Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | CHOLESTEROL_BIOSYNTHESIS |
| Enrichment Score (ES) | 0.71145093 |
| Normalized Enrichment Score (NES) | 1.7705885 |
| Nominal p-value | 0.009708738 |
| FDR q-value | 0.035008736 |
| FWER p-Value | 0.985 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SQLE | SQLE Entrez, Source | squalene epoxidase | 446 | 0.311 | 0.1529 | Yes |
| 2 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 531 | 0.275 | 0.3110 | Yes |
| 3 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 998 | 0.183 | 0.3854 | Yes |
| 4 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 1169 | 0.164 | 0.4704 | Yes |
| 5 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 1211 | 0.160 | 0.5631 | Yes |
| 6 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 1691 | 0.123 | 0.6009 | Yes |
| 7 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 1830 | 0.115 | 0.6595 | Yes |
| 8 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 1998 | 0.108 | 0.7115 | Yes |
| 9 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 3141 | 0.067 | 0.6661 | No |
| 10 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 4118 | 0.042 | 0.6178 | No |
| 11 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 4644 | 0.031 | 0.5971 | No |
| 12 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 5728 | 0.010 | 0.5220 | No |
| 13 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 5880 | 0.008 | 0.5152 | No |
| 14 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 7592 | -0.023 | 0.4008 | No |
| 15 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 8972 | -0.051 | 0.3279 | No |
