Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
Upregulated in class | double_gel_8d |
GeneSet | CELLULAR_CATABOLIC_PROCESS |
Enrichment Score (ES) | 0.5169039 |
Normalized Enrichment Score (NES) | 1.9140096 |
Nominal p-value | 0.0 |
FDR q-value | 0.011085371 |
FWER p-Value | 0.466 |
PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|
1 | HAO2 | HAO2 Entrez,  Source | hydroxyacid oxidase 2 (long chain) | 18 | 1.071 | 0.0591 | Yes |
2 | PFKFB1 | PFKFB1 Entrez,  Source | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 47 | 0.829 | 0.1038 | Yes |
3 | GOT1 | GOT1 Entrez,  Source | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 76 | 0.697 | 0.1410 | Yes |
4 | CPT1A | CPT1A Entrez,  Source | carnitine palmitoyltransferase 1A (liver) | 84 | 0.686 | 0.1792 | Yes |
5 | HGD | HGD Entrez,  Source | homogentisate 1,2-dioxygenase (homogentisate oxidase) | 138 | 0.591 | 0.2086 | Yes |
6 | MIOX | MIOX Entrez,  Source | myo-inositol oxygenase | 146 | 0.570 | 0.2402 | Yes |
7 | FAH | FAH Entrez,  Source | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 232 | 0.457 | 0.2596 | Yes |
8 | GPX3 | GPX3 Entrez,  Source | glutathione peroxidase 3 (plasma) | 242 | 0.449 | 0.2843 | Yes |
9 | SMPD3 | SMPD3 Entrez,  Source | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | 248 | 0.442 | 0.3089 | Yes |
10 | BCKDHA | BCKDHA Entrez,  Source | branched chain keto acid dehydrogenase E1, alpha polypeptide | 258 | 0.431 | 0.3326 | Yes |
11 | DDAH1 | DDAH1 Entrez,  Source | dimethylarginine dimethylaminohydrolase 1 | 276 | 0.416 | 0.3547 | Yes |
12 | ARG1 | ARG1 Entrez,  Source | arginase, liver | 307 | 0.397 | 0.3749 | Yes |
13 | ECHS1 | ECHS1 Entrez,  Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 346 | 0.367 | 0.3928 | Yes |
14 | ECH1 | ECH1 Entrez,  Source | enoyl Coenzyme A hydratase 1, peroxisomal | 350 | 0.365 | 0.4131 | Yes |
15 | APOA4 | APOA4 Entrez,  Source | apolipoprotein A-IV | 383 | 0.346 | 0.4302 | Yes |
16 | HK1 | HK1 Entrez,  Source | hexokinase 1 | 385 | 0.345 | 0.4497 | Yes |
17 | AMPD3 | AMPD3 Entrez,  Source | adenosine monophosphate deaminase (isoform E) | 458 | 0.303 | 0.4613 | Yes |
18 | HACL1 | HACL1 Entrez,  Source | 2-hydroxyacyl-CoA lyase 1 | 490 | 0.289 | 0.4753 | Yes |
19 | ALDH5A1 | ALDH5A1 Entrez,  Source | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 595 | 0.258 | 0.4820 | Yes |
20 | GUSB | GUSB Entrez,  Source | glucuronidase, beta | 637 | 0.247 | 0.4928 | Yes |
21 | MCCC2 | MCCC2 Entrez,  Source | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | 663 | 0.243 | 0.5047 | Yes |
22 | BCKDK | BCKDK Entrez,  Source | branched chain ketoacid dehydrogenase kinase | 869 | 0.200 | 0.5004 | Yes |
23 | BCKDHB | BCKDHB Entrez,  Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 906 | 0.195 | 0.5087 | Yes |
24 | ACO2 | ACO2 Entrez,  Source | aconitase 2, mitochondrial | 940 | 0.189 | 0.5169 | Yes |
25 | STS | STS Entrez,  Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 1105 | 0.170 | 0.5141 | No |
26 | RNASE6 | RNASE6 Entrez,  Source | ribonuclease, RNase A family, k6 | 1232 | 0.158 | 0.5135 | No |
27 | APOA5 | APOA5 Entrez,  Source | apolipoprotein A-V | 1486 | 0.136 | 0.5020 | No |
28 | ACADS | ACADS Entrez,  Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 1544 | 0.132 | 0.5052 | No |
29 | NUDT3 | NUDT3 Entrez,  Source | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | 1587 | 0.129 | 0.5093 | No |
