Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | AGEING_KIDNEY_SPECIFIC_UP |
| Enrichment Score (ES) | 0.5796268 |
| Normalized Enrichment Score (NES) | 2.0690987 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0021959879 |
| FWER p-Value | 0.037 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 12 | 1.254 | 0.0656 | Yes |
| 2 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 25 | 0.995 | 0.1175 | Yes |
| 3 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 43 | 0.843 | 0.1610 | Yes |
| 4 | RGS1 | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 73 | 0.715 | 0.1967 | Yes |
| 5 | BHLHB3 | BHLHB3 Entrez, Source | basic helix-loop-helix domain containing, class B, 3 | 98 | 0.666 | 0.2302 | Yes |
| 6 | CLDN1 | CLDN1 Entrez, Source | claudin 1 | 118 | 0.623 | 0.2619 | Yes |
| 7 | PROM1 | PROM1 Entrez, Source | prominin 1 | 152 | 0.562 | 0.2892 | Yes |
| 8 | VCAM1 | VCAM1 Entrez, Source | vascular cell adhesion molecule 1 | 183 | 0.515 | 0.3142 | Yes |
| 9 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 190 | 0.499 | 0.3402 | Yes |
| 10 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 218 | 0.471 | 0.3632 | Yes |
| 11 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 405 | 0.336 | 0.3669 | Yes |
| 12 | TPBG | TPBG Entrez, Source | trophoblast glycoprotein | 413 | 0.330 | 0.3839 | Yes |
| 13 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 488 | 0.290 | 0.3937 | Yes |
| 14 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 525 | 0.277 | 0.4057 | Yes |
| 15 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 542 | 0.272 | 0.4189 | Yes |
| 16 | PKIB | PKIB Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor beta | 592 | 0.258 | 0.4289 | Yes |
| 17 | CDO1 | CDO1 Entrez, Source | cysteine dioxygenase, type I | 689 | 0.237 | 0.4342 | Yes |
| 18 | MGLL | MGLL Entrez, Source | monoglyceride lipase | 718 | 0.232 | 0.4444 | Yes |
| 19 | ITM2C | ITM2C Entrez, Source | integral membrane protein 2C | 741 | 0.229 | 0.4549 | Yes |
| 20 | CLDN3 | CLDN3 Entrez, Source | claudin 3 | 745 | 0.228 | 0.4667 | Yes |
| 21 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 786 | 0.217 | 0.4752 | Yes |
| 22 | WFDC2 | WFDC2 Entrez, Source | WAP four-disulfide core domain 2 | 794 | 0.215 | 0.4861 | Yes |
| 23 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 863 | 0.201 | 0.4916 | Yes |
| 24 | VTCN1 | VTCN1 Entrez, Source | V-set domain containing T cell activation inhibitor 1 | 893 | 0.197 | 0.4999 | Yes |
| 25 | PRICKLE1 | PRICKLE1 Entrez, Source | prickle homolog 1 (Drosophila) | 927 | 0.191 | 0.5075 | Yes |
| 26 | FBN1 | FBN1 Entrez, Source | fibrillin 1 | 968 | 0.187 | 0.5144 | Yes |
| 27 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 1052 | 0.177 | 0.5175 | Yes |
| 28 | TMED3 | TMED3 Entrez, Source | transmembrane emp24 protein transport domain containing 3 | 1053 | 0.177 | 0.5269 | Yes |
| 29 | FEZ2 | FEZ2 Entrez, Source | fasciculation and elongation protein zeta 2 (zygin II) | 1075 | 0.173 | 0.5345 | Yes |
| 30 | NOV | NOV Entrez, Source | nephroblastoma overexpressed gene | 1086 | 0.172 | 0.5429 | Yes |
| 31 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 1095 | 0.171 | 0.5514 | Yes |
| 32 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 1105 | 0.170 | 0.5597 | Yes |
| 33 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 1195 | 0.161 | 0.5616 | Yes |
| 34 | FN1 | FN1 Entrez, Source | fibronectin 1 | 1246 | 0.156 | 0.5661 | Yes |
| 35 | LOXL1 | LOXL1 Entrez, Source | lysyl oxidase-like 1 | 1282 | 0.152 | 0.5715 | Yes |
| 36 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 1385 | 0.144 | 0.5714 | Yes |
