Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | HOHENKIRK_MONOCYTE_DEND_DN |
| Enrichment Score (ES) | 0.5118254 |
| Normalized Enrichment Score (NES) | 1.7539792 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.03970973 |
| FWER p-Value | 0.995 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LGALS2 | LGALS2 Entrez, Source | lectin, galactoside-binding, soluble, 2 (galectin 2) | 95 | 0.672 | 0.0400 | Yes |
| 2 | LYZ | LYZ Entrez, Source | lysozyme (renal amyloidosis) | 103 | 0.659 | 0.0856 | Yes |
| 3 | CORO1A | CORO1A Entrez, Source | coronin, actin binding protein, 1A | 110 | 0.633 | 0.1296 | Yes |
| 4 | EMP1 | EMP1 Entrez, Source | epithelial membrane protein 1 | 119 | 0.621 | 0.1725 | Yes |
| 5 | IL1R2 | IL1R2 Entrez, Source | interleukin 1 receptor, type II | 140 | 0.582 | 0.2119 | Yes |
| 6 | FBP1 | FBP1 Entrez, Source | fructose-1,6-bisphosphatase 1 | 203 | 0.484 | 0.2411 | Yes |
| 7 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 218 | 0.471 | 0.2731 | Yes |
| 8 | PTK2B | PTK2B Entrez, Source | PTK2B protein tyrosine kinase 2 beta | 224 | 0.463 | 0.3053 | Yes |
| 9 | KYNU | KYNU Entrez, Source | kynureninase (L-kynurenine hydrolase) | 267 | 0.426 | 0.3319 | Yes |
| 10 | PLSCR1 | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 273 | 0.421 | 0.3610 | Yes |
| 11 | ITPR1 | ITPR1 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 1 | 282 | 0.413 | 0.3894 | Yes |
| 12 | MARCKSL1 | MARCKSL1 Entrez, Source | MARCKS-like 1 | 337 | 0.371 | 0.4114 | Yes |
| 13 | PF4 | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 364 | 0.357 | 0.4344 | Yes |
| 14 | AMPD3 | AMPD3 Entrez, Source | adenosine monophosphate deaminase (isoform E) | 458 | 0.303 | 0.4487 | Yes |
| 15 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 565 | 0.265 | 0.4592 | Yes |
| 16 | HADH2 | HADH2 Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase, type II | 638 | 0.247 | 0.4711 | Yes |
| 17 | EMP3 | EMP3 Entrez, Source | epithelial membrane protein 3 | 662 | 0.243 | 0.4864 | Yes |
| 18 | S100A8 | S100A8 Entrez, Source | S100 calcium binding protein A8 | 725 | 0.231 | 0.4979 | Yes |
| 19 | IL2RG | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 879 | 0.198 | 0.5003 | Yes |
| 20 | IER3 | IER3 Entrez, Source | immediate early response 3 | 908 | 0.195 | 0.5118 | Yes |
| 21 | S100A4 | S100A4 Entrez, Source | S100 calcium binding protein A4 | 1285 | 0.152 | 0.4941 | No |
| 22 | SOS2 | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 1312 | 0.149 | 0.5026 | No |
| 23 | ME1 | ME1 Entrez, Source | malic enzyme 1, NADP(+)-dependent, cytosolic | 1647 | 0.125 | 0.4862 | No |
| 24 | CTBP1 | CTBP1 Entrez, Source | C-terminal binding protein 1 | 1682 | 0.124 | 0.4923 | No |
| 25 | ZFP36L2 | ZFP36L2 Entrez, Source | zinc finger protein 36, C3H type-like 2 | 1730 | 0.121 | 0.4973 | No |
| 26 | ATP2A3 | ATP2A3 Entrez, Source | ATPase, Ca++ transporting, ubiquitous | 1837 | 0.115 | 0.4974 | No |
| 27 | SERPINF1 | SERPINF1 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 2361 | 0.093 | 0.4644 | No |
