Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_8d_versus_double_gel_24h.class.cls
#double_gel_8d_versus_double_gel_24h_repos
Phenotypeclass.cls#double_gel_8d_versus_double_gel_24h_repos
Upregulated in classdouble_gel_24h
GeneSetUVC_XPCS_8HR_DN
Enrichment Score (ES)-0.3488632
Normalized Enrichment Score (NES)-1.4572248
Nominal p-value0.008086253
FDR q-value0.25289425
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: UVC_XPCS_8HR_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DPYDDPYD
Entrez,  Source
dihydropyrimidine dehydrogenase1120.6320.0210No
2GRK5GRK5
Entrez,  Source
G protein-coupled receptor kinase 51880.5070.0390No
3SCHIP1SCHIP1
Entrez,  Source
schwannomin interacting protein 12170.4720.0589No
4PLCE1PLCE1
Entrez,  Source
phospholipase C, epsilon 13960.3390.0612No
5FUT8FUT8
Entrez,  Source
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)5670.2650.0607No
6MGLLMGLL
Entrez,  Source
monoglyceride lipase7180.2320.0601No
7IGF2BP3IGF2BP3
Entrez,  Source
insulin-like growth factor 2 mRNA binding protein 37460.2280.0687No
8PEX3PEX3
Entrez,  Source
peroxisomal biogenesis factor 37600.2230.0781No
9CUTL1CUTL1
Entrez,  Source
cut-like 1, CCAAT displacement protein (Drosophila)8070.2120.0845No
10PAWRPAWR
Entrez,  Source
PRKC, apoptosis, WT1, regulator8990.1960.0868No
11TGFB2TGFB2
Entrez,  Source
transforming growth factor, beta 29160.1930.0946No
12F3F3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)9560.1880.1004No
13IL1RAPIL1RAP
Entrez,  Source
interleukin 1 receptor accessory protein10430.1770.1021No
14TRIM2TRIM2
Entrez,  Source
tripartite motif-containing 213000.1500.0897No
15SOS2SOS2
Entrez,  Source
son of sevenless homolog 2 (Drosophila)13120.1490.0958No
16VEGFCVEGFC
Entrez,  Source
vascular endothelial growth factor C14100.1420.0951No
17PRKCAPRKCA
Entrez,  Source
protein kinase C, alpha14230.1410.1008No
18ZFHX1BZFHX1B
Entrez,  Source
zinc finger homeobox 1b14270.1400.1071No
19BARD1BARD1
Entrez,  Source
BRCA1 associated RING domain 115110.1340.1071No
20PTPN2PTPN2
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 215530.1310.1101No
21GNAQGNAQ
Entrez,  Source
guanine nucleotide binding protein (G protein), q polypeptide17220.1220.1030No
22SMARCA2SMARCA2
Entrez,  Source
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 218010.1170.1025No
23NUMBNUMB
Entrez,  Source
numb homolog (Drosophila)19380.1100.0973No
24NR2F2NR2F2
Entrez,  Source
nuclear receptor subfamily 2, group F, member 220480.1060.0940No
25ACSL3ACSL3
Entrez,  Source
acyl-CoA synthetase long-chain family member 321160.1030.0937No
26STK39STK39
Entrez,  Source
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)21510.1010.0959No
27RB1RB1
Entrez,  Source
retinoblastoma 1 (including osteosarcoma)21620.1010.0998No
28RGS7RGS7
Entrez,  Source
regulator of G-protein signalling 722710.0970.0961No
29NRG1NRG1
Entrez,  Source
neuregulin 123470.0940.0948No
30GLRBGLRB
Entrez,  Source
glycine receptor, beta24700.0890.0897No
31XRCC4XRCC4
Entrez,  Source
X-ray repair complementing defective repair in Chinese hamster cells 425990.0830.0839No
32FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES26230.0830.0860No
33ZMYND11ZMYND11
Entrez,  Source
zinc finger, MYND domain containing 1127060.0800.0835No
34STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)27560.0780.0834No
