Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_72h_versus_single_gel_72h.class.cls #double_gel_72h_versus_single_gel_72h_repos |
| Phenotype | class.cls#double_gel_72h_versus_single_gel_72h_repos |
| Upregulated in class | single_gel_72h |
| GeneSet | VERHAAK_AML_NPM1_MUT_VS_WT_DN |
| Enrichment Score (ES) | -0.50910723 |
| Normalized Enrichment Score (NES) | -1.8320962 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.031154241 |
| FWER p-Value | 0.879 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LRP3 | LRP3 Entrez, Source | low density lipoprotein receptor-related protein 3 | 308 | 0.264 | -0.0060 | No |
| 2 | AK3L1 | AK3L1 Entrez, Source | adenylate kinase 3-like 1 | 442 | 0.218 | -0.0017 | No |
| 3 | RGS1 | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 557 | 0.191 | 0.0022 | No |
| 4 | GPM6B | GPM6B Entrez, Source | glycoprotein M6B | 593 | 0.187 | 0.0119 | No |
| 5 | NT5E | NT5E Entrez, Source | 5'-nucleotidase, ecto (CD73) | 752 | 0.167 | 0.0109 | No |
| 6 | H1F0 | H1F0 Entrez, Source | H1 histone family, member 0 | 769 | 0.165 | 0.0205 | No |
| 7 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 901 | 0.153 | 0.0207 | No |
| 8 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 1194 | 0.130 | 0.0071 | No |
| 9 | PALM | PALM Entrez, Source | paralemmin | 1230 | 0.128 | 0.0129 | No |
| 10 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 1307 | 0.124 | 0.0153 | No |
| 11 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 1340 | 0.122 | 0.0209 | No |
| 12 | CYP2E1 | CYP2E1 Entrez, Source | cytochrome P450, family 2, subfamily E, polypeptide 1 | 1369 | 0.121 | 0.0267 | No |
| 13 | ASS1 | ASS1 Entrez, Source | argininosuccinate synthetase 1 | 1382 | 0.120 | 0.0336 | No |
| 14 | CHI3L1 | CHI3L1 Entrez, Source | chitinase 3-like 1 (cartilage glycoprotein-39) | 1617 | 0.108 | 0.0230 | No |
| 15 | CCR2 | CCR2 Entrez, Source | chemokine (C-C motif) receptor 2 | 1845 | 0.100 | 0.0124 | No |
| 16 | DLK1 | DLK1 Entrez, Source | delta-like 1 homolog (Drosophila) | 1871 | 0.099 | 0.0170 | No |
| 17 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 2125 | 0.090 | 0.0038 | No |
| 18 | P2RX5 | P2RX5 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 5 | 2240 | 0.087 | 0.0009 | No |
| 19 | PRODH | PRODH Entrez, Source | proline dehydrogenase (oxidase) 1 | 2331 | 0.084 | -0.0004 | No |
| 20 | SYNGR1 | SYNGR1 Entrez, Source | synaptogyrin 1 | 2342 | 0.084 | 0.0043 | No |
| 21 | SERPINF1 | SERPINF1 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 2345 | 0.084 | 0.0097 | No |
| 22 | DHRS3 | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 2353 | 0.084 | 0.0147 | No |
| 23 | RUNX3 | RUNX3 Entrez, Source | runt-related transcription factor 3 | 2426 | 0.082 | 0.0146 | No |
| 24 | MST1 | MST1 Entrez, Source | macrophage stimulating 1 (hepatocyte growth factor-like) | 2514 | 0.079 | 0.0133 | No |
| 25 | OPTN | OPTN Entrez, Source | optineurin | 2577 | 0.077 | 0.0136 | No |
| 26 | NRXN2 | NRXN2 Entrez, Source | neurexin 2 | 2585 | 0.077 | 0.0182 | No |
| 27 | PTPRM | PTPRM Entrez, Source | protein tyrosine phosphatase, receptor type, M | 2639 | 0.075 | 0.0191 | No |
| 28 | BAALC | BAALC Entrez, Source | brain and acute leukemia, cytoplasmic | 2651 | 0.075 | 0.0232 | No |
