Details for gene set VERHAAK_AML_NPM1_MUT_VS_WT

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_24h.class.cls #double_gel_8d_versus_double_gel_24h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_24h_repos
Upregulated in class	double_gel_8d
GeneSet	VERHAAK_AML_NPM1_MUT_VS_WT_DN
Enrichment Score (ES)	0.50632805
Normalized Enrichment Score (NES)	1.8805141
Nominal p-value	0.0
FDR q-value	0.015295123
FWER p-Value	0.634

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	IGFBP7	IGFBP7 Entrez, Source	insulin-like growth factor binding protein 7	11	1.276	0.0666	Yes
2	CCND2	CCND2 Entrez, Source	cyclin D2	21	1.039	0.1208	Yes
3	RGS1	RGS1 Entrez, Source	regulator of G-protein signalling 1	73	0.715	0.1547	Yes
4	TRPM4	TRPM4 Entrez, Source	transient receptor potential cation channel, subfamily M, member 4	74	0.710	0.1922	Yes
5	EMP1	EMP1 Entrez, Source	epithelial membrane protein 1	119	0.621	0.2217	Yes
6	RAMP1	RAMP1 Entrez, Source	receptor (calcitonin) activity modifying protein 1	136	0.594	0.2518	Yes
7	PROM1	PROM1 Entrez, Source	prominin 1	152	0.562	0.2804	Yes
8	DPYSL2	DPYSL2 Entrez, Source	dihydropyrimidinase-like 2	158	0.552	0.3092	Yes
9	P2RX5	P2RX5 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 5	175	0.523	0.3356	Yes
10	SERPINE2	SERPINE2 Entrez, Source	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	190	0.499	0.3609	Yes
11	GJA1	GJA1 Entrez, Source	gap junction protein, alpha 1, 43kDa (connexin 43)	316	0.387	0.3719	Yes
12	PTGER4	PTGER4 Entrez, Source	prostaglandin E receptor 4 (subtype EP4)	393	0.340	0.3841	Yes
13	SPARC	SPARC Entrez, Source	secreted protein, acidic, cysteine-rich (osteonectin)	480	0.292	0.3930	Yes
14	LAMC1	LAMC1 Entrez, Source	laminin, gamma 1 (formerly LAMB2)	530	0.275	0.4038	Yes
15	ASS1	ASS1 Entrez, Source	argininosuccinate synthetase 1	556	0.268	0.4161	Yes
16	CD48	CD48 Entrez, Source	CD48 molecule	611	0.256	0.4255	Yes
17	FOXO1A	FOXO1A Entrez, Source	forkhead box O1A (rhabdomyosarcoma)	656	0.244	0.4351	Yes
18	GSN	GSN Entrez, Source	gelsolin (amyloidosis, Finnish type)	666	0.242	0.4472	Yes
19	EHD3	EHD3 Entrez, Source	EH-domain containing 3	676	0.241	0.4592	Yes
20	ITM2C	ITM2C Entrez, Source	integral membrane protein 2C	741	0.229	0.4665	Yes
21	LMO4	LMO4 Entrez, Source	LIM domain only 4	824	0.209	0.4713	Yes
22	APP	APP Entrez, Source	amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)	834	0.207	0.4816	Yes
23	B4GALT6	B4GALT6 Entrez, Source	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6	849	0.205	0.4914	Yes
24	OPTN	OPTN Entrez, Source	optineurin	997	0.183	0.4899	Yes
25	TFPI	TFPI Entrez, Source	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	1052	0.177	0.4952	Yes
26	F2RL1	F2RL1 Entrez, Source	coagulation factor II (thrombin) receptor-like 1	1065	0.175	0.5035	Yes
27	VIL2	VIL2 Entrez, Source	villin 2 (ezrin)	1409	0.142	0.4850	Yes
