Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | ALCOHOL_METABOLIC_PROCESS |
| Enrichment Score (ES) | 0.5807573 |
| Normalized Enrichment Score (NES) | 1.8861797 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.014555946 |
| FWER p-Value | 0.595 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PFKFB1 | PFKFB1 Entrez, Source | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 47 | 0.829 | 0.0844 | Yes |
| 2 | SOAT1 | SOAT1 Entrez, Source | sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 | 100 | 0.661 | 0.1506 | Yes |
| 3 | MIOX | MIOX Entrez, Source | myo-inositol oxygenase | 146 | 0.570 | 0.2077 | Yes |
| 4 | ABCG1 | ABCG1 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 1 | 179 | 0.519 | 0.2604 | Yes |
| 5 | FBP1 | FBP1 Entrez, Source | fructose-1,6-bisphosphatase 1 | 203 | 0.484 | 0.3100 | Yes |
| 6 | SULT1B1 | SULT1B1 Entrez, Source | sulfotransferase family, cytosolic, 1B, member 1 | 238 | 0.454 | 0.3556 | Yes |
| 7 | PDK4 | PDK4 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 4 | 285 | 0.410 | 0.3957 | Yes |
| 8 | ADH7 | ADH7 Entrez, Source | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 329 | 0.374 | 0.4321 | Yes |
| 9 | HK1 | HK1 Entrez, Source | hexokinase 1 | 385 | 0.345 | 0.4646 | Yes |
| 10 | SCARB1 | SCARB1 Entrez, Source | scavenger receptor class B, member 1 | 431 | 0.321 | 0.4952 | Yes |
| 11 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 561 | 0.267 | 0.5138 | Yes |
| 12 | PDK2 | PDK2 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 2 | 783 | 0.219 | 0.5204 | Yes |
| 13 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 916 | 0.193 | 0.5310 | Yes |
| 14 | CLN8 | CLN8 Entrez, Source | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 1037 | 0.178 | 0.5408 | Yes |
| 15 | PPARGC1A | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 1066 | 0.174 | 0.5572 | Yes |
| 16 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 1169 | 0.164 | 0.5669 | Yes |
| 17 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 1211 | 0.160 | 0.5808 | Yes |
| 18 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 2111 | 0.103 | 0.5240 | No |
| 19 | ALDOB | ALDOB Entrez, Source | aldolase B, fructose-bisphosphate | 2152 | 0.101 | 0.5318 | No |
| 20 | NR0B2 | NR0B2 Entrez, Source | nuclear receptor subfamily 0, group B, member 2 | 2330 | 0.094 | 0.5284 | No |
| 21 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 2544 | 0.086 | 0.5215 | No |
| 22 | COQ3 | COQ3 Entrez, Source | coenzyme Q3 homolog, methyltransferase (S. cerevisiae) | 2872 | 0.075 | 0.5048 | No |
| 23 | FPGT | FPGT Entrez, Source | fucose-1-phosphate guanylyltransferase | 3102 | 0.068 | 0.4949 | No |
| 24 | ALDOC | ALDOC Entrez, Source | aldolase C, fructose-bisphosphate | 3477 | 0.058 | 0.4729 | No |
| 25 | SLC25A10 | SLC25A10 Entrez, Source | solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 | 3966 | 0.045 | 0.4410 | No |
| 26 | GFPT2 | GFPT2 Entrez, Source | glutamine-fructose-6-phosphate transaminase 2 | 4020 | 0.044 | 0.4416 | No |
| 27 | PFKM | PFKM Entrez, Source | phosphofructokinase, muscle | 4179 | 0.040 | 0.4340 | No |
| 28 | CHST1 | CHST1 Entrez, Source | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | 4227 | 0.039 | 0.4346 | No |
