |
| 47 | ERG | ERG Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog (avian) | 3274 | 0.061 | 0.3302 | No |
| 48 | PLUNC | PLUNC Entrez, Source | palate, lung and nasal epithelium carcinoma associated | 3336 | 0.059 | 0.3294 | No |
| 49 | TCF1 | TCF1 Entrez, Source | transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor | 3566 | 0.054 | 0.3157 | No |
| 50 | ANPEP | ANPEP Entrez, Source | alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) | 3631 | 0.053 | 0.3143 | No |
| 51 | AXIN2 | AXIN2 Entrez, Source | axin 2 (conductin, axil) | 4095 | 0.045 | 0.2822 | No |
| 52 | CS | CS Entrez, Source | citrate synthase | 4175 | 0.043 | 0.2791 | No |
| 53 | TINAG | TINAG Entrez, Source | tubulointerstitial nephritis antigen | 4491 | 0.038 | 0.2577 | No |
| 54 | GUCA2B | GUCA2B Entrez, Source | guanylate cyclase activator 2B (uroguanylin) | 4829 | 0.032 | 0.2343 | No |
| 55 | CSF3 | CSF3 Entrez, Source | colony stimulating factor 3 (granulocyte) | 4957 | 0.030 | 0.2267 | No |
| 56 | GGCX | GGCX Entrez, Source | gamma-glutamyl carboxylase | 5019 | 0.029 | 0.2239 | No |
| 57 | NRXN3 | NRXN3 Entrez, Source | neurexin 3 | 5181 | 0.027 | 0.2135 | No |
| 58 | CLOCK | CLOCK Entrez, Source | clock homolog (mouse) | 5300 | 0.025 | 0.2062 | No |
| 59 | ARF6 | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 5321 | 0.024 | 0.2062 | No |
| 60 | SLC13A2 | SLC13A2 Entrez, Source | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 | 5875 | 0.016 | 0.1655 | No |
| 61 | SFRP4 | SFRP4 Entrez, Source | secreted frizzled-related protein 4 | 6074 | 0.013 | 0.1514 | No |
| 62 | TRDN | TRDN Entrez, Source | triadin | 6145 | 0.012 | 0.1469 | No |
| 63 | BCL11A | BCL11A Entrez, Source | B-cell CLL/lymphoma 11A (zinc finger protein) | 6200 | 0.011 | 0.1435 | No |
| 64 | SERPINA10 | SERPINA10 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | 6262 | 0.010 | 0.1396 | No |
| 65 | LRRFIP2 | LRRFIP2 Entrez, Source | leucine rich repeat (in FLII) interacting protein 2 | 7071 | -0.001 | 0.0786 | No |
| 66 | ALB | ALB Entrez, Source | albumin | 7095 | -0.002 | 0.0770 | No |
| 67 | CDH16 | CDH16 Entrez, Source | cadherin 16, KSP-cadherin | 7601 | -0.009 | 0.0394 | No |
| 68 | CTCF | CTCF Entrez, Source | CCCTC-binding factor (zinc finger protein) | 7648 | -0.010 | 0.0366 | No |
| 69 | RASGRF2 | RASGRF2 Entrez, Source | Ras protein-specific guanine nucleotide-releasing factor 2 | 7811 | -0.012 | 0.0251 | No |
| 70 | PPARGC1A | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 8036 | -0.015 | 0.0092 | No |
| 71 | AGTR2 | AGTR2 Entrez, Source | angiotensin II receptor, type 2 | 8250 | -0.019 | -0.0057 | No |
| 72 | POU3F2 | POU3F2 Entrez, Source | POU domain, class 3, transcription factor 2 | 8521 | -0.023 | -0.0246 | No |
| 73 | ISL1 | ISL1 Entrez, Source | ISL1 transcription factor, LIM/homeodomain, (islet-1) | 8698 | -0.026 | -0.0362 | No |
| 74 | SLC7A13 | SLC7A13 Entrez, Source | solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 | 8780 | -0.028 | -0.0405 | No |
| 75 | PPP1CB | PPP1CB Entrez, Source | protein phosphatase 1, catalytic subunit, beta isoform | 8852 | -0.029 | -0.0439 | No |
| 76 | PDGFRA | PDGFRA Entrez, Source | platelet-derived growth factor receptor, alpha polypeptide | 9383 | -0.039 | -0.0814 | No |
| 77 | TCF12 | TCF12 Entrez, Source | transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) | 9690 | -0.045 | -0.1016 | No |
| 78 | SLC7A9 | SLC7A9 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 | 9816 | -0.048 | -0.1079 | No |
| 79 | NTF3 | NTF3 Entrez, Source | neurotrophin 3 | 9863 | -0.049 | -0.1082 | No |
