Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | MITOTIC_CELL_CYCLE |
| Enrichment Score (ES) | -0.39306682 |
| Normalized Enrichment Score (NES) | -1.395062 |
| Nominal p-value | 0.037593983 |
| FDR q-value | 0.29970983 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | KIF2C | KIF2C Entrez, Source | kinesin family member 2C | 1116 | 0.169 | -0.0577 | No |
| 2 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 1441 | 0.140 | -0.0603 | No |
| 3 | EREG | EREG Entrez, Source | epiregulin | 1968 | 0.109 | -0.0829 | No |
| 4 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 2076 | 0.105 | -0.0746 | No |
| 5 | BUB1B | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 2298 | 0.096 | -0.0763 | No |
| 6 | USH1C | USH1C Entrez, Source | Usher syndrome 1C (autosomal recessive, severe) | 2356 | 0.093 | -0.0661 | No |
| 7 | APBB1 | APBB1 Entrez, Source | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 2372 | 0.093 | -0.0527 | No |
| 8 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 3202 | 0.066 | -0.1049 | No |
| 9 | MAP3K11 | MAP3K11 Entrez, Source | mitogen-activated protein kinase kinase kinase 11 | 3414 | 0.060 | -0.1115 | No |
| 10 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 3725 | 0.052 | -0.1267 | No |
| 11 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 3790 | 0.050 | -0.1237 | No |
| 12 | BCAT1 | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 3938 | 0.046 | -0.1276 | No |
| 13 | GFI1 | GFI1 Entrez, Source | growth factor independent 1 | 4245 | 0.039 | -0.1446 | No |
| 14 | PPP5C | PPP5C Entrez, Source | protein phosphatase 5, catalytic subunit | 4288 | 0.038 | -0.1419 | No |
| 15 | CDKN2B | CDKN2B Entrez, Source | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 4378 | 0.036 | -0.1429 | No |
| 16 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 4610 | 0.032 | -0.1553 | No |
| 17 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 4656 | 0.031 | -0.1539 | No |
| 18 | SPDYA | SPDYA Entrez, Source | speedy homolog A (Drosophila) | 5077 | 0.023 | -0.1820 | No |
| 19 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 5186 | 0.020 | -0.1870 | No |
| 20 | ASNS | ASNS Entrez, Source | asparagine synthetase | 5217 | 0.020 | -0.1861 | No |
| 21 | BTG3 | BTG3 Entrez, Source | BTG family, member 3 | 5592 | 0.013 | -0.2123 | No |
| 22 | SNF1LK | SNF1LK Entrez, Source | SNF1-like kinase | 5650 | 0.012 | -0.2147 | No |
| 23 | DLG1 | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 5702 | 0.011 | -0.2169 | No |
| 24 | BIRC5 | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 5848 | 0.008 | -0.2265 | No |
| 25 | NPM2 | NPM2 Entrez, Source | nucleophosmin/nucleoplasmin, 2 | 6472 | -0.003 | -0.2730 | No |
| 26 | CDKN2C | CDKN2C Entrez, Source | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 6502 | -0.004 | -0.2746 | No |
| 27 | RAD17 | RAD17 Entrez, Source | RAD17 homolog (S. pombe) | 6622 | -0.006 | -0.2826 | No |
| 28 | ACVR1 | ACVR1 Entrez, Source | activin A receptor, type I | 6711 | -0.007 | -0.2881 | No |
| 29 | SPHK1 | SPHK1 Entrez, Source | sphingosine kinase 1 | 7090 | -0.014 | -0.3145 | No |
| 30 | CHFR | CHFR Entrez, Source | checkpoint with forkhead and ring finger domains | 7176 | -0.015 | -0.3185 | No |
| 31 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 7458 | -0.021 | -0.3364 | No |
| 32 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 7606 | -0.024 | -0.3438 | No |
| 33 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 7768 | -0.027 | -0.3517 | No |
| 34 | KPNA2 | KPNA2 Entrez, Source | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 8037 | -0.032 | -0.3669 | No |
| 35 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 8169 | -0.035 | -0.3714 | No |
| 36 | TTN | TTN Entrez, Source | titin | 8210 | -0.035 | -0.3689 | No |
| 37 | ANAPC4 | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 8515 | -0.042 | -0.3853 | Yes |
| 38 | CDC16 | CDC16 Entrez, Source | CDC16 cell division cycle 16 homolog (S. cerevisiae) | 8534 | -0.042 | -0.3800 | Yes |
