Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | BLEO_HUMAN_LYMPH_HIGH_24HRS_UP |
| Enrichment Score (ES) | 0.5418125 |
| Normalized Enrichment Score (NES) | 1.8158815 |
| Nominal p-value | 0.0017421603 |
| FDR q-value | 0.02268017 |
| FWER p-Value | 0.936 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 10 | 0.885 | 0.1116 | Yes |
| 2 | CCL20 | CCL20 Entrez, Source | chemokine (C-C motif) ligand 20 | 50 | 0.641 | 0.1899 | Yes |
| 3 | RGS16 | RGS16 Entrez, Source | regulator of G-protein signalling 16 | 103 | 0.505 | 0.2501 | Yes |
| 4 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 145 | 0.452 | 0.3044 | Yes |
| 5 | GDF15 | GDF15 Entrez, Source | growth differentiation factor 15 | 385 | 0.267 | 0.3202 | Yes |
| 6 | ZFP36L2 | ZFP36L2 Entrez, Source | zinc finger protein 36, C3H type-like 2 | 498 | 0.228 | 0.3407 | Yes |
| 7 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 523 | 0.222 | 0.3671 | Yes |
| 8 | CCR1 | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 564 | 0.213 | 0.3911 | Yes |
| 9 | ANXA4 | ANXA4 Entrez, Source | annexin A4 | 736 | 0.179 | 0.4010 | Yes |
| 10 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 754 | 0.176 | 0.4220 | Yes |
| 11 | CD40 | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 758 | 0.176 | 0.4441 | Yes |
| 12 | LPXN | LPXN Entrez, Source | leupaxin | 785 | 0.172 | 0.4640 | Yes |
| 13 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 880 | 0.159 | 0.4771 | Yes |
| 14 | PLD3 | PLD3 Entrez, Source | phospholipase D family, member 3 | 959 | 0.151 | 0.4903 | Yes |
| 15 | PRKAB1 | PRKAB1 Entrez, Source | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 1059 | 0.140 | 0.5006 | Yes |
| 16 | BASP1 | BASP1 Entrez, Source | brain abundant, membrane attached signal protein 1 | 1105 | 0.136 | 0.5145 | Yes |
| 17 | TAX1BP3 | TAX1BP3 Entrez, Source | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 1166 | 0.131 | 0.5266 | Yes |
| 18 | CAPN1 | CAPN1 Entrez, Source | calpain 1, (mu/I) large subunit | 1394 | 0.114 | 0.5239 | Yes |
| 19 | RUNX3 | RUNX3 Entrez, Source | runt-related transcription factor 3 | 1657 | 0.100 | 0.5168 | Yes |
| 20 | SH3BP5 | SH3BP5 Entrez, Source | SH3-domain binding protein 5 (BTK-associated) | 1659 | 0.100 | 0.5294 | Yes |
| 21 | PKIG | PKIG Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | 1880 | 0.089 | 0.5242 | Yes |
| 22 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 2074 | 0.082 | 0.5201 | Yes |
| 23 | SMARCA2 | SMARCA2 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 2300 | 0.074 | 0.5125 | Yes |
| 24 | LTA | LTA Entrez, Source | lymphotoxin alpha (TNF superfamily, member 1) | 2360 | 0.072 | 0.5172 | Yes |
| 25 | ENC1 | ENC1 Entrez, Source | ectodermal-neural cortex (with BTB-like domain) | 2392 | 0.071 | 0.5239 | Yes |
| 26 | CRYZ | CRYZ Entrez, Source | crystallin, zeta (quinone reductase) | 2492 | 0.068 | 0.5251 | Yes |
| 27 | PRKAR1A | PRKAR1A Entrez, Source | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) | 2585 | 0.065 | 0.5265 | Yes |
| 28 | BTG1 | BTG1 Entrez, Source | B-cell translocation gene 1, anti-proliferative | 2629 | 0.064 | 0.5313 | Yes |
| 29 | CTSH | CTSH Entrez, Source | cathepsin H | 2723 | 0.062 | 0.5322 | Yes |
