Details for gene set CARIES_PULP

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_24h_repos
Upregulated in class	double_gel_8d
GeneSet	CARIES_PULP_UP
Enrichment Score (ES)	0.498368
Normalized Enrichment Score (NES)	1.8037636
Nominal p-value	0.0
FDR q-value	0.027480878
FWER p-Value	0.932

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	RGS2	RGS2 Entrez, Source	regulator of G-protein signalling 2, 24kDa	50	0.810	0.0397	Yes
2	CYP1A1	CYP1A1 Entrez, Source	cytochrome P450, family 1, subfamily A, polypeptide 1	75	0.697	0.0754	Yes
3	MGP	MGP Entrez, Source	matrix Gla protein	108	0.644	0.1075	Yes
4	RNASE1	RNASE1 Entrez, Source	ribonuclease, RNase A family, 1 (pancreatic)	117	0.624	0.1404	Yes
5	BCL2A1	BCL2A1 Entrez, Source	BCL2-related protein A1	147	0.568	0.1688	Yes
6	TNFAIP6	TNFAIP6 Entrez, Source	tumor necrosis factor, alpha-induced protein 6	159	0.550	0.1975	Yes
7	VCAM1	VCAM1 Entrez, Source	vascular cell adhesion molecule 1	183	0.515	0.2234	Yes
8	F13A1	F13A1 Entrez, Source	coagulation factor XIII, A1 polypeptide	186	0.510	0.2507	Yes
9	SERPINE2	SERPINE2 Entrez, Source	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	190	0.499	0.2772	Yes
10	CYBA	CYBA Entrez, Source	cytochrome b-245, alpha polypeptide	264	0.427	0.2947	Yes
11	KYNU	KYNU Entrez, Source	kynureninase (L-kynurenine hydrolase)	267	0.426	0.3174	Yes
12	CCR1	CCR1 Entrez, Source	chemokine (C-C motif) receptor 1	279	0.415	0.3388	Yes
13	CFD	CFD Entrez, Source	complement factor D (adipsin)	286	0.410	0.3604	Yes
14	PTGER4	PTGER4 Entrez, Source	prostaglandin E receptor 4 (subtype EP4)	393	0.340	0.3707	Yes
15	CCL2	CCL2 Entrez, Source	chemokine (C-C motif) ligand 2	405	0.336	0.3879	Yes
16	LTB	LTB Entrez, Source	lymphotoxin beta (TNF superfamily, member 3)	407	0.334	0.4057	Yes
17	UCP2	UCP2 Entrez, Source	uncoupling protein 2 (mitochondrial, proton carrier)	443	0.313	0.4199	Yes
18	CXCL1	CXCL1 Entrez, Source	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	474	0.294	0.4334	Yes
19	CD48	CD48 Entrez, Source	CD48 molecule	611	0.256	0.4369	Yes
20	LBP	LBP Entrez, Source	lipopolysaccharide binding protein	636	0.247	0.4484	Yes
21	S100A8	S100A8 Entrez, Source	S100 calcium binding protein A8	725	0.231	0.4541	Yes
22	ALOX5AP	ALOX5AP Entrez, Source	arachidonate 5-lipoxygenase-activating protein	740	0.229	0.4653	Yes
23	C1QB	C1QB Entrez, Source	complement component 1, q subcomponent, B chain	786	0.217	0.4736	Yes
24	IER3	IER3 Entrez, Source	immediate early response 3	908	0.195	0.4749	Yes
25	TYROBP	TYROBP Entrez, Source	TYRO protein tyrosine kinase binding protein	965	0.187	0.4807	Yes
26	BIRC3	BIRC3 Entrez, Source	baculoviral IAP repeat-containing 3	1025	0.179	0.4859	Yes
27	TIMP1	TIMP1 Entrez, Source	TIMP metallopeptidase inhibitor 1	1095	0.171	0.4899	Yes
28	ABCA1	ABCA1 Entrez, Source	ATP-binding cassette, sub-family A (ABC1), member 1	1319	0.149	0.4810	Yes
