Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | double_gel_72h |
| GeneSet | V$HNF4_Q6 |
| Enrichment Score (ES) | 0.39622533 |
| Normalized Enrichment Score (NES) | 1.5001819 |
| Nominal p-value | 0.009876544 |
| FDR q-value | 0.120796636 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PKLR | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 31 | 0.561 | 0.0434 | Yes |
| 2 | GLYAT | GLYAT Entrez, Source | glycine-N-acyltransferase | 33 | 0.554 | 0.0887 | Yes |
| 3 | NFE2 | NFE2 Entrez, Source | nuclear factor (erythroid-derived 2), 45kDa | 63 | 0.480 | 0.1257 | Yes |
| 4 | HFE2 | HFE2 Entrez, Source | hemochromatosis type 2 (juvenile) | 86 | 0.429 | 0.1590 | Yes |
| 5 | SERPIND1 | SERPIND1 Entrez, Source | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 92 | 0.424 | 0.1933 | Yes |
| 6 | AGMAT | AGMAT Entrez, Source | agmatine ureohydrolase (agmatinase) | 124 | 0.386 | 0.2225 | Yes |
| 7 | LCAT | LCAT Entrez, Source | lecithin-cholesterol acyltransferase | 142 | 0.365 | 0.2510 | Yes |
| 8 | NR5A2 | NR5A2 Entrez, Source | nuclear receptor subfamily 5, group A, member 2 | 206 | 0.307 | 0.2713 | Yes |
| 9 | RARB | RARB Entrez, Source | retinoic acid receptor, beta | 214 | 0.304 | 0.2956 | Yes |
| 10 | GAMT | GAMT Entrez, Source | guanidinoacetate N-methyltransferase | 295 | 0.267 | 0.3114 | Yes |
| 11 | GPD1 | GPD1 Entrez, Source | glycerol-3-phosphate dehydrogenase 1 (soluble) | 296 | 0.267 | 0.3332 | Yes |
| 12 | SLC22A7 | SLC22A7 Entrez, Source | solute carrier family 22 (organic anion transporter), member 7 | 395 | 0.234 | 0.3449 | Yes |
| 13 | AGXT2 | AGXT2 Entrez, Source | alanine-glyoxylate aminotransferase 2 | 475 | 0.209 | 0.3560 | Yes |
| 14 | C9 | C9 Entrez, Source | complement component 9 | 571 | 0.189 | 0.3643 | Yes |
| 15 | ERBB3 | ERBB3 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 588 | 0.187 | 0.3784 | Yes |
| 16 | KIAA1443 | KIAA1443 Entrez, Source | KIAA1443 | 618 | 0.184 | 0.3912 | Yes |
| 17 | INSR | INSR Entrez, Source | insulin receptor | 735 | 0.169 | 0.3962 | Yes |
| 18 | FXC1 | FXC1 Entrez, Source | fracture callus 1 homolog (rat) | 948 | 0.149 | 0.3924 | No |
| 19 | NOSTRIN | NOSTRIN Entrez, Source | nitric oxide synthase trafficker | 1595 | 0.109 | 0.3525 | No |
| 20 | CACNA2D3 | CACNA2D3 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta 3 subunit | 1846 | 0.100 | 0.3417 | No |
| 21 | CBX7 | CBX7 Entrez, Source | chromobox homolog 7 | 2229 | 0.087 | 0.3200 | No |
| 22 | PDZK1 | PDZK1 Entrez, Source | PDZ domain containing 1 | 2470 | 0.081 | 0.3084 | No |
| 23 | MRPL2 | MRPL2 Entrez, Source | mitochondrial ribosomal protein L2 | 2738 | 0.073 | 0.2942 | No |
| 24 | ARFIP2 | ARFIP2 Entrez, Source | ADP-ribosylation factor interacting protein 2 (arfaptin 2) | 2783 | 0.072 | 0.2968 | No |
| 25 | DAP3 | DAP3 Entrez, Source | death associated protein 3 | 2966 | 0.067 | 0.2885 | No |
| 26 | ATF4 | ATF4 Entrez, Source | activating transcription factor 4 (tax-responsive enhancer element B67) | 3058 | 0.065 | 0.2869 | No |
| 27 | NRG2 | NRG2 Entrez, Source | neuregulin 2 | 3401 | 0.058 | 0.2658 | No |
| 28 | SLC25A5 | SLC25A5 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 3418 | 0.058 | 0.2693 | No |
| 29 | TCF1 | TCF1 Entrez, Source | transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor | 3566 | 0.054 | 0.2627 | No |
| 30 | GRB7 | GRB7 Entrez, Source | growth factor receptor-bound protein 7 | 3678 | 0.052 | 0.2586 | No |
| 31 | MMP16 | MMP16 Entrez, Source | matrix metallopeptidase 16 (membrane-inserted) | 4004 | 0.046 | 0.2378 | No |
| 32 | AGPAT1 | AGPAT1 Entrez, Source | 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) | 4028 | 0.046 | 0.2398 | No |
