Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | UVB_NHEK1_DN |
| Enrichment Score (ES) | -0.42566714 |
| Normalized Enrichment Score (NES) | -1.6409305 |
| Nominal p-value | 0.0025 |
| FDR q-value | 0.12777998 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RAPGEF5 | RAPGEF5 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 5 | 331 | 0.373 | 0.0033 | No |
| 2 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 656 | 0.244 | -0.0028 | No |
| 3 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 746 | 0.228 | 0.0077 | No |
| 4 | PSCD1 | PSCD1 Entrez, Source | pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) | 789 | 0.217 | 0.0210 | No |
| 5 | KLF9 | KLF9 Entrez, Source | Kruppel-like factor 9 | 905 | 0.195 | 0.0271 | No |
| 6 | AKAP9 | AKAP9 Entrez, Source | A kinase (PRKA) anchor protein (yotiao) 9 | 933 | 0.190 | 0.0394 | No |
| 7 | ADRB2 | ADRB2 Entrez, Source | adrenergic, beta-2-, receptor, surface | 987 | 0.184 | 0.0494 | No |
| 8 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 1410 | 0.142 | 0.0282 | No |
| 9 | BDKRB2 | BDKRB2 Entrez, Source | bradykinin receptor B2 | 1581 | 0.129 | 0.0252 | No |
| 10 | CCDC131 | CCDC131 Entrez, Source | coiled-coil domain containing 131 | 1709 | 0.122 | 0.0248 | No |
| 11 | FGFR2 | FGFR2 Entrez, Source | ffer syndrome, Jackson-Weiss syndrome) | 1907 | 0.111 | 0.0184 | No |
| 12 | CNOT4 | CNOT4 Entrez, Source | CCR4-NOT transcription complex, subunit 4 | 1951 | 0.110 | 0.0234 | No |
| 13 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 2048 | 0.106 | 0.0242 | No |
| 14 | PIP5K2B | PIP5K2B Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type II, beta | 2439 | 0.090 | 0.0015 | No |
| 15 | INSIG2 | INSIG2 Entrez, Source | insulin induced gene 2 | 2456 | 0.090 | 0.0071 | No |
| 16 | HMGA2 | HMGA2 Entrez, Source | high mobility group AT-hook 2 | 2548 | 0.086 | 0.0067 | No |
| 17 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 2623 | 0.083 | 0.0074 | No |
| 18 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 2628 | 0.083 | 0.0133 | No |
| 19 | DTX2 | DTX2 Entrez, Source | deltex homolog 2 (Drosophila) | 2721 | 0.079 | 0.0124 | No |
| 20 | CEP170 | CEP170 Entrez, Source | centrosomal protein 170kDa | 3004 | 0.071 | -0.0035 | No |
| 21 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 3049 | 0.070 | -0.0016 | No |
| 22 | GNE | GNE Entrez, Source | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 3063 | 0.069 | 0.0027 | No |
| 23 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 3202 | 0.066 | -0.0028 | No |
| 24 | ID1 | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 3286 | 0.063 | -0.0042 | No |
| 25 | TLE4 | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 3506 | 0.057 | -0.0165 | No |
| 26 | SP3 | SP3 Entrez, Source | Sp3 transcription factor | 3514 | 0.057 | -0.0127 | No |
| 27 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 3561 | 0.056 | -0.0119 | No |
| 28 | UBL3 | UBL3 Entrez, Source | ubiquitin-like 3 | 3635 | 0.054 | -0.0134 | No |
| 29 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 3790 | 0.050 | -0.0212 | No |
| 30 | PHC2 | PHC2 Entrez, Source | polyhomeotic homolog 2 (Drosophila) | 3972 | 0.045 | -0.0314 | No |
| 31 | ATRX | ATRX Entrez, Source | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | 4548 | 0.033 | -0.0724 | No |
| 32 | PTPN3 | PTPN3 Entrez, Source | protein tyrosine phosphatase, non-receptor type 3 | 4694 | 0.030 | -0.0811 | No |
| 33 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 4748 | 0.029 | -0.0829 | No |
| 34 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 4778 | 0.028 | -0.0829 | No |
| 35 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 4982 | 0.024 | -0.0964 | No |
| 36 | MYST3 | MYST3 Entrez, Source | MYST histone acetyltransferase (monocytic leukemia) 3 | 5213 | 0.020 | -0.1123 | No |
| 37 | ADORA2B | ADORA2B Entrez, Source | adenosine A2b receptor | 5772 | 0.010 | -0.1537 | No |
