Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | BASSO_GERMINAL_CENTER_CD40_UP |
| Enrichment Score (ES) | 0.5985149 |
| Normalized Enrichment Score (NES) | 1.9689391 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0060355505 |
| FWER p-Value | 0.295 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MAP3K8 | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 12 | 0.878 | 0.1068 | Yes |
| 2 | HLA-DMA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 32 | 0.725 | 0.1943 | Yes |
| 3 | LGALS1 | LGALS1 Entrez, Source | lectin, galactoside-binding, soluble, 1 (galectin 1) | 60 | 0.614 | 0.2675 | Yes |
| 4 | RGS1 | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 75 | 0.565 | 0.3357 | Yes |
| 5 | BCL2A1 | BCL2A1 Entrez, Source | BCL2-related protein A1 | 177 | 0.408 | 0.3782 | Yes |
| 6 | PTK2B | PTK2B Entrez, Source | PTK2B protein tyrosine kinase 2 beta | 256 | 0.337 | 0.4136 | Yes |
| 7 | TMSB4X | TMSB4X Entrez, Source | thymosin, beta 4, X-linked | 315 | 0.295 | 0.4454 | Yes |
| 8 | CCL3 | CCL3 Entrez, Source | chemokine (C-C motif) ligand 3 | 353 | 0.281 | 0.4770 | Yes |
| 9 | IER3 | IER3 Entrez, Source | immediate early response 3 | 392 | 0.264 | 0.5065 | Yes |
| 10 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 523 | 0.222 | 0.5240 | Yes |
| 11 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 754 | 0.176 | 0.5283 | Yes |
| 12 | CD40 | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 758 | 0.176 | 0.5496 | Yes |
| 13 | JUNB | JUNB Entrez, Source | jun B proto-oncogene | 861 | 0.161 | 0.5617 | Yes |
| 14 | RXRA | RXRA Entrez, Source | retinoid X receptor, alpha | 1026 | 0.144 | 0.5670 | Yes |
| 15 | IL1B | IL1B Entrez, Source | interleukin 1, beta | 1197 | 0.128 | 0.5699 | Yes |
| 16 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1210 | 0.127 | 0.5846 | Yes |
| 17 | MAPKAPK2 | MAPKAPK2 Entrez, Source | mitogen-activated protein kinase-activated protein kinase 2 | 1230 | 0.125 | 0.5985 | Yes |
| 18 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 1684 | 0.098 | 0.5764 | No |
| 19 | SNF1LK | SNF1LK Entrez, Source | SNF1-like kinase | 2345 | 0.073 | 0.5356 | No |
| 20 | LTA | LTA Entrez, Source | lymphotoxin alpha (TNF superfamily, member 1) | 2360 | 0.072 | 0.5434 | No |
| 21 | ZFP36L1 | ZFP36L1 Entrez, Source | zinc finger protein 36, C3H type-like 1 | 2445 | 0.070 | 0.5456 | No |
| 22 | DUSP2 | DUSP2 Entrez, Source | dual specificity phosphatase 2 | 2724 | 0.062 | 0.5323 | No |
| 23 | LITAF | LITAF Entrez, Source | lipopolysaccharide-induced TNF factor | 2826 | 0.059 | 0.5320 | No |
| 24 | ELL2 | ELL2 Entrez, Source | elongation factor, RNA polymerase II, 2 | 3352 | 0.046 | 0.4981 | No |
| 25 | DTX2 | DTX2 Entrez, Source | deltex homolog 2 (Drosophila) | 3529 | 0.042 | 0.4901 | No |
| 26 | SYNGR2 | SYNGR2 Entrez, Source | synaptogyrin 2 | 4223 | 0.029 | 0.4414 | No |
| 27 | IFI30 | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 4301 | 0.027 | 0.4390 | No |
| 28 | SH2B3 | SH2B3 Entrez, Source | SH2B adaptor protein 3 | 4523 | 0.023 | 0.4251 | No |
| 29 | TRIP10 | TRIP10 Entrez, Source | thyroid hormone receptor interactor 10 | 5381 | 0.009 | 0.3617 | No |
| 30 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 5682 | 0.005 | 0.3397 | No |
| 31 | EHD1 | EHD1 Entrez, Source | EH-domain containing 1 | 5701 | 0.004 | 0.3389 | No |
| 32 | SNN | SNN Entrez, Source | stannin | 5710 | 0.004 | 0.3388 | No |
| 33 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 5914 | 0.001 | 0.3237 | No |
| 34 | STK10 | STK10 Entrez, Source | serine/threonine kinase 10 | 6042 | -0.001 | 0.3142 | No |
| 35 | CCL22 | CCL22 Entrez, Source | chemokine (C-C motif) ligand 22 | 6089 | -0.001 | 0.3109 | No |
| 36 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 6363 | -0.006 | 0.2910 | No |
| 37 | LAPTM5 | LAPTM5 Entrez, Source | lysosomal associated multispanning membrane protein 5 | 6572 | -0.009 | 0.2764 | No |
| 38 | BLR1 | BLR1 Entrez, Source | Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5) | 6582 | -0.009 | 0.2768 | No |
| 39 | CCL4 | CCL4 Entrez, Source | chemokine (C-C motif) ligand 4 | 6591 | -0.009 | 0.2773 | No |
| 40 | PHACTR1 | PHACTR1 Entrez, Source | phosphatase and actin regulator 1 | 6730 | -0.011 | 0.2683 | No |
| 41 | UNC119 | UNC119 Entrez, Source | unc-119 homolog (C. elegans) | 7505 | -0.023 | 0.2128 | No |
| 42 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 7555 | -0.023 | 0.2120 | No |
| 43 | RAB27A | RAB27A Entrez, Source | RAB27A, member RAS oncogene family | 7609 | -0.024 | 0.2110 | No |
| 44 | PLEK | PLEK Entrez, Source | pleckstrin | 7997 | -0.031 | 0.1856 | No |
| 45 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 8130 | -0.033 | 0.1797 | No |
| 46 | TCEB3 | TCEB3 Entrez, Source | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) | 9004 | -0.047 | 0.1198 | No |
| 47 | LYN | LYN Entrez, Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 9007 | -0.047 | 0.1255 | No |
| 48 | TNFSF9 | TNFSF9 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 9 | 9166 | -0.050 | 0.1197 | No |
| 49 | NEF3 | NEF3 Entrez, Source | neurofilament 3 (150kDa medium) | 9216 | -0.051 | 0.1223 | No |
| 50 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 9267 | -0.052 | 0.1249 | No |
| 51 | STAT5A | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 9723 | -0.060 | 0.0981 | No |
| 52 | PRG1 | PRG1 Entrez, Source | proteoglycan 1, secretory granule | 10004 | -0.066 | 0.0851 | No |
| 53 | KCNN4 | KCNN4 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 10587 | -0.080 | 0.0511 | No |
| 54 | HTR3A | HTR3A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3A | 10609 | -0.080 | 0.0593 | No |
| 55 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 10770 | -0.085 | 0.0576 | No |
| 56 | DDIT4 | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 11645 | -0.111 | 0.0055 | No |
| 57 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 12802 | -0.185 | -0.0588 | No |
| 58 | TAP1 | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 12854 | -0.192 | -0.0390 | No |
| 59 | CD74 | CD74 Entrez, Source | CD74 molecule, major histocompatibility complex, class II invariant chain | 13325 | -0.617 | 0.0013 | No |
