Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | MRNA_PROCESSING_REACTOME |
| Enrichment Score (ES) | -0.6109144 |
| Normalized Enrichment Score (NES) | -2.0917363 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.005672107 |
| FWER p-Value | 0.024 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CUGBP2 | CUGBP2 Entrez, Source | CUG triplet repeat, RNA binding protein 2 | 1501 | 0.135 | -0.0945 | No |
| 2 | SF4 | SF4 Entrez, Source | splicing factor 4 | 2610 | 0.083 | -0.1665 | No |
| 3 | GIPC1 | GIPC1 Entrez, Source | GIPC PDZ domain containing family, member 1 | 3372 | 0.061 | -0.2154 | No |
| 4 | PRPF4B | PRPF4B Entrez, Source | PRP4 pre-mRNA processing factor 4 homolog B (yeast) | 3623 | 0.054 | -0.2268 | No |
| 5 | CUGBP1 | CUGBP1 Entrez, Source | CUG triplet repeat, RNA binding protein 1 | 4049 | 0.043 | -0.2528 | No |
| 6 | NUDT21 | NUDT21 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | 5776 | 0.009 | -0.3815 | No |
| 7 | CPSF3 | CPSF3 Entrez, Source | cleavage and polyadenylation specific factor 3, 73kDa | 6401 | -0.002 | -0.4282 | No |
| 8 | PHF5A | PHF5A Entrez, Source | PHD finger protein 5A | 6646 | -0.006 | -0.4457 | No |
| 9 | SPOP | SPOP Entrez, Source | speckle-type POZ protein | 6946 | -0.011 | -0.4667 | No |
| 10 | SNRPN | SNRPN Entrez, Source | small nuclear ribonucleoprotein polypeptide N | 7006 | -0.012 | -0.4694 | No |
| 11 | U2AF2 | U2AF2 Entrez, Source | U2 small nuclear RNA auxiliary factor 2 | 7498 | -0.022 | -0.5034 | No |
| 12 | DNAJC8 | DNAJC8 Entrez, Source | DnaJ (Hsp40) homolog, subfamily C, member 8 | 7642 | -0.024 | -0.5108 | No |
| 13 | SUPT5H | SUPT5H Entrez, Source | suppressor of Ty 5 homolog (S. cerevisiae) | 7661 | -0.025 | -0.5088 | No |
| 14 | CLK3 | CLK3 Entrez, Source | CDC-like kinase 3 | 7918 | -0.030 | -0.5240 | No |
| 15 | PPM1G | PPM1G Entrez, Source | protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform | 8259 | -0.037 | -0.5446 | No |
| 16 | HNRPR | HNRPR Entrez, Source | heterogeneous nuclear ribonucleoprotein R | 8586 | -0.043 | -0.5632 | No |
| 17 | SFRS8 | SFRS8 Entrez, Source | splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila) | 9013 | -0.052 | -0.5881 | No |
| 18 | DHX8 | DHX8 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 8 | 9167 | -0.055 | -0.5920 | No |
| 19 | SFRS7 | SFRS7 Entrez, Source | splicing factor, arginine/serine-rich 7, 35kDa | 9277 | -0.058 | -0.5923 | No |
| 20 | SFRS5 | SFRS5 Entrez, Source | splicing factor, arginine/serine-rich 5 | 9303 | -0.058 | -0.5862 | No |
| 21 | COL2A1 | COL2A1 Entrez, Source | collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) | 9434 | -0.061 | -0.5876 | No |
| 22 | SFRS9 | SFRS9 Entrez, Source | splicing factor, arginine/serine-rich 9 | 9480 | -0.062 | -0.5824 | No |
| 23 | PRPF4 | PRPF4 Entrez, Source | PRP4 pre-mRNA processing factor 4 homolog (yeast) | 9604 | -0.065 | -0.5827 | No |
| 24 | SF3B4 | SF3B4 Entrez, Source | splicing factor 3b, subunit 4, 49kDa | 9980 | -0.076 | -0.6005 | Yes |
| 25 | PTBP1 | PTBP1 Entrez, Source | polypyrimidine tract binding protein 1 | 10089 | -0.079 | -0.5978 | Yes |
| 26 | HNRPH1 | HNRPH1 Entrez, Source | heterogeneous nuclear ribonucleoprotein H1 (H) | 10163 | -0.081 | -0.5922 | Yes |
| 27 | SNRPN /// SNURF | 10197 | -0.082 | -0.5835 | Yes | ||
| 28 | RBM5 | RBM5 Entrez, Source | RNA binding motif protein 5 | 10207 | -0.082 | -0.5729 | Yes |
| 29 | DHX16 | DHX16 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 16 | 10229 | -0.082 | -0.5632 | Yes |
| 30 | SRPK1 | SRPK1 Entrez, Source | SFRS protein kinase 1 | 10252 | -0.083 | -0.5534 | Yes |