| 38 | CNOT2 | CNOT2 Entrez, Source | CCR4-NOT transcription complex, subunit 2 | 5786 | 0.009 | -0.1540 | No |
| 39 | KIF2A | KIF2A Entrez, Source | kinesin heavy chain member 2A | 5813 | 0.009 | -0.1553 | No |
| 40 | RCHY1 | RCHY1 Entrez, Source | ring finger and CHY zinc finger domain containing 1 | 5935 | 0.006 | -0.1640 | No |
| 41 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 5997 | 0.005 | -0.1682 | No |
| 42 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 6034 | 0.005 | -0.1706 | No |
| 43 | SHOC2 | SHOC2 Entrez, Source | soc-2 suppressor of clear homolog (C. elegans) | 6249 | 0.001 | -0.1867 | No |
| 44 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 6465 | -0.003 | -0.2027 | No |
| 45 | MTM1 | MTM1 Entrez, Source | myotubularin 1 | 6543 | -0.005 | -0.2082 | No |
| 46 | CBLB | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 6744 | -0.008 | -0.2227 | No |
| 47 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 6929 | -0.011 | -0.2358 | No |
| 48 | SPOP | SPOP Entrez, Source | speckle-type POZ protein | 6946 | -0.011 | -0.2361 | No |
| 49 | ZNF148 | ZNF148 Entrez, Source | zinc finger protein 148 | 7364 | -0.019 | -0.2662 | No |
| 50 | TAF11 | TAF11 Entrez, Source | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | 7434 | -0.020 | -0.2699 | No |
| 51 | KEAP1 | KEAP1 Entrez, Source | kelch-like ECH-associated protein 1 | 7472 | -0.021 | -0.2711 | No |
| 52 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 7503 | -0.022 | -0.2717 | No |
| 53 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 7739 | -0.026 | -0.2875 | No |
| 54 | PER2 | PER2 Entrez, Source | period homolog 2 (Drosophila) | 7759 | -0.027 | -0.2869 | No |
| 55 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 7883 | -0.029 | -0.2940 | No |
| 56 | SH2B3 | SH2B3 Entrez, Source | SH2B adaptor protein 3 | 8077 | -0.033 | -0.3061 | No |
| 57 | NAGK | NAGK Entrez, Source | N-acetylglucosamine kinase | 8172 | -0.035 | -0.3106 | No |
| 58 | CTCF | CTCF Entrez, Source | CCCTC-binding factor (zinc finger protein) | 8374 | -0.039 | -0.3228 | No |
| 59 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 8537 | -0.042 | -0.3319 | No |
| 60 | BAZ1B | BAZ1B Entrez, Source | bromodomain adjacent to zinc finger domain, 1B | 9024 | -0.052 | -0.3646 | No |
| 61 | AHR | AHR Entrez, Source | aryl hydrocarbon receptor | 9118 | -0.054 | -0.3676 | No |
| 62 | TAF5L | TAF5L Entrez, Source | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa | 9453 | -0.062 | -0.3881 | No |
| 63 | APPBP2 | APPBP2 Entrez, Source | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 9765 | -0.070 | -0.4064 | No |
| 64 | ATP2B1 | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 9817 | -0.071 | -0.4048 | No |
| 65 | NFE2L2 | NFE2L2 Entrez, Source | nuclear factor (erythroid-derived 2)-like 2 | 9937 | -0.075 | -0.4082 | No |
| 66 | NCOA3 | NCOA3 Entrez, Source | nuclear receptor coactivator 3 | 9971 | -0.076 | -0.4049 | No |
| 67 | STRN | STRN Entrez, Source | striatin, calmodulin binding protein | 10061 | -0.078 | -0.4057 | No |
| 68 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 10239 | -0.083 | -0.4128 | No |
| 69 | DMTF1 | DMTF1 Entrez, Source | cyclin D binding myb-like transcription factor 1 | 10255 | -0.083 | -0.4077 | No |
| 70 | PUM2 | PUM2 Entrez, Source | pumilio homolog 2 (Drosophila) | 10272 | -0.084 | -0.4026 | No |
| 71 | PPP1R12A | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 10350 | -0.086 | -0.4019 | No |
| 72 | PIK3C3 | PIK3C3 Entrez, Source | phosphoinositide-3-kinase, class 3 | 10518 | -0.091 | -0.4076 | No |
| 73 | MTUS1 | MTUS1 Entrez, Source | mitochondrial tumor suppressor 1 | 10665 | -0.096 | -0.4114 | No |
| 74 | UBE2G1 | UBE2G1 Entrez, Source | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) | 10786 | -0.100 | -0.4129 | No |
