Details for gene set ORGANIC_ACID_METABOLIC

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_24h_repos
Upregulated in class	double_gel_8d
GeneSet	ORGANIC_ACID_METABOLIC_PROCESS
Enrichment Score (ES)	0.5557327
Normalized Enrichment Score (NES)	2.0538058
Nominal p-value	0.0
FDR q-value	0.0027482165
FWER p-Value	0.055

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	HAO2	HAO2 Entrez, Source	hydroxyacid oxidase 2 (long chain)	18	1.071	0.0417	Yes
2	FTCD	FTCD Entrez, Source	formiminotransferase cyclodeaminase	46	0.834	0.0732	Yes
3	PFKFB1	PFKFB1 Entrez, Source	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	47	0.829	0.1066	Yes
4	GOT1	GOT1 Entrez, Source	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	76	0.697	0.1325	Yes
5	BBOX1	BBOX1 Entrez, Source	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	78	0.695	0.1604	Yes
6	CPT1A	CPT1A Entrez, Source	carnitine palmitoyltransferase 1A (liver)	84	0.686	0.1876	Yes
7	ACOX2	ACOX2 Entrez, Source	acyl-Coenzyme A oxidase 2, branched chain	97	0.667	0.2135	Yes
8	PAH	PAH Entrez, Source	phenylalanine hydroxylase	133	0.597	0.2349	Yes
9	HGD	HGD Entrez, Source	homogentisate 1,2-dioxygenase (homogentisate oxidase)	138	0.591	0.2584	Yes
10	AGXT	AGXT Entrez, Source	alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)	212	0.475	0.2719	Yes
11	FAH	FAH Entrez, Source	fumarylacetoacetate hydrolase (fumarylacetoacetase)	232	0.457	0.2889	Yes
12	BCKDHA	BCKDHA Entrez, Source	branched chain keto acid dehydrogenase E1, alpha polypeptide	258	0.431	0.3043	Yes
13	GGT1	GGT1 Entrez, Source	gamma-glutamyltransferase 1	271	0.423	0.3204	Yes
14	DDAH1	DDAH1 Entrez, Source	dimethylarginine dimethylaminohydrolase 1	276	0.416	0.3369	Yes
15	ALDH6A1	ALDH6A1 Entrez, Source	aldehyde dehydrogenase 6 family, member A1	300	0.402	0.3513	Yes
16	ARG1	ARG1 Entrez, Source	arginase, liver	307	0.397	0.3668	Yes
17	FADS1	FADS1 Entrez, Source	fatty acid desaturase 1	330	0.373	0.3802	Yes
18	SLC25A15	SLC25A15 Entrez, Source	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	338	0.371	0.3945	Yes
19	ECHS1	ECHS1 Entrez, Source	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	346	0.367	0.4088	Yes
20	ECH1	ECH1 Entrez, Source	enoyl Coenzyme A hydratase 1, peroxisomal	350	0.365	0.4232	Yes
21	MAT1A	MAT1A Entrez, Source	methionine adenosyltransferase I, alpha	362	0.357	0.4368	Yes
22	SLC3A1	SLC3A1 Entrez, Source	1	373	0.349	0.4500	Yes
23	GLYAT	GLYAT Entrez, Source	glycine-N-acyltransferase	379	0.348	0.4636	Yes
24	HACL1	HACL1 Entrez, Source	2-hydroxyacyl-CoA lyase 1	490	0.289	0.4669	Yes
25	GLS2	GLS2 Entrez, Source	glutaminase 2 (liver, mitochondrial)	543	0.271	0.4739	Yes
26	ALDH5A1	ALDH5A1 Entrez, Source	aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)	595	0.258	0.4804	Yes
27	BAAT	BAAT Entrez, Source	bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	602	0.257	0.4903	Yes
28	MCCC2	MCCC2 Entrez, Source	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	663	0.243	0.4955	Yes
29	ADI1	ADI1 Entrez, Source	acireductone dioxygenase 1	682	0.239	0.5038	Yes
30	CDO1	CDO1 Entrez, Source	cysteine dioxygenase, type I	689	0.237	0.5128	Yes
