Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_8d_versus_double_gel_48h.class.cls
#double_gel_8d_versus_double_gel_48h_repos
Phenotypeclass.cls#double_gel_8d_versus_double_gel_48h_repos
Upregulated in classdouble_gel_8d
GeneSetBOQUEST_CD31PLUS_VS_CD31MINUS_DN
Enrichment Score (ES)0.5467743
Normalized Enrichment Score (NES)2.0922647
Nominal p-value0.0
FDR q-value0.0011698724
FWER p-Value0.033
Table: GSEA Results Summary



Fig 1: Enrichment plot: BOQUEST_CD31PLUS_VS_CD31MINUS_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1COL1A2COL1A2
Entrez,  Source
collagen, type I, alpha 261.1540.0586Yes
2COL3A1COL3A1
Entrez,  Source
collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)210.7850.0977Yes
3COL5A2COL5A2
Entrez,  Source
collagen, type V, alpha 2340.7140.1334Yes
4MGPMGP
Entrez,  Source
matrix Gla protein520.6340.1645Yes
5BHLHB3BHLHB3
Entrez,  Source
basic helix-loop-helix domain containing, class B, 3710.5810.1929Yes
6CRYABCRYAB
Entrez,  Source
crystallin, alpha B1060.4940.2156Yes
7OMDOMD
Entrez,  Source
osteomodulin1090.4900.2405Yes
8TNFAIP6TNFAIP6
Entrez,  Source
tumor necrosis factor, alpha-induced protein 61160.4830.2648Yes
9MRC2MRC2
Entrez,  Source
mannose receptor, C type 21200.4760.2890Yes
10SERPINE2SERPINE2
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 21400.4550.3108Yes
11LOXLOX
Entrez,  Source
lysyl oxidase1540.4410.3324Yes
12FSTFST
Entrez,  Source
follistatin1690.4230.3531Yes
13PRELPPRELP
Entrez,  Source
proline/arginine-rich end leucine-rich repeat protein2040.3830.3701Yes
14CFDCFD
Entrez,  Source
complement factor D (adipsin)2280.3650.3870Yes
15PTPRDPTPRD
Entrez,  Source
protein tyrosine phosphatase, receptor type, D3300.2900.3942Yes
16ACOX2ACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain3790.2690.4043Yes
17TMEM176BTMEM176B
Entrez,  Source
transmembrane protein 176B4030.2580.4158Yes
18GSNGSN
Entrez,  Source
gelsolin (amyloidosis, Finnish type)4830.2330.4218Yes
19IGFBP3IGFBP3
Entrez,  Source
insulin-like growth factor binding protein 35710.2120.4260Yes
20PLAGL1PLAGL1
Entrez,  Source
pleiomorphic adenoma gene-like 15760.2110.4365Yes
21SGCESGCE
Entrez,  Source
sarcoglycan, epsilon6500.1970.4411Yes
22COL6A2COL6A2
Entrez,  Source
collagen, type VI, alpha 26580.1950.4505Yes
23COL1A1COL1A1
Entrez,  Source
collagen, type I, alpha 16730.1900.4592Yes
24ALDH1A1ALDH1A1
Entrez,  Source
aldehyde dehydrogenase 1 family, member A17390.1780.4634Yes
25EMP3EMP3
Entrez,  Source
epithelial membrane protein 37550.1760.4713Yes
26TIMP1TIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 17590.1760.4801Yes
27FEZ1FEZ1
Entrez,  Source
fasciculation and elongation protein zeta 1 (zygin I)7940.1700.4862Yes
28GSTM3GSTM3
Entrez,  Source
glutathione S-transferase M3 (brain)8900.1570.4871Yes
29F3F3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)9430.1520.4909Yes
30S100A4S100A4
Entrez,  Source
S100 calcium binding protein A49620.1510.4972Yes
31SCRN1SCRN1
Entrez,  Source
secernin 110230.1450.5001Yes
32PDE4DIPPDE4DIP
Entrez,  Source
phosphodiesterase 4D interacting protein (myomegalin)10770.1380.5031Yes
33BASP1BASP1
Entrez,  Source
brain abundant, membrane attached signal protein 111050.1360.5081Yes
34LIFLIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)12030.1270.5072Yes
35PCOLCEPCOLCE
Entrez,  Source
procollagen C-endopeptidase enhancer12140.1260.5129Yes
36CD302CD302
Entrez,  Source
CD302 molecule12330.1250.5180Yes
37TSPAN8TSPAN8
Entrez,  Source
tetraspanin 813110.1190.5182Yes
38SERPINA5SERPINA5
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 513140.1190.5242Yes
39AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase13730.1150.5257Yes
40TWIST1TWIST1
Entrez,  Source
twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)13800.1150.5311Yes
41PLNPLN
Entrez,  Source
phospholamban14200.1120.5339Yes
42RNASE4RNASE4
Entrez,  Source
ribonuclease, RNase A family, 415250.1070.5314Yes
43DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 215980.1030.5312Yes
44OSR2OSR2
Entrez,  Source
odd-skipped related 2 (Drosophila)16150.1020.5352Yes
45FBN1FBN1
Entrez,  Source
fibrillin 116430.1000.5383Yes
46GPC3GPC3
Entrez,  Source
glypican 316560.1000.5425Yes
47DCXDCX
Entrez,  Source
doublecortex; lissencephaly, X-linked (doublecortin)17080.0970.5436Yes
48FXYD1FXYD1
Entrez,  Source
FXYD domain containing ion transport regulator 1 (phospholemman)17810.0940.5430Yes
49TMED3TMED3
Entrez,  Source
transmembrane emp24 protein transport domain containing 318050.0930.5459Yes
50CXCL14CXCL14
Entrez,  Source
chemokine (C-X-C motif) ligand 1418560.0900.5468Yes
51APOEAPOE
Entrez,  Source
apolipoprotein E21230.0800.5307No
52CHRDL1CHRDL1
Entrez,  Source
chordin-like 121700.0780.5312No
53DZIP1DZIP1
Entrez,  Source
DAZ interacting protein 122290.0760.5307No
54WISP2WISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 222850.0740.5304No
55IGFBP6IGFBP6
Entrez,  Source
insulin-like growth factor binding protein 623560.0720.5288No
56CUGBP2CUGBP2
Entrez,  Source
CUG triplet repeat, RNA binding protein 224510.0690.5252No
57COL5A1COL5A1
Entrez,  Source
collagen, type V, alpha 126600.0630.5127No
58EDG2EDG2
Entrez,  Source
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 226900.0630.5137No
59ANGPT1ANGPT1
Entrez,  Source
angiopoietin 127820.0610.5099No
60CEBPBCEBPB
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), beta28480.0590.5080No
61HTRA1HTRA1
Entrez,  Source
HtrA serine peptidase 128800.0580.5086No
62HNMTHNMT
Entrez,  Source
histamine N-methyltransferase30980.0520.4948No
63MFAP4MFAP4
Entrez,  Source
microfibrillar-associated protein 431050.0520.4970No
64LTBP2LTBP2
Entrez,  Source
latent transforming growth factor beta binding protein 231070.0520.4995No
65MAFBMAFB
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)31220.0510.5011No
66APODAPOD
Entrez,  Source
apolipoprotein D32550.0480.4936No
67PTGFRPTGFR
Entrez,  Source
prostaglandin F receptor (FP)33310.0470.4903No
68DCNDCN
Entrez,  Source
decorin34050.0450.4870No
69PDGFDPDGFD
Entrez,  Source
platelet derived growth factor D34420.0440.4866No
70COL16A1COL16A1
Entrez,  Source
collagen, type XVI, alpha 135300.0420.4821No
71PDLIM3PDLIM3
Entrez,  Source
PDZ and LIM domain 335600.0420.4821No
72KCNK1KCNK1
Entrez,  Source
potassium channel, subfamily K, member 136120.0410.4803No
73ASPAASPA
Entrez,  Source