| 37 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 1410 | 0.142 | 0.5772 | Yes |
| 38 | CTHRC1 | CTHRC1 Entrez, Source | collagen triple helix repeat containing 1 | 1491 | 0.136 | 0.5783 | Yes |
| 39 | SMPD2 | SMPD2 Entrez, Source | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | 1566 | 0.130 | 0.5796 | Yes |
| 40 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 1768 | 0.118 | 0.5707 | No |
| 41 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 1914 | 0.111 | 0.5657 | No |
| 42 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 2036 | 0.106 | 0.5621 | No |
| 43 | DPP3 | DPP3 Entrez, Source | dipeptidyl-peptidase 3 | 2307 | 0.095 | 0.5468 | No |
| 44 | AMBP | AMBP Entrez, Source | alpha-1-microglobulin/bikunin precursor | 2547 | 0.086 | 0.5333 | No |
| 45 | ITPR3 | ITPR3 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 3 | 2561 | 0.085 | 0.5368 | No |
| 46 | RBP1 | RBP1 Entrez, Source | retinol binding protein 1, cellular | 2591 | 0.084 | 0.5390 | No |
| 47 | RAB34 | RAB34 Entrez, Source | RAB34, member RAS oncogene family | 2722 | 0.079 | 0.5334 | No |
| 48 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 2894 | 0.074 | 0.5244 | No |
| 49 | C3 | C3 Entrez, Source | complement component 3 | 2945 | 0.073 | 0.5245 | No |
| 50 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3039 | 0.070 | 0.5212 | No |
| 51 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 3086 | 0.069 | 0.5214 | No |
| 52 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 3222 | 0.065 | 0.5146 | No |
| 53 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 3445 | 0.059 | 0.5010 | No |
| 54 | DEGS1 | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 3581 | 0.055 | 0.4937 | No |
| 55 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 3726 | 0.052 | 0.4856 | No |
| 56 | UBD | UBD Entrez, Source | ubiquitin D | 3783 | 0.050 | 0.4840 | No |
| 57 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 3983 | 0.045 | 0.4714 | No |
| 58 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 4507 | 0.034 | 0.4336 | No |
| 59 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 4835 | 0.027 | 0.4104 | No |
| 60 | EBF1 | EBF1 Entrez, Source | early B-cell factor 1 | 4971 | 0.025 | 0.4015 | No |
| 61 | VSNL1 | VSNL1 Entrez, Source | visinin-like 1 | 5194 | 0.020 | 0.3858 | No |
| 62 | ASNS | ASNS Entrez, Source | asparagine synthetase | 5217 | 0.020 | 0.3852 | No |
| 63 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 5378 | 0.017 | 0.3740 | No |
| 64 | MOXD1 | MOXD1 Entrez, Source | monooxygenase, DBH-like 1 | 5534 | 0.014 | 0.3630 | No |
| 65 | GGTLA1 | GGTLA1 Entrez, Source | gamma-glutamyltransferase-like activity 1 | 5579 | 0.013 | 0.3604 | No |
| 66 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 5660 | 0.012 | 0.3550 | No |
| 67 | NR2F1 | NR2F1 Entrez, Source | nuclear receptor subfamily 2, group F, member 1 | 5904 | 0.007 | 0.3370 | No |
| 68 | HEXB | HEXB Entrez, Source | hexosaminidase B (beta polypeptide) | 6263 | 0.000 | 0.3099 | No |
| 69 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 6293 | -0.000 | 0.3078 | No |
| 70 | RPN2 | RPN2 Entrez, Source | ribophorin II | 6553 | -0.005 | 0.2884 | No |
| 71 | SSR4 | SSR4 Entrez, Source | signal sequence receptor, delta (translocon-associated protein delta) | 6586 | -0.005 | 0.2863 | No |
| 72 | CXCL14 | CXCL14 Entrez, Source | chemokine (C-X-C motif) ligand 14 | 6900 | -0.010 | 0.2632 | No |
| 73 | COL15A1 | COL15A1 Entrez, Source | collagen, type XV, alpha 1 | 6979 | -0.012 | 0.2579 | No |
| 74 | GGTA1 | GGTA1 Entrez, Source | glycoprotein, alpha-galactosyltransferase 1 | 7462 | -0.021 | 0.2226 | No |
