Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | DNA_REPAIR |
| Enrichment Score (ES) | -0.482547 |
| Normalized Enrichment Score (NES) | -1.6751359 |
| Nominal p-value | 0.0023094688 |
| FDR q-value | 0.11048369 |
| FWER p-Value | 0.999 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | POLG | POLG Entrez, Source | polymerase (DNA directed), gamma | 985 | 0.185 | -0.0443 | No |
| 2 | MSH3 | MSH3 Entrez, Source | mutS homolog 3 (E. coli) | 1377 | 0.144 | -0.0505 | No |
| 3 | CIB1 | CIB1 Entrez, Source | calcium and integrin binding 1 (calmyrin) | 1605 | 0.128 | -0.0469 | No |
| 4 | HMGB1 | HMGB1 Entrez, Source | high-mobility group box 1 | 2337 | 0.094 | -0.0868 | No |
| 5 | PARP1 | PARP1 Entrez, Source | poly (ADP-ribose) polymerase family, member 1 | 2474 | 0.089 | -0.0826 | No |
| 6 | XRCC4 | XRCC4 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 4 | 2599 | 0.083 | -0.0785 | No |
| 7 | XRCC6 | XRCC6 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa) | 3080 | 0.069 | -0.1035 | No |
| 8 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 3759 | 0.051 | -0.1463 | No |
| 9 | UBE2B | UBE2B Entrez, Source | ubiquitin-conjugating enzyme E2B (RAD6 homolog) | 3964 | 0.045 | -0.1543 | No |
| 10 | ATRX | ATRX Entrez, Source | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | 4548 | 0.033 | -0.1929 | No |
| 11 | RAD23A | RAD23A Entrez, Source | RAD23 homolog A (S. cerevisiae) | 4946 | 0.025 | -0.2187 | No |
| 12 | MSH2 | MSH2 Entrez, Source | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 5162 | 0.021 | -0.2315 | No |
| 13 | SUMO1 | SUMO1 Entrez, Source | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | 5474 | 0.015 | -0.2524 | No |
| 14 | UBE2N | UBE2N Entrez, Source | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 5570 | 0.013 | -0.2574 | No |
| 15 | RECQL | RECQL Entrez, Source | RecQ protein-like (DNA helicase Q1-like) | 6311 | -0.000 | -0.3131 | No |
| 16 | RAD17 | RAD17 Entrez, Source | RAD17 homolog (S. pombe) | 6622 | -0.006 | -0.3354 | No |
| 17 | OGG1 | OGG1 Entrez, Source | 8-oxoguanine DNA glycosylase | 7089 | -0.014 | -0.3683 | No |
| 18 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7093 | -0.014 | -0.3663 | No |
| 19 | MNAT1 | MNAT1 Entrez, Source | menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) | 7213 | -0.016 | -0.3726 | No |
| 20 | DDB1 | DDB1 Entrez, Source | damage-specific DNA binding protein 1, 127kDa | 7256 | -0.017 | -0.3731 | No |
| 21 | RAD50 | RAD50 Entrez, Source | RAD50 homolog (S. cerevisiae) | 8016 | -0.032 | -0.4251 | No |
| 22 | HTATIP | HTATIP Entrez, Source | HIV-1 Tat interacting protein, 60kDa | 8212 | -0.035 | -0.4341 | No |
| 23 | ATXN3 | ATXN3 Entrez, Source | ataxin 3 | 8313 | -0.038 | -0.4355 | No |
| 24 | TNP1 | TNP1 Entrez, Source | transition protein 1 (during histone to protamine replacement) | 8326 | -0.038 | -0.4303 | No |
| 25 | CSNK1D | CSNK1D Entrez, Source | casein kinase 1, delta | 8498 | -0.041 | -0.4365 | No |
| 26 | NBN | NBN Entrez, Source | nibrin | 8672 | -0.045 | -0.4422 | No |
| 27 | VCP | VCP Entrez, Source | valosin-containing protein | 9171 | -0.055 | -0.4708 | Yes |
