Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_8d_versus_double_gel_24h.class.cls
#double_gel_8d_versus_double_gel_24h_repos
Phenotypeclass.cls#double_gel_8d_versus_double_gel_24h_repos
Upregulated in classdouble_gel_8d
GeneSetHSIAO_LIVER_SPECIFIC_GENES
Enrichment Score (ES)0.5325219
Normalized Enrichment Score (NES)2.0493913
Nominal p-value0.0
FDR q-value0.0027778852
FWER p-Value0.059
Table: GSEA Results Summary



Fig 1: Enrichment plot: HSIAO_LIVER_SPECIFIC_GENES   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAB2DAB2
Entrez,  Source
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)320.9250.0212Yes
2TM4SF4TM4SF4
Entrez,  Source
transmembrane 4 L six family member 4700.7200.0367Yes
3FMO3FMO3
Entrez,  Source
flavin containing monooxygenase 3940.6730.0521Yes
4ACOX2ACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain970.6670.0690Yes
5OTCOTC
Entrez,  Source
ornithine carbamoyltransferase1150.6250.0836Yes
6PCK1PCK1
Entrez,  Source
phosphoenolpyruvate carboxykinase 1 (soluble)1270.6100.0984Yes
7AZGP1AZGP1
Entrez,  Source
alpha-2-glycoprotein 1, zinc1290.6030.1137Yes
8CPS1CPS1
Entrez,  Source
carbamoyl-phosphate synthetase 1, mitochondrial1300.6020.1290Yes
9HGDHGD
Entrez,  Source
homogentisate 1,2-dioxygenase (homogentisate oxidase)1380.5910.1436Yes
10CBSCBS
Entrez,  Source
cystathionine-beta-synthase1480.5660.1573Yes
11CES2CES2
Entrez,  Source
carboxylesterase 2 (intestine, liver)1490.5640.1717Yes
12TDO2TDO2
Entrez,  Source
tryptophan 2,3-dioxygenase1700.5320.1838Yes
13GYS2GYS2
Entrez,  Source
glycogen synthase 2 (liver)1720.5270.1971Yes
14HMGCS2HMGCS2
Entrez,  Source
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)1730.5250.2105Yes
15ALDH1A1ALDH1A1
Entrez,  Source
aldehyde dehydrogenase 1 family, member A11850.5100.2227Yes
16FBP1FBP1
Entrez,  Source
fructose-1,6-bisphosphatase 12030.4840.2338Yes
17AGXTAGXT
Entrez,  Source
alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)2120.4750.2453Yes
18AGTR1AGTR1
Entrez,  Source
angiotensin II receptor, type 12200.4690.2567Yes
19FAHFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)2320.4570.2675Yes
20KYNUKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)2670.4260.2758Yes
21CRPCRP
Entrez,  Source
C-reactive protein, pentraxin-related2720.4220.2863Yes
22DPYSDPYS
Entrez,  Source
dihydropyrimidinase2870.4100.2956Yes
23CYP27A1CYP27A1
Entrez,  Source
cytochrome P450, family 27, subfamily A, polypeptide 12970.4030.3052Yes
24ALDH6A1ALDH6A1
Entrez,  Source
aldehyde dehydrogenase 6 family, member A13000.4020.3154Yes
25ARG1ARG1
Entrez,  Source
arginase, liver3070.3970.3250Yes
26RBP4RBP4
Entrez,  Source
retinol binding protein 4, plasma3230.3780.3335Yes
27G6PCG6PC
Entrez,  Source
glucose-6-phosphatase, catalytic subunit3470.3660.3411Yes
28CYB5ACYB5A
Entrez,  Source
cytochrome b5 type A (microsomal)3590.3590.3494Yes
29F9F9
Entrez,  Source
coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)3690.3520.3577Yes
30TATTAT
Entrez,  Source
tyrosine aminotransferase3900.3410.3649Yes
31FMO5FMO5
Entrez,  Source
flavin containing monooxygenase 53950.3390.3733Yes
32HSD11B1HSD11B1
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 14320.3200.3787Yes
33DECR1DECR1
Entrez,  Source
2,4-dienoyl CoA reductase 1, mitochondrial4860.2910.3821Yes
34SLC10A1SLC10A1