| 30 | DUSP2 | DUSP2 Entrez, Source | dual specificity phosphatase 2 | 2724 | 0.062 | 0.5401 | Yes |
| 31 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 2803 | 0.060 | 0.5418 | Yes |
| 32 | PTP4A1 | PTP4A1 Entrez, Source | protein tyrosine phosphatase type IVA, member 1 | 3208 | 0.049 | 0.5177 | No |
| 33 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 3506 | 0.043 | 0.5007 | No |
| 34 | EI24 | EI24 Entrez, Source | etoposide induced 2.4 mRNA | 4045 | 0.032 | 0.4643 | No |
| 35 | HCLS1 | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 4075 | 0.031 | 0.4661 | No |
| 36 | SMTN | SMTN Entrez, Source | smoothelin | 4588 | 0.022 | 0.4303 | No |
| 37 | CCNG1 | CCNG1 Entrez, Source | cyclin G1 | 4877 | 0.017 | 0.4108 | No |
| 38 | RPS6KA1 | RPS6KA1 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 5579 | 0.006 | 0.3588 | No |
| 39 | BRD2 | BRD2 Entrez, Source | bromodomain containing 2 | 6500 | -0.008 | 0.2905 | No |
| 40 | LAPTM5 | LAPTM5 Entrez, Source | lysosomal associated multispanning membrane protein 5 | 6572 | -0.009 | 0.2862 | No |
| 41 | CCL4 | CCL4 Entrez, Source | chemokine (C-C motif) ligand 4 | 6591 | -0.009 | 0.2860 | No |
| 42 | STAT3 | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 6946 | -0.014 | 0.2611 | No |
| 43 | FDXR | FDXR Entrez, Source | ferredoxin reductase | 7264 | -0.019 | 0.2397 | No |
| 44 | MRPL49 | MRPL49 Entrez, Source | mitochondrial ribosomal protein L49 | 7448 | -0.022 | 0.2287 | No |
| 45 | HIF1A | HIF1A Entrez, Source | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 7751 | -0.027 | 0.2093 | No |
| 46 | WDR1 | WDR1 Entrez, Source | WD repeat domain 1 | 7900 | -0.029 | 0.2019 | No |
| 47 | PLEK | PLEK Entrez, Source | pleckstrin | 7997 | -0.031 | 0.1986 | No |
| 48 | CCL5 | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 8913 | -0.046 | 0.1355 | No |
| 49 | MARCKS | MARCKS Entrez, Source | myristoylated alanine-rich protein kinase C substrate | 8955 | -0.047 | 0.1383 | No |
| 50 | TNFSF9 | TNFSF9 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 9 | 9166 | -0.050 | 0.1289 | No |
| 51 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 9267 | -0.052 | 0.1279 | No |
| 52 | PLXNB2 | PLXNB2 Entrez, Source | plexin B2 | 9951 | -0.066 | 0.0848 | No |
| 53 | PRG1 | PRG1 Entrez, Source | proteoglycan 1, secretory granule | 10004 | -0.066 | 0.0893 | No |
| 54 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 10152 | -0.069 | 0.0871 | No |
| 55 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 10770 | -0.085 | 0.0513 | No |
| 56 | NCOA3 | NCOA3 Entrez, Source | nuclear receptor coactivator 3 | 11864 | -0.120 | -0.0157 | No |
| 57 | GCH1 | GCH1 Entrez, Source | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 12523 | -0.156 | -0.0455 | No |
| 58 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 12777 | -0.181 | -0.0415 | No |
| 59 | GPX1 | GPX1 Entrez, Source | glutathione peroxidase 1 | 12783 | -0.183 | -0.0187 | No |
| 60 | MYO5A | MYO5A Entrez, Source | myosin VA (heavy chain 12, myoxin) | 12912 | -0.201 | -0.0029 | No |
| 61 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 13164 | -0.277 | 0.0134 | No |