| 29 | SLC38A1 | SLC38A1 Entrez, Source | solute carrier family 38, member 1 | 2719 | 0.073 | 0.0229 | No |
| 30 | NARFL | NARFL Entrez, Source | nuclear prelamin A recognition factor-like | 2903 | 0.069 | 0.0136 | No |
| 31 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 2930 | 0.068 | 0.0161 | No |
| 32 | ERG | ERG Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog (avian) | 3274 | 0.061 | -0.0058 | No |
| 33 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3307 | 0.060 | -0.0043 | No |
| 34 | TPSAB1 | TPSAB1 Entrez, Source | tryptase alpha/beta 1 | 3360 | 0.059 | -0.0044 | No |
| 35 | RAMP1 | RAMP1 Entrez, Source | receptor (calcitonin) activity modifying protein 1 | 3434 | 0.057 | -0.0062 | No |
| 36 | EHD3 | EHD3 Entrez, Source | EH-domain containing 3 | 3481 | 0.056 | -0.0060 | No |
| 37 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 3721 | 0.052 | -0.0207 | No |
| 38 | CD2 | CD2 Entrez, Source | CD2 molecule | 3794 | 0.050 | -0.0228 | No |
| 39 | SCCPDH | SCCPDH Entrez, Source | saccharopine dehydrogenase (putative) | 3830 | 0.049 | -0.0222 | No |
| 40 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 3861 | 0.049 | -0.0213 | No |
| 41 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 3864 | 0.049 | -0.0182 | No |
| 42 | POU4F1 | POU4F1 Entrez, Source | POU domain, class 4, transcription factor 1 | 4112 | 0.044 | -0.0340 | No |
| 43 | TRPM4 | TRPM4 Entrez, Source | transient receptor potential cation channel, subfamily M, member 4 | 4249 | 0.042 | -0.0415 | No |
| 44 | SNCA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 4378 | 0.040 | -0.0486 | No |
| 45 | HPGD | HPGD Entrez, Source | hydroxyprostaglandin dehydrogenase 15-(NAD) | 4803 | 0.032 | -0.0785 | No |
| 46 | RPS6KA2 | RPS6KA2 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 5082 | 0.028 | -0.0977 | No |
| 47 | NCAM1 | NCAM1 Entrez, Source | neural cell adhesion molecule 1 | 5294 | 0.025 | -0.1121 | No |
| 48 | NPR3 | NPR3 Entrez, Source | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) | 5375 | 0.024 | -0.1166 | No |
| 49 | CIITA | CIITA Entrez, Source | class II, major histocompatibility complex, transactivator | 5468 | 0.022 | -0.1221 | No |
| 50 | ADCY3 | ADCY3 Entrez, Source | adenylate cyclase 3 | 5521 | 0.021 | -0.1246 | No |
| 51 | ROBO1 | ROBO1 Entrez, Source | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 5528 | 0.021 | -0.1236 | No |
| 52 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 5548 | 0.021 | -0.1237 | No |
| 53 | ST18 | ST18 Entrez, Source | suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) | 5573 | 0.021 | -0.1241 | No |
| 54 | ALAS2 | ALAS2 Entrez, Source | aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) | 5606 | 0.020 | -0.1252 | No |
| 55 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 5846 | 0.017 | -0.1422 | No |
| 56 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5854 | 0.016 | -0.1417 | No |
| 57 | DPYSL2 | DPYSL2 Entrez, Source | dihydropyrimidinase-like 2 | 6036 | 0.014 | -0.1545 | No |
| 58 | FGFR1 | FGFR1 Entrez, Source | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 6041 | 0.014 | -0.1539 | No |
| 59 | GJA1 | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 6120 | 0.013 | -0.1590 | No |