35MBNL1MBNL1
Entrez,  Source
muscleblind-like (Drosophila)29300.0730.0737No
36CEP170CEP170
Entrez,  Source
centrosomal protein 170kDa30040.0710.0715No
37MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 331130.0680.0664No
38FGF2FGF2
Entrez,  Source
fibroblast growth factor 2 (basic)32100.0650.0622No
39ID1ID1
Entrez,  Source
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein32860.0630.0595No
40ATP2C1ATP2C1
Entrez,  Source
ATPase, Ca++ transporting, type 2C, member 133610.0610.0567No
41PPM1BPPM1B
Entrez,  Source
protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform34220.0600.0549No
42IFRD1IFRD1
Entrez,  Source
interferon-related developmental regulator 134720.0580.0539No
43TLE4TLE4
Entrez,  Source
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)35060.0570.0541No
44PLEKHC1PLEKHC1
Entrez,  Source
pleckstrin homology domain containing, family C (with FERM domain) member 135610.0560.0526No
45UBL3UBL3
Entrez,  Source
ubiquitin-like 336350.0540.0496No
46ZHX3ZHX3
Entrez,  Source
zinc fingers and homeoboxes 336770.0530.0489No
47SMAD3SMAD3
Entrez,  Source
SMAD, mothers against DPP homolog 3 (Drosophila)37900.0500.0428No
48FARS2FARS2
Entrez,  Source
phenylalanine-tRNA synthetase 2 (mitochondrial)38260.0500.0424No
49IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor38900.0480.0398No
50WDR7WDR7
Entrez,  Source
WD repeat domain 739240.0470.0395No
51NPEPPSNPEPPS
Entrez,  Source
aminopeptidase puromycin sensitive40430.0440.0326No
52MYO1BMYO1B
Entrez,  Source
myosin IB40740.0430.0323No
53PDE8APDE8A
Entrez,  Source
phosphodiesterase 8A41610.0410.0277No
54TDRD7TDRD7
Entrez,  Source
tudor domain containing 742200.0390.0251No
55SLIT2SLIT2
Entrez,  Source
slit homolog 2 (Drosophila)43300.0370.0185No
56HERC4HERC4
Entrez,  Source
hect domain and RLD 444840.0340.0085No
57RRAS2RRAS2
Entrez,  Source
related RAS viral (r-ras) oncogene homolog 245020.0340.0088No
58ATRXATRX
Entrez,  Source
alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)45480.0330.0069No
59PLCB4PLCB4
Entrez,  Source
phospholipase C, beta 447210.030-0.0048No
60THBS2THBS2
Entrez,  Source
thrombospondin 247380.029-0.0046No
61ORC2LORC2L
Entrez,  Source
origin recognition complex, subunit 2-like (yeast)47480.029-0.0039No
62RYKRYK
Entrez,  Source
RYK receptor-like tyrosine kinase47730.028-0.0044No
63NFKB1NFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)47780.028-0.0034No
64MSH2MSH2
Entrez,  Source
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)51620.021-0.0315No
65MYST3MYST3
Entrez,  Source
MYST histone acetyltransferase (monocytic leukemia) 352130.020-0.0344No
66KLF6KLF6
Entrez,  Source
Kruppel-like factor 654470.016-0.0513No
67DLG1DLG1
Entrez,  Source
discs, large homolog 1 (Drosophila)57020.011-0.0701No
68R3HDM1R3HDM1
Entrez,  Source
R3H domain containing 157450.010-0.0728No
69CNOT2CNOT2
Entrez,  Source
CCR4-NOT transcription complex, subunit 257860.009-0.0755No
70CTBP2CTBP2
Entrez,  Source
C-terminal binding protein 259970.005-0.0912No
71CDH2CDH2
Entrez,  Source
cadherin 2, type 1, N-cadherin (neuronal)61220.003-0.1005No
72NUP98NUP98
Entrez,  Source
nucleoporin 98kDa62680.000-0.1115No
73RAB6ARAB6A
Entrez,  Source
RAB6A, member RAS oncogene family6313-0.000-0.1148No
74PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 26465-0.003-0.1261No
