Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | ET743_SARCOMA_DN |
| Enrichment Score (ES) | -0.34687114 |
| Normalized Enrichment Score (NES) | -1.3667263 |
| Nominal p-value | 0.03314917 |
| FDR q-value | 0.33645806 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 37 | 0.888 | 0.0565 | No |
| 2 | SPRY2 | SPRY2 Entrez, Source | sprouty homolog 2 (Drosophila) | 314 | 0.388 | 0.0616 | No |
| 3 | JAG1 | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 318 | 0.386 | 0.0871 | No |
| 4 | ELOVL6 | ELOVL6 Entrez, Source | ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) | 433 | 0.319 | 0.0998 | No |
| 5 | CYHR1 | CYHR1 Entrez, Source | cysteine/histidine-rich 1 | 498 | 0.287 | 0.1142 | No |
| 6 | FZD1 | FZD1 Entrez, Source | frizzled homolog 1 (Drosophila) | 708 | 0.233 | 0.1139 | No |
| 7 | SYNE1 | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 726 | 0.230 | 0.1280 | No |
| 8 | RNF14 | RNF14 Entrez, Source | ring finger protein 14 | 836 | 0.207 | 0.1336 | No |
| 9 | PLAG1 | PLAG1 Entrez, Source | pleiomorphic adenoma gene 1 | 1115 | 0.169 | 0.1238 | No |
| 10 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 1410 | 0.142 | 0.1111 | No |
| 11 | NET1 | NET1 Entrez, Source | neuroepithelial cell transforming gene 1 | 1732 | 0.121 | 0.0948 | No |
| 12 | ACSL3 | ACSL3 Entrez, Source | acyl-CoA synthetase long-chain family member 3 | 2116 | 0.103 | 0.0727 | No |
| 13 | RAP1B | RAP1B Entrez, Source | RAP1B, member of RAS oncogene family | 2132 | 0.102 | 0.0784 | No |
| 14 | SPIN | SPIN Entrez, Source | spindlin | 2620 | 0.083 | 0.0471 | No |
| 15 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 2623 | 0.083 | 0.0525 | No |
| 16 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 2686 | 0.081 | 0.0532 | No |
| 17 | MCTS1 | MCTS1 Entrez, Source | malignant T cell amplified sequence 1 | 3084 | 0.069 | 0.0277 | No |
| 18 | BTG1 | BTG1 Entrez, Source | B-cell translocation gene 1, anti-proliferative | 3329 | 0.062 | 0.0134 | No |
| 19 | MAPK14 | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 3602 | 0.055 | -0.0035 | No |
| 20 | CMPK | CMPK Entrez, Source | cytidylate kinase | 3852 | 0.049 | -0.0191 | No |
| 21 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 3983 | 0.045 | -0.0260 | No |
| 22 | TMPO | TMPO Entrez, Source | thymopoietin | 4229 | 0.039 | -0.0419 | No |
| 23 | HERC4 | HERC4 Entrez, Source | hect domain and RLD 4 | 4484 | 0.034 | -0.0589 | No |
| 24 | WNT5B | WNT5B Entrez, Source | wingless-type MMTV integration site family, member 5B | 4602 | 0.032 | -0.0656 | No |
| 25 | LUZP1 | LUZP1 Entrez, Source | leucine zipper protein 1 | 4920 | 0.026 | -0.0879 | No |
| 26 | PPP1CC | PPP1CC Entrez, Source | protein phosphatase 1, catalytic subunit, gamma isoform | 4996 | 0.024 | -0.0919 | No |
| 27 | GGPS1 | GGPS1 Entrez, Source | geranylgeranyl diphosphate synthase 1 | 5108 | 0.022 | -0.0989 | No |
| 28 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 5186 | 0.020 | -0.1033 | No |
| 29 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 5378 | 0.017 | -0.1166 | No |
| 30 | MID1IP1 | MID1IP1 Entrez, Source | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | 5440 | 0.016 | -0.1202 | No |
| 31 | SIRPA | SIRPA Entrez, Source | signal-regulatory protein alpha | 5901 | 0.007 | -0.1545 | No |
| 32 | CXXC5 | CXXC5 Entrez, Source | CXXC finger 5 | 5992 | 0.005 | -0.1610 | No |
| 33 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 6034 | 0.005 | -0.1638 | No |