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 14990.2860.3885Yes
35SERPIND1SERPIND1
Entrez,  Source
serpin peptidase inhibitor, clade D (heparin cofactor), member 15040.2840.3954Yes
36HRGHRG
Entrez,  Source
histidine-rich glycoprotein5150.2800.4018Yes
37PORPOR
Entrez,  Source
P450 (cytochrome) oxidoreductase5230.2780.4084Yes
38RGL2RGL2
Entrez,  Source
ral guanine nucleotide dissociation stimulator-like 25470.2700.4135Yes
39ASS1ASS1
Entrez,  Source
argininosuccinate synthetase 15560.2680.4197Yes
40DHCR24DHCR24
Entrez,  Source
24-dehydrocholesterol reductase5610.2670.4262Yes
41GGCXGGCX
Entrez,  Source
gamma-glutamyl carboxylase5630.2660.4329Yes
42IGFBP1IGFBP1
Entrez,  Source
insulin-like growth factor binding protein 15960.2580.4371Yes
43BAATBAAT
Entrez,  Source
bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)6020.2570.4433Yes
44ACAA2ACAA2
Entrez,  Source
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)6240.2510.4481Yes
45LBPLBP
Entrez,  Source
lipopolysaccharide binding protein6360.2470.4535Yes
46APOA1APOA1
Entrez,  Source
apolipoprotein A-I6460.2460.4591Yes
47AADACAADAC
Entrez,  Source
arylacetamide deacetylase (esterase)6490.2450.4652Yes
48HRSP12HRSP12
Entrez,  Source
heat-responsive protein 126540.2440.4711Yes
49FSTFST
Entrez,  Source
follistatin6780.2400.4755Yes
50CDO1CDO1
Entrez,  Source
cysteine dioxygenase, type I6890.2370.4808Yes
51GJB1GJB1
Entrez,  Source
gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)6900.2370.4868Yes
52NAT2NAT2
Entrez,  Source
N-acetyltransferase 2 (arylamine N-acetyltransferase)7030.2340.4919Yes
53APOBAPOB
Entrez,  Source
apolipoprotein B (including Ag(x) antigen)7090.2330.4974Yes
54ABCB4ABCB4
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 47560.2240.4997Yes
55HPNHPN
Entrez,  Source
hepsin (transmembrane protease, serine 1)7750.2210.5039Yes
56SEPP1SEPP1
Entrez,  Source
selenoprotein P, plasma, 18230.2090.5057Yes
57SERPINA5SERPINA5
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 58760.1990.5068Yes
58SDSSDS
Entrez,  Source
serine dehydratase10070.1820.5016Yes
59MTTPMTTP
Entrez,  Source
microsomal triglyceride transfer protein10390.1770.5037Yes
60PZPPZP
Entrez,  Source
pregnancy-zone protein10500.1770.5075Yes
61TFPITFPI
Entrez,  Source
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)10520.1770.5119Yes
62BHMTBHMT
Entrez,  Source
betaine-homocysteine methyltransferase10540.1770.5163Yes
63GHRGHR
Entrez,  Source
growth hormone receptor10570.1760.5207Yes
64PCCBPCCB
Entrez,  Source
propionyl Coenzyme A carboxylase, beta polypeptide11520.1650.5177Yes
65PON3PON3
Entrez,  Source
paraoxonase 312040.1610.5179Yes
66FN1FN1
Entrez,  Source
fibronectin 112460.1560.5188Yes
67SLC38A3SLC38A3
Entrez,  Source
solute carrier family 38, member 313230.1490.5168Yes
68ITIH3ITIH3
Entrez,  Source
inter-alpha (globulin) inhibitor H313380.1480.5195Yes
69ACAT2ACAT2
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)13430.1470.5230Yes
70IL8RBIL8RB
Entrez,  Source
interleukin 8 receptor, beta13450.1470.5267Yes
71PROCPROC
Entrez,  Source
protein C (inactivator of coagulation factors Va and VIIIa)13940.1430.5267Yes
72CYP2C9CYP2C9
Entrez,  Source
cytochrome P450, family 2, subfamily C, polypeptide 914460.1390.5263Yes
73ACAT1ACAT1
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)14820.1360.5272Yes
74HSD17B4HSD17B4