aspartoacylase (Canavan disease)36810.0390.4771No
74GAS7GAS7
Entrez,  Source
growth arrest-specific 739560.0340.4581No
75FGF7FGF7
Entrez,  Source
fibroblast growth factor 7 (keratinocyte growth factor)41560.0300.4445No
76CYBRD1CYBRD1
Entrez,  Source
cytochrome b reductase 145110.0230.4189No
77LUMLUM
Entrez,  Source
lumican45330.0230.4184No
78GDF10GDF10
Entrez,  Source
growth differentiation factor 1045640.0220.4173No
79PTGISPTGIS
Entrez,  Source
prostaglandin I2 (prostacyclin) synthase46530.0210.4117No
80PLA2G4APLA2G4A
Entrez,  Source
phospholipase A2, group IVA (cytosolic, calcium-dependent)46880.0200.4101No
81SERPINF1SERPINF1
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 146970.0200.4106No
82GFPT2GFPT2
Entrez,  Source
glutamine-fructose-6-phosphate transaminase 249650.0160.3911No
83NET1NET1
Entrez,  Source
neuroepithelial cell transforming gene 150250.0150.3874No
84INHBAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)50810.0140.3840No
85PLA2G2APLA2G2A
Entrez,  Source
phospholipase A2, group IIA (platelets, synovial fluid)51990.0120.3757No
86CFBCFB
Entrez,  Source
complement factor B52510.0110.3724No
87SLIT2SLIT2
Entrez,  Source
slit homolog 2 (Drosophila)52930.0100.3698No
88CXCL12CXCL12
Entrez,  Source
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)53020.0100.3697No
89LRP1LRP1
Entrez,  Source
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)57700.0030.3345No
90MMP2MMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)57800.0030.3339No
91BMPR1ABMPR1A
Entrez,  Source
bone morphogenetic protein receptor, type IA6028-0.0000.3152No
92PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide6101-0.0020.3098No
93CDO1CDO1
Entrez,  Source
cysteine dioxygenase, type I6103-0.0020.3099No
94GPC4GPC4
Entrez,  Source
glypican 46215-0.0030.3016No
95SPOCK1SPOCK1
Entrez,  Source
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 16415-0.0060.2869No
96GSTM5GSTM5
Entrez,  Source
glutathione S-transferase M56680-0.0100.2674No
97THBS2THBS2
Entrez,  Source
thrombospondin 26731-0.0110.2642No
98CRABP2CRABP2
Entrez,  Source
cellular retinoic acid binding protein 26879-0.0130.2537No
99ANPEPANPEP
Entrez,  Source
alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)6961-0.0140.2483No
100CDKN2CCDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)7011-0.0150.2453No
101CDH11CDH11
Entrez,  Source
cadherin 11, type 2, OB-cadherin (osteoblast)7101-0.0170.2395No
102CFHCFH
Entrez,  Source
complement factor H7191-0.0180.2336No
103SFRP4SFRP4
Entrez,  Source
secreted frizzled-related protein 47370-0.0210.2212No
104PDGFRLPDGFRL
Entrez,  Source
platelet-derived growth factor receptor-like7568-0.0240.2075No
105MMEMME
Entrez,  Source
membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)7622-0.0250.2047No
106NOVA1NOVA1
Entrez,  Source
neuro-oncological ventral antigen 17658-0.0250.2033No
107NT5ENT5E
Entrez,  Source
5'-nucleotidase, ecto (CD73)7715-0.0260.2004No
108C6C6
Entrez,  Source
complement component 67841-0.0280.1924No
109F10F10
Entrez,  Source
coagulation factor X7895-0.0290.1899No
110IGF1IGF1
Entrez,  Source
insulin-like growth factor 1 (somatomedin C)7950-0.0300.1873No
111FBLN5FBLN5
Entrez,  Source