| 34 | LRRC8C | LRRC8C Entrez, Source | leucine rich repeat containing 8 family, member C | 6300 | -0.000 | -0.1839 | No |
| 35 | RAB6A | RAB6A Entrez, Source | RAB6A, member RAS oncogene family | 6313 | -0.000 | -0.1847 | No |
| 36 | CDC5L | CDC5L Entrez, Source | CDC5 cell division cycle 5-like (S. pombe) | 6411 | -0.002 | -0.1920 | No |
| 37 | XRCC5 | XRCC5 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) | 6550 | -0.005 | -0.2021 | No |
| 38 | RAB1A | RAB1A Entrez, Source | RAB1A, member RAS oncogene family | 6729 | -0.008 | -0.2151 | No |
| 39 | PSMB1 | PSMB1 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 1 | 6762 | -0.008 | -0.2169 | No |
| 40 | GTF2B | GTF2B Entrez, Source | general transcription factor IIB | 6968 | -0.012 | -0.2317 | No |
| 41 | TOP1 | TOP1 Entrez, Source | topoisomerase (DNA) I | 7017 | -0.013 | -0.2344 | No |
| 42 | CDK7 | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 7106 | -0.014 | -0.2402 | No |
| 43 | HIST1H4B | HIST1H4B Entrez, Source | histone cluster 1, H4b | 7178 | -0.015 | -0.2445 | No |
| 44 | UBE2D2 | UBE2D2 Entrez, Source | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 7273 | -0.017 | -0.2505 | No |
| 45 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 7458 | -0.021 | -0.2630 | No |
| 46 | CDK5R1 | CDK5R1 Entrez, Source | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 7459 | -0.021 | -0.2616 | No |
| 47 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 7544 | -0.022 | -0.2665 | No |
| 48 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 7553 | -0.023 | -0.2656 | No |
| 49 | GDI2 | GDI2 Entrez, Source | GDP dissociation inhibitor 2 | 7674 | -0.025 | -0.2730 | No |
| 50 | EIF3S10 | EIF3S10 Entrez, Source | eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa | 7771 | -0.027 | -0.2785 | No |
| 51 | CSNK2A1 | CSNK2A1 Entrez, Source | casein kinase 2, alpha 1 polypeptide | 7813 | -0.028 | -0.2797 | No |
| 52 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 7883 | -0.029 | -0.2830 | No |
| 53 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 7897 | -0.029 | -0.2821 | No |
| 54 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 8008 | -0.031 | -0.2883 | No |
| 55 | DNAJA2 | DNAJA2 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 2 | 8188 | -0.035 | -0.2995 | No |
| 56 | RAB5A | RAB5A Entrez, Source | RAB5A, member RAS oncogene family | 8227 | -0.036 | -0.3000 | No |
| 57 | FNTA | FNTA Entrez, Source | farnesyltransferase, CAAX box, alpha | 8270 | -0.037 | -0.3007 | No |
| 58 | STAU1 | STAU1 Entrez, Source | staufen, RNA binding protein, homolog 1 (Drosophila) | 8393 | -0.039 | -0.3073 | No |
| 59 | NBN | NBN Entrez, Source | nibrin | 8672 | -0.045 | -0.3253 | No |
| 60 | YWHAE | YWHAE Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 8704 | -0.045 | -0.3247 | No |
| 61 | PJA2 | PJA2 Entrez, Source | praja 2, RING-H2 motif containing | 8736 | -0.046 | -0.3239 | No |
| 62 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 8748 | -0.046 | -0.3216 | No |
| 63 | CRLF3 | CRLF3 Entrez, Source | cytokine receptor-like factor 3 | 8904 | -0.050 | -0.3300 | No |
| 64 | PKN2 | PKN2 Entrez, Source | protein kinase N2 | 9045 | -0.053 | -0.3371 | No |
| 65 | RAD23B | RAD23B Entrez, Source | RAD23 homolog B (S. cerevisiae) | 9175 | -0.055 | -0.3432 | Yes |
| 66 | BUB3 | BUB3 Entrez, Source | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | 9220 | -0.056 | -0.3427 | Yes |
| 67 | LRRC42 | LRRC42 Entrez, Source | leucine rich repeat containing 42 | 9227 | -0.057 | -0.3394 | Yes |