75AFAPAFAP
Entrez,  Source
-6545-0.005-0.1319No
76NFYCNFYC
Entrez,  Source
nuclear transcription factor Y, gamma6617-0.006-0.1370No
77DLC1DLC1
Entrez,  Source
deleted in liver cancer 16645-0.006-0.1388No
78EIF4EEIF4E
Entrez,  Source
eukaryotic translation initiation factor 4E6696-0.007-0.1423No
79CBLBCBLB
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence b6744-0.008-0.1455No
80MTX2MTX2
Entrez,  Source
metaxin 27134-0.014-0.1743No
81ADAM10ADAM10
Entrez,  Source
ADAM metallopeptidase domain 107189-0.016-0.1777No
82UBE2D2UBE2D2
Entrez,  Source
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)7273-0.017-0.1832No
83ZNF148ZNF148
Entrez,  Source
zinc finger protein 1487364-0.019-0.1892No
84CREB3L2CREB3L2
Entrez,  Source
cAMP responsive element binding protein 3-like 27503-0.022-0.1986No
85CENTB2CENTB2
Entrez,  Source
centaurin, beta 27595-0.023-0.2045No
86PRKCIPRKCI
Entrez,  Source
protein kinase C, iota7723-0.026-0.2129No
87SEPT9SEPT9
Entrez,  Source
septin 97780-0.027-0.2159No
88TSPAN5TSPAN5
Entrez,  Source
tetraspanin 57785-0.027-0.2149No
89SLKSLK
Entrez,  Source
STE20-like kinase (yeast)7815-0.028-0.2159No
90MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 47969-0.031-0.2261No
91PARGPARG
Entrez,  Source
poly (ADP-ribose) glycohydrolase7997-0.031-0.2267No
92CDC42BPACDC42BPA
Entrez,  Source
CDC42 binding protein kinase alpha (DMPK-like)8008-0.031-0.2260No
93KPNA3KPNA3
Entrez,  Source
karyopherin alpha 3 (importin alpha 4)8218-0.036-0.2402No
94STRN3STRN3
Entrez,  Source
striatin, calmodulin binding protein 38342-0.038-0.2477No
95WWP1WWP1
Entrez,  Source
WW domain containing E3 ubiquitin protein ligase 18375-0.039-0.2483No
96PICALMPICALM
Entrez,  Source
phosphatidylinositol binding clathrin assembly protein8462-0.041-0.2530No
97CDC2L5CDC2L5
Entrez,  Source
cell division cycle 2-like 5 (cholinesterase-related cell division controller)8548-0.042-0.2575No
98DUSP5DUSP5
Entrez,  Source
dual specificity phosphatase 58551-0.042-0.2556No
99STAU2STAU2
Entrez,  Source
staufen, RNA binding protein, homolog 2 (Drosophila)8584-0.043-0.2560No
100NBNNBN
Entrez,  Source
nibrin8672-0.045-0.2606No
101PJA2PJA2
Entrez,  Source
praja 2, RING-H2 motif containing8736-0.046-0.2632No
102ATRNATRN
Entrez,  Source
attractin8885-0.050-0.2721No
103PKN2PKN2
Entrez,  Source
protein kinase N29045-0.053-0.2817No
104PTPN12PTPN12
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 129058-0.053-0.2802No
105FGF5FGF5
Entrez,  Source
fibroblast growth factor 59095-0.054-0.2804No
106RAD23BRAD23B
Entrez,  Source
RAD23 homolog B (S. cerevisiae)9175-0.055-0.2838No
107SONSON
Entrez,  Source
SON DNA binding protein9229-0.057-0.2852No
108TIAM1TIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 19463-0.062-0.3000No
109APPBP2APPBP2
Entrez,  Source
amyloid beta precursor protein (cytoplasmic tail) binding protein 29765-0.070-0.3196No
110ATP2B1ATP2B1
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 19817-0.071-0.3202No
111MKLN1MKLN1
Entrez,  Source
muskelin 1, intracellular mediator containing kelch motifs9943-0.075-0.3262No
112NCOA3NCOA3
Entrez,  Source
nuclear receptor coactivator 39971-0.076-0.3247No
113TJP2TJP2
Entrez,  Source
tight junction protein 2 (zona occludens 2)10032-0.077-0.3256No
114EPS15EPS15
Entrez,  Source