29	CTSH	CTSH Entrez, Source	cathepsin H	1401	0.143	0.4825	Yes
30	CCL3	CCL3 Entrez, Source	chemokine (C-C motif) ligand 3	1508	0.134	0.4817	Yes
31	ACSL1	ACSL1 Entrez, Source	acyl-CoA synthetase long-chain family member 1	1627	0.127	0.4796	Yes
32	ALOX5	ALOX5 Entrez, Source	arachidonate 5-lipoxygenase	1736	0.120	0.4779	Yes
33	VAMP8	VAMP8 Entrez, Source	vesicle-associated membrane protein 8 (endobrevin)	1782	0.118	0.4808	Yes
34	PTPRC	PTPRC Entrez, Source	protein tyrosine phosphatase, receptor type, C	1844	0.115	0.4824	Yes
35	RAB31	RAB31 Entrez, Source	RAB31, member RAS oncogene family	1866	0.113	0.4869	Yes
36	ARPC1B	ARPC1B Entrez, Source	actin related protein 2/3 complex, subunit 1B, 41kDa	1872	0.113	0.4926	Yes
37	LCP2	LCP2 Entrez, Source	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	1877	0.113	0.4984	Yes
38	CFI	CFI Entrez, Source	complement factor I	2096	0.104	0.4875	No
39	SPP1	SPP1 Entrez, Source	secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)	2345	0.094	0.4737	No
40	IL10RA	IL10RA Entrez, Source	interleukin 10 receptor, alpha	2351	0.093	0.4784	No
41	ARHGDIB	ARHGDIB Entrez, Source	Rho GDP dissociation inhibitor (GDI) beta	2541	0.086	0.4687	No
42	SAMSN1	SAMSN1 Entrez, Source	SAM domain, SH3 domain and nuclear localisation signals, 1	2606	0.083	0.4683	No
43	APOE	APOE Entrez, Source	apolipoprotein E	2619	0.083	0.4719	No
44	CEBPD	CEBPD Entrez, Source	CCAAT/enhancer binding protein (C/EBP), delta	2628	0.083	0.4757	No
45	BLNK	BLNK Entrez, Source	B-cell linker	2743	0.079	0.4713	No
46	HBB	HBB Entrez, Source	hemoglobin, beta	2786	0.077	0.4723	No
47	IRF8	IRF8 Entrez, Source	interferon regulatory factor 8	2808	0.077	0.4748	No
48	CSF1R	CSF1R Entrez, Source	colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog	2829	0.076	0.4774	No
49	CAPG	CAPG Entrez, Source	capping protein (actin filament), gelsolin-like	2891	0.074	0.4768	No
50	CD53	CD53 Entrez, Source	CD53 molecule	2932	0.073	0.4777	No
51	C3	C3 Entrez, Source	complement component 3	2945	0.073	0.4807	No
52	FGL2	FGL2 Entrez, Source	fibrinogen-like 2	3128	0.068	0.4706	No
53	RAB7L1	RAB7L1 Entrez, Source	RAB7, member RAS oncogene family-like 1	3207	0.066	0.4682	No
54	CXCL5	CXCL5 Entrez, Source	chemokine (C-X-C motif) ligand 5	3208	0.065	0.4717	No
55	CHI3L1	CHI3L1 Entrez, Source	chitinase 3-like 1 (cartilage glycoprotein-39)	3449	0.059	0.4568	No
56	MAN2B1	MAN2B1 Entrez, Source	mannosidase, alpha, class 2B, member 1	3637	0.054	0.4455	No
57	CXCR4	CXCR4 Entrez, Source	chemokine (C-X-C motif) receptor 4	3767	0.051	0.4385	No
58	UBD	UBD Entrez, Source	ubiquitin D	3783	0.050	0.4400	No
59	LRRC15	LRRC15 Entrez, Source	leucine rich repeat containing 15	3844	0.049	0.4381	No
60	CD93	CD93 Entrez, Source	CD93 molecule	3868	0.048	0.4390	No
61	HCLS1	HCLS1 Entrez, Source	hematopoietic cell-specific Lyn substrate 1	3872	0.048	0.4414	No
