Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | APOPTOSIS |
| Enrichment Score (ES) | -0.42202583 |
| Normalized Enrichment Score (NES) | -1.3827643 |
| Nominal p-value | 0.06430155 |
| FDR q-value | 0.31506282 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 565 | 0.265 | 0.0235 | No |
| 2 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 1025 | 0.179 | 0.0336 | No |
| 3 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 1530 | 0.133 | 0.0287 | No |
| 4 | NFKBIB | NFKBIB Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 2031 | 0.106 | 0.0176 | No |
| 5 | MAPK10 | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 2865 | 0.075 | -0.0263 | No |
| 6 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 3164 | 0.067 | -0.0321 | No |
| 7 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 3256 | 0.064 | -0.0230 | No |
| 8 | PRF1 | PRF1 Entrez, Source | perforin 1 (pore forming protein) | 3708 | 0.052 | -0.0440 | No |
| 9 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 4187 | 0.040 | -0.0700 | No |
| 10 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 4606 | 0.032 | -0.0935 | No |
| 11 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 4778 | 0.028 | -0.0993 | No |
| 12 | BIRC4 | BIRC4 Entrez, Source | baculoviral IAP repeat-containing 4 | 4947 | 0.025 | -0.1057 | No |
| 13 | CASP1 | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 5002 | 0.024 | -0.1037 | No |
| 14 | DFFA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 5035 | 0.023 | -0.1003 | No |
| 15 | TRADD | TRADD Entrez, Source | TNFRSF1A-associated via death domain | 5653 | 0.012 | -0.1438 | No |
| 16 | BNIP3L | BNIP3L Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 5729 | 0.010 | -0.1468 | No |
| 17 | BIRC5 | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 5848 | 0.008 | -0.1537 | No |
| 18 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 5892 | 0.007 | -0.1551 | No |
| 19 | IRF3 | IRF3 Entrez, Source | interferon regulatory factor 3 | 6029 | 0.005 | -0.1642 | No |
| 20 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 6181 | 0.001 | -0.1752 | No |
| 21 | JUN | JUN Entrez, Source | jun oncogene | 6649 | -0.006 | -0.2087 | No |
| 22 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 6828 | -0.009 | -0.2198 | No |
| 23 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 6929 | -0.011 | -0.2246 | No |
| 24 | IRF1 | IRF1 Entrez, Source | interferon regulatory factor 1 | 7528 | -0.022 | -0.2641 | No |
| 25 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 7532 | -0.022 | -0.2588 | No |
| 26 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 7544 | -0.022 | -0.2540 | No |
| 27 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 7883 | -0.029 | -0.2722 | No |
| 28 | MAP2K4 | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 7969 | -0.031 | -0.2710 | No |
| 29 | CASP6 | CASP6 Entrez, Source | caspase 6, apoptosis-related cysteine peptidase | 8068 | -0.033 | -0.2702 | No |
| 30 | FASLG | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 8217 | -0.036 | -0.2725 | No |
| 31 | LTA | LTA Entrez, Source | lymphotoxin alpha (TNF superfamily, member 1) | 8246 | -0.036 | -0.2655 | No |
| 32 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 8306 | -0.037 | -0.2606 | No |
| 33 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 8748 | -0.046 | -0.2822 | No |
| 34 | DFFB | DFFB Entrez, Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 9437 | -0.061 | -0.3187 | No |
| 35 | GZMB | GZMB Entrez, Source | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 9634 | -0.066 | -0.3169 | No |
| 36 | BAX | BAX Entrez, Source | BCL2-associated X protein | 10485 | -0.090 | -0.3585 | No |
| 37 | BCL2L11 | BCL2L11 Entrez, Source | BCL2-like 11 (apoptosis facilitator) | 11005 | -0.108 | -0.3705 | No |
| 38 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11266 | -0.119 | -0.3604 | No |
| 39 | BID | BID Entrez, Source | BH3 interacting domain death agonist | 12086 | -0.163 | -0.3814 | Yes |
| 40 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 12249 | -0.175 | -0.3498 | Yes |
| 41 | MAP3K1 | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 12410 | -0.189 | -0.3149 | Yes |
| 42 | CASP7 | CASP7 Entrez, Source | caspase 7, apoptosis-related cysteine peptidase | 12574 | -0.208 | -0.2754 | Yes |
| 43 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 12738 | -0.231 | -0.2302 | Yes |
| 44 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 13119 | -0.337 | -0.1748 | Yes |
| 45 | CASP2 | CASP2 Entrez, Source | caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) | 13151 | -0.360 | -0.0874 | Yes |
| 46 | CASP4 | CASP4 Entrez, Source | caspase 4, apoptosis-related cysteine peptidase | 13204 | -0.408 | 0.0104 | Yes |