30 | RNASEH2A | RNASEH2A Entrez,  Source | ribonuclease H2, subunit A | 1815 | 0.116 | 0.4987 | No |
31 | DDAH2 | DDAH2 Entrez,  Source | dimethylarginine dimethylaminohydrolase 2 | 1832 | 0.115 | 0.5039 | No |
32 | TST | TST Entrez,  Source | thiosulfate sulfurtransferase (rhodanese) | 1969 | 0.109 | 0.4998 | No |
33 | ASPA | ASPA Entrez,  Source | aspartoacylase (Canavan disease) | 2090 | 0.104 | 0.4966 | No |
34 | AKR1D1 | AKR1D1 Entrez,  Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 2111 | 0.103 | 0.5009 | No |
35 | ALDOB | ALDOB Entrez,  Source | aldolase B, fructose-bisphosphate | 2152 | 0.101 | 0.5036 | No |
36 | AMT | AMT Entrez,  Source | aminomethyltransferase | 2221 | 0.098 | 0.5040 | No |
37 | PPT1 | PPT1 Entrez,  Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 2353 | 0.093 | 0.4994 | No |
38 | LYPLA3 | LYPLA3 Entrez,  Source | lysophospholipase 3 (lysosomal phospholipase A2) | 2431 | 0.090 | 0.4987 | No |
39 | ZFP36 | ZFP36 Entrez,  Source | zinc finger protein 36, C3H type, homolog (mouse) | 2480 | 0.089 | 0.5000 | No |
40 | UBE4A | UBE4A Entrez,  Source | ubiquitination factor E4A (UFD2 homolog, yeast) | 2612 | 0.083 | 0.4948 | No |
41 | GNS | GNS Entrez,  Source | glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) | 2618 | 0.083 | 0.4991 | No |
42 | COLQ | COLQ Entrez,  Source | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 2670 | 0.081 | 0.4998 | No |
43 | SDHD | SDHD Entrez,  Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 2818 | 0.077 | 0.4931 | No |
44 | PYGB | PYGB Entrez,  Source | phosphorylase, glycogen; brain | 2973 | 0.072 | 0.4855 | No |
45 | ACADVL | ACADVL Entrez,  Source | acyl-Coenzyme A dehydrogenase, very long chain | 3002 | 0.071 | 0.4874 | No |
46 | CYCS | CYCS Entrez,  Source | cytochrome c, somatic | 3256 | 0.064 | 0.4718 | No |
47 | SDHC | SDHC Entrez,  Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 3311 | 0.062 | 0.4713 | No |
48 | SIAH2 | SIAH2 Entrez,  Source | seven in absentia homolog 2 (Drosophila) | 3412 | 0.060 | 0.4671 | No |
49 | GAA | GAA Entrez,  Source | glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II) | 3547 | 0.056 | 0.4601 | No |
50 | MPST | MPST Entrez,  Source | mercaptopyruvate sulfurtransferase | 3621 | 0.054 | 0.4577 | No |
51 | PDHB | PDHB Entrez,  Source | pyruvate dehydrogenase (lipoamide) beta | 3755 | 0.051 | 0.4505 | No |
52 | ACADM | ACADM Entrez,  Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 3794 | 0.050 | 0.4504 | No |
53 | ACLY | ACLY Entrez,  Source | ATP citrate lyase | 3867 | 0.048 | 0.4477 | No |
54 | GCSH | GCSH Entrez,  Source | glycine cleavage system protein H (aminomethyl carrier) | 3887 | 0.048 | 0.4490 | No |
55 | UBE2B | UBE2B Entrez,  Source | ubiquitin-conjugating enzyme E2B (RAD6 homolog) | 3964 | 0.045 | 0.4458 | No |
56 | PFKM | PFKM Entrez,  Source | phosphofructokinase, muscle | 4179 | 0.040 | 0.4319 | No |
57 | SDHA | SDHA Entrez,  Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 4257 | 0.038 | 0.4282 | No |
58 | GLUD1 | GLUD1 Entrez,  Source | glutamate dehydrogenase 1 | 4297 | 0.038 | 0.4274 | No |
59 | BTRC | BTRC Entrez,  Source | beta-transducin repeat containing | 4316 | 0.037 | 0.4281 | No |
60 | GBA2 | GBA2 Entrez,  Source | glucosidase, beta (bile acid) 2 | 4489 | 0.034 | 0.4171 | No |
61 | CDKN2A | CDKN2A Entrez,  Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 4610 | 0.032 | 0.4098 | No |