epidermal growth factor receptor pathway substrate 1510074-0.079-0.3251No
115SLC7A1SLC7A1
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 110239-0.083-0.3337No
116LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog10258-0.083-0.3312No
117PUM2PUM2
Entrez,  Source
pumilio homolog 2 (Drosophila)10272-0.084-0.3282No
118PPP1R12APPP1R12A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 12A10350-0.086-0.3301No
119MID1MID1
Entrez,  Source
midline 1 (Opitz/BBB syndrome)10356-0.086-0.3264No
120PIK3C3PIK3C3
Entrez,  Source
phosphoinositide-3-kinase, class 310518-0.091-0.3344No
121RAGERAGE
Entrez,  Source
renal tumor antigen10582-0.093-0.3349No
122PTPRKPTPRK
Entrez,  Source
protein tyrosine phosphatase, receptor type, K10767-0.100-0.3442Yes
123RBM16RBM16
Entrez,  Source
RNA binding motif protein 1610775-0.100-0.3401Yes
124UBE2G1UBE2G1
Entrez,  Source
ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)10786-0.100-0.3361Yes
125OPA1OPA1
Entrez,  Source
optic atrophy 1 (autosomal dominant)10860-0.103-0.3369Yes
126ITSN1ITSN1
Entrez,  Source
intersectin 1 (SH3 domain protein)10914-0.105-0.3360Yes
127CLASP1CLASP1
Entrez,  Source
cytoplasmic linker associated protein 110986-0.108-0.3363Yes
128CREBBPCREBBP
Entrez,  Source
CREB binding protein (Rubinstein-Taybi syndrome)11078-0.111-0.3381Yes
129LRPPRCLRPPRC
Entrez,  Source
leucine-rich PPR-motif containing11099-0.112-0.3343Yes
130ARHGEF7ARHGEF7
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 711215-0.117-0.3376Yes
131GMPSGMPS
Entrez,  Source
guanine monphosphate synthetase11250-0.118-0.3347Yes
132MYO9BMYO9B
Entrez,  Source
myosin IXB11288-0.120-0.3319Yes
133ABCE1ABCE1
Entrez,  Source
ATP-binding cassette, sub-family E (OABP), member 111335-0.122-0.3297Yes
134CEP350CEP350
Entrez,  Source
centrosomal protein 350kDa11387-0.124-0.3278Yes
135TOP2ATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa11410-0.125-0.3236Yes
136ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 211450-0.127-0.3206Yes
137NIPBLNIPBL
Entrez,  Source
Nipped-B homolog (Drosophila)11464-0.127-0.3157Yes
138TCF12TCF12
Entrez,  Source
transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)11550-0.131-0.3160Yes
139HOMER1HOMER1
Entrez,  Source
homer homolog 1 (Drosophila)11571-0.132-0.3113Yes
140CKAP5CKAP5
Entrez,  Source
cytoskeleton associated protein 511613-0.134-0.3082Yes
141TRIP12TRIP12
Entrez,  Source
thyroid hormone receptor interactor 1211740-0.140-0.3112Yes
142CLOCKCLOCK
Entrez,  Source
clock homolog (mouse)11770-0.143-0.3068Yes
143CLASP2CLASP2
Entrez,  Source
cytoplasmic linker associated protein 211792-0.144-0.3016Yes
144RASA1RASA1
Entrez,  Source
RAS p21 protein activator (GTPase activating protein) 111793-0.144-0.2949Yes
145PAFAH1B1PAFAH1B1
Entrez,  Source
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa11805-0.145-0.2890Yes
146OGTOGT
Entrez,  Source
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)11813-0.145-0.2827Yes
147PTENPTEN
Entrez,  Source
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)11925-0.152-0.2841Yes
148GSK3BGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta11989-0.156-0.2816Yes
149XPO6XPO6
Entrez,  Source
exportin 612092-0.164-0.2817Yes
150RSNRSN
Entrez,  Source
restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)12170-0.169-0.2796Yes
151PRIM2APRIM2A
Entrez,  Source