| 80 | SOX18 | SOX18 Entrez, Source | SRY (sex determining region Y)-box 18 | 9896 | -0.050 | -0.1074 | No |
| 81 | SEMA3A | SEMA3A Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 10163 | -0.056 | -0.1239 | No |
| 82 | NCOR1 | NCOR1 Entrez, Source | nuclear receptor co-repressor 1 | 10165 | -0.056 | -0.1203 | No |
| 83 | MAP2K5 | MAP2K5 Entrez, Source | mitogen-activated protein kinase kinase 5 | 10218 | -0.057 | -0.1205 | No |
| 84 | HNRPR | HNRPR Entrez, Source | heterogeneous nuclear ribonucleoprotein R | 10233 | -0.058 | -0.1178 | No |
| 85 | PDE4D | PDE4D Entrez, Source | phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) | 10306 | -0.059 | -0.1194 | No |
| 86 | HTR7 | HTR7 Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) | 10547 | -0.065 | -0.1333 | No |
| 87 | TFEC | TFEC Entrez, Source | transcription factor EC | 10663 | -0.069 | -0.1375 | No |
| 88 | RNASE4 | RNASE4 Entrez, Source | ribonuclease, RNase A family, 4 | 10748 | -0.071 | -0.1392 | No |
| 89 | SULF2 | SULF2 Entrez, Source | sulfatase 2 | 10768 | -0.072 | -0.1360 | No |
| 90 | PRICKLE1 | PRICKLE1 Entrez, Source | prickle homolog 1 (Drosophila) | 10850 | -0.074 | -0.1373 | No |
| 91 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 11218 | -0.087 | -0.1594 | No |
| 92 | DLX1 | DLX1 Entrez, Source | distal-less homeobox 1 | 11264 | -0.089 | -0.1570 | No |
| 93 | DDX17 | DDX17 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | 11390 | -0.094 | -0.1603 | No |
| 94 | F2RL1 | F2RL1 Entrez, Source | coagulation factor II (thrombin) receptor-like 1 | 11450 | -0.098 | -0.1585 | No |
| 95 | TCF2 | TCF2 Entrez, Source | transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor | 11711 | -0.110 | -0.1710 | No |
| 96 | PPP2R2B | PPP2R2B Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform | 11938 | -0.121 | -0.1802 | No |
| 97 | NFIX | NFIX Entrez, Source | nuclear factor I/X (CCAAT-binding transcription factor) | 12153 | -0.135 | -0.1876 | No |
| 98 | PHLDB1 | PHLDB1 Entrez, Source | pleckstrin homology-like domain, family B, member 1 | 12160 | -0.135 | -0.1792 | No |
| 99 | PBX2 | PBX2 Entrez, Source | pre-B-cell leukemia transcription factor 2 | 12188 | -0.138 | -0.1723 | No |
| 100 | FLI1 | FLI1 Entrez, Source | Friend leukemia virus integration 1 | 12198 | -0.139 | -0.1639 | No |
| 101 | SLC4A4 | SLC4A4 Entrez, Source | solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 12225 | -0.142 | -0.1566 | No |
| 102 | PLAG1 | PLAG1 Entrez, Source | pleiomorphic adenoma gene 1 | 12351 | -0.153 | -0.1561 | No |
| 103 | TM4SF4 | TM4SF4 Entrez, Source | transmembrane 4 L six family member 4 | 12583 | -0.182 | -0.1617 | No |
| 104 | RBMS1 | RBMS1 Entrez, Source | RNA binding motif, single stranded interacting protein 1 | 12691 | -0.203 | -0.1566 | No |
| 105 | PDLIM1 | PDLIM1 Entrez, Source | PDZ and LIM domain 1 (elfin) | 12713 | -0.207 | -0.1447 | No |
| 106 | TLE4 | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 12889 | -0.247 | -0.1418 | No |
| 107 | TMEM27 | TMEM27 Entrez, Source | transmembrane protein 27 | 12915 | -0.257 | -0.1269 | No |
| 108 | ARHGAP24 | ARHGAP24 Entrez, Source | Rho GTPase activating protein 24 | 12979 | -0.284 | -0.1132 | No |
| 109 | RUNX1 | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 13073 | -0.336 | -0.0984 | No |
| 110 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 13080 | -0.340 | -0.0767 | No |
| 111 | CDH17 | CDH17 Entrez, Source | cadherin 17, LI cadherin (liver-intestine) | 13091 | -0.347 | -0.0548 | No |
| 112 | CITED2 | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 13211 | -0.481 | -0.0325 | No |
| 113 | LIPC | LIPC Entrez, Source | lipase, hepatic | 13275 | -0.650 | 0.0051 | No |