| 75 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 10956 | -0.107 | -0.4176 | Yes |
| 76 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 10986 | -0.108 | -0.4116 | Yes |
| 77 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 11078 | -0.111 | -0.4101 | Yes |
| 78 | ARHGEF7 | ARHGEF7 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 7 | 11215 | -0.117 | -0.4115 | Yes |
| 79 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 11226 | -0.117 | -0.4034 | Yes |
| 80 | SERTAD2 | SERTAD2 Entrez, Source | SERTA domain containing 2 | 11257 | -0.119 | -0.3967 | Yes |
| 81 | CEP350 | CEP350 Entrez, Source | centrosomal protein 350kDa | 11387 | -0.124 | -0.3971 | Yes |
| 82 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 11410 | -0.125 | -0.3893 | Yes |
| 83 | ELF1 | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 11435 | -0.126 | -0.3815 | Yes |
| 84 | NIPBL | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 11464 | -0.127 | -0.3740 | Yes |
| 85 | ANKRD15 | ANKRD15 Entrez, Source | ankyrin repeat domain 15 | 11802 | -0.145 | -0.3885 | Yes |
| 86 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 11805 | -0.145 | -0.3777 | Yes |
| 87 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 11948 | -0.154 | -0.3768 | Yes |
| 88 | NUP153 | NUP153 Entrez, Source | nucleoporin 153kDa | 11979 | -0.156 | -0.3673 | Yes |
| 89 | BRD8 | BRD8 Entrez, Source | bromodomain containing 8 | 12049 | -0.161 | -0.3603 | Yes |
| 90 | DDIT4 | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 12217 | -0.173 | -0.3598 | Yes |
| 91 | AURKA | AURKA Entrez, Source | aurora kinase A | 12238 | -0.175 | -0.3481 | Yes |
| 92 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 12249 | -0.175 | -0.3356 | Yes |
| 93 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 12272 | -0.177 | -0.3239 | Yes |
| 94 | ADNP | ADNP Entrez, Source | activity-dependent neuroprotector | 12323 | -0.181 | -0.3139 | Yes |
| 95 | MTIF2 | MTIF2 Entrez, Source | mitochondrial translational initiation factor 2 | 12340 | -0.183 | -0.3013 | Yes |
| 96 | SKAP2 | SKAP2 Entrez, Source | src kinase associated phosphoprotein 2 | 12493 | -0.198 | -0.2978 | Yes |
| 97 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 12589 | -0.209 | -0.2891 | Yes |
| 98 | MECP2 | MECP2 Entrez, Source | methyl CpG binding protein 2 (Rett syndrome) | 12609 | -0.212 | -0.2745 | Yes |
| 99 | USP1 | USP1 Entrez, Source | ubiquitin specific peptidase 1 | 12629 | -0.215 | -0.2597 | Yes |
| 100 | ATF2 | ATF2 Entrez, Source | activating transcription factor 2 | 12642 | -0.216 | -0.2442 | Yes |
| 101 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 12648 | -0.217 | -0.2281 | Yes |
| 102 | DYRK1A | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 12656 | -0.218 | -0.2121 | Yes |
| 103 | EDD1 | EDD1 Entrez, Source | E3 ubiquitin protein ligase, HECT domain containing, 1 | 12711 | -0.226 | -0.1991 | Yes |
| 104 | EIF2C2 | EIF2C2 Entrez, Source | eukaryotic translation initiation factor 2C, 2 | 12721 | -0.227 | -0.1826 | Yes |
| 105 | SMAD5 | SMAD5 Entrez, Source | SMAD, mothers against DPP homolog 5 (Drosophila) | 12778 | -0.238 | -0.1688 | Yes |
| 106 | REV3L | REV3L Entrez, Source | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 12847 | -0.253 | -0.1547 | Yes |
| 107 | PHLPP | PHLPP Entrez, Source | PH domain and leucine rich repeat protein phosphatase | 13038 | -0.305 | -0.1460 | Yes |
| 108 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 13090 | -0.322 | -0.1255 | Yes |
| 109 | XPO1 | XPO1 Entrez, Source | exportin 1 (CRM1 homolog, yeast) | 13111 | -0.334 | -0.1017 | Yes |
| 110 | GCLC | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 13249 | -0.480 | -0.0757 | Yes |
| 111 | PPP1R3C | PPP1R3C Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 3C | 13269 | -0.522 | -0.0376 | Yes |
| 112 | OTUD4 | OTUD4 Entrez, Source | OTU domain containing 4 | 13292 | -0.569 | 0.0038 | Yes |