62	CCR2	CCR2 Entrez, Source	chemokine (C-C motif) receptor 2	3950	0.046	0.4380	No
63	APOC1	APOC1 Entrez, Source	apolipoprotein C-I	4022	0.044	0.4350	No
64	CD37	CD37 Entrez, Source	CD37 molecule	4350	0.037	0.4122	No
65	IFI30	IFI30 Entrez, Source	interferon, gamma-inducible protein 30	4454	0.035	0.4063	No
66	CTSC	CTSC Entrez, Source	cathepsin C	4468	0.035	0.4072	No
67	IGFBP4	IGFBP4 Entrez, Source	insulin-like growth factor binding protein 4	4578	0.032	0.4007	No
68	SLC1A4	SLC1A4 Entrez, Source	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	4800	0.028	0.3854	No
69	C3AR1	C3AR1 Entrez, Source	complement component 3a receptor 1	4875	0.027	0.3813	No
70	PTGS2	PTGS2 Entrez, Source	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	5155	0.021	0.3613	No
71	IBSP	IBSP Entrez, Source	integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)	5170	0.021	0.3614	No
72	PRG1	PRG1 Entrez, Source	proteoglycan 1, secretory granule	5264	0.019	0.3554	No
73	IL6	IL6 Entrez, Source	interleukin 6 (interferon, beta 2)	5285	0.019	0.3549	No
74	ORM1	ORM1 Entrez, Source	orosomucoid 1	5606	0.013	0.3314	No
75	LAPTM5	LAPTM5 Entrez, Source	lysosomal associated multispanning membrane protein 5	5827	0.009	0.3152	No
76	SFRP4	SFRP4 Entrez, Source	secreted frizzled-related protein 4	5920	0.007	0.3086	No
77	SERPINA1	SERPINA1 Entrez, Source	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	6063	0.004	0.2980	No
78	C5AR1	C5AR1 Entrez, Source	complement component 5a receptor 1	6304	-0.000	0.2799	No
79	RAC2	RAC2 Entrez, Source	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	6381	-0.001	0.2742	No
80	CCL5	CCL5 Entrez, Source	chemokine (C-C motif) ligand 5	6393	-0.002	0.2735	No
81	ANGPTL2	ANGPTL2 Entrez, Source	angiopoietin-like 2	6574	-0.005	0.2601	No
82	SSR4	SSR4 Entrez, Source	signal sequence receptor, delta (translocon-associated protein delta)	6586	-0.005	0.2596	No
83	ICAM1	ICAM1 Entrez, Source	intercellular adhesion molecule 1 (CD54), human rhinovirus receptor	6591	-0.005	0.2596	No
84	SERPINB2	SERPINB2 Entrez, Source	serpin peptidase inhibitor, clade B (ovalbumin), member 2	6630	-0.006	0.2570	No
85	MNDA	MNDA Entrez, Source	myeloid cell nuclear differentiation antigen	6790	-0.009	0.2454	No
86	PLEK	PLEK Entrez, Source	pleckstrin	6970	-0.012	0.2325	No
87	COL15A1	COL15A1 Entrez, Source	collagen, type XV, alpha 1	6979	-0.012	0.2326	No
88	LCP1	LCP1 Entrez, Source	lymphocyte cytosolic protein 1 (L-plastin)	7308	-0.018	0.2087	No
89	THBS4	THBS4 Entrez, Source	thrombospondin 4	7541	-0.022	0.1924	No
90	TRIB1	TRIB1 Entrez, Source	tribbles homolog 1 (Drosophila)	7632	-0.024	0.1869	No
91	INHBA	INHBA Entrez, Source	inhibin, beta A (activin A, activin AB alpha polypeptide)	7768	-0.027	0.1781	No
92	KPNA2	KPNA2 Entrez, Source	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	8037	-0.032	0.1595	No