| 60 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 6175 | 0.012 | -0.1623 | No |
| 61 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 6257 | 0.010 | -0.1677 | No |
| 62 | LCN2 | LCN2 Entrez, Source | lipocalin 2 (oncogene 24p3) | 6284 | 0.010 | -0.1690 | No |
| 63 | LMO4 | LMO4 Entrez, Source | LIM domain only 4 | 6402 | 0.008 | -0.1774 | No |
| 64 | MSLN | MSLN Entrez, Source | mesothelin | 6411 | 0.008 | -0.1775 | No |
| 65 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 6461 | 0.007 | -0.1807 | No |
| 66 | SNRPN /// SNURF | 6649 | 0.005 | -0.1946 | No | ||
| 67 | ARHGEF12 | ARHGEF12 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 12 | 6688 | 0.004 | -0.1972 | No |
| 68 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 6721 | 0.004 | -0.1994 | No |
| 69 | GNG7 | GNG7 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 7 | 6736 | 0.003 | -0.2002 | No |
| 70 | BPGM | BPGM Entrez, Source | 2,3-bisphosphoglycerate mutase | 7060 | -0.001 | -0.2246 | No |
| 71 | IL5RA | IL5RA Entrez, Source | interleukin 5 receptor, alpha | 7380 | -0.006 | -0.2483 | No |
| 72 | RAP2A | RAP2A Entrez, Source | RAP2A, member of RAS oncogene family | 7385 | -0.006 | -0.2482 | No |
| 73 | TRH | TRH Entrez, Source | thyrotropin-releasing hormone | 7594 | -0.009 | -0.2634 | No |
| 74 | CD200 | CD200 Entrez, Source | CD200 molecule | 7661 | -0.010 | -0.2677 | No |
| 75 | PDE3B | PDE3B Entrez, Source | phosphodiesterase 3B, cGMP-inhibited | 8189 | -0.018 | -0.3064 | No |
| 76 | GATA3 | GATA3 Entrez, Source | GATA binding protein 3 | 8231 | -0.019 | -0.3083 | No |
| 77 | CD48 | CD48 Entrez, Source | CD48 molecule | 8344 | -0.021 | -0.3154 | No |
| 78 | ADIPOR1 | ADIPOR1 Entrez, Source | adiponectin receptor 1 | 8460 | -0.022 | -0.3227 | No |
| 79 | FGF13 | FGF13 Entrez, Source | fibroblast growth factor 13 | 8816 | -0.028 | -0.3477 | No |
| 80 | BZRAP1 | BZRAP1 Entrez, Source | benzodiazapine receptor (peripheral) associated protein 1 | 9092 | -0.034 | -0.3662 | No |
| 81 | TMEM158 | TMEM158 Entrez, Source | transmembrane protein 158 | 9629 | -0.044 | -0.4039 | No |
| 82 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 9787 | -0.048 | -0.4126 | No |
| 83 | FCER1A | FCER1A Entrez, Source | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 10066 | -0.053 | -0.4301 | No |
| 84 | EGFL7 | EGFL7 Entrez, Source | EGF-like-domain, multiple 7 | 10344 | -0.060 | -0.4471 | No |
| 85 | ELA2 | ELA2 Entrez, Source | elastase 2, neutrophil | 10427 | -0.062 | -0.4493 | No |
| 86 | GMPR | GMPR Entrez, Source | guanosine monophosphate reductase | 10520 | -0.065 | -0.4520 | No |
| 87 | PDE4B | PDE4B Entrez, Source | phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) | 10834 | -0.073 | -0.4708 | No |
| 88 | TACSTD2 | TACSTD2 Entrez, Source | tumor-associated calcium signal transducer 2 | 11339 | -0.092 | -0.5029 | Yes |
| 89 | BLNK | BLNK Entrez, Source | B-cell linker | 11422 | -0.096 | -0.5028 | Yes |
| 90 | F2RL1 | F2RL1 Entrez, Source | coagulation factor II (thrombin) receptor-like 1 | 11450 | -0.098 | -0.4984 | Yes |
| 91 | CD3D | CD3D Entrez, Source | CD3d molecule, delta (CD3-TCR complex) | 11471 | -0.098 | -0.4935 | Yes |
| 92 | GATM | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 11580 | -0.103 | -0.4949 | Yes |
