Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | MANALO_HYPOXIA_DN |
| Enrichment Score (ES) | -0.6342624 |
| Normalized Enrichment Score (NES) | -2.057412 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0040866756 |
| FWER p-Value | 0.041 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | POLG | POLG Entrez, Source | polymerase (DNA directed), gamma | 985 | 0.185 | -0.0456 | No |
| 2 | BARD1 | BARD1 Entrez, Source | BRCA1 associated RING domain 1 | 1511 | 0.134 | -0.0644 | No |
| 3 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2162 | 0.101 | -0.0977 | No |
| 4 | CCNF | CCNF Entrez, Source | cyclin F | 2662 | 0.081 | -0.1226 | No |
| 5 | DHFR | DHFR Entrez, Source | dihydrofolate reductase | 2681 | 0.081 | -0.1115 | No |
| 6 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 3049 | 0.070 | -0.1283 | No |
| 7 | ID1 | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 3286 | 0.063 | -0.1363 | No |
| 8 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 5532 | 0.014 | -0.3030 | No |
| 9 | MFN2 | MFN2 Entrez, Source | mitofusin 2 | 5952 | 0.006 | -0.3335 | No |
| 10 | MRPL40 | MRPL40 Entrez, Source | mitochondrial ribosomal protein L40 | 6471 | -0.003 | -0.3720 | No |
| 11 | ELK1 | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 8398 | -0.039 | -0.5107 | No |
| 12 | UMPS | UMPS Entrez, Source | uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) | 9665 | -0.067 | -0.5956 | No |
| 13 | PSME4 | PSME4 Entrez, Source | proteasome (prosome, macropain) activator subunit 4 | 9912 | -0.074 | -0.6026 | No |
| 14 | UCHL5 | UCHL5 Entrez, Source | ubiquitin carboxyl-terminal hydrolase L5 | 10092 | -0.079 | -0.6039 | No |
| 15 | ATIC | ATIC Entrez, Source | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | 10497 | -0.090 | -0.6204 | Yes |
| 16 | POLD2 | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 10527 | -0.091 | -0.6085 | Yes |
| 17 | NEK4 | NEK4 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 4 | 10801 | -0.101 | -0.6135 | Yes |
| 18 | ORC6L | ORC6L Entrez, Source | origin recognition complex, subunit 6 like (yeast) | 10987 | -0.108 | -0.6107 | Yes |
| 19 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 11096 | -0.112 | -0.6016 | Yes |
| 20 | MLLT10 | MLLT10 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 11170 | -0.115 | -0.5893 | Yes |
| 21 | MRPL46 | MRPL46 Entrez, Source | mitochondrial ribosomal protein L46 | 11276 | -0.119 | -0.5788 | Yes |
| 22 | ZWINT | ZWINT Entrez, Source | ZW10 interactor | 11637 | -0.135 | -0.5850 | Yes |
| 23 | GTPBP4 | GTPBP4 Entrez, Source | GTP binding protein 4 | 11715 | -0.139 | -0.5694 | Yes |
| 24 | BOP1 | BOP1 Entrez, Source | block of proliferation 1 | 11822 | -0.146 | -0.5549 | Yes |
| 25 | RFC2 | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 11931 | -0.152 | -0.5395 | Yes |
| 26 | TFAM | TFAM Entrez, Source | transcription factor A, mitochondrial | 11975 | -0.156 | -0.5187 | Yes |
| 27 | SFRS2 | SFRS2 Entrez, Source | splicing factor, arginine/serine-rich 2 | 12039 | -0.160 | -0.4988 | Yes |
| 28 | DDX18 | DDX18 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 12109 | -0.165 | -0.4785 | Yes |
| 29 | TRIP13 | TRIP13 Entrez, Source | thyroid hormone receptor interactor 13 | 12163 | -0.169 | -0.4564 | Yes |
| 30 | PRPS1 | PRPS1 Entrez, Source | phosphoribosyl pyrophosphate synthetase 1 | 12339 | -0.183 | -0.4414 | Yes |
| 31 | PSME3 | PSME3 Entrez, Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 12583 | -0.209 | -0.4275 | Yes |
| 32 | NOL5A | NOL5A Entrez, Source | nucleolar protein 5A (56kDa with KKE/D repeat) | 12614 | -0.213 | -0.3970 | Yes |
| 33 | NOLC1 | NOLC1 Entrez, Source | nucleolar and coiled-body phosphoprotein 1 | 12621 | -0.214 | -0.3645 | Yes |
| 34 | USP1 | USP1 Entrez, Source | ubiquitin specific peptidase 1 | 12629 | -0.215 | -0.3318 | Yes |
| 35 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 12712 | -0.226 | -0.3031 | Yes |
| 36 | HNRPDL | HNRPDL Entrez, Source | heterogeneous nuclear ribonucleoprotein D-like | 12742 | -0.232 | -0.2695 | Yes |
| 37 | HNRPU | HNRPU Entrez, Source | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 12753 | -0.234 | -0.2342 | Yes |
| 38 | RPL39 | RPL39 Entrez, Source | ribosomal protein L39 | 12758 | -0.234 | -0.1984 | Yes |
| 39 | ILF3 | ILF3 Entrez, Source | interleukin enhancer binding factor 3, 90kDa | 12940 | -0.274 | -0.1698 | Yes |
| 40 | PA2G4 | PA2G4 Entrez, Source | proliferation-associated 2G4, 38kDa | 13030 | -0.302 | -0.1299 | Yes |
| 41 | HNRPD | HNRPD Entrez, Source | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 13227 | -0.440 | -0.0768 | Yes |
| 42 | MCM6 | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 13288 | -0.553 | 0.0041 | Yes |
