Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | SERUM_FIBROBLAST_CORE_DN |
| Enrichment Score (ES) | 0.5070773 |
| Normalized Enrichment Score (NES) | 1.7669407 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.035871442 |
| FWER p-Value | 0.988 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MAF | MAF Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) | 31 | 0.935 | 0.0638 | Yes |
| 2 | TIMP2 | TIMP2 Entrez, Source | TIMP metallopeptidase inhibitor 2 | 49 | 0.810 | 0.1197 | Yes |
| 3 | DPYSL2 | DPYSL2 Entrez, Source | dihydropyrimidinase-like 2 | 158 | 0.552 | 0.1506 | Yes |
| 4 | GSTM2 | GSTM2 Entrez, Source | glutathione S-transferase M2 (muscle) | 200 | 0.487 | 0.1819 | Yes |
| 5 | LPIN1 | LPIN1 Entrez, Source | lipin 1 | 216 | 0.473 | 0.2142 | Yes |
| 6 | TSC22D3 | TSC22D3 Entrez, Source | TSC22 domain family, member 3 | 257 | 0.432 | 0.2417 | Yes |
| 7 | CYP27A1 | CYP27A1 Entrez, Source | cytochrome P450, family 27, subfamily A, polypeptide 1 | 297 | 0.403 | 0.2673 | Yes |
| 8 | FADS1 | FADS1 Entrez, Source | fatty acid desaturase 1 | 330 | 0.373 | 0.2913 | Yes |
| 9 | PGCP | PGCP Entrez, Source | - | 406 | 0.335 | 0.3093 | Yes |
| 10 | DPP7 | DPP7 Entrez, Source | dipeptidyl-peptidase 7 | 414 | 0.330 | 0.3321 | Yes |
| 11 | SQLE | SQLE Entrez, Source | squalene epoxidase | 446 | 0.311 | 0.3518 | Yes |
| 12 | POR | POR Entrez, Source | P450 (cytochrome) oxidoreductase | 523 | 0.278 | 0.3656 | Yes |
| 13 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 531 | 0.275 | 0.3845 | Yes |
| 14 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 542 | 0.272 | 0.4030 | Yes |
| 15 | FUT8 | FUT8 Entrez, Source | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 567 | 0.265 | 0.4199 | Yes |
| 16 | PDK2 | PDK2 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 2 | 783 | 0.219 | 0.4192 | Yes |
| 17 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 834 | 0.207 | 0.4300 | Yes |
| 18 | FADS2 | FADS2 Entrez, Source | fatty acid desaturase 2 | 934 | 0.190 | 0.4360 | Yes |
| 19 | PKIG | PKIG Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | 1121 | 0.169 | 0.4338 | Yes |
| 20 | APOD | APOD Entrez, Source | apolipoprotein D | 1122 | 0.169 | 0.4458 | Yes |
| 21 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 1211 | 0.160 | 0.4504 | Yes |
| 22 | PLD3 | PLD3 Entrez, Source | phospholipase D family, member 3 | 1469 | 0.137 | 0.4408 | Yes |
| 23 | CST3 | CST3 Entrez, Source | cystatin C (amyloid angiopathy and cerebral hemorrhage) | 1513 | 0.134 | 0.4470 | Yes |
| 24 | CSF1 | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 1644 | 0.126 | 0.4461 | Yes |
| 25 | INSIG1 | INSIG1 Entrez, Source | insulin induced gene 1 | 1681 | 0.124 | 0.4521 | Yes |
| 26 | CNTNAP1 | CNTNAP1 Entrez, Source | contactin associated protein 1 | 1684 | 0.124 | 0.4607 | Yes |
| 27 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 1691 | 0.123 | 0.4689 | Yes |
| 28 | SCD | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 1803 | 0.117 | 0.4688 | Yes |
| 29 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 1830 | 0.115 | 0.4750 | Yes |
| 30 | LSR | LSR Entrez, Source | lipolysis stimulated lipoprotein receptor | 1885 | 0.112 | 0.4789 | Yes |
| 31 | FCGRT | FCGRT Entrez, Source | Fc fragment of IgG, receptor, transporter, alpha | 1897 | 0.112 | 0.4859 | Yes |