| 93 | MLLT3 | MLLT3 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 11753 | -0.111 | -0.5006 | Yes |
| 94 | TGFB1I1 | TGFB1I1 Entrez, Source | transforming growth factor beta 1 induced transcript 1 | 11764 | -0.112 | -0.4940 | Yes |
| 95 | C1ORF24 | C1ORF24 Entrez, Source | chromosome 1 open reading frame 24 | 11910 | -0.119 | -0.4971 | Yes |
| 96 | B4GALT6 | B4GALT6 Entrez, Source | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | 11958 | -0.122 | -0.4926 | Yes |
| 97 | JUP | JUP Entrez, Source | junction plakoglobin | 12003 | -0.125 | -0.4877 | Yes |
| 98 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 12119 | -0.132 | -0.4877 | Yes |
| 99 | PTGER4 | PTGER4 Entrez, Source | prostaglandin E receptor 4 (subtype EP4) | 12179 | -0.137 | -0.4832 | Yes |
| 100 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12398 | -0.157 | -0.4893 | Yes |
| 101 | FZD6 | FZD6 Entrez, Source | frizzled homolog 6 (Drosophila) | 12417 | -0.160 | -0.4802 | Yes |
| 102 | TMOD1 | TMOD1 Entrez, Source | tropomodulin 1 | 12458 | -0.165 | -0.4724 | Yes |
| 103 | VLDLR | VLDLR Entrez, Source | very low density lipoprotein receptor | 12472 | -0.167 | -0.4624 | Yes |
| 104 | ITM2C | ITM2C Entrez, Source | integral membrane protein 2C | 12556 | -0.179 | -0.4569 | Yes |
| 105 | CD38 | CD38 Entrez, Source | CD38 molecule | 12627 | -0.189 | -0.4498 | Yes |
| 106 | FZD2 | FZD2 Entrez, Source | frizzled homolog 2 (Drosophila) | 12634 | -0.191 | -0.4377 | Yes |
| 107 | WASF1 | WASF1 Entrez, Source | WAS protein family, member 1 | 12675 | -0.199 | -0.4276 | Yes |
| 108 | SH3BP4 | SH3BP4 Entrez, Source | SH3-domain binding protein 4 | 12682 | -0.201 | -0.4149 | Yes |
| 109 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 12847 | -0.236 | -0.4118 | Yes |
| 110 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12855 | -0.239 | -0.3966 | Yes |
| 111 | UGCG | UGCG Entrez, Source | UDP-glucose ceramide glucosyltransferase | 12906 | -0.254 | -0.3837 | Yes |
| 112 | IFI44 | IFI44 Entrez, Source | interferon-induced protein 44 | 12935 | -0.264 | -0.3685 | Yes |
| 113 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 13018 | -0.300 | -0.3550 | Yes |
| 114 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 13080 | -0.340 | -0.3372 | Yes |
| 115 | EMP1 | EMP1 Entrez, Source | epithelial membrane protein 1 | 13109 | -0.363 | -0.3155 | Yes |
| 116 | PROM1 | PROM1 Entrez, Source | prominin 1 | 13138 | -0.389 | -0.2920 | Yes |
| 117 | SCRN1 | SCRN1 Entrez, Source | secernin 1 | 13140 | -0.392 | -0.2664 | Yes |
| 118 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13160 | -0.412 | -0.2407 | Yes |
| 119 | VIL2 | VIL2 Entrez, Source | villin 2 (ezrin) | 13200 | -0.467 | -0.2130 | Yes |
| 120 | NBL1 | NBL1 Entrez, Source | neuroblastoma, suppression of tumorigenicity 1 | 13217 | -0.493 | -0.1818 | Yes |
| 121 | SERINC5 | SERINC5 Entrez, Source | serine incorporator 5 | 13225 | -0.503 | -0.1492 | Yes |
| 122 | GNAI1 | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 13262 | -0.580 | -0.1138 | Yes |
| 123 | CD69 | CD69 Entrez, Source | CD69 molecule | 13310 | -0.833 | -0.0627 | Yes |
| 124 | IGFBP7 | IGFBP7 Entrez, Source | insulin-like growth factor binding protein 7 | 13322 | -0.989 | 0.0015 | Yes |