| 68 | SON | SON Entrez, Source | SON DNA binding protein | 9229 | -0.057 | -0.3357 | Yes |
| 69 | PPP2R1B | PPP2R1B Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform | 9290 | -0.058 | -0.3364 | Yes |
| 70 | HSPE1 | HSPE1 Entrez, Source | heat shock 10kDa protein 1 (chaperonin 10) | 9296 | -0.058 | -0.3329 | Yes |
| 71 | THRAP3 | THRAP3 Entrez, Source | thyroid hormone receptor associated protein 3 | 9349 | -0.059 | -0.3329 | Yes |
| 72 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 9365 | -0.060 | -0.3300 | Yes |
| 73 | HSPA8 | HSPA8 Entrez, Source | heat shock 70kDa protein 8 | 9449 | -0.062 | -0.3322 | Yes |
| 74 | SFRS9 | SFRS9 Entrez, Source | splicing factor, arginine/serine-rich 9 | 9480 | -0.062 | -0.3303 | Yes |
| 75 | SUPV3L1 | SUPV3L1 Entrez, Source | suppressor of var1, 3-like 1 (S. cerevisiae) | 9489 | -0.063 | -0.3267 | Yes |
| 76 | PSMC2 | PSMC2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 9566 | -0.064 | -0.3281 | Yes |
| 77 | PSMA4 | PSMA4 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 4 | 9615 | -0.066 | -0.3274 | Yes |
| 78 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 9619 | -0.066 | -0.3232 | Yes |
| 79 | USP3 | USP3 Entrez, Source | ubiquitin specific peptidase 3 | 9792 | -0.070 | -0.3315 | Yes |
| 80 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 9797 | -0.071 | -0.3271 | Yes |
| 81 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 9974 | -0.076 | -0.3354 | Yes |
| 82 | STK17B | STK17B Entrez, Source | serine/threonine kinase 17b (apoptosis-inducing) | 9987 | -0.076 | -0.3312 | Yes |
| 83 | EPS15 | EPS15 Entrez, Source | epidermal growth factor receptor pathway substrate 15 | 10074 | -0.079 | -0.3324 | Yes |
| 84 | CLCN7 | CLCN7 Entrez, Source | chloride channel 7 | 10076 | -0.079 | -0.3273 | Yes |
| 85 | RAB2 | RAB2 Entrez, Source | RAB2, member RAS oncogene family | 10106 | -0.079 | -0.3242 | Yes |
| 86 | LBR | LBR Entrez, Source | lamin B receptor | 10137 | -0.080 | -0.3211 | Yes |
| 87 | ARPC5L | ARPC5L Entrez, Source | actin related protein 2/3 complex, subunit 5-like | 10169 | -0.081 | -0.3180 | Yes |
| 88 | ERCC3 | ERCC3 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 10351 | -0.086 | -0.3260 | Yes |
| 89 | FAF1 | FAF1 Entrez, Source | Fas (TNFRSF6) associated factor 1 | 10352 | -0.086 | -0.3203 | Yes |
| 90 | ATF1 | ATF1 Entrez, Source | activating transcription factor 1 | 10381 | -0.087 | -0.3166 | Yes |
| 91 | NCOA6 | NCOA6 Entrez, Source | nuclear receptor coactivator 6 | 10541 | -0.091 | -0.3225 | Yes |
| 92 | NMI | NMI Entrez, Source | N-myc (and STAT) interactor | 10574 | -0.093 | -0.3187 | Yes |
| 93 | PTPRK | PTPRK Entrez, Source | protein tyrosine phosphatase, receptor type, K | 10767 | -0.100 | -0.3266 | Yes |
| 94 | CRSP6 | CRSP6 Entrez, Source | cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa | 10881 | -0.104 | -0.3282 | Yes |
| 95 | CCNH | CCNH Entrez, Source | cyclin H | 10890 | -0.105 | -0.3218 | Yes |
| 96 | PSMA5 | PSMA5 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 5 | 11084 | -0.111 | -0.3290 | Yes |
| 97 | RABGGTB | RABGGTB Entrez, Source | Rab geranylgeranyltransferase, beta subunit | 11200 | -0.116 | -0.3300 | Yes |
| 98 | RBM17 | RBM17 Entrez, Source | RNA binding motif protein 17 | 11216 | -0.117 | -0.3233 | Yes |
| 99 | SNIP1 | SNIP1 Entrez, Source | Smad nuclear interacting protein 1 | 11379 | -0.124 | -0.3273 | Yes |
| 100 | TDG | TDG Entrez, Source | thymine-DNA glycosylase | 11393 | -0.124 | -0.3200 | Yes |
