Details for gene set SMOOTH_MUSCLE

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_24h_repos
Upregulated in class	double_gel_8d
GeneSet	SMOOTH_MUSCLE_CONTRACTION
Enrichment Score (ES)	0.57906765
Normalized Enrichment Score (NES)	2.126217
Nominal p-value	0.0
FDR q-value	0.0010515748
FWER p-Value	0.011

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	FOS	FOS Entrez, Source	v-fos FBJ murine osteosarcoma viral oncogene homolog	3	1.622	0.0994	Yes
2	RGS2	RGS2 Entrez, Source	regulator of G-protein signalling 2, 24kDa	50	0.810	0.1456	Yes
3	ACTA1	ACTA1 Entrez, Source	actin, alpha 1, skeletal muscle	60	0.762	0.1917	Yes
4	RGS1	RGS1 Entrez, Source	regulator of G-protein signalling 1	73	0.715	0.2346	Yes
5	RGS5	RGS5 Entrez, Source	regulator of G-protein signalling 5	125	0.616	0.2686	Yes
6	RAMP1	RAMP1 Entrez, Source	receptor (calcitonin) activity modifying protein 1	136	0.594	0.3043	Yes
7	GRK5	GRK5 Entrez, Source	G protein-coupled receptor kinase 5	188	0.507	0.3316	Yes
8	RGS16	RGS16 Entrez, Source	regulator of G-protein signalling 16	205	0.482	0.3600	Yes
9	PRKAR2B	PRKAR2B Entrez, Source	protein kinase, cAMP-dependent, regulatory, type II, beta	214	0.474	0.3885	Yes
10	RGS10	RGS10 Entrez, Source	regulator of G-protein signalling 10	247	0.443	0.4132	Yes
11	ITPR1	ITPR1 Entrez, Source	inositol 1,4,5-triphosphate receptor, type 1	282	0.413	0.4360	Yes
12	RGS3	RGS3 Entrez, Source	regulator of G-protein signalling 3	301	0.402	0.4593	Yes
13	GJA1	GJA1 Entrez, Source	gap junction protein, alpha 1, 43kDa (connexin 43)	316	0.387	0.4820	Yes
14	RAMP3	RAMP3 Entrez, Source	receptor (calcitonin) activity modifying protein 3	518	0.280	0.4840	Yes
15	IGFBP3	IGFBP3 Entrez, Source	insulin-like growth factor binding protein 3	533	0.274	0.4997	Yes
16	PKIA	PKIA Entrez, Source	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	588	0.260	0.5116	Yes
17	PKIB	PKIB Entrez, Source	protein kinase (cAMP-dependent, catalytic) inhibitor beta	592	0.258	0.5272	Yes
18	IGFBP1	IGFBP1 Entrez, Source	insulin-like growth factor binding protein 1	596	0.258	0.5428	Yes
19	RGS4	RGS4 Entrez, Source	regulator of G-protein signalling 4	639	0.247	0.5548	Yes
20	PRKAR1B	PRKAR1B Entrez, Source	protein kinase, cAMP-dependent, regulatory, type I, beta	1117	0.169	0.5291	Yes
21	PKIG	PKIG Entrez, Source	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	1121	0.169	0.5392	Yes
22	EDG2	EDG2 Entrez, Source	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2	1399	0.143	0.5270	Yes
23	PRKCA	PRKCA Entrez, Source	protein kinase C, alpha	1423	0.141	0.5339	Yes
24	YWHAQ	YWHAQ Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	1447	0.139	0.5407	Yes
25	ADCY5	ADCY5 Entrez, Source	adenylate cyclase 5	1541	0.132	0.5418	Yes
26	IGFBP2	IGFBP2 Entrez, Source	insulin-like growth factor binding protein 2, 36kDa	1556	0.131	0.5488	Yes
27	ADMR	ADMR Entrez, Source	adrenomedullin receptor	1561	0.131	0.5565	Yes
28	ADCY6	ADCY6 Entrez, Source	adenylate cyclase 6	1649	0.125	0.5576	Yes
29	GNAQ	GNAQ Entrez, Source	guanine nucleotide binding protein (G protein), q polypeptide	1722	0.122	0.5596	Yes
30	ATP2A3	ATP2A3 Entrez, Source	ATPase, Ca++ transporting, ubiquitous	1837	0.115	0.5581	Yes
31	PLCD1	PLCD1 Entrez, Source	phospholipase C, delta 1	1867	0.113	0.5628	Yes
32	CALM3	CALM3 Entrez, Source	calmodulin 3 (phosphorylase kinase, delta)	1983	0.109	0.5608	Yes
33	GUCA2B	GUCA2B Entrez, Source	guanylate cyclase activator 2B (uroguanylin)	2013	0.107	0.5652	Yes
34	PLCG2	PLCG2 Entrez, Source	phospholipase C, gamma 2 (phosphatidylinositol-specific)	2030	0.106	0.5705	Yes
35	ATF3	ATF3 Entrez, Source	activating transcription factor 3	2035	0.106	0.5767	Yes
36	CRH	CRH Entrez, Source	corticotropin releasing hormone	2185	0.100	0.5716	Yes