| 32 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 1998 | 0.108 | 0.4860 | Yes |
| 33 | KLHL24 | KLHL24 Entrez, Source | kelch-like 24 (Drosophila) | 2012 | 0.107 | 0.4926 | Yes |
| 34 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 2036 | 0.106 | 0.4984 | Yes |
| 35 | ABHD14B | ABHD14B Entrez, Source | abhydrolase domain containing 14B | 2102 | 0.104 | 0.5008 | Yes |
| 36 | ACSL3 | ACSL3 Entrez, Source | acyl-CoA synthetase long-chain family member 3 | 2116 | 0.103 | 0.5071 | Yes |
| 37 | AXIN2 | AXIN2 Entrez, Source | axin 2 (conductin, axil) | 2363 | 0.093 | 0.4951 | No |
| 38 | FABP3 | FABP3 Entrez, Source | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) | 2423 | 0.091 | 0.4970 | No |
| 39 | PBXIP1 | PBXIP1 Entrez, Source | pre-B-cell leukemia transcription factor interacting protein 1 | 2435 | 0.090 | 0.5026 | No |
| 40 | CALCOCO1 | CALCOCO1 Entrez, Source | calcium binding and coiled-coil domain 1 | 2600 | 0.083 | 0.4961 | No |
| 41 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3039 | 0.070 | 0.4680 | No |
| 42 | LDLR | LDLR Entrez, Source | low density lipoprotein receptor (familial hypercholesterolemia) | 3238 | 0.064 | 0.4576 | No |
| 43 | ST6GAL1 | ST6GAL1 Entrez, Source | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 3452 | 0.059 | 0.4457 | No |
| 44 | CTSF | CTSF Entrez, Source | cathepsin F | 3540 | 0.056 | 0.4431 | No |
| 45 | SLC22A17 | SLC22A17 Entrez, Source | solute carrier family 22 (organic cation transporter), member 17 | 3545 | 0.056 | 0.4468 | No |
| 46 | ERRFI1 | ERRFI1 Entrez, Source | ERBB receptor feedback inhibitor 1 | 3633 | 0.054 | 0.4440 | No |
| 47 | RNF146 | RNF146 Entrez, Source | ring finger protein 146 | 3779 | 0.051 | 0.4366 | No |
| 48 | LRP1 | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 4204 | 0.039 | 0.4074 | No |
| 49 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 4575 | 0.033 | 0.3818 | No |
| 50 | SLC27A1 | SLC27A1 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 1 | 4732 | 0.030 | 0.3721 | No |
| 51 | IGBP1 | IGBP1 Entrez, Source | immunoglobulin (CD79A) binding protein 1 | 4832 | 0.027 | 0.3666 | No |
| 52 | CYBRD1 | CYBRD1 Entrez, Source | cytochrome b reductase 1 | 5173 | 0.021 | 0.3424 | No |
| 53 | GABBR1 | GABBR1 Entrez, Source | gamma-aminobutyric acid (GABA) B receptor, 1 | 5513 | 0.014 | 0.3178 | No |
| 54 | MXI1 | MXI1 Entrez, Source | MAX interactor 1 | 5523 | 0.014 | 0.3181 | No |
| 55 | ADD3 | ADD3 Entrez, Source | adducin 3 (gamma) | 5820 | 0.009 | 0.2964 | No |
| 56 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 5880 | 0.008 | 0.2924 | No |
| 57 | CD82 | CD82 Entrez, Source | CD82 molecule | 6202 | 0.001 | 0.2683 | No |
| 58 | DNM1 | DNM1 Entrez, Source | dynamin 1 | 6592 | -0.005 | 0.2393 | No |
| 59 | IL1R1 | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 6718 | -0.007 | 0.2304 | No |
| 60 | AZI2 | AZI2 Entrez, Source | 5-azacytidine induced 2 | 6750 | -0.008 | 0.2286 | No |
| 61 | SFTPB | SFTPB Entrez, Source | surfactant, pulmonary-associated protein B | 6951 | -0.011 | 0.2143 | No |
| 62 | F10 | F10 Entrez, Source | coagulation factor X | 7144 | -0.015 | 0.2009 | No |
| 63 | ITPKB | ITPKB Entrez, Source | inositol 1,4,5-trisphosphate 3-kinase B | 7323 | -0.018 | 0.1887 | No |
| 64 | ATP6V0A1 | ATP6V0A1 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a1 | 7965 | -0.031 | 0.1425 | No |
