Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_8d_versus_double_gel_24h.class.cls
#double_gel_8d_versus_double_gel_24h_repos
Phenotypeclass.cls#double_gel_8d_versus_double_gel_24h_repos
Upregulated in classdouble_gel_8d
GeneSetBOQUEST_CD31PLUS_VS_CD31MINUS_DN
Enrichment Score (ES)0.56108236
Normalized Enrichment Score (NES)2.0988724
Nominal p-value0.0
FDR q-value0.0016635908
FWER p-Value0.024
Table: GSEA Results Summary



Fig 1: Enrichment plot: BOQUEST_CD31PLUS_VS_CD31MINUS_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1COL1A2COL1A2
Entrez,  Source
collagen, type I, alpha 2121.2540.0499Yes
2COL3A1COL3A1
Entrez,  Source
collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)430.8430.0818Yes
3COL5A2COL5A2
Entrez,  Source
collagen, type V, alpha 2610.7590.1113Yes
4CRYABCRYAB
Entrez,  Source
crystallin, alpha B620.7560.1419Yes
5ACOX2ACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain970.6670.1664Yes
6BHLHB3BHLHB3
Entrez,  Source
basic helix-loop-helix domain containing, class B, 3980.6660.1934Yes
7MGPMGP
Entrez,  Source
matrix Gla protein1080.6440.2188Yes
8OMDOMD
Entrez,  Source
osteomodulin1550.5560.2378Yes
9TNFAIP6TNFAIP6
Entrez,  Source
tumor necrosis factor, alpha-induced protein 61590.5500.2599Yes
10MRC2MRC2
Entrez,  Source
mannose receptor, C type 21610.5470.2820Yes
11TMEM176BTMEM176B
Entrez,  Source
transmembrane protein 176B1680.5350.3032Yes
12ALDH1A1ALDH1A1
Entrez,  Source
aldehyde dehydrogenase 1 family, member A11850.5100.3227Yes
13SERPINE2SERPINE2
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 21900.4990.3426Yes
14PRELPPRELP
Entrez,  Source
proline/arginine-rich end leucine-rich repeat protein2290.4590.3583Yes
15CFDCFD
Entrez,  Source
complement factor D (adipsin)2860.4100.3707Yes
16COL1A1COL1A1
Entrez,  Source
collagen, type I, alpha 15250.2770.3638Yes
17IGFBP3IGFBP3
Entrez,  Source
insulin-like growth factor binding protein 35330.2740.3744Yes
18LOXLOX
Entrez,  Source
lysyl oxidase5580.2670.3834Yes
19GPC4GPC4
Entrez,  Source
glypican 45770.2620.3927Yes
20COL6A2COL6A2
Entrez,  Source
collagen, type VI, alpha 25790.2620.4032Yes
21GSTM3GSTM3
Entrez,  Source
glutathione S-transferase M3 (brain)6060.2560.4116Yes
22EMP3EMP3
Entrez,  Source
epithelial membrane protein 36620.2430.4173Yes
23GSNGSN
Entrez,  Source
gelsolin (amyloidosis, Finnish type)6660.2420.4269Yes
24FSTFST
Entrez,  Source
follistatin6780.2400.4358Yes
25CDO1CDO1
Entrez,  Source
cysteine dioxygenase, type I6890.2370.4446Yes
26PTPRDPTPRD
Entrez,  Source
protein tyrosine phosphatase, receptor type, D7310.2290.4508Yes
27CD302CD302
Entrez,  Source
CD302 molecule7470.2270.4589Yes
28GPC3GPC3
Entrez,  Source
glypican 37570.2240.4673Yes
29PLAGL1PLAGL1
Entrez,  Source
pleiomorphic adenoma gene-like 17640.2230.4759Yes
30PCOLCEPCOLCE
Entrez,  Source
procollagen C-endopeptidase enhancer8040.2130.4815Yes
31TWIST1TWIST1
Entrez,  Source
twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)8130.2110.4895Yes
32MAFBMAFB
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)8560.2030.4945Yes
33SERPINA5SERPINA5
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 58760.1990.5011Yes
34F3F3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)9560.1880.5027Yes
35FBN1FBN1
Entrez,  Source
fibrillin 19680.1870.5094Yes
36PLNPLN
Entrez,  Source
phospholamban9940.1830.5150Yes
37TSPAN8TSPAN8
Entrez,  Source
