Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | AGEING_KIDNEY_SPECIFIC_UP |
| Enrichment Score (ES) | 0.5778744 |
| Normalized Enrichment Score (NES) | 2.1348855 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.301989E-4 |
| FWER p-Value | 0.017 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 6 | 1.154 | 0.0729 | Yes |
| 2 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 11 | 0.884 | 0.1287 | Yes |
| 3 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 21 | 0.785 | 0.1780 | Yes |
| 4 | BHLHB3 | BHLHB3 Entrez, Source | basic helix-loop-helix domain containing, class B, 3 | 71 | 0.581 | 0.2112 | Yes |
| 5 | RGS1 | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 75 | 0.565 | 0.2469 | Yes |
| 6 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 138 | 0.458 | 0.2713 | Yes |
| 7 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 140 | 0.455 | 0.3002 | Yes |
| 8 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 145 | 0.452 | 0.3286 | Yes |
| 9 | CLDN1 | CLDN1 Entrez, Source | claudin 1 | 158 | 0.436 | 0.3554 | Yes |
| 10 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 288 | 0.316 | 0.3658 | Yes |
| 11 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 316 | 0.294 | 0.3824 | Yes |
| 12 | PKIB | PKIB Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor beta | 446 | 0.246 | 0.3883 | Yes |
| 13 | ITM2C | ITM2C Entrez, Source | integral membrane protein 2C | 491 | 0.231 | 0.3996 | Yes |
| 14 | MGLL | MGLL Entrez, Source | monoglyceride lipase | 510 | 0.224 | 0.4125 | Yes |
| 15 | VCAM1 | VCAM1 Entrez, Source | vascular cell adhesion molecule 1 | 516 | 0.223 | 0.4263 | Yes |
| 16 | PROM1 | PROM1 Entrez, Source | prominin 1 | 530 | 0.220 | 0.4393 | Yes |
| 17 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 550 | 0.217 | 0.4516 | Yes |
| 18 | TPBG | TPBG Entrez, Source | trophoblast glycoprotein | 607 | 0.205 | 0.4604 | Yes |
| 19 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 673 | 0.190 | 0.4676 | Yes |
| 20 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 759 | 0.176 | 0.4724 | Yes |
| 21 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 778 | 0.173 | 0.4820 | Yes |
| 22 | CLDN3 | CLDN3 Entrez, Source | claudin 3 | 788 | 0.172 | 0.4923 | Yes |
| 23 | WFDC2 | WFDC2 Entrez, Source | WAP four-disulfide core domain 2 | 805 | 0.169 | 0.5018 | Yes |
| 24 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 843 | 0.163 | 0.5094 | Yes |
| 25 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 870 | 0.160 | 0.5176 | Yes |
| 26 | LOXL1 | LOXL1 Entrez, Source | lysyl oxidase-like 1 | 1035 | 0.143 | 0.5143 | Yes |
| 27 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 1054 | 0.141 | 0.5219 | Yes |
| 28 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 1078 | 0.138 | 0.5289 | Yes |
| 29 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 1094 | 0.137 | 0.5365 | Yes |
| 30 | NOV | NOV Entrez, Source | nephroblastoma overexpressed gene | 1227 | 0.126 | 0.5345 | Yes |
| 31 | VTCN1 | VTCN1 Entrez, Source | V-set domain containing T cell activation inhibitor 1 | 1285 | 0.121 | 0.5379 | Yes |
| 32 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 1342 | 0.117 | 0.5411 | Yes |
| 33 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 1373 | 0.115 | 0.5461 | Yes |
| 34 | PRICKLE1 | PRICKLE1 Entrez, Source | prickle homolog 1 (Drosophila) | 1377 | 0.115 | 0.5532 | Yes |
| 35 | CTHRC1 | CTHRC1 Entrez, Source | collagen triple helix repeat containing 1 | 1418 | 0.112 | 0.5573 | Yes |
| 36 | SMPD2 | SMPD2 Entrez, Source | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | 1500 | 0.108 | 0.5581 | Yes |
