Details for gene set HSA04510_FOCAL

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_24h_repos
Upregulated in class	double_gel_8d
GeneSet	HSA04510_FOCAL_ADHESION
Enrichment Score (ES)	0.5096855
Normalized Enrichment Score (NES)	1.881156
Nominal p-value	0.0
FDR q-value	0.015180133
FWER p-Value	0.628

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	COL1A2	COL1A2 Entrez, Source	collagen, type I, alpha 2	12	1.254	0.0678	Yes
2	CCND2	CCND2 Entrez, Source	cyclin D2	21	1.039	0.1241	Yes
3	LAMC2	LAMC2 Entrez, Source	laminin, gamma 2	23	1.021	0.1800	Yes
4	COL3A1	COL3A1 Entrez, Source	collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)	43	0.843	0.2248	Yes
5	COL5A2	COL5A2 Entrez, Source	collagen, type V, alpha 2	61	0.759	0.2651	Yes
6	COL4A1	COL4A1 Entrez, Source	collagen, type IV, alpha 1	89	0.680	0.3003	Yes
7	ITGB4	ITGB4 Entrez, Source	integrin, beta 4	266	0.426	0.3104	Yes
8	LAMA5	LAMA5 Entrez, Source	laminin, alpha 5	368	0.352	0.3220	Yes
9	CCND1	CCND1 Entrez, Source	cyclin D1	391	0.341	0.3390	Yes
10	COL1A1	COL1A1 Entrez, Source	collagen, type I, alpha 1	525	0.277	0.3441	Yes
11	LAMC1	LAMC1 Entrez, Source	laminin, gamma 1 (formerly LAMB2)	530	0.275	0.3589	Yes
12	PIP5K1C	PIP5K1C Entrez, Source	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	538	0.273	0.3733	Yes
13	CCND3	CCND3 Entrez, Source	cyclin D3	574	0.263	0.3851	Yes
14	COL6A2	COL6A2 Entrez, Source	collagen, type VI, alpha 2	579	0.262	0.3991	Yes
15	LAMB2	LAMB2 Entrez, Source	laminin, beta 2 (laminin S)	590	0.260	0.4126	Yes
16	PXN	PXN Entrez, Source	paxillin	594	0.258	0.4265	Yes
17	PAK1	PAK1 Entrez, Source	p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)	643	0.247	0.4364	Yes
18	MAPK9	MAPK9 Entrez, Source	mitogen-activated protein kinase 9	674	0.242	0.4474	Yes
19	PDGFA	PDGFA Entrez, Source	platelet-derived growth factor alpha polypeptide	729	0.230	0.4559	Yes
20	ERBB2	ERBB2 Entrez, Source	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	738	0.229	0.4678	Yes
21	MAPK3	MAPK3 Entrez, Source	mitogen-activated protein kinase 3	787	0.217	0.4761	Yes
22	FLT1	FLT1 Entrez, Source	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	835	0.207	0.4838	Yes
23	ITGA9	ITGA9 Entrez, Source	integrin, alpha 9	923	0.192	0.4878	Yes
24	BIRC3	BIRC3 Entrez, Source	baculoviral IAP repeat-containing 3	1025	0.179	0.4899	Yes
25	ITGB6	ITGB6 Entrez, Source	integrin, beta 6	1195	0.161	0.4860	Yes
26	FN1	FN1 Entrez, Source	fibronectin 1	1246	0.156	0.4908	Yes
27	ACTN3	ACTN3 Entrez, Source	actinin, alpha 3	1290	0.152	0.4958	Yes
28	SOS2	SOS2 Entrez, Source	son of sevenless homolog 2 (Drosophila)	1312	0.149	0.5024	Yes
29	VEGFC	VEGFC Entrez, Source	vascular endothelial growth factor C	1410	0.142	0.5029	Yes
30	PRKCA	PRKCA Entrez, Source	protein kinase C, alpha	1423	0.141	0.5097	Yes
31	BAD	BAD Entrez, Source	BCL2-antagonist of cell death	1530	0.133	0.5089	No
32	AKT1	AKT1 Entrez, Source	v-akt murine thymoma viral oncogene homolog 1	1652	0.125	0.5066	No