| 101 | SERBP1 | SERBP1 Entrez, Source | SERPINE1 mRNA binding protein 1 | 11399 | -0.125 | -0.3120 | Yes |
| 102 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 11410 | -0.125 | -0.3044 | Yes |
| 103 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 11449 | -0.127 | -0.2988 | Yes |
| 104 | DKC1 | DKC1 Entrez, Source | dyskeratosis congenita 1, dyskerin | 11541 | -0.131 | -0.2969 | Yes |
| 105 | CCT4 | CCT4 Entrez, Source | chaperonin containing TCP1, subunit 4 (delta) | 11585 | -0.133 | -0.2913 | Yes |
| 106 | FBXL3 | FBXL3 Entrez, Source | F-box and leucine-rich repeat protein 3 | 11676 | -0.137 | -0.2890 | Yes |
| 107 | ARFGAP1 | ARFGAP1 Entrez, Source | ADP-ribosylation factor GTPase activating protein 1 | 11713 | -0.139 | -0.2824 | Yes |
| 108 | PSMC6 | PSMC6 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 11752 | -0.141 | -0.2759 | Yes |
| 109 | SLC2A1 | SLC2A1 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 1 | 11795 | -0.144 | -0.2694 | Yes |
| 110 | OGT | OGT Entrez, Source | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | 11813 | -0.145 | -0.2610 | Yes |
| 111 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 11948 | -0.154 | -0.2609 | Yes |
| 112 | NUFIP1 | NUFIP1 Entrez, Source | nuclear fragile X mental retardation protein interacting protein 1 | 11965 | -0.155 | -0.2518 | Yes |
| 113 | DDX20 | DDX20 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 | 12161 | -0.169 | -0.2553 | Yes |
| 114 | PRIM2A | PRIM2A Entrez, Source | primase, polypeptide 2A, 58kDa | 12178 | -0.170 | -0.2451 | Yes |
| 115 | AURKA | AURKA Entrez, Source | aurora kinase A | 12238 | -0.175 | -0.2379 | Yes |
| 116 | EP400 | EP400 Entrez, Source | E1A binding protein p400 | 12246 | -0.175 | -0.2268 | Yes |
| 117 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 12249 | -0.175 | -0.2152 | Yes |
| 118 | PANX1 | PANX1 Entrez, Source | pannexin 1 | 12336 | -0.182 | -0.2095 | Yes |
| 119 | MTIF2 | MTIF2 Entrez, Source | mitochondrial translational initiation factor 2 | 12340 | -0.183 | -0.1976 | Yes |
| 120 | CDC27 | CDC27 Entrez, Source | cell division cycle 27 | 12536 | -0.203 | -0.1988 | Yes |
| 121 | PSME3 | PSME3 Entrez, Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 12583 | -0.209 | -0.1883 | Yes |
| 122 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 12589 | -0.209 | -0.1747 | Yes |
| 123 | XBP1 | XBP1 Entrez, Source | X-box binding protein 1 | 12599 | -0.210 | -0.1614 | Yes |
| 124 | TARDBP | TARDBP Entrez, Source | TAR DNA binding protein | 12761 | -0.235 | -0.1579 | Yes |
| 125 | EIF4B | EIF4B Entrez, Source | eukaryotic translation initiation factor 4B | 12823 | -0.247 | -0.1460 | Yes |
| 126 | FOSL1 | FOSL1 Entrez, Source | FOS-like antigen 1 | 12920 | -0.270 | -0.1352 | Yes |
| 127 | ARFGEF2 | ARFGEF2 Entrez, Source | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 12937 | -0.273 | -0.1182 | Yes |
| 128 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 12946 | -0.276 | -0.1003 | Yes |
| 129 | TXNRD1 | TXNRD1 Entrez, Source | thioredoxin reductase 1 | 12967 | -0.282 | -0.0830 | Yes |
| 130 | HSPH1 | HSPH1 Entrez, Source | heat shock 105kDa/110kDa protein 1 | 13031 | -0.302 | -0.0676 | Yes |
| 131 | JMJD1C | JMJD1C Entrez, Source | jumonji domain containing 1C | 13108 | -0.331 | -0.0512 | Yes |
| 132 | DCK | DCK Entrez, Source | deoxycytidine kinase | 13222 | -0.428 | -0.0312 | Yes |
| 133 | MAT2A | MAT2A Entrez, Source | methionine adenosyltransferase II, alpha | 13299 | -0.601 | 0.0033 | Yes |