31	AS3MT	AS3MT Entrez, Source	arsenic (+3 oxidation state) methyltransferase	771	0.221	0.5156	Yes
32	MLYCD	MLYCD Entrez, Source	malonyl-CoA decarboxylase	817	0.210	0.5207	Yes
33	BCKDK	BCKDK Entrez, Source	branched chain ketoacid dehydrogenase kinase	869	0.200	0.5248	Yes
34	PECI	PECI Entrez, Source	peroxisomal D3,D2-enoyl-CoA isomerase	886	0.197	0.5316	Yes
35	BCKDHB	BCKDHB Entrez, Source	branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)	906	0.195	0.5380	Yes
36	FADS2	FADS2 Entrez, Source	fatty acid desaturase 2	934	0.190	0.5435	Yes
37	ACO2	ACO2 Entrez, Source	aconitase 2, mitochondrial	940	0.189	0.5508	Yes
38	SDS	SDS Entrez, Source	serine dehydratase	1007	0.182	0.5531	Yes
39	PPARGC1A	PPARGC1A Entrez, Source	peroxisome proliferative activated receptor, gamma, coactivator 1, alpha	1066	0.174	0.5557	Yes
40	MSRA	MSRA Entrez, Source	methionine sulfoxide reductase A	1379	0.144	0.5379	No
41	PTS	PTS Entrez, Source	6-pyruvoyltetrahydropterin synthase	1478	0.137	0.5360	No
42	GAMT	GAMT Entrez, Source	guanidinoacetate N-methyltransferase	1535	0.132	0.5371	No
43	ACADS	ACADS Entrez, Source	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain	1544	0.132	0.5418	No
44	ME1	ME1 Entrez, Source	malic enzyme 1, NADP(+)-dependent, cytosolic	1647	0.125	0.5391	No
45	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	1689	0.123	0.5409	No
46	SLC7A2	SLC7A2 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	1713	0.122	0.5441	No
47	ACADSB	ACADSB Entrez, Source	acyl-Coenzyme A dehydrogenase, short/branched chain	1715	0.122	0.5490	No
48	DDAH2	DDAH2 Entrez, Source	dimethylarginine dimethylaminohydrolase 2	1832	0.115	0.5448	No
49	TST	TST Entrez, Source	thiosulfate sulfurtransferase (rhodanese)	1969	0.109	0.5389	No
50	ASPA	ASPA Entrez, Source	aspartoacylase (Canavan disease)	2090	0.104	0.5340	No
51	AKR1D1	AKR1D1 Entrez, Source	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	2111	0.103	0.5366	No
52	HDC	HDC Entrez, Source	histidine decarboxylase	2155	0.101	0.5374	No
53	AMT	AMT Entrez, Source	aminomethyltransferase	2221	0.098	0.5365	No
54	LYPLA3	LYPLA3 Entrez, Source	lysophospholipase 3 (lysosomal phospholipase A2)	2431	0.090	0.5243	No
55	ACOT12	ACOT12 Entrez, Source	acyl-CoA thioesterase 12	2485	0.088	0.5238	No
56	AGPAT1	AGPAT1 Entrez, Source	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)	2510	0.088	0.5255	No
57	NFS1	NFS1 Entrez, Source	NFS1 nitrogen fixation 1 (S. cerevisiae)	2570	0.085	0.5245	No
58	ACADVL	ACADVL Entrez, Source	acyl-Coenzyme A dehydrogenase, very long chain	3002	0.071	0.4947	No
59	GNE	GNE Entrez, Source	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	3063	0.069	0.4930	No
60	FAAH	FAAH Entrez, Source	fatty acid amide hydrolase	3091	0.069	0.4937	No
61	IDH1	IDH1 Entrez, Source	isocitrate dehydrogenase 1 (NADP+), soluble	3161	0.067	0.4911	No
62	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	3394	0.060	0.4760	No
63	ACO1	ACO1 Entrez, Source	aconitase 1, soluble	3462	0.059	0.4733	No
64	LTA4H	LTA4H Entrez, Source	leukotriene A4 hydrolase	3505	0.057	0.4724	No
65	SLC7A9	SLC7A9 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	3559	0.056	0.4707	No