| 28 | DUSP6 | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 2490 | 0.088 | 0.4609 | No |
| 29 | CSF1R | CSF1R Entrez, Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 2829 | 0.076 | 0.4408 | No |
| 30 | C3 | C3 Entrez, Source | complement component 3 | 2945 | 0.073 | 0.4372 | No |
| 31 | FGL2 | FGL2 Entrez, Source | fibrinogen-like 2 | 3128 | 0.068 | 0.4282 | No |
| 32 | SPINK1 | SPINK1 Entrez, Source | serine peptidase inhibitor, Kazal type 1 | 3138 | 0.068 | 0.4323 | No |
| 33 | CXCL5 | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 3208 | 0.065 | 0.4317 | No |
| 34 | CHI3L1 | CHI3L1 Entrez, Source | chitinase 3-like 1 (cartilage glycoprotein-39) | 3449 | 0.059 | 0.4177 | No |
| 35 | LTA4H | LTA4H Entrez, Source | leukotriene A4 hydrolase | 3505 | 0.057 | 0.4176 | No |
| 36 | ITGAL | ITGAL Entrez, Source | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 3736 | 0.051 | 0.4039 | No |
| 37 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 3759 | 0.051 | 0.4058 | No |
| 38 | BCAT1 | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 3938 | 0.046 | 0.3956 | No |
| 39 | CCR2 | CCR2 Entrez, Source | chemokine (C-C motif) receptor 2 | 3950 | 0.046 | 0.3980 | No |
| 40 | CD37 | CD37 Entrez, Source | CD37 molecule | 4350 | 0.037 | 0.3704 | No |
| 41 | SDC2 | SDC2 Entrez, Source | syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) | 4569 | 0.033 | 0.3563 | No |
| 42 | TAX1BP3 | TAX1BP3 Entrez, Source | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 4614 | 0.032 | 0.3552 | No |
| 43 | LST1 | LST1 Entrez, Source | leukocyte specific transcript 1 | 4729 | 0.030 | 0.3487 | No |
| 44 | C3AR1 | C3AR1 Entrez, Source | complement component 3a receptor 1 | 4875 | 0.027 | 0.3396 | No |
| 45 | LGMN | LGMN Entrez, Source | legumain | 4915 | 0.026 | 0.3385 | No |
| 46 | DOK1 | DOK1 Entrez, Source | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | 5013 | 0.024 | 0.3328 | No |
| 47 | NAP1L4 | NAP1L4 Entrez, Source | nucleosome assembly protein 1-like 4 | 5089 | 0.022 | 0.3287 | No |
| 48 | RTN1 | RTN1 Entrez, Source | reticulon 1 | 5323 | 0.018 | 0.3124 | No |
| 49 | PPIB | PPIB Entrez, Source | peptidylprolyl isomerase B (cyclophilin B) | 5568 | 0.013 | 0.2950 | No |
| 50 | BST1 | BST1 Entrez, Source | bone marrow stromal cell antigen 1 | 5870 | 0.008 | 0.2728 | No |
| 51 | PPBP | PPBP Entrez, Source | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 5909 | 0.007 | 0.2704 | No |
| 52 | SERPINA1 | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 6063 | 0.004 | 0.2591 | No |
| 53 | NCF1 | NCF1 Entrez, Source | neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) | 6138 | 0.003 | 0.2537 | No |
| 54 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 6181 | 0.001 | 0.2507 | No |
| 55 | C5AR1 | C5AR1 Entrez, Source | complement component 5a receptor 1 | 6304 | -0.000 | 0.2415 | No |
| 56 | PPIF | PPIF Entrez, Source | peptidylprolyl isomerase F (cyclophilin F) | 6391 | -0.002 | 0.2351 | No |
| 57 | NFYC | NFYC Entrez, Source | nuclear transcription factor Y, gamma | 6617 | -0.006 | 0.2185 | No |