62 | PRDX6 | PRDX6 Entrez,  Source | peroxiredoxin 6 | 4883 | 0.026 | 0.3907 | No |
63 | NEU3 | NEU3 Entrez,  Source | sialidase 3 (membrane sialidase) | 4899 | 0.026 | 0.3910 | No |
64 | DFFA | DFFA Entrez,  Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 5035 | 0.023 | 0.3821 | No |
65 | ALDOA | ALDOA Entrez,  Source | aldolase A, fructose-bisphosphate | 5039 | 0.023 | 0.3832 | No |
66 | CEL | CEL Entrez,  Source | carboxyl ester lipase (bile salt-stimulated lipase) | 5047 | 0.023 | 0.3840 | No |
67 | CPT1B | CPT1B Entrez,  Source | carnitine palmitoyltransferase 1B (muscle) | 5265 | 0.019 | 0.3687 | No |
68 | TREH | TREH Entrez,  Source | trehalase (brush-border membrane glycoprotein) | 5501 | 0.015 | 0.3517 | No |
69 | PPARD | PPARD Entrez,  Source | peroxisome proliferative activated receptor, delta | 5532 | 0.014 | 0.3502 | No |
70 | UBE2N | UBE2N Entrez,  Source | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 5570 | 0.013 | 0.3482 | No |
71 | PFKL | PFKL Entrez,  Source | phosphofructokinase, liver | 5889 | 0.007 | 0.3245 | No |
72 | ALDH1L1 | ALDH1L1 Entrez,  Source | aldehyde dehydrogenase 1 family, member L1 | 5998 | 0.005 | 0.3167 | No |
73 | ASRGL1 | ASRGL1 Entrez,  Source | asparaginase like 1 | 6099 | 0.003 | 0.3093 | No |
74 | HPD | HPD Entrez,  Source | 4-hydroxyphenylpyruvate dioxygenase | 6481 | -0.003 | 0.2806 | No |
75 | ASL | ASL Entrez,  Source | argininosuccinate lyase | 6773 | -0.008 | 0.2591 | No |
76 | SOD1 | SOD1 Entrez,  Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7093 | -0.014 | 0.2358 | No |
77 | STUB1 | STUB1 Entrez,  Source | STIP1 homology and U-box containing protein 1 | 7226 | -0.016 | 0.2267 | No |
78 | UBE2D2 | UBE2D2 Entrez,  Source | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 7273 | -0.017 | 0.2242 | No |
79 | DHPS | DHPS Entrez,  Source | deoxyhypusine synthase | 7301 | -0.018 | 0.2232 | No |
80 | NPLOC4 | NPLOC4 Entrez,  Source | nuclear protein localization 4 homolog (S. cerevisiae) | 7452 | -0.021 | 0.2130 | No |
81 | ANAPC2 | ANAPC2 Entrez,  Source | anaphase promoting complex subunit 2 | 7474 | -0.021 | 0.2126 | No |
82 | YWHAH | YWHAH Entrez,  Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 7564 | -0.023 | 0.2072 | No |
83 | GAPDHS | GAPDHS Entrez,  Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 7619 | -0.024 | 0.2044 | No |
84 | PSMC5 | PSMC5 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 7735 | -0.026 | 0.1972 | No |
85 | HADHB | HADHB Entrez,  Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 7978 | -0.031 | 0.1806 | No |
86 | UBB | UBB Entrez,  Source | ubiquitin B | 8206 | -0.035 | 0.1654 | No |
87 | TPP1 | TPP1 Entrez,  Source | tripeptidyl peptidase I | 8284 | -0.037 | 0.1617 | No |
88 | FBXO22 | FBXO22 Entrez,  Source | F-box protein 22 | 8288 | -0.037 | 0.1636 | No |
89 | NEDD8 | NEDD8 Entrez,  Source | neural precursor cell expressed, developmentally down-regulated 8 | 8297 | -0.037 | 0.1651 | No |
90 | UBE2I | UBE2I Entrez,  Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 8446 | -0.040 | 0.1562 | No |
91 | ANAPC4 | ANAPC4 Entrez,  Source | anaphase promoting complex subunit 4 | 8515 | -0.042 | 0.1534 | No |
92 | VCP | VCP Entrez,  Source | valosin-containing protein | 9171 | -0.055 | 0.1070 | No |
93 | GAD1 | GAD1 Entrez,  Source | glutamate decarboxylase 1 (brain, 67kDa) | 9270 | -0.057 | 0.1028 | No |