93	LSP1	LSP1 Entrez, Source	lymphocyte-specific protein 1	8463	-0.041	0.1296	No
94	S100A9	S100A9 Entrez, Source	S100 calcium binding protein A9	8582	-0.043	0.1230	No
95	HCK	HCK Entrez, Source	hemopoietic cell kinase	8632	-0.044	0.1216	No
96	AQP3	AQP3 Entrez, Source	aquaporin 3 (Gill blood group)	9501	-0.063	0.0593	No
97	GZMB	GZMB Entrez, Source	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	9634	-0.066	0.0529	No
98	CYBB	CYBB Entrez, Source	cytochrome b-245, beta polypeptide (chronic granulomatous disease)	9683	-0.067	0.0529	No
99	IL1B	IL1B Entrez, Source	interleukin 1, beta	9721	-0.069	0.0538	No
100	SOCS3	SOCS3 Entrez, Source	suppressor of cytokine signaling 3	9839	-0.072	0.0488	No
101	SLA	SLA Entrez, Source	Src-like-adaptor	9920	-0.074	0.0468	No
102	ITGB2	ITGB2 Entrez, Source	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	10160	-0.081	0.0330	No
103	LYN	LYN Entrez, Source	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	10258	-0.083	0.0301	No
104	MMP9	MMP9 Entrez, Source	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	10293	-0.084	0.0321	No
105	IL11	IL11 Entrez, Source	interleukin 11	10348	-0.086	0.0326	No
106	SELE	SELE Entrez, Source	selectin E (endothelial adhesion molecule 1)	10650	-0.095	0.0150	No
107	NFIL3	NFIL3 Entrez, Source	nuclear factor, interleukin 3 regulated	10654	-0.095	0.0199	No
108	ANPEP	ANPEP Entrez, Source	alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)	10917	-0.106	0.0057	No
109	GPNMB	GPNMB Entrez, Source	glycoprotein (transmembrane) nmb	10958	-0.107	0.0084	No
110	PBEF1	PBEF1 Entrez, Source	pre-B-cell colony enhancing factor 1	10965	-0.107	0.0137	No
111	CTSB	CTSB Entrez, Source	cathepsin B	11060	-0.110	0.0126	No
112	ADM	ADM Entrez, Source	adrenomedullin	11063	-0.110	0.0184	No
113	CD44	CD44 Entrez, Source	CD44 molecule (Indian blood group)	11461	-0.127	-0.0048	No
114	IL1RN	IL1RN Entrez, Source	interleukin 1 receptor antagonist	11709	-0.139	-0.0161	No
115	PLAUR	PLAUR Entrez, Source	plasminogen activator, urokinase receptor	11843	-0.147	-0.0182	No
116	SOD2	SOD2 Entrez, Source	superoxide dismutase 2, mitochondrial	11883	-0.149	-0.0132	No
117	WARS	WARS Entrez, Source	tryptophanyl-tRNA synthetase	12088	-0.163	-0.0198	No
118	PLAU	PLAU Entrez, Source	plasminogen activator, urokinase	12137	-0.167	-0.0145	No
119	CXCL12	CXCL12 Entrez, Source	chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)	12188	-0.170	-0.0091	No
120	CD14	CD14 Entrez, Source	CD14 molecule	12462	-0.194	-0.0193	No
121	SKAP2	SKAP2 Entrez, Source	src kinase associated phosphoprotein 2	12493	-0.198	-0.0109	No
122	G0S2	G0S2 Entrez, Source	G0/G1switch 2	13097	-0.326	-0.0390	No
123	PHLDA1	PHLDA1 Entrez, Source	pleckstrin homology-like domain, family A, member 1	13228	-0.440	-0.0252	No
124	CD74	CD74 Entrez, Source	CD74 molecule, major histocompatibility complex, class II invariant chain	13307	-0.629	0.0026	No