Details for gene set CARBOXYLIC_ACID_METABOLIC

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_24h_repos
Upregulated in class	double_gel_8d
GeneSet	CARBOXYLIC_ACID_METABOLIC_PROCESS
Enrichment Score (ES)	0.5599325
Normalized Enrichment Score (NES)	2.080857
Nominal p-value	0.0
FDR q-value	0.0019684639
FWER p-Value	0.03

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	HAO2	HAO2 Entrez, Source	hydroxyacid oxidase 2 (long chain)	18	1.071	0.0420	Yes
2	FTCD	FTCD Entrez, Source	formiminotransferase cyclodeaminase	46	0.834	0.0738	Yes
3	PFKFB1	PFKFB1 Entrez, Source	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	47	0.829	0.1073	Yes
4	GOT1	GOT1 Entrez, Source	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	76	0.697	0.1334	Yes
5	BBOX1	BBOX1 Entrez, Source	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	78	0.695	0.1615	Yes
6	CPT1A	CPT1A Entrez, Source	carnitine palmitoyltransferase 1A (liver)	84	0.686	0.1889	Yes
7	ACOX2	ACOX2 Entrez, Source	acyl-Coenzyme A oxidase 2, branched chain	97	0.667	0.2150	Yes
8	PAH	PAH Entrez, Source	phenylalanine hydroxylase	133	0.597	0.2365	Yes
9	HGD	HGD Entrez, Source	homogentisate 1,2-dioxygenase (homogentisate oxidase)	138	0.591	0.2601	Yes
10	AGXT	AGXT Entrez, Source	alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)	212	0.475	0.2738	Yes
11	FAH	FAH Entrez, Source	fumarylacetoacetate hydrolase (fumarylacetoacetase)	232	0.457	0.2909	Yes
12	BCKDHA	BCKDHA Entrez, Source	branched chain keto acid dehydrogenase E1, alpha polypeptide	258	0.431	0.3065	Yes
13	GGT1	GGT1 Entrez, Source	gamma-glutamyltransferase 1	271	0.423	0.3227	Yes
14	DDAH1	DDAH1 Entrez, Source	dimethylarginine dimethylaminohydrolase 1	276	0.416	0.3392	Yes
15	ALDH6A1	ALDH6A1 Entrez, Source	aldehyde dehydrogenase 6 family, member A1	300	0.402	0.3538	Yes
16	ARG1	ARG1 Entrez, Source	arginase, liver	307	0.397	0.3694	Yes
17	FADS1	FADS1 Entrez, Source	fatty acid desaturase 1	330	0.373	0.3828	Yes
18	SLC25A15	SLC25A15 Entrez, Source	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	338	0.371	0.3973	Yes
19	ECHS1	ECHS1 Entrez, Source	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	346	0.367	0.4116	Yes
20	ECH1	ECH1 Entrez, Source	enoyl Coenzyme A hydratase 1, peroxisomal	350	0.365	0.4262	Yes
21	MAT1A	MAT1A Entrez, Source	methionine adenosyltransferase I, alpha	362	0.357	0.4398	Yes
22	SLC3A1	SLC3A1 Entrez, Source	1	373	0.349	0.4532	Yes
23	GLYAT	GLYAT Entrez, Source	glycine-N-acyltransferase	379	0.348	0.4669	Yes
24	HACL1	HACL1 Entrez, Source	2-hydroxyacyl-CoA lyase 1	490	0.289	0.4703	Yes
25	GLS2	GLS2 Entrez, Source	glutaminase 2 (liver, mitochondrial)	543	0.271	0.4773	Yes
26	ALDH5A1	ALDH5A1 Entrez, Source	aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)	595	0.258	0.4839	Yes
27	BAAT	BAAT Entrez, Source	bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	602	0.257	0.4938	Yes
28	MCCC2	MCCC2 Entrez, Source	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	663	0.243	0.4991	Yes
29	ADI1	ADI1 Entrez, Source	acireductone dioxygenase 1	682	0.239	0.5074	Yes
30	CDO1	CDO1 Entrez, Source	cysteine dioxygenase, type I	689	0.237	0.5166	Yes