| 58 | ADAM10 | ADAM10 Entrez, Source | ADAM metallopeptidase domain 10 | 7189 | -0.016 | 0.1766 | No |
| 59 | SLC1A3 | SLC1A3 Entrez, Source | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 7511 | -0.022 | 0.1539 | No |
| 60 | DNAJC8 | DNAJC8 Entrez, Source | DnaJ (Hsp40) homolog, subfamily C, member 8 | 7642 | -0.024 | 0.1458 | No |
| 61 | S100A9 | S100A9 Entrez, Source | S100 calcium binding protein A9 | 8582 | -0.043 | 0.0780 | No |
| 62 | DHX8 | DHX8 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 8 | 9167 | -0.055 | 0.0378 | No |
| 63 | PPP2R5D | PPP2R5D Entrez, Source | protein phosphatase 2, regulatory subunit B (B56), delta isoform | 9440 | -0.061 | 0.0216 | No |
| 64 | CYBB | CYBB Entrez, Source | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 9683 | -0.067 | 0.0081 | No |
| 65 | HTRA1 | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 9698 | -0.068 | 0.0117 | No |
| 66 | IL1B | IL1B Entrez, Source | interleukin 1, beta | 9721 | -0.069 | 0.0149 | No |
| 67 | SF3B4 | SF3B4 Entrez, Source | splicing factor 3b, subunit 4, 49kDa | 9980 | -0.076 | 0.0008 | No |
| 68 | BRD2 | BRD2 Entrez, Source | bromodomain containing 2 | 10248 | -0.083 | -0.0136 | No |
| 69 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 10293 | -0.084 | -0.0110 | No |
| 70 | SIAHBP1 | SIAHBP1 Entrez, Source | - | 10678 | -0.096 | -0.0332 | No |
| 71 | ANPEP | ANPEP Entrez, Source | alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) | 10917 | -0.106 | -0.0438 | No |
| 72 | PBEF1 | PBEF1 Entrez, Source | pre-B-cell colony enhancing factor 1 | 10965 | -0.107 | -0.0398 | No |
| 73 | RASA3 | RASA3 Entrez, Source | RAS p21 protein activator 3 | 11272 | -0.119 | -0.0545 | No |
| 74 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 11461 | -0.127 | -0.0598 | No |
| 75 | PSEN1 | PSEN1 Entrez, Source | presenilin 1 (Alzheimer disease 3) | 11576 | -0.132 | -0.0591 | No |
| 76 | TSC22D1 | TSC22D1 Entrez, Source | TSC22 domain family, member 1 | 11757 | -0.142 | -0.0627 | No |
| 77 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 11843 | -0.147 | -0.0589 | No |
| 78 | SOD2 | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 11883 | -0.149 | -0.0513 | No |
| 79 | PDLIM7 | PDLIM7 Entrez, Source | PDZ and LIM domain 7 (enigma) | 11900 | -0.150 | -0.0420 | No |
| 80 | ALG3 | ALG3 Entrez, Source | asparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase) | 12084 | -0.163 | -0.0444 | No |
| 81 | BAT2 | BAT2 Entrez, Source | HLA-B associated transcript 2 | 12112 | -0.166 | -0.0348 | No |
| 82 | CD14 | CD14 Entrez, Source | CD14 molecule | 12462 | -0.194 | -0.0475 | No |
| 83 | NINJ1 | NINJ1 Entrez, Source | ninjurin 1 | 12892 | -0.265 | -0.0613 | No |
| 84 | TXNIP | TXNIP Entrez, Source | thioredoxin interacting protein | 13000 | -0.292 | -0.0489 | No |
| 85 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 13119 | -0.337 | -0.0341 | No |
| 86 | CES1 | CES1 Entrez, Source | carboxylesterase 1 (monocyte/macrophage serine esterase 1) | 13135 | -0.348 | -0.0109 | No |
| 87 | GSR | GSR Entrez, Source | glutathione reductase | 13171 | -0.376 | 0.0129 | No |