| 65 | CFB | CFB Entrez, Source | complement factor B | 8083 | -0.033 | 0.1360 | No |
| 66 | MBP | MBP Entrez, Source | myelin basic protein | 8096 | -0.033 | 0.1375 | No |
| 67 | PTPRU | PTPRU Entrez, Source | protein tyrosine phosphatase, receptor type, U | 8180 | -0.035 | 0.1337 | No |
| 68 | EEF1A1 | EEF1A1 Entrez, Source | eukaryotic translation elongation factor 1 alpha 1 | 8406 | -0.039 | 0.1195 | No |
| 69 | MAGI2 | MAGI2 Entrez, Source | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 8516 | -0.042 | 0.1142 | No |
| 70 | ACIN1 | ACIN1 Entrez, Source | apoptotic chromatin condensation inducer 1 | 8577 | -0.043 | 0.1127 | No |
| 71 | HDAC5 | HDAC5 Entrez, Source | histone deacetylase 5 | 8654 | -0.044 | 0.1101 | No |
| 72 | ZBTB17 | ZBTB17 Entrez, Source | zinc finger and BTB domain containing 17 | 8655 | -0.045 | 0.1133 | No |
| 73 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 8685 | -0.045 | 0.1143 | No |
| 74 | LUM | LUM Entrez, Source | lumican | 8919 | -0.050 | 0.1002 | No |
| 75 | GLS | GLS Entrez, Source | glutaminase | 9073 | -0.053 | 0.0924 | No |
| 76 | RPL37 | RPL37 Entrez, Source | ribosomal protein L37 | 9243 | -0.057 | 0.0837 | No |
| 77 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 9354 | -0.059 | 0.0796 | No |
| 78 | HSD17B7 | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 9685 | -0.067 | 0.0595 | No |
| 79 | TBRG1 | TBRG1 Entrez, Source | transforming growth factor beta regulator 1 | 9897 | -0.074 | 0.0487 | No |
| 80 | NCOA3 | NCOA3 Entrez, Source | nuclear receptor coactivator 3 | 9971 | -0.076 | 0.0486 | No |
| 81 | PSMB7 | PSMB7 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 7 | 10088 | -0.079 | 0.0454 | No |
| 82 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 10104 | -0.079 | 0.0499 | No |
| 83 | WSB1 | WSB1 Entrez, Source | WD repeat and SOCS box-containing 1 | 10301 | -0.084 | 0.0410 | No |
| 84 | SF3B1 | SF3B1 Entrez, Source | splicing factor 3b, subunit 1, 155kDa | 10411 | -0.088 | 0.0390 | No |
| 85 | MEF2D | MEF2D Entrez, Source | MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) | 10414 | -0.088 | 0.0451 | No |
| 86 | GATM | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 10782 | -0.100 | 0.0244 | No |
| 87 | BRF2 | BRF2 Entrez, Source | BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like | 11488 | -0.129 | -0.0197 | No |
| 88 | EXOSC7 | EXOSC7 Entrez, Source | exosome component 7 | 11683 | -0.137 | -0.0246 | No |
| 89 | TSC22D1 | TSC22D1 Entrez, Source | TSC22 domain family, member 1 | 11757 | -0.142 | -0.0201 | No |
| 90 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 11803 | -0.145 | -0.0133 | No |
| 91 | SOD2 | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 11883 | -0.149 | -0.0087 | No |
| 92 | KLHL5 | KLHL5 Entrez, Source | kelch-like 5 (Drosophila) | 12040 | -0.160 | -0.0092 | No |
| 93 | SLC29A2 | SLC29A2 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 2 | 12332 | -0.182 | -0.0183 | No |
| 94 | REV3L | REV3L Entrez, Source | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 12847 | -0.253 | -0.0392 | No |
| 95 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 12874 | -0.260 | -0.0228 | No |
| 96 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 12946 | -0.276 | -0.0087 | No |
| 97 | DDIT3 | DDIT3 Entrez, Source | DNA-damage-inducible transcript 3 | 13285 | -0.545 | 0.0043 | No |