| 75 | SLC1A3 | SLC1A3 Entrez, Source | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 7511 | -0.022 | 0.2202 | No |
| 76 | ANTXR1 | ANTXR1 Entrez, Source | anthrax toxin receptor 1 | 7631 | -0.024 | 0.2124 | No |
| 77 | TSPAN1 | TSPAN1 Entrez, Source | tetraspanin 1 | 7845 | -0.028 | 0.1978 | No |
| 78 | SPARCL1 | SPARCL1 Entrez, Source | SPARC-like 1 (mast9, hevin) | 7928 | -0.030 | 0.1932 | No |
| 79 | CFB | CFB Entrez, Source | complement factor B | 8083 | -0.033 | 0.1834 | No |
| 80 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 8088 | -0.033 | 0.1848 | No |
| 81 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 8442 | -0.040 | 0.1603 | No |
| 82 | RPN1 | RPN1 Entrez, Source | ribophorin I | 8815 | -0.048 | 0.1347 | No |
| 83 | LUM | LUM Entrez, Source | lumican | 8919 | -0.050 | 0.1296 | No |
| 84 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 8951 | -0.051 | 0.1299 | No |
| 85 | PLOD3 | PLOD3 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 9471 | -0.062 | 0.0940 | No |
| 86 | COL27A1 | COL27A1 Entrez, Source | collagen, type XXVII, alpha 1 | 9515 | -0.063 | 0.0941 | No |
| 87 | SYMPK | SYMPK Entrez, Source | symplekin | 9605 | -0.065 | 0.0909 | No |
| 88 | GPR56 | GPR56 Entrez, Source | G protein-coupled receptor 56 | 9622 | -0.066 | 0.0932 | No |
| 89 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 9839 | -0.072 | 0.0807 | No |
| 90 | FGG | FGG Entrez, Source | fibrinogen gamma chain | 9841 | -0.072 | 0.0844 | No |
| 91 | RARRES1 | RARRES1 Entrez, Source | retinoic acid receptor responder (tazarotene induced) 1 | 9927 | -0.075 | 0.0819 | No |
| 92 | P4HB | P4HB Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | 10130 | -0.080 | 0.0709 | No |
| 93 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 10344 | -0.086 | 0.0594 | No |
| 94 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 10455 | -0.089 | 0.0558 | No |
| 95 | RPL35 | RPL35 Entrez, Source | ribosomal protein L35 | 10613 | -0.094 | 0.0489 | No |
| 96 | UBE2Z | UBE2Z Entrez, Source | ubiquitin-conjugating enzyme E2Z (putative) | 10856 | -0.103 | 0.0361 | No |
| 97 | VARS | VARS Entrez, Source | valyl-tRNA synthetase | 10921 | -0.106 | 0.0369 | No |
| 98 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 10944 | -0.106 | 0.0408 | No |
| 99 | GPNMB | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 10958 | -0.107 | 0.0455 | No |
| 100 | PHLDA3 | PHLDA3 Entrez, Source | pleckstrin homology-like domain, family A, member 3 | 10983 | -0.108 | 0.0494 | No |
| 101 | GGA2 | GGA2 Entrez, Source | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | 11485 | -0.128 | 0.0184 | No |
| 102 | RPL35A | RPL35A Entrez, Source | ribosomal protein L35a | 11499 | -0.129 | 0.0242 | No |
| 103 | NFIX | NFIX Entrez, Source | nuclear factor I/X (CCAAT-binding transcription factor) | 12029 | -0.159 | -0.0073 | No |
| 104 | HOMER3 | HOMER3 Entrez, Source | homer homolog 3 (Drosophila) | 12210 | -0.172 | -0.0118 | No |
| 105 | RPS25 | RPS25 Entrez, Source | ribosomal protein S25 | 12343 | -0.183 | -0.0120 | No |
| 106 | PDGFC | PDGFC Entrez, Source | platelet derived growth factor C | 12749 | -0.233 | -0.0303 | No |
| 107 | PDIA4 | PDIA4 Entrez, Source | protein disulfide isomerase family A, member 4 | 12902 | -0.267 | -0.0276 | No |
| 108 | AATF | AATF Entrez, Source | apoptosis antagonizing transcription factor | 12959 | -0.279 | -0.0170 | No |
| 109 | ABCC3 | ABCC3 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 13059 | -0.310 | -0.0081 | No |
| 110 | CRELD2 | CRELD2 Entrez, Source | cysteine-rich with EGF-like domains 2 | 13289 | -0.554 | 0.0040 | No |