33	VTN	VTN Entrez, Source	vitronectin	1776	0.118	0.5038	No
34	ITGA1	ITGA1 Entrez, Source	integrin, alpha 1	1891	0.112	0.5013	No
35	RAP1B	RAP1B Entrez, Source	RAP1B, member of RAS oncogene family	2132	0.102	0.4887	No
36	SPP1	SPP1 Entrez, Source	secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)	2345	0.094	0.4778	No
37	VWF	VWF Entrez, Source	von Willebrand factor	2400	0.092	0.4788	No
38	BRAF	BRAF Entrez, Source	v-raf murine sarcoma viral oncogene homolog B1	2605	0.083	0.4679	No
39	FYN	FYN Entrez, Source	FYN oncogene related to SRC, FGR, YES	2623	0.083	0.4712	No
40	PIK3R3	PIK3R3 Entrez, Source	phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)	2744	0.079	0.4664	No
41	HRAS	HRAS Entrez, Source	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	2761	0.078	0.4694	No
42	MAPK10	MAPK10 Entrez, Source	mitogen-activated protein kinase 10	2865	0.075	0.4658	No
43	PDGFRB	PDGFRB Entrez, Source	platelet-derived growth factor receptor, beta polypeptide	2919	0.074	0.4658	No
44	COL11A1	COL11A1 Entrez, Source	collagen, type XI, alpha 1	2981	0.072	0.4651	No
45	AKT3	AKT3 Entrez, Source	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	3130	0.068	0.4576	No
46	COL5A1	COL5A1 Entrez, Source	collagen, type V, alpha 1	3222	0.065	0.4543	No
47	BCAR1	BCAR1 Entrez, Source	breast cancer anti-estrogen resistance 1	3291	0.063	0.4526	No
48	COL4A4	COL4A4 Entrez, Source	collagen, type IV, alpha 4	3320	0.062	0.4539	No
49	LAMA3	LAMA3 Entrez, Source	laminin, alpha 3	3344	0.061	0.4555	No
50	SRC	SRC Entrez, Source	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	3420	0.060	0.4531	No
51	ACTN1	ACTN1 Entrez, Source	actinin, alpha 1	3460	0.059	0.4534	No
52	IGF1R	IGF1R Entrez, Source	insulin-like growth factor 1 receptor	3890	0.048	0.4235	No
53	BCL2	BCL2 Entrez, Source	B-cell CLL/lymphoma 2	4187	0.040	0.4033	No
54	PDGFRA	PDGFRA Entrez, Source	platelet-derived growth factor receptor, alpha polypeptide	4352	0.037	0.3929	No
55	RELN	RELN Entrez, Source	reelin	4416	0.035	0.3901	No
56	KDR	KDR Entrez, Source	kinase insert domain receptor (a type III receptor tyrosine kinase)	4442	0.035	0.3901	No
57	ROCK1	ROCK1 Entrez, Source	Rho-associated, coiled-coil containing protein kinase 1	4600	0.032	0.3800	No
58	RAPGEF1	RAPGEF1 Entrez, Source	Rap guanine nucleotide exchange factor (GEF) 1	4621	0.032	0.3802	No
59	THBS2	THBS2 Entrez, Source	thrombospondin 2	4738	0.029	0.3730	No
60	VEGFB	VEGFB Entrez, Source	vascular endothelial growth factor B	4859	0.027	0.3654	No
61	BIRC4	BIRC4 Entrez, Source	baculoviral IAP repeat-containing 4	4947	0.025	0.3602	No
62	CAV3	CAV3 Entrez, Source	caveolin 3	4995	0.024	0.3580	No
63	PPP1CC	PPP1CC Entrez, Source	protein phosphatase 1, catalytic subunit, gamma isoform	4996	0.024	0.3593	No
64	IBSP	IBSP Entrez, Source	integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)	5170	0.021	0.3473	No
65	ACTB	ACTB Entrez, Source	actin, beta	5788	0.009	0.3011	No
66	ILK	ILK Entrez, Source	integrin-linked kinase	6045	0.004	0.2820	No