Entrez,  Source
hydroxysteroid (17-beta) dehydrogenase 414890.1360.5302Yes
75ACSL1ACSL1
Entrez,  Source
acyl-CoA synthetase long-chain family member 116270.1270.5230Yes
76SLC2A2SLC2A2
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 216450.1260.5249Yes
77ACADSBACADSB
Entrez,  Source
acyl-Coenzyme A dehydrogenase, short/branched chain17150.1220.5228Yes
78CPB2CPB2
Entrez,  Source
carboxypeptidase B2 (plasma, carboxypeptidase U)17380.1200.5242Yes
79VTNVTN
Entrez,  Source
vitronectin17760.1180.5244Yes
80SERPINF2SERPINF2
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 217870.1180.5266Yes
81APOC3APOC3
Entrez,  Source
apolipoprotein C-III18820.1130.5223Yes
82LSRLSR
Entrez,  Source
lipolysis stimulated lipoprotein receptor18850.1120.5250Yes
83PROS1PROS1
Entrez,  Source
protein S (alpha)19010.1120.5267Yes
84FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 419240.1110.5279Yes
85TSTTST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)19690.1090.5273Yes
86APOHAPOH
Entrez,  Source
apolipoprotein H (beta-2-glycoprotein I)20110.1070.5269Yes
87F12F12
Entrez,  Source
coagulation factor XII (Hageman factor)20560.1050.5263Yes
88RNASE4RNASE4
Entrez,  Source
ribonuclease, RNase A family, 420640.1050.5284Yes
89CFICFI
Entrez,  Source
complement factor I20960.1040.5287Yes
90AKR1D1AKR1D1
Entrez,  Source
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)21110.1030.5303Yes
91LGALS4LGALS4
Entrez,  Source
lectin, galactoside-binding, soluble, 4 (galectin 4)21260.1030.5318Yes
92ALDOBALDOB
Entrez,  Source
aldolase B, fructose-bisphosphate21520.1010.5325Yes
93NR0B2NR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 223300.0940.5215No
94HPHP
Entrez,  Source
haptoglobin23420.0940.5230No
95SERPINF1SERPINF1
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 123610.0930.5240No
96DDTDDT
Entrez,  Source
D-dopachrome tautomerase24530.0900.5194No
97AHSGAHSG
Entrez,  Source
alpha-2-HS-glycoprotein24670.0890.5207No
98ALDH2ALDH2
Entrez,  Source
aldehyde dehydrogenase 2 family (mitochondrial)25440.0860.5171No
99CRHBPCRHBP
Entrez,  Source
corticotropin releasing hormone binding protein25670.0850.5176No
100MGST1MGST1
Entrez,  Source
microsomal glutathione S-transferase 126660.0810.5122No
101LCATLCAT
Entrez,  Source
lecithin-cholesterol acyltransferase28880.0750.4973No
102MST1MST1
Entrez,  Source
macrophage stimulating 1 (hepatocyte growth factor-like)28990.0740.4984No
103C3C3
Entrez,  Source
complement component 329450.0730.4969No
104HNMTHNMT
Entrez,  Source
histamine N-methyltransferase29860.0720.4956No
105SERPING1SERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)30390.0700.4935No
106HGFACHGFAC
Entrez,  Source
HGF activator31980.0660.4832No
107C4BPAC4BPA
Entrez,  Source
complement component 4 binding protein, alpha32110.0650.4839No
108F2F2
Entrez,  Source
coagulation factor II (thrombin)35520.0560.4595No
109PYGLPYGL
Entrez,  Source
phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)35670.0560.4598No
110SERPINA4SERPINA4
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 435700.0560.4611No
111SEPHS2SEPHS2
Entrez,  Source
selenophosphate synthetase 236850.0530.4538No
112APOC1APOC1
Entrez,  Source
apolipoprotein C-I40220.0440.4294No
113SAA4SAA4
Entrez,  Source
serum amyloid A4, constitutive41280.0420.4224No
114LAMP2LAMP2
Entrez,  Source
