Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | TUMOR_SUPRESSOR |
| Enrichment Score (ES) | -0.5417915 |
| Normalized Enrichment Score (NES) | -1.5095983 |
| Nominal p-value | 0.04121475 |
| FDR q-value | 0.2257382 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2162 | 0.101 | -0.1026 | No |
| 2 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 3202 | 0.066 | -0.1417 | No |
| 3 | VHL | VHL Entrez, Source | von Hippel-Lindau tumor suppressor | 4901 | 0.026 | -0.2539 | No |
| 4 | MSH2 | MSH2 Entrez, Source | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 5162 | 0.021 | -0.2610 | No |
| 5 | ACTB | ACTB Entrez, Source | actin, beta | 5788 | 0.009 | -0.3024 | No |
| 6 | WT1 | WT1 Entrez, Source | Wilms tumor 1 | 5809 | 0.009 | -0.2987 | No |
| 7 | LCMT2 | LCMT2 Entrez, Source | leucine carboxyl methyltransferase 2 | 6873 | -0.010 | -0.3725 | No |
| 8 | IRF1 | IRF1 Entrez, Source | interferon regulatory factor 1 | 7528 | -0.022 | -0.4085 | No |
| 9 | APC | APC Entrez, Source | adenomatosis polyposis coli | 7641 | -0.024 | -0.4025 | No |
| 10 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 9497 | -0.063 | -0.5047 | Yes |
| 11 | NF2 | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 9513 | -0.063 | -0.4686 | Yes |
| 12 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 10104 | -0.079 | -0.4660 | Yes |
| 13 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 10720 | -0.098 | -0.4545 | Yes |
| 14 | TSC2 | TSC2 Entrez, Source | tuberous sclerosis 2 | 10848 | -0.103 | -0.4033 | Yes |
| 15 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 11078 | -0.111 | -0.3548 | Yes |
| 16 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 11096 | -0.112 | -0.2899 | Yes |
| 17 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 11106 | -0.112 | -0.2242 | Yes |
| 18 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11266 | -0.119 | -0.1658 | Yes |
| 19 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 11338 | -0.122 | -0.0991 | Yes |
| 20 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 11382 | -0.124 | -0.0292 | Yes |
| 21 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 11835 | -0.147 | 0.0235 | Yes |
| 22 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 11925 | -0.152 | 0.1064 | Yes |