31	AS3MT	AS3MT Entrez, Source	arsenic (+3 oxidation state) methyltransferase	771	0.221	0.5194	Yes
32	MLYCD	MLYCD Entrez, Source	malonyl-CoA decarboxylase	817	0.210	0.5245	Yes
33	BCKDK	BCKDK Entrez, Source	branched chain ketoacid dehydrogenase kinase	869	0.200	0.5287	Yes
34	PECI	PECI Entrez, Source	peroxisomal D3,D2-enoyl-CoA isomerase	886	0.197	0.5355	Yes
35	BCKDHB	BCKDHB Entrez, Source	branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)	906	0.195	0.5420	Yes
36	FADS2	FADS2 Entrez, Source	fatty acid desaturase 2	934	0.190	0.5476	Yes
37	ACO2	ACO2 Entrez, Source	aconitase 2, mitochondrial	940	0.189	0.5549	Yes
38	SDS	SDS Entrez, Source	serine dehydratase	1007	0.182	0.5573	Yes
39	PPARGC1A	PPARGC1A Entrez, Source	peroxisome proliferative activated receptor, gamma, coactivator 1, alpha	1066	0.174	0.5599	Yes
40	MSRA	MSRA Entrez, Source	methionine sulfoxide reductase A	1379	0.144	0.5422	No
41	PTS	PTS Entrez, Source	6-pyruvoyltetrahydropterin synthase	1478	0.137	0.5403	No
42	GAMT	GAMT Entrez, Source	guanidinoacetate N-methyltransferase	1535	0.132	0.5414	No
43	ACADS	ACADS Entrez, Source	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain	1544	0.132	0.5461	No
44	ME1	ME1 Entrez, Source	malic enzyme 1, NADP(+)-dependent, cytosolic	1647	0.125	0.5435	No
45	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	1689	0.123	0.5454	No
46	SLC7A2	SLC7A2 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	1713	0.122	0.5486	No
47	ACADSB	ACADSB Entrez, Source	acyl-Coenzyme A dehydrogenase, short/branched chain	1715	0.122	0.5534	No
48	DDAH2	DDAH2 Entrez, Source	dimethylarginine dimethylaminohydrolase 2	1832	0.115	0.5493	No
49	ASPA	ASPA Entrez, Source	aspartoacylase (Canavan disease)	2090	0.104	0.5341	No
50	AKR1D1	AKR1D1 Entrez, Source	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	2111	0.103	0.5367	No
51	HDC	HDC Entrez, Source	histidine decarboxylase	2155	0.101	0.5376	No
52	AMT	AMT Entrez, Source	aminomethyltransferase	2221	0.098	0.5367	No
53	LYPLA3	LYPLA3 Entrez, Source	lysophospholipase 3 (lysosomal phospholipase A2)	2431	0.090	0.5245	No
54	ACOT12	ACOT12 Entrez, Source	acyl-CoA thioesterase 12	2485	0.088	0.5241	No
55	AGPAT1	AGPAT1 Entrez, Source	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)	2510	0.088	0.5258	No
56	NFS1	NFS1 Entrez, Source	NFS1 nitrogen fixation 1 (S. cerevisiae)	2570	0.085	0.5247	No
57	ACADVL	ACADVL Entrez, Source	acyl-Coenzyme A dehydrogenase, very long chain	3002	0.071	0.4950	No
58	GNE	GNE Entrez, Source	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	3063	0.069	0.4933	No
59	FAAH	FAAH Entrez, Source	fatty acid amide hydrolase	3091	0.069	0.4940	No
60	IDH1	IDH1 Entrez, Source	isocitrate dehydrogenase 1 (NADP+), soluble	3161	0.067	0.4915	No
61	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	3394	0.060	0.4764	No
62	ACO1	ACO1 Entrez, Source	aconitase 1, soluble	3462	0.059	0.4737	No
63	LTA4H	LTA4H Entrez, Source	leukotriene A4 hydrolase	3505	0.057	0.4728	No
64	SLC7A9	SLC7A9 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	3559	0.056	0.4711	No