| 29 | MBTPS2 | MBTPS2 Entrez, Source | membrane-bound transcription factor peptidase, site 2 | 4585 | 0.032 | 0.4111 | No |
| 30 | ADH6 | ADH6 Entrez, Source | alcohol dehydrogenase 6 (class V) | 4624 | 0.032 | 0.4116 | No |
| 31 | ALDOA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 5039 | 0.023 | 0.3829 | No |
| 32 | CEL | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 5047 | 0.023 | 0.3848 | No |
| 33 | IPPK | IPPK Entrez, Source | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | 5187 | 0.020 | 0.3766 | No |
| 34 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 5532 | 0.014 | 0.3522 | No |
| 35 | GALT | GALT Entrez, Source | galactose-1-phosphate uridylyltransferase | 5550 | 0.014 | 0.3523 | No |
| 36 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 5728 | 0.010 | 0.3401 | No |
| 37 | PFKL | PFKL Entrez, Source | phosphofructokinase, liver | 5889 | 0.007 | 0.3288 | No |
| 38 | ATF4 | ATF4 Entrez, Source | activating transcription factor 4 (tax-responsive enhancer element B67) | 6295 | -0.000 | 0.2983 | No |
| 39 | ADH4 | ADH4 Entrez, Source | alcohol dehydrogenase 4 (class II), pi polypeptide | 6589 | -0.005 | 0.2769 | No |
| 40 | GMDS | GMDS Entrez, Source | GDP-mannose 4,6-dehydratase | 6723 | -0.008 | 0.2677 | No |
| 41 | FBP2 | FBP2 Entrez, Source | fructose-1,6-bisphosphatase 2 | 7034 | -0.013 | 0.2457 | No |
| 42 | SPHK1 | SPHK1 Entrez, Source | sphingosine kinase 1 | 7090 | -0.014 | 0.2430 | No |
| 43 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7093 | -0.014 | 0.2443 | No |
| 44 | GFPT1 | GFPT1 Entrez, Source | glutamine-fructose-6-phosphate transaminase 1 | 7247 | -0.017 | 0.2346 | No |
| 45 | ACN9 | ACN9 Entrez, Source | ACN9 homolog (S. cerevisiae) | 7494 | -0.022 | 0.2184 | No |
| 46 | GAPDHS | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 7619 | -0.024 | 0.2116 | No |
| 47 | AKR1A1 | AKR1A1 Entrez, Source | aldo-keto reductase family 1, member A1 (aldehyde reductase) | 8947 | -0.051 | 0.1171 | No |
| 48 | ARPP-19 | ARPP-19 Entrez, Source | - | 9233 | -0.057 | 0.1016 | No |
| 49 | HPRT1 | HPRT1 Entrez, Source | hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) | 9384 | -0.060 | 0.0967 | No |
| 50 | HDLBP | HDLBP Entrez, Source | high density lipoprotein binding protein (vigilin) | 9423 | -0.061 | 0.1003 | No |
| 51 | PDK1 | PDK1 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 1 | 11028 | -0.109 | -0.0089 | No |
| 52 | ALDH3B1 | ALDH3B1 Entrez, Source | aldehyde dehydrogenase 3 family, member B1 | 11040 | -0.109 | 0.0019 | No |
| 53 | GALK1 | GALK1 Entrez, Source | galactokinase 1 | 11136 | -0.114 | 0.0068 | No |
| 54 | CNBP | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 11520 | -0.130 | -0.0082 | No |
| 55 | IL4 | IL4 Entrez, Source | interleukin 4 | 11640 | -0.135 | -0.0028 | No |
| 56 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 11925 | -0.152 | -0.0081 | No |
| 57 | GCK | GCK Entrez, Source | glucokinase (hexokinase 4, maturity onset diabetes of the young 2) | 13052 | -0.307 | -0.0603 | No |
| 58 | UGDH | UGDH Entrez, Source | UDP-glucose dehydrogenase | 13138 | -0.352 | -0.0293 | No |
| 59 | UGP2 | UGP2 Entrez, Source | UDP-glucose pyrophosphorylase 2 | 13213 | -0.421 | 0.0097 | No |