lysosomal-associated membrane protein 242800.0380.4119No
115GLUD1GLUD1
Entrez,  Source
glutamate dehydrogenase 142970.0380.4117No
116KCNH2KCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 247850.0280.3754No
117PRDX4PRDX4
Entrez,  Source
peroxiredoxin 449530.0250.3633No
118CPCP
Entrez,  Source
ceruloplasmin (ferroxidase)50930.0220.3533No
119SULT2A1SULT2A1
Entrez,  Source
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 151840.0210.3470No
120PCSK6PCSK6
Entrez,  Source
proprotein convertase subtilisin/kexin type 652500.0200.3425No
121ABCC6ABCC6
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 653960.0170.3320No
122ORM1ORM1
Entrez,  Source
orosomucoid 156060.0130.3164No
123SERPINC1SERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 158060.0090.3015No
124HALHAL
Entrez,  Source
histidine ammonia-lyase58560.0080.2980No
125SC4MOLSC4MOL
Entrez,  Source
sterol-C4-methyl oxidase-like58800.0080.2964No
126ASGR2ASGR2
Entrez,  Source
asialoglycoprotein receptor 260420.0040.2843No
127SPP2SPP2
Entrez,  Source
secreted phosphoprotein 2, 24kDa60540.0040.2835No
128SERPINA1SERPINA1
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 160630.0040.2830No
129CDH2CDH2
Entrez,  Source
cadherin 2, type 1, N-cadherin (neuronal)61220.0030.2787No
130ALBALB
Entrez,  Source
albumin62750.0000.2672No
131LIPCLIPC
Entrez,  Source
lipase, hepatic6430-0.0020.2555No
132HPDHPD
Entrez,  Source
4-hydroxyphenylpyruvate dioxygenase6481-0.0030.2518No
133ADH4ADH4
Entrez,  Source
alcohol dehydrogenase 4 (class II), pi polypeptide6589-0.0050.2438No
134TAF6TAF6
Entrez,  Source
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa6603-0.0060.2429No
135GPTGPT
Entrez,  Source
glutamic-pyruvate transaminase (alanine aminotransferase)6620-0.0060.2419No
136IL13IL13
Entrez,  Source
interleukin 136740-0.0080.2330No
137PCBD1PCBD1
Entrez,  Source
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)6764-0.0080.2315No
138ASLASL
Entrez,  Source
argininosuccinate lyase6773-0.0080.2311No
139FABP1FABP1
Entrez,  Source
fatty acid binding protein 1, liver6898-0.0100.2219No
140HMGCLHMGCL
Entrez,  Source
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)7083-0.0140.2083No
141SOD1SOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))7093-0.0140.2080No
142F10F10
Entrez,  Source
coagulation factor X7144-0.0150.2045No
143MTHFD1MTHFD1
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase7607-0.0240.1700No
144SHMT1SHMT1
Entrez,  Source
serine hydroxymethyltransferase 1 (soluble)7827-0.0280.1541No
145CFBCFB
Entrez,  Source
complement factor B8083-0.0330.1355No
146CYP4F2CYP4F2
Entrez,  Source
cytochrome P450, family 4, subfamily F, polypeptide 28129-0.0340.1330No
147ASGR1ASGR1
Entrez,  Source
asialoglycoprotein receptor 18158-0.0340.1317No
148HPXHPX
Entrez,  Source
hemopexin8287-0.0370.1229No
149ADFPADFP
Entrez,  Source
adipose differentiation-related protein8468-0.0410.1103No
150TOMM40TOMM40
Entrez,  Source
translocase of outer mitochondrial membrane 40 homolog (yeast)8638-0.0440.0986No
151CATCAT
Entrez,  Source
catalase8873-0.0490.0820No
152CYP3A4CYP3A4
Entrez,  Source
cytochrome P450, family 3, subfamily A, polypeptide 49007-0.0520.0733No
153PLGPLG
Entrez,  Source
plasminogen9113-0.0540.0667No
154PGRMC1PGRMC1
Entrez,  Source
progesterone receptor membrane component 19378-0.0600.0481No