65	DEGS1	DEGS1 Entrez, Source	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	3581	0.055	0.4717	No
66	ACADM	ACADM Entrez, Source	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	3794	0.050	0.4577	No
67	FARS2	FARS2 Entrez, Source	phenylalanine-tRNA synthetase 2 (mitochondrial)	3826	0.050	0.4574	No
68	SCLY	SCLY Entrez, Source	selenocysteine lyase	3833	0.049	0.4589	No
69	ACLY	ACLY Entrez, Source	ATP citrate lyase	3867	0.048	0.4584	No
70	GCSH	GCSH Entrez, Source	glycine cleavage system protein H (aminomethyl carrier)	3887	0.048	0.4589	No
71	BCAT1	BCAT1 Entrez, Source	branched chain aminotransferase 1, cytosolic	3938	0.046	0.4569	No
72	SLC25A10	SLC25A10 Entrez, Source	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	3966	0.045	0.4567	No
73	GLUD1	GLUD1 Entrez, Source	glutamate dehydrogenase 1	4297	0.038	0.4333	No
74	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	4489	0.034	0.4202	No
75	ACOT2	ACOT2 Entrez, Source	acyl-CoA thioesterase 2	5165	0.021	0.3700	No
76	ABCD2	ABCD2 Entrez, Source	ATP-binding cassette, sub-family D (ALD), member 2	5216	0.020	0.3670	No
77	CPT1B	CPT1B Entrez, Source	carnitine palmitoyltransferase 1B (muscle)	5265	0.019	0.3641	No
78	ADIPOR2	ADIPOR2 Entrez, Source	adiponectin receptor 2	5506	0.014	0.3466	No
79	PPARD	PPARD Entrez, Source	peroxisome proliferative activated receptor, delta	5532	0.014	0.3452	No
80	PTGS1	PTGS1 Entrez, Source	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	5556	0.014	0.3440	No
81	GGTLA1	GGTLA1 Entrez, Source	gamma-glutamyltransferase-like activity 1	5579	0.013	0.3429	No
82	SLC7A8	SLC7A8 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	5837	0.008	0.3238	No
83	SC4MOL	SC4MOL Entrez, Source	sterol-C4-methyl oxidase-like	5880	0.008	0.3209	No
84	PTGDS	PTGDS Entrez, Source	prostaglandin D2 synthase 21kDa (brain)	5900	0.007	0.3198	No
85	ALDH1L1	ALDH1L1 Entrez, Source	aldehyde dehydrogenase 1 family, member L1	5998	0.005	0.3126	No
86	ASRGL1	ASRGL1 Entrez, Source	asparaginase like 1	6099	0.003	0.3052	No
87	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	6295	-0.000	0.2905	No
88	PTGES	PTGES Entrez, Source	prostaglandin E synthase	6415	-0.002	0.2815	No
89	HPD	HPD Entrez, Source	4-hydroxyphenylpyruvate dioxygenase	6481	-0.003	0.2767	No
90	ASL	ASL Entrez, Source	argininosuccinate lyase	6773	-0.008	0.2551	No
91	SLC6A6	SLC6A6 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	6923	-0.011	0.2442	No
92	CYP7B1	CYP7B1 Entrez, Source	cytochrome P450, family 7, subfamily B, polypeptide 1	7069	-0.014	0.2338	No
93	QDPR	QDPR Entrez, Source	quinoid dihydropteridine reductase	7441	-0.021	0.2065	No
94	ACN9	ACN9 Entrez, Source	ACN9 homolog (S. cerevisiae)	7494	-0.022	0.2035	No
95	GSS	GSS Entrez, Source	glutathione synthetase	7538	-0.022	0.2011	No
96	NANP	NANP Entrez, Source	N-acetylneuraminic acid phosphatase	7570	-0.023	0.1997	No
97	HADHB	HADHB Entrez, Source	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit	7978	-0.031	0.1701	No
98	CYP4F2	CYP4F2 Entrez, Source	cytochrome P450, family 4, subfamily F, polypeptide 2	8129	-0.034	0.1602	No