66	DEGS1	DEGS1 Entrez, Source	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	3581	0.055	0.4713	No
67	MPST	MPST Entrez, Source	mercaptopyruvate sulfurtransferase	3621	0.054	0.4705	No
68	ACADM	ACADM Entrez, Source	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	3794	0.050	0.4595	No
69	FARS2	FARS2 Entrez, Source	phenylalanine-tRNA synthetase 2 (mitochondrial)	3826	0.050	0.4592	No
70	SCLY	SCLY Entrez, Source	selenocysteine lyase	3833	0.049	0.4607	No
71	ACLY	ACLY Entrez, Source	ATP citrate lyase	3867	0.048	0.4601	No
72	GCSH	GCSH Entrez, Source	glycine cleavage system protein H (aminomethyl carrier)	3887	0.048	0.4606	No
73	BCAT1	BCAT1 Entrez, Source	branched chain aminotransferase 1, cytosolic	3938	0.046	0.4587	No
74	SLC25A10	SLC25A10 Entrez, Source	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	3966	0.045	0.4585	No
75	GLUD1	GLUD1 Entrez, Source	glutamate dehydrogenase 1	4297	0.038	0.4350	No
76	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	4489	0.034	0.4219	No
77	ACOT2	ACOT2 Entrez, Source	acyl-CoA thioesterase 2	5165	0.021	0.3717	No
78	ABCD2	ABCD2 Entrez, Source	ATP-binding cassette, sub-family D (ALD), member 2	5216	0.020	0.3687	No
79	CPT1B	CPT1B Entrez, Source	carnitine palmitoyltransferase 1B (muscle)	5265	0.019	0.3658	No
80	ADIPOR2	ADIPOR2 Entrez, Source	adiponectin receptor 2	5506	0.014	0.3482	No
81	PPARD	PPARD Entrez, Source	peroxisome proliferative activated receptor, delta	5532	0.014	0.3469	No
82	PTGS1	PTGS1 Entrez, Source	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	5556	0.014	0.3457	No
83	GGTLA1	GGTLA1 Entrez, Source	gamma-glutamyltransferase-like activity 1	5579	0.013	0.3446	No
84	SLC7A8	SLC7A8 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	5837	0.008	0.3255	No
85	SC4MOL	SC4MOL Entrez, Source	sterol-C4-methyl oxidase-like	5880	0.008	0.3226	No
86	PTGDS	PTGDS Entrez, Source	prostaglandin D2 synthase 21kDa (brain)	5900	0.007	0.3214	No
87	ALDH1L1	ALDH1L1 Entrez, Source	aldehyde dehydrogenase 1 family, member L1	5998	0.005	0.3143	No
88	ASRGL1	ASRGL1 Entrez, Source	asparaginase like 1	6099	0.003	0.3069	No
89	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	6295	-0.000	0.2921	No
90	PTGES	PTGES Entrez, Source	prostaglandin E synthase	6415	-0.002	0.2832	No
91	HPD	HPD Entrez, Source	4-hydroxyphenylpyruvate dioxygenase	6481	-0.003	0.2784	No
92	ASL	ASL Entrez, Source	argininosuccinate lyase	6773	-0.008	0.2567	No
93	SLC6A6	SLC6A6 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	6923	-0.011	0.2459	No
94	CYP7B1	CYP7B1 Entrez, Source	cytochrome P450, family 7, subfamily B, polypeptide 1	7069	-0.014	0.2354	No
95	QDPR	QDPR Entrez, Source	quinoid dihydropteridine reductase	7441	-0.021	0.2082	No
96	ACN9	ACN9 Entrez, Source	ACN9 homolog (S. cerevisiae)	7494	-0.022	0.2051	No
97	GSS	GSS Entrez, Source	glutathione synthetase	7538	-0.022	0.2027	No
98	NANP	NANP Entrez, Source	N-acetylneuraminic acid phosphatase	7570	-0.023	0.2013	No
99	HADHB	HADHB Entrez, Source	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit	7978	-0.031	0.1717	No
100	CYP4F2	CYP4F2 Entrez, Source	cytochrome P450, family 4, subfamily F, polypeptide 2	8129	-0.034	0.1618	No