94 | CDC23 | CDC23 Entrez,  Source | CDC23 (cell division cycle 23, yeast, homolog) | 9365 | -0.060 | 0.0991 | No |
95 | BLVRA | BLVRA Entrez,  Source | biliverdin reductase A | 9379 | -0.060 | 0.1015 | No |
96 | DFFB | DFFB Entrez,  Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 9437 | -0.061 | 0.1006 | No |
97 | GOT2 | GOT2 Entrez,  Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 9641 | -0.066 | 0.0890 | No |
98 | UBE2D3 | UBE2D3 Entrez,  Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 9797 | -0.071 | 0.0813 | No |
99 | BNIP3 | BNIP3 Entrez,  Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 9855 | -0.073 | 0.0811 | No |
100 | PABPC4 | PABPC4 Entrez,  Source | poly(A) binding protein, cytoplasmic 4 (inducible form) | 10277 | -0.084 | 0.0539 | No |
101 | PARK2 | PARK2 Entrez,  Source | Parkinson disease (autosomal recessive, juvenile) 2, parkin | 10307 | -0.085 | 0.0565 | No |
102 | SQSTM1 | SQSTM1 Entrez,  Source | sequestosome 1 | 10340 | -0.086 | 0.0589 | No |
103 | ERCC3 | ERCC3 Entrez,  Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 10351 | -0.086 | 0.0630 | No |
104 | TSG101 | TSG101 Entrez,  Source | tumor susceptibility gene 101 | 10354 | -0.086 | 0.0677 | No |
105 | BAX | BAX Entrez,  Source | BCL2-associated X protein | 10485 | -0.090 | 0.0630 | No |
106 | INDO | INDO Entrez,  Source | indoleamine-pyrrole 2,3 dioxygenase | 10558 | -0.092 | 0.0627 | No |
107 | GSPT1 | GSPT1 Entrez,  Source | G1 to S phase transition 1 | 10578 | -0.093 | 0.0665 | No |
108 | UBE2G1 | UBE2G1 Entrez,  Source | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) | 10786 | -0.100 | 0.0565 | No |
109 | RNASEH1 | RNASEH1 Entrez,  Source | ribonuclease H1 | 10932 | -0.106 | 0.0515 | No |
110 | GAD2 | GAD2 Entrez,  Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 11204 | -0.116 | 0.0376 | No |
111 | ABCE1 | ABCE1 Entrez,  Source | ATP-binding cassette, sub-family E (OABP), member 1 | 11335 | -0.122 | 0.0346 | No |
112 | CDC20 | CDC20 Entrez,  Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 11434 | -0.126 | 0.0344 | No |
113 | UBE2V2 | UBE2V2 Entrez,  Source | ubiquitin-conjugating enzyme E2 variant 2 | 11529 | -0.130 | 0.0346 | No |
114 | SYVN1 | SYVN1 Entrez,  Source | synovial apoptosis inhibitor 1, synoviolin | 11594 | -0.133 | 0.0373 | No |
115 | UBE2A | UBE2A Entrez,  Source | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 11635 | -0.135 | 0.0419 | No |
116 | FBXO7 | FBXO7 Entrez,  Source | F-box protein 7 | 11665 | -0.136 | 0.0474 | No |
117 | USP33 | USP33 Entrez,  Source | ubiquitin specific peptidase 33 | 11679 | -0.137 | 0.0541 | No |
118 | NUDT5 | NUDT5 Entrez,  Source | nudix (nucleoside diphosphate linked moiety X)-type motif 5 | 11827 | -0.146 | 0.0513 | No |
119 | ISG20 | ISG20 Entrez,  Source | interferon stimulated exonuclease gene 20kDa | 11943 | -0.153 | 0.0512 | No |
120 | UFD1L | UFD1L Entrez,  Source | ubiquitin fusion degradation 1 like (yeast) | 11964 | -0.154 | 0.0584 | No |
121 | ARIH1 | ARIH1 Entrez,  Source | ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) | 12297 | -0.179 | 0.0434 | No |
122 | PPARA | PPARA Entrez,  Source | peroxisome proliferative activated receptor, alpha | 12405 | -0.189 | 0.0460 | No |
123 | HNRPD | HNRPD Entrez,  Source | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 13227 | -0.440 | 0.0087 | No |