| 39 | CDKN3 | CDKN3 Entrez, Source | cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) | 8545 | -0.042 | -0.3742 | Yes |
| 40 | CDC2L5 | CDC2L5 Entrez, Source | cell division cycle 2-like 5 (cholinesterase-related cell division controller) | 8548 | -0.042 | -0.3677 | Yes |
| 41 | NBN | NBN Entrez, Source | nibrin | 8672 | -0.045 | -0.3699 | Yes |
| 42 | CDK10 | CDK10 Entrez, Source | cyclin-dependent kinase (CDC2-like) 10 | 8682 | -0.045 | -0.3636 | Yes |
| 43 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 8685 | -0.045 | -0.3567 | Yes |
| 44 | CDC25B | CDC25B Entrez, Source | cell division cycle 25B | 8722 | -0.046 | -0.3522 | Yes |
| 45 | DCTN2 | DCTN2 Entrez, Source | dynactin 2 (p50) | 8962 | -0.051 | -0.3623 | Yes |
| 46 | CETN1 | CETN1 Entrez, Source | centrin, EF-hand protein, 1 | 9141 | -0.055 | -0.3671 | Yes |
| 47 | NEK6 | NEK6 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 6 | 9217 | -0.056 | -0.3640 | Yes |
| 48 | KHDRBS1 | KHDRBS1 Entrez, Source | KH domain containing, RNA binding, signal transduction associated 1 | 9255 | -0.057 | -0.3579 | Yes |
| 49 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 9365 | -0.060 | -0.3567 | Yes |
| 50 | ZW10 | ZW10 Entrez, Source | ZW10, kinetochore associated, homolog (Drosophila) | 9428 | -0.061 | -0.3518 | Yes |
| 51 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 9497 | -0.063 | -0.3472 | Yes |
| 52 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 10104 | -0.079 | -0.3805 | Yes |
| 53 | PPP6C | PPP6C Entrez, Source | protein phosphatase 6, catalytic subunit | 10116 | -0.079 | -0.3689 | Yes |
| 54 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 10438 | -0.088 | -0.3792 | Yes |
| 55 | TBRG4 | TBRG4 Entrez, Source | transforming growth factor beta regulator 4 | 10477 | -0.090 | -0.3681 | Yes |
| 56 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 10571 | -0.092 | -0.3607 | Yes |
| 57 | GSPT1 | GSPT1 Entrez, Source | G1 to S phase transition 1 | 10578 | -0.093 | -0.3466 | Yes |
| 58 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 10658 | -0.096 | -0.3376 | Yes |
| 59 | NUMA1 | NUMA1 Entrez, Source | nuclear mitotic apparatus protein 1 | 10675 | -0.096 | -0.3238 | Yes |
| 60 | CIT | CIT Entrez, Source | citron (rho-interacting, serine/threonine kinase 21) | 10772 | -0.100 | -0.3154 | Yes |
| 61 | SUGT1 | SUGT1 Entrez, Source | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | 10813 | -0.101 | -0.3026 | Yes |
| 62 | MAD2L2 | MAD2L2 Entrez, Source | MAD2 mitotic arrest deficient-like 2 (yeast) | 10862 | -0.103 | -0.2900 | Yes |
| 63 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 10944 | -0.106 | -0.2795 | Yes |
| 64 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 10956 | -0.107 | -0.2637 | Yes |
| 65 | RAN | RAN Entrez, Source | RAN, member RAS oncogene family | 11423 | -0.126 | -0.2791 | Yes |
| 66 | ZWINT | ZWINT Entrez, Source | ZW10 interactor | 11637 | -0.135 | -0.2740 | Yes |
| 67 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 11805 | -0.145 | -0.2640 | Yes |
| 68 | AURKA | AURKA Entrez, Source | aurora kinase A | 12238 | -0.175 | -0.2693 | Yes |
| 69 | STMN1 | STMN1 Entrez, Source | stathmin 1/oncoprotein 18 | 12244 | -0.175 | -0.2423 | Yes |
| 70 | AKAP8 | AKAP8 Entrez, Source | A kinase (PRKA) anchor protein 8 | 12267 | -0.177 | -0.2163 | Yes |
| 71 | CDC27 | CDC27 Entrez, Source | cell division cycle 27 | 12536 | -0.203 | -0.2048 | Yes |
| 72 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 12591 | -0.209 | -0.1762 | Yes |
| 73 | KATNA1 | KATNA1 Entrez, Source | katanin p60 (ATPase-containing) subunit A 1 | 12593 | -0.209 | -0.1435 | Yes |
| 74 | NOLC1 | NOLC1 Entrez, Source | nucleolar and coiled-body phosphoprotein 1 | 12621 | -0.214 | -0.1122 | Yes |
| 75 | TARDBP | TARDBP Entrez, Source | TAR DNA binding protein | 12761 | -0.235 | -0.0860 | Yes |
| 76 | CD28 | CD28 Entrez, Source | CD28 molecule | 12792 | -0.240 | -0.0507 | Yes |
| 77 | KIF22 | KIF22 Entrez, Source | kinesin family member 22 | 12933 | -0.273 | -0.0186 | Yes |
| 78 | CUL5 | CUL5 Entrez, Source | cullin 5 | 13074 | -0.316 | 0.0202 | Yes |