| 37 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 1523 | 0.107 | 0.5632 | Yes |
| 38 | DEGS1 | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 1621 | 0.101 | 0.5623 | Yes |
| 39 | AMBP | AMBP Entrez, Source | alpha-1-microglobulin/bikunin precursor | 1630 | 0.101 | 0.5681 | Yes |
| 40 | FBN1 | FBN1 Entrez, Source | fibrillin 1 | 1643 | 0.100 | 0.5736 | Yes |
| 41 | DPP3 | DPP3 Entrez, Source | dipeptidyl-peptidase 3 | 1734 | 0.096 | 0.5729 | Yes |
| 42 | TMED3 | TMED3 Entrez, Source | transmembrane emp24 protein transport domain containing 3 | 1805 | 0.093 | 0.5735 | Yes |
| 43 | CXCL14 | CXCL14 Entrez, Source | chemokine (C-X-C motif) ligand 14 | 1856 | 0.090 | 0.5754 | Yes |
| 44 | FEZ2 | FEZ2 Entrez, Source | fasciculation and elongation protein zeta 2 (zygin II) | 1960 | 0.087 | 0.5731 | Yes |
| 45 | RAB34 | RAB34 Entrez, Source | RAB34, member RAS oncogene family | 2039 | 0.084 | 0.5726 | Yes |
| 46 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 2040 | 0.084 | 0.5779 | Yes |
| 47 | HEXB | HEXB Entrez, Source | hexosaminidase B (beta polypeptide) | 2133 | 0.080 | 0.5760 | No |
| 48 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 2402 | 0.071 | 0.5602 | No |
| 49 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 2485 | 0.069 | 0.5584 | No |
| 50 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 2524 | 0.067 | 0.5598 | No |
| 51 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 2660 | 0.063 | 0.5536 | No |
| 52 | FN1 | FN1 Entrez, Source | fibronectin 1 | 2715 | 0.062 | 0.5535 | No |
| 53 | NR2F1 | NR2F1 Entrez, Source | nuclear receptor subfamily 2, group F, member 1 | 2825 | 0.059 | 0.5490 | No |
| 54 | ITPR3 | ITPR3 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 3 | 2923 | 0.057 | 0.5453 | No |
| 55 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 3017 | 0.054 | 0.5417 | No |
| 56 | MOXD1 | MOXD1 Entrez, Source | monooxygenase, DBH-like 1 | 3603 | 0.041 | 0.5001 | No |
| 57 | SPARCL1 | SPARCL1 Entrez, Source | SPARC-like 1 (mast9, hevin) | 3771 | 0.037 | 0.4898 | No |
| 58 | GGTA1 | GGTA1 Entrez, Source | glycoprotein, alpha-galactosyltransferase 1 | 3898 | 0.035 | 0.4825 | No |
| 59 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 3949 | 0.034 | 0.4809 | No |
| 60 | VSNL1 | VSNL1 Entrez, Source | visinin-like 1 | 4001 | 0.033 | 0.4791 | No |
| 61 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 4269 | 0.028 | 0.4607 | No |
| 62 | ANTXR1 | ANTXR1 Entrez, Source | anthrax toxin receptor 1 | 4328 | 0.027 | 0.4580 | No |
| 63 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 4348 | 0.026 | 0.4582 | No |
| 64 | LUM | LUM Entrez, Source | lumican | 4533 | 0.023 | 0.4458 | No |
| 65 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 4730 | 0.020 | 0.4322 | No |
| 66 | GGTLA1 | GGTLA1 Entrez, Source | gamma-glutamyltransferase-like activity 1 | 4761 | 0.019 | 0.4312 | No |
| 67 | EBF1 | EBF1 Entrez, Source | early B-cell factor 1 | 5193 | 0.012 | 0.3993 | No |
| 68 | CFB | CFB Entrez, Source | complement factor B | 5251 | 0.011 | 0.3957 | No |
| 69 | C3 | C3 Entrez, Source | complement component 3 | 5333 | 0.010 | 0.3902 | No |
| 70 | RBP1 | RBP1 Entrez, Source | retinol binding protein 1, cellular | 5430 | 0.008 | 0.3835 | No |
| 71 | CDO1 | CDO1 Entrez, Source | cysteine dioxygenase, type I | 6103 | -0.002 | 0.3328 | No |
| 72 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 6107 | -0.002 | 0.3327 | No |
| 73 | GGA2 | GGA2 Entrez, Source | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | 6723 | -0.011 | 0.2869 | No |
| 74 | PLOD3 | PLOD3 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 6920 | -0.014 | 0.2730 | No |