37	ARRB1	ARRB1 Entrez, Source	arrestin, beta 1	2228	0.098	0.5744	Yes
38	RGS7	RGS7 Entrez, Source	regulator of G-protein signalling 7	2271	0.097	0.5772	Yes
39	GNB5	GNB5 Entrez, Source	guanine nucleotide binding protein (G protein), beta 5	2462	0.089	0.5683	Yes
40	PRKCH	PRKCH Entrez, Source	protein kinase C, eta	2545	0.086	0.5673	Yes
41	ITPR3	ITPR3 Entrez, Source	inositol 1,4,5-triphosphate receptor, type 3	2561	0.085	0.5714	Yes
42	ATF5	ATF5 Entrez, Source	activating transcription factor 5	2578	0.084	0.5754	Yes
43	IGFBP6	IGFBP6 Entrez, Source	insulin-like growth factor binding protein 6	2598	0.084	0.5791	Yes
44	OXT	OXT Entrez, Source	oxytocin, prepro- (neurophysin I)	2750	0.079	0.5725	No
45	GUCY1A3	GUCY1A3 Entrez, Source	guanylate cyclase 1, soluble, alpha 3	2816	0.077	0.5723	No
46	GNB3	GNB3 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 3	2846	0.076	0.5747	No
47	NOS3	NOS3 Entrez, Source	nitric oxide synthase 3 (endothelial cell)	2951	0.072	0.5713	No
48	GNG3	GNG3 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 3	2978	0.072	0.5737	No
49	GNB4	GNB4 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 4	3031	0.070	0.5741	No
50	PRKAR2A	PRKAR2A Entrez, Source	protein kinase, cAMP-dependent, regulatory, type II, alpha	3077	0.069	0.5749	No
51	RLN1	RLN1 Entrez, Source	relaxin 1	3126	0.068	0.5755	No
52	CORIN	CORIN Entrez, Source	corin, serine peptidase	3274	0.063	0.5683	No
53	RGS6	RGS6 Entrez, Source	regulator of G-protein signalling 6	3368	0.061	0.5650	No
54	SLC8A1	SLC8A1 Entrez, Source	solute carrier family 8 (sodium/calcium exchanger), member 1	3484	0.058	0.5598	No
55	PRKCZ	PRKCZ Entrez, Source	protein kinase C, zeta	3870	0.048	0.5337	No
56	CACNB3	CACNB3 Entrez, Source	calcium channel, voltage-dependent, beta 3 subunit	3904	0.047	0.5341	No
57	ARRB2	ARRB2 Entrez, Source	arrestin, beta 2	3976	0.045	0.5315	No
58	ADCY2	ADCY2 Entrez, Source	adenylate cyclase 2 (brain)	4158	0.041	0.5203	No
59	GNG7	GNG7 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 7	4166	0.041	0.5223	No
60	CRHR1	CRHR1 Entrez, Source	corticotropin releasing hormone receptor 1	4173	0.040	0.5243	No
61	CAMK2A	CAMK2A Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha	4303	0.037	0.5168	No
62	CREB3	CREB3 Entrez, Source	cAMP responsive element binding protein 3	4320	0.037	0.5179	No
63	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	4489	0.034	0.5073	No
64	IGFBP4	IGFBP4 Entrez, Source	insulin-like growth factor binding protein 4	4578	0.032	0.5026	No
65	DGKZ	DGKZ Entrez, Source	diacylglycerol kinase, zeta 104kDa	4589	0.032	0.5038	No
66	RYR1	RYR1 Entrez, Source	ryanodine receptor 1 (skeletal)	4695	0.030	0.4977	No
67	CREBL1	CREBL1 Entrez, Source	cAMP responsive element binding protein-like 1	4717	0.030	0.4980	No
68	ITPR2	ITPR2 Entrez, Source	inositol 1,4,5-triphosphate receptor, type 2	4733	0.030	0.4987	No
69	PRKAR1A	PRKAR1A Entrez, Source	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	4750	0.029	0.4992	No
70	NFKB1	NFKB1 Entrez, Source	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)	4778	0.028	0.4989	No
71	RAMP2	RAMP2 Entrez, Source	receptor (calcitonin) activity modifying protein 2	4826	0.027	0.4971	No
72	ACTA2	ACTA2 Entrez, Source	actin, alpha 2, smooth muscle, aorta	4827	0.027	0.4987	No
73	RGS19	RGS19 Entrez, Source	regulator of G-protein signalling 19	5241	0.020	0.4687	No
74	NOS1	NOS1 Entrez, Source	nitric oxide synthase 1 (neuronal)	5282	0.019	0.4669	No
75	IL6	IL6 Entrez, Source	interleukin 6 (interferon, beta 2)	5285	0.019	0.4679	No
76	PLCB3	PLCB3 Entrez, Source	phospholipase C, beta 3 (phosphatidylinositol-specific)	5675	0.011	0.4392	No
77	GNB2	GNB2 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 2	5801	0.009	0.4303	No