67	MYLK2	MYLK2 Entrez, Source	myosin light chain kinase 2, skeletal muscle	6310	-0.000	0.2620	No
68	PIK3R2	PIK3R2 Entrez, Source	phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)	6330	-0.001	0.2606	No
69	RAC2	RAC2 Entrez, Source	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	6381	-0.001	0.2569	No
70	CAPN2	CAPN2 Entrez, Source	calpain 2, (m/II) large subunit	6436	-0.002	0.2530	No
71	PTK2	PTK2 Entrez, Source	PTK2 protein tyrosine kinase 2	6465	-0.003	0.2510	No
72	JUN	JUN Entrez, Source	jun oncogene	6649	-0.006	0.2375	No
73	FLNB	FLNB Entrez, Source	filamin B, beta (actin binding protein 278)	7002	-0.012	0.2115	No
74	CAV2	CAV2 Entrez, Source	caveolin 2	7012	-0.012	0.2115	No
75	ITGA6	ITGA6 Entrez, Source	integrin, alpha 6	7051	-0.013	0.2094	No
76	VAV1	VAV1 Entrez, Source	vav 1 oncogene	7192	-0.016	0.1996	No
77	PPP1CA	PPP1CA Entrez, Source	protein phosphatase 1, catalytic subunit, alpha isoform	7240	-0.017	0.1970	No
78	ITGB5	ITGB5 Entrez, Source	integrin, beta 5	7282	-0.018	0.1948	No
79	ITGA7	ITGA7 Entrez, Source	integrin, alpha 7	7298	-0.018	0.1947	No
80	THBS4	THBS4 Entrez, Source	thrombospondin 4	7541	-0.022	0.1776	No
81	RAP1A	RAP1A Entrez, Source	RAP1A, member of RAS oncogene family	7676	-0.025	0.1688	No
82	CHAD	CHAD Entrez, Source	chondroadherin	7677	-0.025	0.1702	No
83	SHC1	SHC1 Entrez, Source	SHC (Src homology 2 domain containing) transforming protein 1	7776	-0.027	0.1642	No
84	MYL2	MYL2 Entrez, Source	myosin, light chain 2, regulatory, cardiac, slow	7811	-0.028	0.1632	No
85	PPP1CB	PPP1CB Entrez, Source	protein phosphatase 1, catalytic subunit, beta isoform	7860	-0.028	0.1611	No
86	PDPK1	PDPK1 Entrez, Source	3-phosphoinositide dependent protein kinase-1	7864	-0.028	0.1624	No
87	BIRC2	BIRC2 Entrez, Source	baculoviral IAP repeat-containing 2	7883	-0.029	0.1627	No
88	FLNC	FLNC Entrez, Source	filamin C, gamma (actin binding protein 280)	7939	-0.030	0.1601	No
89	PDGFD	PDGFD Entrez, Source	platelet derived growth factor D	7976	-0.031	0.1591	No
90	ITGB1	ITGB1 Entrez, Source	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	8134	-0.034	0.1491	No
91	CTNNB1	CTNNB1 Entrez, Source	catenin (cadherin-associated protein), beta 1, 88kDa	8141	-0.034	0.1505	No
92	MAPK1	MAPK1 Entrez, Source	mitogen-activated protein kinase 1	8182	-0.035	0.1494	No
93	RHOA	RHOA Entrez, Source	ras homolog gene family, member A	8243	-0.036	0.1468	No
94	PAK3	PAK3 Entrez, Source	p21 (CDKN1A)-activated kinase 3	8370	-0.039	0.1394	No
95	ELK1	ELK1 Entrez, Source	ELK1, member of ETS oncogene family	8398	-0.039	0.1395	No
96	PARVA	PARVA Entrez, Source	parvin, alpha	8673	-0.045	0.1213	No
97	TLN1	TLN1 Entrez, Source	talin 1	8697	-0.045	0.1220	No
98	PGF	PGF Entrez, Source	placental growth factor, vascular endothelial growth factor-related protein	8718	-0.046	0.1230	No
99	CDC42	CDC42 Entrez, Source	cell division cycle 42 (GTP binding protein, 25kDa)	8893	-0.050	0.1125	No
100	HGF	HGF Entrez, Source	hepatocyte growth factor (hepapoietin A; scatter factor)	8951	-0.051	0.1110	No
