Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | HSA00100_BIOSYNTHESIS_OF_STEROIDS |
| Enrichment Score (ES) | 0.70924586 |
| Normalized Enrichment Score (NES) | 1.9087135 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.011477537 |
| FWER p-Value | 0.49 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SQLE | SQLE Entrez, Source | squalene epoxidase | 446 | 0.311 | 0.0780 | Yes |
| 2 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 531 | 0.275 | 0.1701 | Yes |
| 3 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 561 | 0.267 | 0.2634 | Yes |
| 4 | GGCX | GGCX Entrez, Source | gamma-glutamyl carboxylase | 563 | 0.266 | 0.3586 | Yes |
| 5 | EBP | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 743 | 0.228 | 0.4268 | Yes |
| 6 | VKORC1 | VKORC1 Entrez, Source | vitamin K epoxide reductase complex, subunit 1 | 841 | 0.206 | 0.4933 | Yes |
| 7 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 998 | 0.183 | 0.5470 | Yes |
| 8 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 1169 | 0.164 | 0.5927 | Yes |
| 9 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 1211 | 0.160 | 0.6470 | Yes |
| 10 | TM7SF2 | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 1828 | 0.115 | 0.6420 | Yes |
| 11 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 1830 | 0.115 | 0.6832 | Yes |
| 12 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 1998 | 0.108 | 0.7092 | Yes |
| 13 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 3141 | 0.067 | 0.6476 | No |
| 14 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 4118 | 0.042 | 0.5893 | No |
| 15 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 4644 | 0.031 | 0.5610 | No |
| 16 | GGPS1 | GGPS1 Entrez, Source | geranylgeranyl diphosphate synthase 1 | 5108 | 0.022 | 0.5341 | No |
| 17 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 5728 | 0.010 | 0.4914 | No |
| 18 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 5880 | 0.008 | 0.4828 | No |
| 19 | CYP27B1 | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 7135 | -0.014 | 0.3938 | No |
| 20 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 7592 | -0.023 | 0.3679 | No |
| 21 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 8972 | -0.051 | 0.2827 | No |
| 22 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 9332 | -0.059 | 0.2768 | No |
| 23 | HSD17B7 | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 9685 | -0.067 | 0.2745 | No |
