Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION |
| Enrichment Score (ES) | 0.65651387 |
| Normalized Enrichment Score (NES) | 1.943312 |
| Nominal p-value | 0.0018416207 |
| FDR q-value | 0.008392284 |
| FWER p-Value | 0.321 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HMGCS2 | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 173 | 0.525 | 0.0721 | Yes |
| 2 | BCKDHA | BCKDHA Entrez, Source | branched chain keto acid dehydrogenase E1, alpha polypeptide | 258 | 0.431 | 0.1357 | Yes |
| 3 | ALDH6A1 | ALDH6A1 Entrez, Source | aldehyde dehydrogenase 6 family, member A1 | 300 | 0.402 | 0.1978 | Yes |
| 4 | ECHS1 | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 346 | 0.367 | 0.2540 | Yes |
| 5 | EHHADH | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 375 | 0.349 | 0.3084 | Yes |
| 6 | ALDH3A2 | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 526 | 0.277 | 0.3420 | Yes |
| 7 | DBT | DBT Entrez, Source | dihydrolipoamide branched chain transacylase E2 | 541 | 0.272 | 0.3850 | Yes |
| 8 | ACAA2 | ACAA2 Entrez, Source | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) | 624 | 0.251 | 0.4195 | Yes |
| 9 | MCCC2 | MCCC2 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | 663 | 0.243 | 0.4559 | Yes |
| 10 | IVD | IVD Entrez, Source | isovaleryl Coenzyme A dehydrogenase | 800 | 0.213 | 0.4803 | Yes |
| 11 | BCKDHB | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 906 | 0.195 | 0.5040 | Yes |
| 12 | PCCB | PCCB Entrez, Source | propionyl Coenzyme A carboxylase, beta polypeptide | 1152 | 0.165 | 0.5123 | Yes |
| 13 | ALDH7A1 | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 1179 | 0.163 | 0.5368 | Yes |
| 14 | HIBADH | HIBADH Entrez, Source | 3-hydroxyisobutyrate dehydrogenase | 1229 | 0.158 | 0.5587 | Yes |
| 15 | ACAT2 | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 1343 | 0.147 | 0.5741 | Yes |
| 16 | ALDH3A1 | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 1428 | 0.140 | 0.5905 | Yes |
| 17 | ACAT1 | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 1482 | 0.136 | 0.6087 | Yes |
| 18 | HSD17B4 | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 1489 | 0.136 | 0.6302 | Yes |
| 19 | ACADS | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 1544 | 0.132 | 0.6475 | Yes |
| 20 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 1691 | 0.123 | 0.6565 | Yes |
| 21 | HADHA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 2173 | 0.101 | 0.6367 | No |
| 22 | ABAT | ABAT Entrez, Source | 4-aminobutyrate aminotransferase | 2398 | 0.092 | 0.6347 | No |
| 23 | MCCC1 | MCCC1 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) | 2454 | 0.090 | 0.6451 | No |
| 24 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 2544 | 0.086 | 0.6523 | No |
| 25 | ALDH9A1 | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 2893 | 0.074 | 0.6382 | No |
| 26 | HADH | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 3083 | 0.069 | 0.6352 | No |
| 27 | ACADM | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 3794 | 0.050 | 0.5900 | No |
| 28 | BCAT1 | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 3938 | 0.046 | 0.5867 | No |
| 29 | ALDH1B1 | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 4375 | 0.036 | 0.5598 | No |
| 30 | BCAT2 | BCAT2 Entrez, Source | branched chain aminotransferase 2, mitochondrial | 6086 | 0.004 | 0.4319 | No |
| 31 | DLD | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 6088 | 0.003 | 0.4324 | No |
| 32 | HMGCL | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 7083 | -0.014 | 0.3599 | No |
| 33 | HADHB | HADHB Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 7978 | -0.031 | 0.2977 | No |
| 34 | HIBCH | HIBCH Entrez, Source | 3-hydroxyisobutyryl-Coenzyme A hydrolase | 8146 | -0.034 | 0.2907 | No |
| 35 | AOX1 | AOX1 Entrez, Source | aldehyde oxidase 1 | 13304 | -0.615 | 0.0029 | No |