101	TNFRSF1A	TNFRSF1A Entrez, Source	tumor necrosis factor receptor superfamily, member 1A	8306	-0.037	0.1499	No
102	HSD3B7	HSD3B7 Entrez, Source	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	8340	-0.038	0.1490	No
103	IDH3B	IDH3B Entrez, Source	isocitrate dehydrogenase 3 (NAD+) beta	8861	-0.049	0.1116	No
104	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	9134	-0.055	0.0932	No
105	ARPP-19	ARPP-19 Entrez, Source	-	9233	-0.057	0.0880	No
106	GAD1	GAD1 Entrez, Source	glutamate decarboxylase 1 (brain, 67kDa)	9270	-0.057	0.0876	No
107	GOT2	GOT2 Entrez, Source	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	9641	-0.066	0.0623	No
108	NR1H4	NR1H4 Entrez, Source	nuclear receptor subfamily 1, group H, member 4	9939	-0.075	0.0428	No
109	YARS	YARS Entrez, Source	tyrosyl-tRNA synthetase	9947	-0.075	0.0453	No
110	INDO	INDO Entrez, Source	indoleamine-pyrrole 2,3 dioxygenase	10558	-0.092	0.0028	No
111	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	10782	-0.100	-0.0100	No
112	ACOX3	ACOX3 Entrez, Source	acyl-Coenzyme A oxidase 3, pristanoyl	10884	-0.104	-0.0135	No
113	KARS	KARS Entrez, Source	lysyl-tRNA synthetase	10927	-0.106	-0.0124	No
114	BRCA1	BRCA1 Entrez, Source	breast cancer 1, early onset	11096	-0.112	-0.0206	No
115	GAD2	GAD2 Entrez, Source	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	11204	-0.116	-0.0240	No
116	PLOD1	PLOD1 Entrez, Source	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	11305	-0.121	-0.0268	No
117	GNPAT	GNPAT Entrez, Source	glyceronephosphate O-acyltransferase	11617	-0.134	-0.0449	No
118	SLC7A7	SLC7A7 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	11894	-0.150	-0.0598	No
119	CROT	CROT Entrez, Source	carnitine O-octanoyltransferase	11938	-0.152	-0.0569	No
120	DARS	DARS Entrez, Source	aspartyl-tRNA synthetase	12016	-0.158	-0.0563	No
121	WARS	WARS Entrez, Source	tryptophanyl-tRNA synthetase	12088	-0.163	-0.0551	No
122	AARS	AARS Entrez, Source	alanyl-tRNA synthetase	12234	-0.174	-0.0591	No
123	MIF	MIF Entrez, Source	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	12291	-0.179	-0.0562	No
124	SCYE1	SCYE1 Entrez, Source	small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)	12401	-0.188	-0.0568	No
125	PPARA	PPARA Entrez, Source	peroxisome proliferative activated receptor, alpha	12405	-0.189	-0.0495	No
126	SMS	SMS Entrez, Source	spermine synthase	12527	-0.202	-0.0505	No
127	GCLM	GCLM Entrez, Source	glutamate-cysteine ligase, modifier subunit	12784	-0.238	-0.0603	No
128	SLC7A5	SLC7A5 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	12884	-0.262	-0.0573	No
129	GCK	GCK Entrez, Source	glucokinase (hexokinase 4, maturity onset diabetes of the young 2)	13052	-0.307	-0.0576	No
130	UGDH	UGDH Entrez, Source	UDP-glucose dehydrogenase	13138	-0.352	-0.0499	No
131	GCLC	GCLC Entrez, Source	glutamate-cysteine ligase, catalytic subunit	13249	-0.480	-0.0389	No
132	SLC27A5	SLC27A5 Entrez, Source	solute carrier family 27 (fatty acid transporter), member 5	13261	-0.509	-0.0192	No
133	CD74	CD74 Entrez, Source	CD74 molecule, major histocompatibility complex, class II invariant chain	13307	-0.629	0.0026	No