primase, polypeptide 2A, 58kDa12178-0.170-0.2722Yes
152CXCL12CXCL12
Entrez,  Source
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)12188-0.170-0.2649Yes
153MYCMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)12249-0.175-0.2613Yes
154TUBGCP3TUBGCP3
Entrez,  Source
tubulin, gamma complex associated protein 312272-0.177-0.2547Yes
155ARIH1ARIH1
Entrez,  Source
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)12297-0.179-0.2481Yes
156CDS2CDS2
Entrez,  Source
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 212417-0.190-0.2483Yes
157PCMT1PCMT1
Entrez,  Source
protein-L-isoaspartate (D-aspartate) O-methyltransferase12428-0.191-0.2402Yes
158CDC27CDC27
Entrez,  Source
cell division cycle 2712536-0.203-0.2388Yes
159RUNX1RUNX1
Entrez,  Source
runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)12547-0.204-0.2301Yes
160CASKCASK
Entrez,  Source
calcium/calmodulin-dependent serine protein kinase (MAGUK family)12559-0.206-0.2213Yes
161PARD3PARD3
Entrez,  Source
par-3 partitioning defective 3 homolog (C. elegans)12567-0.207-0.2122Yes
162PRKCBP1PRKCBP1
Entrez,  Source
protein kinase C binding protein 112589-0.209-0.2040Yes
163ATF2ATF2
Entrez,  Source
activating transcription factor 212642-0.216-0.1978Yes
164DOCK9DOCK9
Entrez,  Source
dedicator of cytokinesis 912648-0.217-0.1881Yes
165DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A12656-0.218-0.1784Yes
166EDD1EDD1
Entrez,  Source
E3 ubiquitin protein ligase, HECT domain containing, 112711-0.226-0.1719Yes
167HNRPDLHNRPDL
Entrez,  Source
heterogeneous nuclear ribonucleoprotein D-like12742-0.232-0.1634Yes
168GBE1GBE1
Entrez,  Source
glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)12796-0.240-0.1562Yes
169MDN1MDN1
Entrez,  Source
MDN1, midasin homolog (yeast)12799-0.241-0.1451Yes
170SLC4A7SLC4A7
Entrez,  Source
solute carrier family 4, sodium bicarbonate cotransporter, member 712805-0.242-0.1341Yes
171ADARB1ADARB1
Entrez,  Source
adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)12846-0.253-0.1254Yes
172REV3LREV3L
Entrez,  Source
REV3-like, catalytic subunit of DNA polymerase zeta (yeast)12847-0.253-0.1135Yes
173GTF2F2GTF2F2
Entrez,  Source
general transcription factor IIF, polypeptide 2, 30kDa12872-0.260-0.1032Yes
174NMT2NMT2
Entrez,  Source
N-myristoyltransferase 212888-0.263-0.0921Yes
175MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 112906-0.268-0.0808Yes
176EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)12946-0.276-0.0709Yes
177SERPINE1SERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 112951-0.277-0.0583Yes
178PDLIM5PDLIM5
Entrez,  Source
PDZ and LIM domain 512986-0.289-0.0474Yes
179TRIOTRIO
Entrez,  Source
triple functional domain (PTPRF interacting)13021-0.298-0.0360Yes
180PHLPPPHLPP
Entrez,  Source
PH domain and leucine rich repeat protein phosphatase13038-0.305-0.0230Yes
181E2F5E2F5
Entrez,  Source
E2F transcription factor 5, p130-binding13090-0.322-0.0118Yes
182PRMT3PRMT3
Entrez,  Source
protein arginine methyltransferase 313098-0.3260.0029Yes
183XPO1XPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)13111-0.3340.0176Yes
Table: GSEA details [plain text format]



Fig 2: UVC_XPCS_8HR_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: UVC_XPCS_8HR_DN: Random ES distribution   
Gene set null distribution of ES for UVC_XPCS_8HR_DN