28	SNCA	SNCA Entrez, Source	synuclein, alpha (non A4 component of amyloid precursor)	1455	0.139	0.4890	Yes
29	MLLT3	MLLT3 Entrez, Source	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	1488	0.136	0.4937	Yes
30	SCRN1	SCRN1 Entrez, Source	secernin 1	1507	0.134	0.4995	Yes
31	SLC38A1	SLC38A1 Entrez, Source	solute carrier family 38, member 1	1676	0.124	0.4933	Yes
32	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	1689	0.123	0.4989	Yes
33	RUNX3	RUNX3 Entrez, Source	runt-related transcription factor 3	1723	0.121	0.5028	Yes
34	LRP3	LRP3 Entrez, Source	low density lipoprotein receptor-related protein 3	1822	0.116	0.5015	Yes
35	FCER1A	FCER1A Entrez, Source	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	1840	0.115	0.5063	Yes
36	TRH	TRH Entrez, Source	thyrotropin-releasing hormone	2124	0.103	0.4903	No
37	TMOD1	TMOD1 Entrez, Source	tropomodulin 1	2135	0.102	0.4950	No
38	SERPINF1	SERPINF1 Entrez, Source	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	2361	0.093	0.4829	No
39	ALDH2	ALDH2 Entrez, Source	aldehyde dehydrogenase 2 family (mitochondrial)	2544	0.086	0.4737	No
40	BLNK	BLNK Entrez, Source	B-cell linker	2743	0.079	0.4628	No
41	TGFB1I1	TGFB1I1 Entrez, Source	transforming growth factor beta 1 induced transcript 1	2804	0.077	0.4624	No
42	CD2	CD2 Entrez, Source	CD2 molecule	2852	0.076	0.4628	No
43	MST1	MST1 Entrez, Source	macrophage stimulating 1 (hepatocyte growth factor-like)	2899	0.074	0.4632	No
44	NBL1	NBL1 Entrez, Source	neuroblastoma, suppression of tumorigenicity 1	2982	0.072	0.4608	No
45	SERPING1	SERPING1 Entrez, Source	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)	3039	0.070	0.4603	No
46	ERG	ERG Entrez, Source	v-ets erythroblastosis virus E26 oncogene homolog (avian)	3040	0.070	0.4640	No
47	ALAS2	ALAS2 Entrez, Source	aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)	3103	0.068	0.4629	No
48	RPS6KA2	RPS6KA2 Entrez, Source	ribosomal protein S6 kinase, 90kDa, polypeptide 2	3107	0.068	0.4663	No
49	SH3BP4	SH3BP4 Entrez, Source	SH3-domain binding protein 4	3232	0.065	0.4603	No
50	BPGM	BPGM Entrez, Source	2,3-bisphosphoglycerate mutase	3358	0.061	0.4541	No
51	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	3394	0.060	0.4546	No
52	IL5RA	IL5RA Entrez, Source	interleukin 5 receptor, alpha	3448	0.059	0.4537	No
53	CHI3L1	CHI3L1 Entrez, Source	chitinase 3-like 1 (cartilage glycoprotein-39)	3449	0.059	0.4569	No
54	BAALC	BAALC Entrez, Source	brain and acute leukemia, cytoplasmic	3598	0.055	0.4486	No
55	SPON1	SPON1 Entrez, Source	spondin 1, extracellular matrix protein	3726	0.052	0.4417	No
56	CCR2	CCR2 Entrez, Source	chemokine (C-C motif) receptor 2	3950	0.046	0.4272	No
57	TGFBI	TGFBI Entrez, Source	transforming growth factor, beta-induced, 68kDa	4125	0.042	0.4163	No
58	GNG7	GNG7 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 7	4166	0.041	0.4154	No
