Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | UVB_NHEK1_C6 |
| Enrichment Score (ES) | -0.44444123 |
| Normalized Enrichment Score (NES) | -1.5213803 |
| Nominal p-value | 0.029411765 |
| FDR q-value | 0.22509143 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 656 | 0.244 | -0.0114 | No |
| 2 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 746 | 0.228 | 0.0174 | No |
| 3 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 1410 | 0.142 | -0.0104 | No |
| 4 | FGFR2 | FGFR2 Entrez, Source | ffer syndrome, Jackson-Weiss syndrome) | 1907 | 0.111 | -0.0303 | No |
| 5 | CNOT4 | CNOT4 Entrez, Source | CCR4-NOT transcription complex, subunit 4 | 1951 | 0.110 | -0.0165 | No |
| 6 | PIP5K2B | PIP5K2B Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type II, beta | 2439 | 0.090 | -0.0391 | No |
| 7 | INSIG2 | INSIG2 Entrez, Source | insulin induced gene 2 | 2456 | 0.090 | -0.0264 | No |
| 8 | HMGA2 | HMGA2 Entrez, Source | high mobility group AT-hook 2 | 2548 | 0.086 | -0.0199 | No |
| 9 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 2623 | 0.083 | -0.0125 | No |
| 10 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 2628 | 0.083 | 0.0001 | No |
| 11 | GNE | GNE Entrez, Source | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 3063 | 0.069 | -0.0218 | No |
| 12 | TLE4 | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 3506 | 0.057 | -0.0461 | No |
| 13 | SP3 | SP3 Entrez, Source | Sp3 transcription factor | 3514 | 0.057 | -0.0377 | No |
| 14 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 3561 | 0.056 | -0.0325 | No |
| 15 | UBL3 | UBL3 Entrez, Source | ubiquitin-like 3 | 3635 | 0.054 | -0.0296 | No |
| 16 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 3790 | 0.050 | -0.0334 | No |
| 17 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 4748 | 0.029 | -0.1009 | No |
| 18 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 4778 | 0.028 | -0.0986 | No |
| 19 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 4982 | 0.024 | -0.1101 | No |
| 20 | MYST3 | MYST3 Entrez, Source | MYST histone acetyltransferase (monocytic leukemia) 3 | 5213 | 0.020 | -0.1243 | No |
| 21 | CNOT2 | CNOT2 Entrez, Source | CCR4-NOT transcription complex, subunit 2 | 5786 | 0.009 | -0.1659 | No |
| 22 | KIF2A | KIF2A Entrez, Source | kinesin heavy chain member 2A | 5813 | 0.009 | -0.1665 | No |
| 23 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 5997 | 0.005 | -0.1794 | No |
| 24 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 6034 | 0.005 | -0.1814 | No |
| 25 | SHOC2 | SHOC2 Entrez, Source | soc-2 suppressor of clear homolog (C. elegans) | 6249 | 0.001 | -0.1975 | No |
| 26 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 6465 | -0.003 | -0.2132 | No |
| 27 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 6929 | -0.011 | -0.2463 | No |
| 28 | SPOP | SPOP Entrez, Source | speckle-type POZ protein | 6946 | -0.011 | -0.2457 | No |
| 29 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 7503 | -0.022 | -0.2842 | No |
| 30 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 7883 | -0.029 | -0.3082 | No |
| 31 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 8537 | -0.042 | -0.3508 | No |
| 32 | APPBP2 | APPBP2 Entrez, Source | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 9765 | -0.070 | -0.4323 | Yes |
| 33 | ATP2B1 | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 9817 | -0.071 | -0.4250 | Yes |
| 34 | STRN | STRN Entrez, Source | striatin, calmodulin binding protein | 10061 | -0.078 | -0.4311 | Yes |
| 35 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 10239 | -0.083 | -0.4316 | Yes |
| 36 | PPP1R12A | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 10350 | -0.086 | -0.4265 | Yes |
| 37 | PIK3C3 | PIK3C3 Entrez, Source | phosphoinositide-3-kinase, class 3 | 10518 | -0.091 | -0.4249 | Yes |
| 38 | MTUS1 | MTUS1 Entrez, Source | mitochondrial tumor suppressor 1 | 10665 | -0.096 | -0.4209 | Yes |
| 39 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 10956 | -0.107 | -0.4261 | Yes |
| 40 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 10986 | -0.108 | -0.4115 | Yes |
| 41 | ARHGEF7 | ARHGEF7 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 7 | 11215 | -0.117 | -0.4105 | Yes |
| 42 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 11226 | -0.117 | -0.3931 | Yes |
| 43 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 11410 | -0.125 | -0.3873 | Yes |
| 44 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 11805 | -0.145 | -0.3944 | Yes |
| 45 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 12272 | -0.177 | -0.4019 | Yes |
| 46 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 12589 | -0.209 | -0.3931 | Yes |
| 47 | MECP2 | MECP2 Entrez, Source | methyl CpG binding protein 2 (Rett syndrome) | 12609 | -0.212 | -0.3615 | Yes |
| 48 | ATF2 | ATF2 Entrez, Source | activating transcription factor 2 | 12642 | -0.216 | -0.3302 | Yes |
| 49 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 12648 | -0.217 | -0.2967 | Yes |
| 50 | EDD1 | EDD1 Entrez, Source | E3 ubiquitin protein ligase, HECT domain containing, 1 | 12711 | -0.226 | -0.2662 | Yes |
| 51 | EIF2C2 | EIF2C2 Entrez, Source | eukaryotic translation initiation factor 2C, 2 | 12721 | -0.227 | -0.2314 | Yes |
| 52 | REV3L | REV3L Entrez, Source | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 12847 | -0.253 | -0.2014 | Yes |
| 53 | PHLPP | PHLPP Entrez, Source | PH domain and leucine rich repeat protein phosphatase | 13038 | -0.305 | -0.1682 | Yes |
| 54 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 13090 | -0.322 | -0.1218 | Yes |
| 55 | XPO1 | XPO1 Entrez, Source | exportin 1 (CRM1 homolog, yeast) | 13111 | -0.334 | -0.0713 | Yes |
| 56 | OTUD4 | OTUD4 Entrez, Source | OTU domain containing 4 | 13292 | -0.569 | 0.0038 | Yes |