tetraspanin 810160.1800.5207Yes
38BASP1BASP1
Entrez,  Source
brain abundant, membrane attached signal protein 110310.1780.5268Yes
39TMED3TMED3
Entrez,  Source
transmembrane emp24 protein transport domain containing 310530.1770.5324Yes
40FEZ1FEZ1
Entrez,  Source
fasciculation and elongation protein zeta 1 (zygin I)10770.1730.5377Yes
41TIMP1TIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 110950.1710.5433Yes
42PTGISPTGIS
Entrez,  Source
prostaglandin I2 (prostacyclin) synthase11070.1700.5494Yes
43APODAPOD
Entrez,  Source
apolipoprotein D11220.1690.5552Yes
44PDE4DIPPDE4DIP
Entrez,  Source
phosphodiesterase 4D interacting protein (myomegalin)11340.1670.5611Yes
45S100A4S100A4
Entrez,  Source
S100 calcium binding protein A412850.1520.5559No
46EDG2EDG2
Entrez,  Source
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 213990.1430.5531No
47CUGBP2CUGBP2
Entrez,  Source
CUG triplet repeat, RNA binding protein 215010.1350.5509No
48SCRN1SCRN1
Entrez,  Source
secernin 115070.1340.5560No
49FXYD1FXYD1
Entrez,  Source
FXYD domain containing ion transport regulator 1 (phospholemman)17210.1220.5447No
50NET1NET1
Entrez,  Source
neuroepithelial cell transforming gene 117320.1210.5489No
51DZIP1DZIP1
Entrez,  Source
DAZ interacting protein 119600.1090.5361No
52DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 220210.1070.5359No
53RNASE4RNASE4
Entrez,  Source
ribonuclease, RNase A family, 420640.1050.5369No
54ASPAASPA
Entrez,  Source
aspartoacylase (Canavan disease)20900.1040.5393No
55LIFLIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)22040.0990.5347No
56SGCESGCE
Entrez,  Source
sarcoglycan, epsilon22740.0960.5334No
57SERPINF1SERPINF1
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 123610.0930.5306No
58IGFBP6IGFBP6
Entrez,  Source
insulin-like growth factor binding protein 625980.0840.5161No
59APOEAPOE
Entrez,  Source
apolipoprotein E26190.0830.5180No
60MFAP4MFAP4
Entrez,  Source
microfibrillar-associated protein 426440.0820.5195No
61C6C6
Entrez,  Source
complement component 629220.0740.5015No
62HNMTHNMT
Entrez,  Source
histamine N-methyltransferase29860.0720.4996No
63OSR2OSR2
Entrez,  Source
odd-skipped related 2 (Drosophila)30290.0700.4993No
64AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase30860.0690.4978No
65FGF7FGF7
Entrez,  Source
fibroblast growth factor 7 (keratinocyte growth factor)31880.0660.4928No
66COL5A1COL5A1
Entrez,  Source
collagen, type V, alpha 132220.0650.4929No
67LTBP2LTBP2
Entrez,  Source
latent transforming growth factor beta binding protein 233240.0620.4878No
68EFEMP1EFEMP1
Entrez,  Source
EGF-containing fibulin-like extracellular matrix protein 133780.0610.4862No
69DCAMKL1DCAMKL1
Entrez,  Source
doublecortin and CaM kinase-like 136150.0540.4706No
70PLA2G2APLA2G2A
Entrez,  Source
phospholipase A2, group IIA (platelets, synovial fluid)36180.0540.4726No
71NOVA1NOVA1
Entrez,  Source
neuro-oncological ventral antigen 136640.0530.4714No
72PDLIM3PDLIM3
Entrez,  Source
PDZ and LIM domain 336800.0530.4723No
73PLA2G4APLA2G4A
Entrez,  Source
phospholipase A2, group IVA (cytosolic, calcium-dependent)37850.0500.4665No
74KCNK1KCNK1
Entrez,  Source
potassium channel, subfamily K, member 139130.0470.4588No
75CDH11CDH11
Entrez,  Source
cadherin 11, type 2, OB-cadherin (osteoblast)39830.0450.4554No
76GFPT2GFPT2
Entrez,  Source
glutamine-fructose-6-phosphate transaminase 240200.0440.4544No