78	RGS9	RGS9 Entrez, Source	regulator of G-protein signalling 9	5873	0.008	0.4254	No
79	PDE4D	PDE4D Entrez, Source	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	5890	0.007	0.4246	No
80	OXTR	OXTR Entrez, Source	oxytocin receptor	5940	0.006	0.4213	No
81	CAMK2D	CAMK2D Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II delta	5975	0.006	0.4191	No
82	GRK4	GRK4 Entrez, Source	G protein-coupled receptor kinase 4	5984	0.005	0.4188	No
83	GRK6	GRK6 Entrez, Source	G protein-coupled receptor kinase 6	6012	0.005	0.4171	No
84	PRKACA	PRKACA Entrez, Source	protein kinase, cAMP-dependent, catalytic, alpha	6017	0.005	0.4170	No
85	YWHAB	YWHAB Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	6058	0.004	0.4143	No
86	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	6295	-0.000	0.3964	No
87	MYLK2	MYLK2 Entrez, Source	myosin light chain kinase 2, skeletal muscle	6310	-0.000	0.3954	No
88	JUN	JUN Entrez, Source	jun oncogene	6649	-0.006	0.3702	No
89	CALM2	CALM2 Entrez, Source	calmodulin 2 (phosphorylase kinase, delta)	6851	-0.010	0.3556	No
90	CNN1	CNN1 Entrez, Source	calponin 1, basic, smooth muscle	7011	-0.012	0.3443	No
91	CALCA	CALCA Entrez, Source	calcitonin/calcitonin-related polypeptide, alpha	7138	-0.014	0.3357	No
92	PDE4B	PDE4B Entrez, Source	phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)	7179	-0.015	0.3336	No
93	GNG5	GNG5 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 5	7340	-0.018	0.3227	No
94	YWHAH	YWHAH Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	7564	-0.023	0.3072	No
95	CAMK2G	CAMK2G Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma	7620	-0.024	0.3045	No
96	RCP9	RCP9 Entrez, Source	-	7655	-0.025	0.3035	No
97	PRKCD	PRKCD Entrez, Source	protein kinase C, delta	7739	-0.026	0.2988	No
98	MYL2	MYL2 Entrez, Source	myosin, light chain 2, regulatory, cardiac, slow	7811	-0.028	0.2951	No
99	PRKCQ	PRKCQ Entrez, Source	protein kinase C, theta	7952	-0.030	0.2864	No
100	RGS14	RGS14 Entrez, Source	regulator of G-protein signalling 14	8231	-0.036	0.2676	No
101	RYR2	RYR2 Entrez, Source	ryanodine receptor 2 (cardiac)	8394	-0.039	0.2577	No
102	CAMK2B	CAMK2B Entrez, Source	calcium/calmodulin-dependent protein kinase (CaM kinase) II beta	8471	-0.041	0.2545	No
103	ADCY3	ADCY3 Entrez, Source	adenylate cyclase 3	8509	-0.042	0.2542	No
104	ATP2A2	ATP2A2 Entrez, Source	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	8616	-0.044	0.2489	No
105	PLCG1	PLCG1 Entrez, Source	phospholipase C, gamma 1	8918	-0.050	0.2292	No
106	GNG12	GNG12 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 12	9591	-0.065	0.1824	No
107	IL1B	IL1B Entrez, Source	interleukin 1, beta	9721	-0.069	0.1769	No
108	ADCY8	ADCY8 Entrez, Source	adenylate cyclase 8 (brain)	9950	-0.075	0.1642	No
109	SP1	SP1 Entrez, Source	Sp1 transcription factor	10287	-0.084	0.1440	No
110	ATF1	ATF1 Entrez, Source	activating transcription factor 1	10381	-0.087	0.1423	No
111	PRKCE	PRKCE Entrez, Source	protein kinase C, epsilon	10468	-0.089	0.1412	No
112	ADCY4	ADCY4 Entrez, Source	adenylate cyclase 4	10641	-0.095	0.1341	No
113	CALM1	CALM1 Entrez, Source	calmodulin 1 (phosphorylase kinase, delta)	10674	-0.096	0.1376	No
114	ADM	ADM Entrez, Source	adrenomedullin	11063	-0.110	0.1150	No
115	GUCA2A	GUCA2A Entrez, Source	guanylate cyclase activator 2A (guanylin)	11148	-0.114	0.1156	No
116	PRKD1	PRKD1 Entrez, Source	protein kinase D1	11159	-0.115	0.1219	No
117	PRKCB1	PRKCB1 Entrez, Source	protein kinase C, beta 1	11650	-0.136	0.0932	No
118	GNB1	GNB1 Entrez, Source	guanine nucleotide binding protein (G protein), beta polypeptide 1	11879	-0.149	0.0851	No
119	GSTO1	GSTO1 Entrez, Source	glutathione S-transferase omega 1	12484	-0.197	0.0515	No
120	ATF2	ATF2 Entrez, Source	activating transcription factor 2	12642	-0.216	0.0529	No