| 31 | RNPS1 | RNPS1 Entrez, Source | RNA binding protein S1, serine-rich domain | 10325 | -0.085 | -0.5471 | Yes |
| 32 | HNRPAB | HNRPAB Entrez, Source | heterogeneous nuclear ribonucleoprotein A/B | 10402 | -0.087 | -0.5408 | Yes |
| 33 | SF3B1 | SF3B1 Entrez, Source | splicing factor 3b, subunit 1, 155kDa | 10411 | -0.088 | -0.5294 | Yes |
| 34 | SF3A2 | SF3A2 Entrez, Source | splicing factor 3a, subunit 2, 66kDa | 10842 | -0.103 | -0.5477 | Yes |
| 35 | SNRPB | SNRPB Entrez, Source | small nuclear ribonucleoprotein polypeptides B and B1 | 11009 | -0.109 | -0.5453 | Yes |
| 36 | CLK4 | CLK4 Entrez, Source | CDC-like kinase 4 | 11152 | -0.114 | -0.5402 | Yes |
| 37 | RBM17 | RBM17 Entrez, Source | RNA binding motif protein 17 | 11216 | -0.117 | -0.5290 | Yes |
| 38 | RNMT | RNMT Entrez, Source | RNA (guanine-7-) methyltransferase | 11293 | -0.120 | -0.5182 | Yes |
| 39 | NXF1 | NXF1 Entrez, Source | nuclear RNA export factor 1 | 11487 | -0.128 | -0.5151 | Yes |
| 40 | DDX1 | DDX1 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 | 11603 | -0.133 | -0.5054 | Yes |
| 41 | HNRPL | HNRPL Entrez, Source | heterogeneous nuclear ribonucleoprotein L | 11652 | -0.136 | -0.4904 | Yes |
| 42 | HNRPC | HNRPC Entrez, Source | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 11772 | -0.143 | -0.4797 | Yes |
| 43 | HNRPA3 | HNRPA3 Entrez, Source | heterogeneous nuclear ribonucleoprotein A3 | 11806 | -0.145 | -0.4623 | Yes |
| 44 | PRPF8 | PRPF8 Entrez, Source | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) | 11985 | -0.156 | -0.4543 | Yes |
| 45 | SFRS2 | SFRS2 Entrez, Source | splicing factor, arginine/serine-rich 2 | 12039 | -0.160 | -0.4363 | Yes |
| 46 | PABPN1 | PABPN1 Entrez, Source | poly(A) binding protein, nuclear 1 | 12068 | -0.162 | -0.4162 | Yes |
| 47 | NCBP1 | NCBP1 Entrez, Source | nuclear cap binding protein subunit 1, 80kDa | 12145 | -0.168 | -0.3988 | Yes |
| 48 | METTL3 | METTL3 Entrez, Source | methyltransferase like 3 | 12152 | -0.168 | -0.3762 | Yes |
| 49 | SFRS12 | SFRS12 Entrez, Source | splicing factor, arginine/serine-rich 12 | 12159 | -0.169 | -0.3534 | Yes |
| 50 | DDX20 | DDX20 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 | 12161 | -0.169 | -0.3303 | Yes |
| 51 | SFRS10 | SFRS10 Entrez, Source | splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) | 12334 | -0.182 | -0.3183 | Yes |
| 52 | SF3A3 | SF3A3 Entrez, Source | splicing factor 3a, subunit 3, 60kDa | 12402 | -0.188 | -0.2975 | Yes |
| 53 | FUSIP1 | FUSIP1 Entrez, Source | FUS interacting protein (serine/arginine-rich) 1 | 12534 | -0.203 | -0.2795 | Yes |
| 54 | CSTF1 | CSTF1 Entrez, Source | cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa | 12665 | -0.219 | -0.2592 | Yes |
| 55 | HNRPU | HNRPU Entrez, Source | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 12753 | -0.234 | -0.2336 | Yes |
| 56 | SNRPA | SNRPA Entrez, Source | small nuclear ribonucleoprotein polypeptide A | 12756 | -0.234 | -0.2016 | Yes |
| 57 | PTBP2 | PTBP2 Entrez, Source | polypyrimidine tract binding protein 2 | 12789 | -0.239 | -0.1712 | Yes |
| 58 | DICER1 | DICER1 Entrez, Source | Dicer1, Dcr-1 homolog (Drosophila) | 12873 | -0.260 | -0.1418 | Yes |
| 59 | FUS | FUS Entrez, Source | fusion (involved in t(12;16) in malignant liposarcoma) | 13034 | -0.303 | -0.1122 | Yes |
| 60 | HNRPD | HNRPD Entrez, Source | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 13227 | -0.440 | -0.0662 | Yes |
| 61 | DDIT3 | DDIT3 Entrez, Source | DNA-damage-inducible transcript 3 | 13285 | -0.545 | 0.0043 | Yes |