59	CD38	CD38 Entrez, Source	CD38 molecule	4439	0.035	0.3967	No
60	ST18	ST18 Entrez, Source	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	4497	0.034	0.3941	No
61	FZD6	FZD6 Entrez, Source	frizzled homolog 6 (Drosophila)	4516	0.034	0.3946	No
62	FZD2	FZD2 Entrez, Source	frizzled homolog 2 (Drosophila)	4530	0.033	0.3953	No
63	KIT	KIT Entrez, Source	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	4575	0.033	0.3937	No
64	TMEM158	TMEM158 Entrez, Source	transmembrane protein 158	4671	0.031	0.3882	No
65	NRXN2	NRXN2 Entrez, Source	neurexin 2	5341	0.018	0.3385	No
66	UGCG	UGCG Entrez, Source	UDP-glucose ceramide glucosyltransferase	5384	0.017	0.3362	No
67	FHL1	FHL1 Entrez, Source	four and a half LIM domains 1	5660	0.012	0.3160	No
68	ELA2	ELA2 Entrez, Source	elastase 2, neutrophil	5704	0.011	0.3134	No
69	EVL	EVL Entrez, Source	Enah/Vasp-like	5789	0.009	0.3075	No
70	PDE3B	PDE3B Entrez, Source	phosphodiesterase 3B, cGMP-inhibited	6112	0.003	0.2833	No
71	PTPRM	PTPRM Entrez, Source	protein tyrosine phosphatase, receptor type, M	6136	0.003	0.2817	No
72	GATA3	GATA3 Entrez, Source	GATA binding protein 3	6151	0.002	0.2807	No
73	EGFL7	EGFL7 Entrez, Source	EGF-like-domain, multiple 7	6196	0.001	0.2775	No
74	TACSTD2	TACSTD2 Entrez, Source	tumor-associated calcium signal transducer 2	6245	0.001	0.2739	No
75	CIITA	CIITA Entrez, Source	class II, major histocompatibility complex, transactivator	6298	-0.000	0.2700	No
76	POU4F1	POU4F1 Entrez, Source	POU domain, class 4, transcription factor 1	6349	-0.001	0.2662	No
77	DLK1	DLK1 Entrez, Source	delta-like 1 homolog (Drosophila)	6389	-0.002	0.2634	No
78	LCN2	LCN2 Entrez, Source	lipocalin 2 (oncogene 24p3)	6435	-0.002	0.2601	No
79	PRODH	PRODH Entrez, Source	proline dehydrogenase (oxidase) 1	6759	-0.008	0.2361	No
80	MSLN	MSLN Entrez, Source	mesothelin	6799	-0.009	0.2336	No
81	WASF1	WASF1 Entrez, Source	WAS protein family, member 1	6866	-0.010	0.2291	No
82	NCAM1	NCAM1 Entrez, Source	neural cell adhesion molecule 1	6887	-0.010	0.2281	No
83	ROBO1	ROBO1 Entrez, Source	roundabout, axon guidance receptor, homolog 1 (Drosophila)	6932	-0.011	0.2254	No
84	MX1	MX1 Entrez, Source	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	6942	-0.011	0.2253	No
85	FLNB	FLNB Entrez, Source	filamin B, beta (actin binding protein 278)	7002	-0.012	0.2215	No
86	ITGA6	ITGA6 Entrez, Source	integrin, alpha 6	7051	-0.013	0.2186	No
87	PDE4B	PDE4B Entrez, Source	phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)	7179	-0.015	0.2098	No
88	FGF13	FGF13 Entrez, Source	fibroblast growth factor 13	7222	-0.016	0.2075	No
89	TPSAB1	TPSAB1 Entrez, Source	tryptase alpha/beta 1	7261	-0.017	0.2055	No
90	GNAI1	GNAI1 Entrez, Source	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	7518	-0.022	0.1873	No
91	NARFL	NARFL Entrez, Source	nuclear prelamin A recognition factor-like	7560	-0.023	0.1854	No