77LRP1LRP1
Entrez,  Source
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)42040.0390.4421No
78CFHCFH
Entrez,  Source
complement factor H42090.0390.4434No
79SLIT2SLIT2
Entrez,  Source
slit homolog 2 (Drosophila)43300.0370.4358No
80PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide43520.0370.4357No
81SDC2SDC2
Entrez,  Source
syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)45690.0330.4207No
82NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 245740.0330.4217No
83THBS2THBS2
Entrez,  Source
thrombospondin 247380.0290.4105No
84ATP1A2ATP1A2
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide49430.0250.3961No
85GAS7GAS7
Entrez,  Source
growth arrest-specific 750520.0230.3888No
86SRPXSRPX
Entrez,  Source
sushi-repeat-containing protein, X-linked51530.0210.3821No
87CYBRD1CYBRD1
Entrez,  Source
cytochrome b reductase 151730.0210.3815No
88CAPN6CAPN6
Entrez,  Source
calpain 652470.0200.3768No
89BMPR1ABMPR1A
Entrez,  Source
bone morphogenetic protein receptor, type IA53090.0190.3729No
90COL16A1COL16A1
Entrez,  Source
collagen, type XVI, alpha 153880.0170.3677No
91MMP2MMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)55400.0140.3568No
92SPOCK1SPOCK1
Entrez,  Source
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 156370.0120.3500No
93NPY1RNPY1R
Entrez,  Source
neuropeptide Y receptor Y156630.0120.3486No
94SLIT3SLIT3
Entrez,  Source
slit homolog 3 (Drosophila)57340.0100.3437No
95MYOCMYOC
Entrez,  Source
myocilin, trabecular meshwork inducible glucocorticoid response58770.0080.3332No
96PTGDSPTGDS
Entrez,  Source
prostaglandin D2 synthase 21kDa (brain)59000.0070.3318No
97SFRP4SFRP4
Entrez,  Source
secreted frizzled-related protein 459200.0070.3307No
98CEBPBCEBPB
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), beta60620.0040.3201No
99WISP2WISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 261340.0030.3149No
100DCXDCX
Entrez,  Source
doublecortex; lissencephaly, X-linked (doublecortin)61860.0010.3110No
101CDKN2CCDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)6502-0.0040.2873No
102PRRX1PRRX1
Entrez,  Source
paired related homeobox 16636-0.0060.2775No
103FMODFMOD
Entrez,  Source
fibromodulin6665-0.0070.2756No
104CXCL14CXCL14
Entrez,  Source
chemokine (C-X-C motif) ligand 146900-0.0100.2583No
105ROBO1ROBO1
Entrez,  Source
roundabout, axon guidance receptor, homolog 1 (Drosophila)6932-0.0110.2564No
106F10F10
Entrez,  Source
coagulation factor X7144-0.0150.2410No
107DCNDCN
Entrez,  Source
decorin7217-0.0160.2362No
108CHRDL1CHRDL1
Entrez,  Source
chordin-like 17218-0.0160.2369No
109CRABP2CRABP2
Entrez,  Source
cellular retinoic acid binding protein 27366-0.0190.2265No
110KCND2KCND2
Entrez,  Source
potassium voltage-gated channel, Shal-related subfamily, member 27584-0.0230.2110No
111INHBAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)7768-0.0270.1982No
112CSPG2CSPG2
Entrez,  Source
chondroitin sulfate proteoglycan 2 (versican)7897-0.0290.1897No
113PDGFDPDGFD
Entrez,  Source
platelet derived growth factor D7976-0.0310.1850No
114CFBCFB
Entrez,  Source
complement factor B8083-0.0330.1783No
115MBPMBP
Entrez,  Source
myelin basic protein8096-0.0330.1788No
116PTGFRPTGFR
Entrez,  Source
prostaglandin F receptor (FP)8181-0.0350.1738No
117MYH11MYH11
Entrez,  Source
myosin, heavy chain 11, smooth muscle8278-0.0370.1680No