155FGGFGG
Entrez,  Source
fibrinogen gamma chain9841-0.0720.0148No
156SSRP1SSRP1
Entrez,  Source
structure specific recognition protein 19875-0.0730.0142No
157NR1H4NR1H4
Entrez,  Source
nuclear receptor subfamily 1, group H, member 49939-0.0750.0113No
158ABCC2ABCC2
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 29965-0.0750.0113No
159ALAS1ALAS1
Entrez,  Source
aminolevulinate, delta-, synthase 19995-0.0760.0111No
160C1RC1R
Entrez,  Source
complement component 1, r subcomponent10455-0.089-0.0215No
161C2C2
Entrez,  Source
complement component 210542-0.091-0.0258No
162GATMGATM
Entrez,  Source
glycine amidinotransferase (L-arginine:glycine amidinotransferase)10782-0.100-0.0414No
163PBEF1PBEF1
Entrez,  Source
pre-B-cell colony enhancing factor 110965-0.107-0.0525No
164SORDSORD
Entrez,  Source
sorbitol dehydrogenase11093-0.112-0.0593No
165APOA2APOA2
Entrez,  Source
apolipoprotein A-II11263-0.119-0.0691No
166CFHR1CFHR1
Entrez,  Source
complement factor H-related 111475-0.128-0.0819No
167FGAFGA
Entrez,  Source
fibrinogen alpha chain11480-0.128-0.0789No
168APCSAPCS
Entrez,  Source
amyloid P component, serum11626-0.135-0.0865No
169BZW1BZW1
Entrez,  Source
basic leucine zipper and W2 domains 111682-0.137-0.0872No
170FGL1FGL1
Entrez,  Source
fibrinogen-like 111898-0.150-0.0997No
171CYP2E1CYP2E1
Entrez,  Source
cytochrome P450, family 2, subfamily E, polypeptide 111911-0.151-0.0968No
172MBL2MBL2
Entrez,  Source
mannose-binding lectin (protein C) 2, soluble (opsonic defect)11957-0.154-0.0963No
173FGBFGB
Entrez,  Source
fibrinogen beta chain12236-0.175-0.1130No
174IL13RA1IL13RA1
Entrez,  Source
interleukin 13 receptor, alpha 112296-0.179-0.1129No
175GCH1GCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)12298-0.179-0.1084No
176EPHX1EPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)12370-0.186-0.1090No
177GSTO1GSTO1
Entrez,  Source
glutathione S-transferase omega 112484-0.197-0.1126No
178CASC3CASC3
Entrez,  Source
cancer susceptibility candidate 312604-0.211-0.1163No
179SERPINE1SERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 112951-0.277-0.1355No
180AGTAGT
Entrez,  Source
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)13048-0.306-0.1350No
181CES1CES1
Entrez,  Source
carboxylesterase 1 (monocyte/macrophage serine esterase 1)13135-0.348-0.1326No
182ACSM3ACSM3
Entrez,  Source
acyl-CoA synthetase medium-chain family member 313175-0.381-0.1259No
183KLKB1KLKB1
Entrez,  Source
kallikrein B, plasma (Fletcher factor) 113257-0.500-0.1193No
184TFTF
Entrez,  Source
transferrin13296-0.585-0.1072No
185GSTA2GSTA2
Entrez,  Source
glutathione S-transferase A213300-0.608-0.0920No
186AOX1AOX1
Entrez,  Source
aldehyde oxidase 113304-0.615-0.0765No
187LTB4DHLTB4DH
Entrez,  Source
leukotriene B4 12-hydroxydehydrogenase13306-0.626-0.0606No
188BDH1BDH1
Entrez,  Source
3-hydroxybutyrate dehydrogenase, type 113310-0.654-0.0442No
189SERPINA7SERPINA7
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 713325-0.823-0.0242No
190RGNRGN
Entrez,  Source
regucalcin (senescence marker protein-30)13333-0.9980.0007No
Table: GSEA details [plain text format]



Fig 2: HSIAO_LIVER_SPECIFIC_GENES   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HSIAO_LIVER_SPECIFIC_GENES: Random ES distribution   
Gene set null distribution of ES for HSIAO_LIVER_SPECIFIC_GENES