| 75 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 7101 | -0.017 | 0.2605 | No |
| 76 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 7114 | -0.017 | 0.2606 | No |
| 77 | COL15A1 | COL15A1 Entrez, Source | collagen, type XV, alpha 1 | 7379 | -0.021 | 0.2420 | No |
| 78 | TSPAN1 | TSPAN1 Entrez, Source | tetraspanin 1 | 7605 | -0.024 | 0.2265 | No |
| 79 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 7799 | -0.027 | 0.2137 | No |
| 80 | RPN2 | RPN2 Entrez, Source | ribophorin II | 7834 | -0.028 | 0.2129 | No |
| 81 | UBD | UBD Entrez, Source | ubiquitin D | 8096 | -0.032 | 0.1952 | No |
| 82 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 8114 | -0.032 | 0.1960 | No |
| 83 | ASNS | ASNS Entrez, Source | asparagine synthetase | 8596 | -0.040 | 0.1622 | No |
| 84 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 8819 | -0.044 | 0.1483 | No |
| 85 | P4HB | P4HB Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | 9064 | -0.048 | 0.1329 | No |
| 86 | GPNMB | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 9192 | -0.050 | 0.1265 | No |
| 87 | SSR4 | SSR4 Entrez, Source | signal sequence receptor, delta (translocon-associated protein delta) | 9596 | -0.058 | 0.0997 | No |
| 88 | UBE2Z | UBE2Z Entrez, Source | ubiquitin-conjugating enzyme E2Z (putative) | 9729 | -0.061 | 0.0936 | No |
| 89 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 9857 | -0.063 | 0.0880 | No |
| 90 | FGG | FGG Entrez, Source | fibrinogen gamma chain | 9982 | -0.066 | 0.0828 | No |
| 91 | HOMER3 | HOMER3 Entrez, Source | homer homolog 3 (Drosophila) | 10174 | -0.070 | 0.0728 | No |
| 92 | SLC1A3 | SLC1A3 Entrez, Source | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 10194 | -0.070 | 0.0759 | No |
| 93 | SYMPK | SYMPK Entrez, Source | symplekin | 10270 | -0.072 | 0.0748 | No |
| 94 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 10443 | -0.076 | 0.0666 | No |
| 95 | PDGFC | PDGFC Entrez, Source | platelet derived growth factor C | 11176 | -0.095 | 0.0173 | No |
| 96 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 11237 | -0.097 | 0.0189 | No |
| 97 | RPN1 | RPN1 Entrez, Source | ribophorin I | 11310 | -0.099 | 0.0198 | No |
| 98 | RPL35 | RPL35 Entrez, Source | ribosomal protein L35 | 11505 | -0.106 | 0.0119 | No |
| 99 | NFIX | NFIX Entrez, Source | nuclear factor I/X (CCAAT-binding transcription factor) | 11585 | -0.109 | 0.0128 | No |
| 100 | VARS | VARS Entrez, Source | valyl-tRNA synthetase | 11640 | -0.111 | 0.0158 | No |
| 101 | PHLDA3 | PHLDA3 Entrez, Source | pleckstrin homology-like domain, family A, member 3 | 11766 | -0.116 | 0.0137 | No |
| 102 | GPR56 | GPR56 Entrez, Source | G protein-coupled receptor 56 | 12030 | -0.128 | 0.0019 | No |
| 103 | RPL35A | RPL35A Entrez, Source | ribosomal protein L35a | 12045 | -0.129 | 0.0090 | No |
| 104 | PDIA4 | PDIA4 Entrez, Source | protein disulfide isomerase family A, member 4 | 12175 | -0.136 | 0.0079 | No |
| 105 | COL27A1 | COL27A1 Entrez, Source | collagen, type XXVII, alpha 1 | 12236 | -0.139 | 0.0122 | No |
| 106 | RPS25 | RPS25 Entrez, Source | ribosomal protein S25 | 12629 | -0.166 | -0.0069 | No |
| 107 | RARRES1 | RARRES1 Entrez, Source | retinoic acid receptor responder (tazarotene induced) 1 | 12923 | -0.203 | -0.0161 | No |
| 108 | ABCC3 | ABCC3 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 12946 | -0.209 | -0.0045 | No |
| 109 | AATF | AATF Entrez, Source | apoptosis antagonizing transcription factor | 13019 | -0.222 | 0.0041 | No |
| 110 | CRELD2 | CRELD2 Entrez, Source | cysteine-rich with EGF-like domains 2 | 13222 | -0.318 | 0.0091 | No |