| 28 | RAD23B | RAD23B Entrez, Source | RAD23 homolog B (S. cerevisiae) | 9175 | -0.055 | -0.4621 | Yes |
| 29 | FANCC | FANCC Entrez, Source | Fanconi anemia, complementation group C | 9324 | -0.059 | -0.4637 | Yes |
| 30 | UNG | UNG Entrez, Source | uracil-DNA glycosylase | 9382 | -0.060 | -0.4583 | Yes |
| 31 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 9497 | -0.063 | -0.4568 | Yes |
| 32 | MUTYH | MUTYH Entrez, Source | mutY homolog (E. coli) | 9606 | -0.065 | -0.4543 | Yes |
| 33 | IGHMBP2 | IGHMBP2 Entrez, Source | immunoglobulin mu binding protein 2 | 9982 | -0.076 | -0.4703 | Yes |
| 34 | MPG | MPG Entrez, Source | N-methylpurine-DNA glycosylase | 10047 | -0.078 | -0.4625 | Yes |
| 35 | APEX1 | APEX1 Entrez, Source | APEX nuclease (multifunctional DNA repair enzyme) 1 | 10112 | -0.079 | -0.4545 | Yes |
| 36 | ERCC3 | ERCC3 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 10351 | -0.086 | -0.4586 | Yes |
| 37 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 10438 | -0.088 | -0.4508 | Yes |
| 38 | LIG3 | LIG3 Entrez, Source | ligase III, DNA, ATP-dependent | 10605 | -0.094 | -0.4481 | Yes |
| 39 | WRNIP1 | WRNIP1 Entrez, Source | Werner helicase interacting protein 1 | 10609 | -0.094 | -0.4332 | Yes |
| 40 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 10658 | -0.096 | -0.4214 | Yes |
| 41 | GTF2H4 | GTF2H4 Entrez, Source | general transcription factor IIH, polypeptide 4, 52kDa | 10727 | -0.098 | -0.4107 | Yes |
| 42 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 11096 | -0.112 | -0.4203 | Yes |
| 43 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 11106 | -0.112 | -0.4028 | Yes |
| 44 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11266 | -0.119 | -0.3956 | Yes |
| 45 | TDG | TDG Entrez, Source | thymine-DNA glycosylase | 11393 | -0.124 | -0.3850 | Yes |
| 46 | UBE2V2 | UBE2V2 Entrez, Source | ubiquitin-conjugating enzyme E2 variant 2 | 11529 | -0.130 | -0.3741 | Yes |
| 47 | UBE2A | UBE2A Entrez, Source | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 11635 | -0.135 | -0.3602 | Yes |
| 48 | RUVBL2 | RUVBL2 Entrez, Source | RuvB-like 2 (E. coli) | 11685 | -0.137 | -0.3417 | Yes |
| 49 | CSNK1E | CSNK1E Entrez, Source | casein kinase 1, epsilon | 11711 | -0.139 | -0.3212 | Yes |
| 50 | PNKP | PNKP Entrez, Source | polynucleotide kinase 3'-phosphatase | 12212 | -0.172 | -0.3310 | Yes |
| 51 | XAB2 | XAB2 Entrez, Source | XPA binding protein 2 | 12377 | -0.186 | -0.3133 | Yes |
| 52 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 12556 | -0.205 | -0.2935 | Yes |
| 53 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 12712 | -0.226 | -0.2687 | Yes |
| 54 | LIG1 | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 12917 | -0.270 | -0.2404 | Yes |
| 55 | FEN1 | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 12971 | -0.283 | -0.1987 | Yes |
| 56 | MRE11A | MRE11A Entrez, Source | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 13163 | -0.372 | -0.1531 | Yes |
| 57 | APTX | APTX Entrez, Source | aprataxin | 13232 | -0.441 | -0.0869 | Yes |
| 58 | GADD45G | GADD45G Entrez, Source | growth arrest and DNA-damage-inducible, gamma | 13297 | -0.589 | 0.0034 | Yes |