92	NPR3	NPR3 Entrez, Source	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	7707	-0.025	0.1757	No
93	FGFR1	FGFR1 Entrez, Source	fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)	7859	-0.028	0.1658	No
94	PALM	PALM Entrez, Source	paralemmin	7979	-0.031	0.1584	No
95	GPM6B	GPM6B Entrez, Source	glycoprotein M6B	8060	-0.032	0.1541	No
96	RAP2A	RAP2A Entrez, Source	RAP2A, member of RAS oncogene family	8205	-0.035	0.1450	No
97	MYH11	MYH11 Entrez, Source	myosin, heavy chain 11, smooth muscle	8278	-0.037	0.1415	No
98	GMPR	GMPR Entrez, Source	guanosine monophosphate reductase	8380	-0.039	0.1360	No
99	ADCY3	ADCY3 Entrez, Source	adenylate cyclase 3	8509	-0.042	0.1285	No
100	BZRAP1	BZRAP1 Entrez, Source	benzodiazapine receptor (peripheral) associated protein 1	8527	-0.042	0.1294	No
101	HGF	HGF Entrez, Source	hepatocyte growth factor (hepapoietin A; scatter factor)	8951	-0.051	0.1001	No
102	CD200	CD200 Entrez, Source	CD200 molecule	9392	-0.060	0.0700	No
103	SYNGR1	SYNGR1 Entrez, Source	synaptogyrin 1	9654	-0.067	0.0538	No
104	CD3D	CD3D Entrez, Source	CD3d molecule, delta (CD3-TCR complex)	9702	-0.068	0.0538	No
105	JUP	JUP Entrez, Source	junction plakoglobin	9963	-0.075	0.0381	No
106	SNRPN /// SNURF			10197	-0.082	0.0248	No
107	MMP9	MMP9 Entrez, Source	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	10293	-0.084	0.0221	No
108	SCCPDH	SCCPDH Entrez, Source	saccharopine dehydrogenase (putative)	10543	-0.092	0.0081	No
109	SERINC5	SERINC5 Entrez, Source	serine incorporator 5	10779	-0.100	-0.0044	No
110	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	10782	-0.100	0.0007	No
111	PAM	PAM Entrez, Source	peptidylglycine alpha-amidating monooxygenase	10944	-0.106	-0.0058	No
112	CYP2E1	CYP2E1 Entrez, Source	cytochrome P450, family 2, subfamily E, polypeptide 1	11911	-0.151	-0.0710	No
113	ISG20	ISG20 Entrez, Source	interferon stimulated exonuclease gene 20kDa	11943	-0.153	-0.0652	No
114	AK3L1	AK3L1 Entrez, Source	adenylate kinase 3-like 1	12108	-0.165	-0.0689	No
115	VEGF	VEGF Entrez, Source	vascular endothelial growth factor	12221	-0.173	-0.0682	No
116	C1ORF24	C1ORF24 Entrez, Source	chromosome 1 open reading frame 24	12324	-0.182	-0.0664	No
117	CD69	CD69 Entrez, Source	CD69 molecule	12507	-0.200	-0.0695	No
118	DHRS3	DHRS3 Entrez, Source	dehydrogenase/reductase (SDR family) member 3	12528	-0.202	-0.0604	No
119	ARHGEF12	ARHGEF12 Entrez, Source	Rho guanine nucleotide exchange factor (GEF) 12	12699	-0.225	-0.0614	No
120	NT5E	NT5E Entrez, Source	5'-nucleotidase, ecto (CD73)	12800	-0.241	-0.0562	No
121	HSPB1	HSPB1 Entrez, Source	heat shock 27kDa protein 1	13125	-0.341	-0.0627	No
122	H1F0	H1F0 Entrez, Source	H1 histone family, member 0	13165	-0.372	-0.0460	No
123	VLDLR	VLDLR Entrez, Source	very low density lipoprotein receptor	13233	-0.442	-0.0277	No
124	IFI44	IFI44 Entrez, Source	interferon-induced protein 44	13315	-0.679	0.0020	No