| 33 | XPNPEP2 | XPNPEP2 Entrez, Source | X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound | 4093 | 0.045 | 0.2386 | No |
| 34 | BMF | BMF Entrez, Source | Bcl2 modifying factor | 4128 | 0.044 | 0.2397 | No |
| 35 | XRCC5 | XRCC5 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) | 4343 | 0.040 | 0.2268 | No |
| 36 | SFRS15 | SFRS15 Entrez, Source | splicing factor, arginine/serine-rich 15 | 4449 | 0.039 | 0.2220 | No |
| 37 | GRIA3 | GRIA3 Entrez, Source | glutamate receptor, ionotrophic, AMPA 3 | 4541 | 0.037 | 0.2182 | No |
| 38 | PELO | PELO Entrez, Source | pelota homolog (Drosophila) | 4563 | 0.037 | 0.2196 | No |
| 39 | ZNF403 | ZNF403 Entrez, Source | zinc finger protein 403 | 4602 | 0.036 | 0.2197 | No |
| 40 | GPX2 | GPX2 Entrez, Source | glutathione peroxidase 2 (gastrointestinal) | 4722 | 0.034 | 0.2135 | No |
| 41 | SPINT1 | SPINT1 Entrez, Source | serine peptidase inhibitor, Kunitz type 1 | 4814 | 0.032 | 0.2092 | No |
| 42 | GATA4 | GATA4 Entrez, Source | GATA binding protein 4 | 5021 | 0.029 | 0.1960 | No |
| 43 | EFNB1 | EFNB1 Entrez, Source | ephrin-B1 | 5440 | 0.023 | 0.1663 | No |
| 44 | ITGA1 | ITGA1 Entrez, Source | integrin, alpha 1 | 5518 | 0.021 | 0.1622 | No |
| 45 | EXOSC7 | EXOSC7 Entrez, Source | exosome component 7 | 5539 | 0.021 | 0.1624 | No |
| 46 | PTPRH | PTPRH Entrez, Source | protein tyrosine phosphatase, receptor type, H | 5772 | 0.018 | 0.1463 | No |
| 47 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 5846 | 0.017 | 0.1422 | No |
| 48 | ART3 | ART3 Entrez, Source | ADP-ribosyltransferase 3 | 5951 | 0.015 | 0.1355 | No |
| 49 | PROS1 | PROS1 Entrez, Source | protein S (alpha) | 6244 | 0.011 | 0.1143 | No |
| 50 | SLN | SLN Entrez, Source | sarcolipin | 6350 | 0.009 | 0.1071 | No |
| 51 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 6773 | 0.003 | 0.0755 | No |
| 52 | FUT11 | FUT11 Entrez, Source | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 6854 | 0.002 | 0.0696 | No |
| 53 | RAB1A | RAB1A Entrez, Source | RAB1A, member RAS oncogene family | 7133 | -0.002 | 0.0488 | No |
| 54 | GBA2 | GBA2 Entrez, Source | glucosidase, beta (bile acid) 2 | 7269 | -0.004 | 0.0389 | No |
| 55 | NUMB | NUMB Entrez, Source | numb homolog (Drosophila) | 7901 | -0.014 | -0.0076 | No |
| 56 | SLC5A2 | SLC5A2 Entrez, Source | solute carrier family 5 (sodium/glucose cotransporter), member 2 | 7902 | -0.014 | -0.0065 | No |
| 57 | LHX1 | LHX1 Entrez, Source | LIM homeobox 1 | 7934 | -0.014 | -0.0077 | No |
| 58 | MID1 | MID1 Entrez, Source | midline 1 (Opitz/BBB syndrome) | 7962 | -0.014 | -0.0086 | No |
| 59 | CACNB2 | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 8013 | -0.015 | -0.0111 | No |
| 60 | RARA | RARA Entrez, Source | retinoic acid receptor, alpha | 8106 | -0.016 | -0.0167 | No |
| 61 | NAV2 | NAV2 Entrez, Source | neuron navigator 2 | 8223 | -0.018 | -0.0240 | No |
| 62 | SLC7A8 | SLC7A8 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 | 8292 | -0.020 | -0.0275 | No |
| 63 | DYRK1A | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 8340 | -0.020 | -0.0294 | No |
| 64 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 8581 | -0.024 | -0.0455 | No |
| 65 | HTATIP | HTATIP Entrez, Source | HIV-1 Tat interacting protein, 60kDa | 8687 | -0.026 | -0.0513 | No |
| 66 | RNF40 | RNF40 Entrez, Source | ring finger protein 40 | 8848 | -0.029 | -0.0611 | No |
| 67 | LRRC17 | LRRC17 Entrez, Source | leucine rich repeat containing 17 | 8928 | -0.031 | -0.0645 | No |
| 68 | MOBP | MOBP Entrez, Source | myelin-associated oligodendrocyte basic protein | 9009 | -0.032 | -0.0679 | No |
| 69 | FUT2 | FUT2 Entrez, Source | fucosyltransferase 2 (secretor status included) | 9061 | -0.033 | -0.0691 | No |