99	TNFRSF1A	TNFRSF1A Entrez, Source	tumor necrosis factor receptor superfamily, member 1A	8306	-0.037	0.1484	No
100	HSD3B7	HSD3B7 Entrez, Source	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	8340	-0.038	0.1474	No
101	IDH3B	IDH3B Entrez, Source	isocitrate dehydrogenase 3 (NAD+) beta	8861	-0.049	0.1100	No
102	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	9134	-0.055	0.0917	No
103	ARPP-19	ARPP-19 Entrez, Source	-	9233	-0.057	0.0865	No
104	GAD1	GAD1 Entrez, Source	glutamate decarboxylase 1 (brain, 67kDa)	9270	-0.057	0.0861	No
105	GOT2	GOT2 Entrez, Source	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	9641	-0.066	0.0608	No
106	NR1H4	NR1H4 Entrez, Source	nuclear receptor subfamily 1, group H, member 4	9939	-0.075	0.0414	No
107	YARS	YARS Entrez, Source	tyrosyl-tRNA synthetase	9947	-0.075	0.0439	No
108	INDO	INDO Entrez, Source	indoleamine-pyrrole 2,3 dioxygenase	10558	-0.092	0.0014	No
109	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	10782	-0.100	-0.0114	No
110	ACOX3	ACOX3 Entrez, Source	acyl-Coenzyme A oxidase 3, pristanoyl	10884	-0.104	-0.0148	No
111	KARS	KARS Entrez, Source	lysyl-tRNA synthetase	10927	-0.106	-0.0137	No
112	BRCA1	BRCA1 Entrez, Source	breast cancer 1, early onset	11096	-0.112	-0.0219	No
113	GAD2	GAD2 Entrez, Source	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	11204	-0.116	-0.0253	No
114	PLOD1	PLOD1 Entrez, Source	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	11305	-0.121	-0.0280	No
115	GNPAT	GNPAT Entrez, Source	glyceronephosphate O-acyltransferase	11617	-0.134	-0.0461	No
116	SLC7A7	SLC7A7 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	11894	-0.150	-0.0609	No
117	CROT	CROT Entrez, Source	carnitine O-octanoyltransferase	11938	-0.152	-0.0580	No
118	DARS	DARS Entrez, Source	aspartyl-tRNA synthetase	12016	-0.158	-0.0574	No
119	WARS	WARS Entrez, Source	tryptophanyl-tRNA synthetase	12088	-0.163	-0.0561	No
120	AARS	AARS Entrez, Source	alanyl-tRNA synthetase	12234	-0.174	-0.0601	No
121	MIF	MIF Entrez, Source	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	12291	-0.179	-0.0571	No
122	SCYE1	SCYE1 Entrez, Source	small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)	12401	-0.188	-0.0577	No
123	PPARA	PPARA Entrez, Source	peroxisome proliferative activated receptor, alpha	12405	-0.189	-0.0503	No
124	SMS	SMS Entrez, Source	spermine synthase	12527	-0.202	-0.0513	No
125	GCLM	GCLM Entrez, Source	glutamate-cysteine ligase, modifier subunit	12784	-0.238	-0.0610	No
126	SLC7A5	SLC7A5 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	12884	-0.262	-0.0579	No
127	GCK	GCK Entrez, Source	glucokinase (hexokinase 4, maturity onset diabetes of the young 2)	13052	-0.307	-0.0581	No
128	UGDH	UGDH Entrez, Source	UDP-glucose dehydrogenase	13138	-0.352	-0.0503	No
129	GCLC	GCLC Entrez, Source	glutamate-cysteine ligase, catalytic subunit	13249	-0.480	-0.0392	No
130	SLC27A5	SLC27A5 Entrez, Source	solute carrier family 27 (fatty acid transporter), member 5	13261	-0.509	-0.0194	No
131	CD74	CD74 Entrez, Source	CD74 molecule, major histocompatibility complex, class II invariant chain	13307	-0.629	0.0026	No