101	RAC1	RAC1 Entrez, Source	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	9101	-0.054	0.1027	No
102	PIK3CA	PIK3CA Entrez, Source	phosphoinositide-3-kinase, catalytic, alpha polypeptide	9133	-0.055	0.1033	No
103	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	9134	-0.055	0.1063	No
104	ITGB7	ITGB7 Entrez, Source	integrin, beta 7	9146	-0.055	0.1085	No
105	COMP	COMP Entrez, Source	cartilage oligomeric matrix protein	9154	-0.055	0.1110	No
106	ACTN4	ACTN4 Entrez, Source	actinin, alpha 4	9335	-0.059	0.1006	No
107	ARHGAP5	ARHGAP5 Entrez, Source	Rho GTPase activating protein 5	9336	-0.059	0.1038	No
108	PIK3CB	PIK3CB Entrez, Source	phosphoinositide-3-kinase, catalytic, beta polypeptide	9345	-0.059	0.1065	No
109	COL2A1	COL2A1 Entrez, Source	collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)	9434	-0.061	0.1032	No
110	PAK2	PAK2 Entrez, Source	p21 (CDKN1A)-activated kinase 2	9645	-0.066	0.0909	No
111	FIGF	FIGF Entrez, Source	c-fos induced growth factor (vascular endothelial growth factor D)	9671	-0.067	0.0927	No
112	AKT2	AKT2 Entrez, Source	v-akt murine thymoma viral oncogene homolog 2	9889	-0.073	0.0803	No
113	CRK	CRK Entrez, Source	v-crk sarcoma virus CT10 oncogene homolog (avian)	9974	-0.076	0.0781	No
114	PPP1R12A	PPP1R12A Entrez, Source	protein phosphatase 1, regulatory (inhibitor) subunit 12A	10350	-0.086	0.0544	No
115	ZYX	ZYX Entrez, Source	zyxin	10834	-0.102	0.0235	No
116	TNR	TNR Entrez, Source	tenascin R (restrictin, janusin)	10977	-0.107	0.0186	No
117	PIK3R1	PIK3R1 Entrez, Source	phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)	11304	-0.121	0.0006	No
118	RAF1	RAF1 Entrez, Source	v-raf-1 murine leukemia viral oncogene homolog 1	11362	-0.123	0.0030	No
119	COL5A3	COL5A3 Entrez, Source	collagen, type V, alpha 3	11366	-0.123	0.0095	No
120	ROCK2	ROCK2 Entrez, Source	Rho-associated, coiled-coil containing protein kinase 2	11450	-0.127	0.0102	No
121	MET	MET Entrez, Source	met proto-oncogene (hepatocyte growth factor receptor)	11573	-0.132	0.0082	No
122	PRKCB1	PRKCB1 Entrez, Source	protein kinase C, beta 1	11650	-0.136	0.0099	No
123	GRB2	GRB2 Entrez, Source	growth factor receptor-bound protein 2	11803	-0.145	0.0063	No
124	PTEN	PTEN Entrez, Source	phosphatase and tensin homolog (mutated in multiple advanced cancers 1)	11925	-0.152	0.0054	No
125	GSK3B	GSK3B Entrez, Source	glycogen synthase kinase 3 beta	11989	-0.156	0.0093	No
126	CRKL	CRKL Entrez, Source	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	12518	-0.201	-0.0197	No
127	EGF	EGF Entrez, Source	epidermal growth factor (beta-urogastrone)	12591	-0.209	-0.0137	No
128	PDGFC	PDGFC Entrez, Source	platelet derived growth factor C	12749	-0.233	-0.0128	No
129	MAP2K1	MAP2K1 Entrez, Source	mitogen-activated protein kinase kinase 1	12906	-0.268	-0.0099	No
130	EGFR	EGFR Entrez, Source	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	12946	-0.276	0.0023	No
131	LAMB3	LAMB3 Entrez, Source	laminin, beta 3	13259	-0.504	0.0063	No