| 70 | SFRP2 | SFRP2 Entrez, Source | secreted frizzled-related protein 2 | 9201 | -0.036 | -0.0766 | No |
| 71 | RALY | RALY Entrez, Source | RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)) | 9224 | -0.036 | -0.0753 | No |
| 72 | MAP2K6 | MAP2K6 Entrez, Source | mitogen-activated protein kinase kinase 6 | 9252 | -0.037 | -0.0744 | No |
| 73 | KIFC3 | KIFC3 Entrez, Source | kinesin family member C3 | 9267 | -0.037 | -0.0724 | No |
| 74 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 9287 | -0.038 | -0.0708 | No |
| 75 | TREH | TREH Entrez, Source | trehalase (brush-border membrane glycoprotein) | 9359 | -0.039 | -0.0730 | No |
| 76 | HPCA | HPCA Entrez, Source | hippocalcin | 9596 | -0.043 | -0.0872 | No |
| 77 | LMO3 | LMO3 Entrez, Source | LIM domain only 3 (rhombotin-like 2) | 9664 | -0.045 | -0.0886 | No |
| 78 | RASSF5 | RASSF5 Entrez, Source | Ras association (RalGDS/AF-6) domain family 5 | 9803 | -0.048 | -0.0952 | No |
| 79 | APC | APC Entrez, Source | adenomatosis polyposis coli | 9845 | -0.049 | -0.0943 | No |
| 80 | HOXA5 | HOXA5 Entrez, Source | homeobox A5 | 10111 | -0.055 | -0.1098 | No |
| 81 | RND1 | RND1 Entrez, Source | Rho family GTPase 1 | 10116 | -0.055 | -0.1057 | No |
| 82 | AQP3 | AQP3 Entrez, Source | aquaporin 3 (Gill blood group) | 10174 | -0.056 | -0.1054 | No |
| 83 | SP140 | SP140 Entrez, Source | SP140 nuclear body protein | 10267 | -0.058 | -0.1076 | No |
| 84 | CAB39L | CAB39L Entrez, Source | calcium binding protein 39-like | 10545 | -0.065 | -0.1232 | No |
| 85 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 10788 | -0.072 | -0.1356 | No |
| 86 | ZDHHC3 | ZDHHC3 Entrez, Source | zinc finger, DHHC-type containing 3 | 10824 | -0.073 | -0.1323 | No |
| 87 | LUZP1 | LUZP1 Entrez, Source | leucine zipper protein 1 | 10915 | -0.076 | -0.1329 | No |
| 88 | MAGED1 | MAGED1 Entrez, Source | melanoma antigen family D, 1 | 10946 | -0.077 | -0.1289 | No |
| 89 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 10974 | -0.078 | -0.1246 | No |
| 90 | USH1C | USH1C Entrez, Source | Usher syndrome 1C (autosomal recessive, severe) | 11196 | -0.086 | -0.1343 | No |
| 91 | PTMS | PTMS Entrez, Source | parathymosin | 11251 | -0.088 | -0.1312 | No |
| 92 | RAB3D | RAB3D Entrez, Source | RAB3D, member RAS oncogene family | 11442 | -0.097 | -0.1376 | No |
| 93 | JMJD1C | JMJD1C Entrez, Source | jumonji domain containing 1C | 11508 | -0.100 | -0.1343 | No |
| 94 | SLC9A3R1 | SLC9A3R1 Entrez, Source | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 11571 | -0.103 | -0.1306 | No |
| 95 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 11622 | -0.106 | -0.1258 | No |
| 96 | SMAD6 | SMAD6 Entrez, Source | SMAD, mothers against DPP homolog 6 (Drosophila) | 11893 | -0.118 | -0.1366 | No |
| 97 | FOXA1 | FOXA1 Entrez, Source | forkhead box A1 | 12239 | -0.143 | -0.1509 | No |
| 98 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 12313 | -0.149 | -0.1442 | No |
| 99 | JUB | JUB Entrez, Source | jub, ajuba homolog (Xenopus laevis) | 12625 | -0.189 | -0.1523 | No |
| 100 | PICALM | PICALM Entrez, Source | phosphatidylinositol binding clathrin assembly protein | 12640 | -0.193 | -0.1377 | No |
| 101 | ASB2 | ASB2 Entrez, Source | ankyrin repeat and SOCS box-containing 2 | 12641 | -0.193 | -0.1219 | No |
| 102 | TAGLN2 | TAGLN2 Entrez, Source | transgelin 2 | 12837 | -0.233 | -0.1176 | No |
| 103 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 12949 | -0.272 | -0.1038 | No |
| 104 | EMP1 | EMP1 Entrez, Source | epithelial membrane protein 1 | 13109 | -0.363 | -0.0861 | No |
| 105 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 13260 | -0.571 | -0.0508 | No |
| 106 | ADM | ADM Entrez, Source | adrenomedullin | 13287 | -0.697 | 0.0042 | No |
