Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | STEROID_METABOLIC_PROCESS |
| Enrichment Score (ES) | 0.6467187 |
| Normalized Enrichment Score (NES) | 1.9624797 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0074250204 |
| FWER p-Value | 0.257 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ACOX2 | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 97 | 0.667 | 0.1089 | Yes |
| 2 | SOAT1 | SOAT1 Entrez, Source | sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 | 100 | 0.661 | 0.2238 | Yes |
| 3 | ABCG1 | ABCG1 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 1 | 179 | 0.519 | 0.3083 | Yes |
| 4 | SCARB1 | SCARB1 Entrez, Source | scavenger receptor class B, member 1 | 431 | 0.321 | 0.3452 | Yes |
| 5 | HSD3B1 | HSD3B1 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 501 | 0.286 | 0.3898 | Yes |
| 6 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 561 | 0.267 | 0.4318 | Yes |
| 7 | BAAT | BAAT Entrez, Source | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) | 602 | 0.257 | 0.4735 | Yes |
| 8 | NR1I2 | NR1I2 Entrez, Source | nuclear receptor subfamily 1, group I, member 2 | 609 | 0.256 | 0.5176 | Yes |
| 9 | SCP2 | SCP2 Entrez, Source | sterol carrier protein 2 | 890 | 0.197 | 0.5308 | Yes |
| 10 | CLN8 | CLN8 Entrez, Source | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 1037 | 0.178 | 0.5507 | Yes |
| 11 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 1105 | 0.170 | 0.5753 | Yes |
| 12 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 1169 | 0.164 | 0.5990 | Yes |
| 13 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 1211 | 0.160 | 0.6238 | Yes |
| 14 | TSPO | TSPO Entrez, Source | translocator protein (18kDa) | 1265 | 0.154 | 0.6467 | Yes |
| 15 | DHRS9 | DHRS9 Entrez, Source | dehydrogenase/reductase (SDR family) member 9 | 1778 | 0.118 | 0.6287 | No |
| 16 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 2111 | 0.103 | 0.6217 | No |
| 17 | NR0B2 | NR0B2 Entrez, Source | nuclear receptor subfamily 0, group B, member 2 | 2330 | 0.094 | 0.6217 | No |
| 18 | CYP19A1 | CYP19A1 Entrez, Source | cytochrome P450, family 19, subfamily A, polypeptide 1 | 2640 | 0.082 | 0.6128 | No |
| 19 | BMP6 | BMP6 Entrez, Source | bone morphogenetic protein 6 | 3348 | 0.061 | 0.5703 | No |
| 20 | HSD11B2 | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 4357 | 0.037 | 0.5009 | No |
| 21 | GBA2 | GBA2 Entrez, Source | glucosidase, beta (bile acid) 2 | 4489 | 0.034 | 0.4970 | No |
| 22 | MBTPS2 | MBTPS2 Entrez, Source | membrane-bound transcription factor peptidase, site 2 | 4585 | 0.032 | 0.4955 | No |
| 23 | CYP11A1 | CYP11A1 Entrez, Source | cytochrome P450, family 11, subfamily A, polypeptide 1 | 4649 | 0.031 | 0.4961 | No |
| 24 | CEL | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 5047 | 0.023 | 0.4703 | No |
| 25 | SULT2A1 | SULT2A1 Entrez, Source | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | 5184 | 0.021 | 0.4636 | No |
| 26 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 5532 | 0.014 | 0.4400 | No |
| 27 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 5728 | 0.010 | 0.4271 | No |
| 28 | CYP7B1 | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 7069 | -0.014 | 0.3288 | No |
| 29 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7093 | -0.014 | 0.3294 | No |
| 30 | FDXR | FDXR Entrez, Source | ferredoxin reductase | 7183 | -0.015 | 0.3254 | No |
| 31 | STUB1 | STUB1 Entrez, Source | STIP1 homology and U-box containing protein 1 | 7226 | -0.016 | 0.3252 | No |
| 32 | NR0B1 | NR0B1 Entrez, Source | nuclear receptor subfamily 0, group B, member 1 | 7399 | -0.020 | 0.3157 | No |
| 33 | YWHAH | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 7564 | -0.023 | 0.3073 | No |
| 34 | SHH | SHH Entrez, Source | sonic hedgehog homolog (Drosophila) | 8114 | -0.034 | 0.2719 | No |
| 35 | HSD3B7 | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 8340 | -0.038 | 0.2616 | No |
| 36 | AKR1B10 | AKR1B10 Entrez, Source | aldo-keto reductase family 1, member B10 (aldose reductase) | 8361 | -0.039 | 0.2668 | No |
| 37 | HDLBP | HDLBP Entrez, Source | high density lipoprotein binding protein (vigilin) | 9423 | -0.061 | 0.1977 | No |
| 38 | NR1H4 | NR1H4 Entrez, Source | nuclear receptor subfamily 1, group H, member 4 | 9939 | -0.075 | 0.1720 | No |
| 39 | ACOX3 | ACOX3 Entrez, Source | acyl-Coenzyme A oxidase 3, pristanoyl | 10884 | -0.104 | 0.1192 | No |
| 40 | ADM | ADM Entrez, Source | adrenomedullin | 11063 | -0.110 | 0.1250 | No |
| 41 | CNBP | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 11520 | -0.130 | 0.1134 | No |
| 42 | IL4 | IL4 Entrez, Source | interleukin 4 | 11640 | -0.135 | 0.1280 | No |