118LSP1LSP1
Entrez,  Source
lymphocyte-specific protein 18463-0.0410.1557No
119FBLN5FBLN5
Entrez,  Source
fibulin 58504-0.0420.1544No
120SHOX2SHOX2
Entrez,  Source
short stature homeobox 28562-0.0430.1518No
121SLC22A3SLC22A3
Entrez,  Source
solute carrier family 22 (extraneuronal monoamine transporter), member 38585-0.0430.1519No
122WNT5AWNT5A
Entrez,  Source
wingless-type MMTV integration site family, member 5A8849-0.0490.1339No
123LUMLUM
Entrez,  Source
lumican8919-0.0500.1307No
124CTSKCTSK
Entrez,  Source
cathepsin K (pycnodysostosis)8999-0.0520.1268No
125IGF1IGF1
Entrez,  Source
insulin-like growth factor 1 (somatomedin C)9134-0.0550.1189No
126FIGFFIGF
Entrez,  Source
c-fos induced growth factor (vascular endothelial growth factor D)9671-0.0670.0810No
127HTRA1HTRA1
Entrez,  Source
HtrA serine peptidase 19698-0.0680.0817No
128GDF10GDF10
Entrez,  Source
growth differentiation factor 1010049-0.0780.0584No
129ANGPT1ANGPT1
Entrez,  Source
angiopoietin 110068-0.0790.0602No
130FAPFAP
Entrez,  Source
fibroblast activation protein, alpha10470-0.0890.0334No
131LRRC17LRRC17
Entrez,  Source
leucine rich repeat containing 1710475-0.0900.0367No
132GSTM5GSTM5
Entrez,  Source
glutathione S-transferase M510537-0.0910.0358No
133SPON2SPON2
Entrez,  Source
spondin 2, extracellular matrix protein10694-0.0970.0279No
134ANPEPANPEP
Entrez,  Source
alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)10917-0.1060.0154No
135GPNMBGPNMB
Entrez,  Source
glycoprotein (transmembrane) nmb10958-0.1070.0167No
136SOX9SOX9
Entrez,  Source
SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)11038-0.1090.0151No
137PDGFRLPDGFRL
Entrez,  Source
platelet-derived growth factor receptor-like11182-0.1160.0089No
138IRS1IRS1
Entrez,  Source
insulin receptor substrate 111226-0.1170.0104No
139CD44CD44
Entrez,  Source
CD44 molecule (Indian blood group)11461-0.127-0.0022No
140COLEC12COLEC12
Entrez,  Source
collectin sub-family member 1211746-0.141-0.0180No
141OGTOGT
Entrez,  Source
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)11813-0.145-0.0171No
142MMEMME
Entrez,  Source
membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)11986-0.156-0.0238No
143CXCL12CXCL12
Entrez,  Source
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)12188-0.170-0.0322No
144HSPB8HSPB8
Entrez,  Source
heat shock 22kDa protein 812237-0.175-0.0287No
145C1ORF24C1ORF24
Entrez,  Source
chromosome 1 open reading frame 2412324-0.182-0.0279No
146NOTCH2NOTCH2
Entrez,  Source
Notch homolog 2 (Drosophila)12747-0.232-0.0505No
147NT5ENT5E
Entrez,  Source
5'-nucleotidase, ecto (CD73)12800-0.241-0.0446No
148FMO1FMO1
Entrez,  Source
flavin containing monooxygenase 112848-0.253-0.0379No
149GRIA3GRIA3
Entrez,  Source
glutamate receptor, ionotrophic, AMPA 312877-0.261-0.0295No
150EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)12946-0.276-0.0235No
151CES1CES1
Entrez,  Source
carboxylesterase 1 (monocyte/macrophage serine esterase 1)13135-0.348-0.0236No
152UGDHUGDH
Entrez,  Source
UDP-glucose dehydrogenase13138-0.352-0.0095No
153AOX1AOX1
Entrez,  Source
aldehyde oxidase 113304-0.6150.0029No
Table: GSEA details [plain text format]



Fig 2: BOQUEST_CD31PLUS_VS_CD31MINUS_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: BOQUEST_CD31PLUS_VS_CD31MINUS_DN: Random ES distribution   
Gene set null distribution of ES for BOQUEST_CD31PLUS_VS_CD31MINUS_DN