fibulin 58019-0.0310.1837No
112NPY1RNPY1R
Entrez,  Source
neuropeptide Y receptor Y18092-0.0320.1799No
113CTSKCTSK
Entrez,  Source
cathepsin K (pycnodysostosis)8117-0.0320.1798No
114EFEMP1EFEMP1
Entrez,  Source
EGF-containing fibulin-like extracellular matrix protein 18124-0.0330.1810No
115PTGDSPTGDS
Entrez,  Source
prostaglandin D2 synthase 21kDa (brain)8146-0.0330.1811No
116LRRC17LRRC17
Entrez,  Source
leucine rich repeat containing 178238-0.0350.1760No
117FMODFMOD
Entrez,  Source
fibromodulin8247-0.0350.1771No
118KCND2KCND2
Entrez,  Source
potassium voltage-gated channel, Shal-related subfamily, member 28361-0.0370.1705No
119CAPN6CAPN6
Entrez,  Source
calpain 68491-0.0390.1627No
120SLIT3SLIT3
Entrez,  Source
slit homolog 3 (Drosophila)8691-0.0420.1497No
121SPON2SPON2
Entrez,  Source
spondin 2, extracellular matrix protein8759-0.0430.1468No
122SDC2SDC2
Entrez,  Source
syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)8914-0.0460.1375No
123PRRX1PRRX1
Entrez,  Source
paired related homeobox 18971-0.0470.1357No
124MBPMBP
Entrez,  Source
myelin basic protein8983-0.0470.1372No
125GPNMBGPNMB
Entrez,  Source
glycoprotein (transmembrane) nmb9192-0.0500.1241No
126CSPG2CSPG2
Entrez,  Source
chondroitin sulfate proteoglycan 2 (versican)9690-0.0600.0894No
127DCAMKL1DCAMKL1
Entrez,  Source
doublecortin and CaM kinase-like 19719-0.0600.0904No
128IRS1IRS1
Entrez,  Source
insulin receptor substrate 19795-0.0620.0879No
129ATP1A2ATP1A2
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide9825-0.0630.0889No
130GRIA3GRIA3
Entrez,  Source
glutamate receptor, ionotrophic, AMPA 39917-0.0650.0853No
131MYH11MYH11
Entrez,  Source
myosin, heavy chain 11, smooth muscle10036-0.0670.0798No
132MYOCMYOC
Entrez,  Source
myocilin, trabecular meshwork inducible glucocorticoid response10189-0.0700.0719No
133COLEC12COLEC12
Entrez,  Source
collectin sub-family member 1210217-0.0710.0734No
134HSPB8HSPB8
Entrez,  Source
heat shock 22kDa protein 810232-0.0710.0760No
135SLC22A3SLC22A3
Entrez,  Source
solute carrier family 22 (extraneuronal monoamine transporter), member 310247-0.0710.0786No
136SRPXSRPX
Entrez,  Source
sushi-repeat-containing protein, X-linked10360-0.0740.0739No
137FIGFFIGF
Entrez,  Source
c-fos induced growth factor (vascular endothelial growth factor D)10740-0.0840.0495No
138FAPFAP
Entrez,  Source
fibroblast activation protein, alpha11212-0.0960.0187No
139WNT5AWNT5A
Entrez,  Source
wingless-type MMTV integration site family, member 5A11232-0.0970.0222No
140NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 211369-0.1010.0170No
141SHOX2SHOX2
Entrez,  Source
short stature homeobox 211372-0.1010.0221No
142LSP1LSP1
Entrez,  Source
lymphocyte-specific protein 111557-0.1080.0136No
143OGTOGT
Entrez,  Source
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)11749-0.1150.0050No
144ROBO1ROBO1
Entrez,  Source
roundabout, axon guidance receptor, homolog 1 (Drosophila)12116-0.133-0.0159No
145SOX9SOX9
Entrez,  Source
SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)12407-0.149-0.0303No
146C1ORF24C1ORF24
Entrez,  Source
chromosome 1 open reading frame 2412569-0.160-0.0343No
147NOTCH2NOTCH2
Entrez,  Source
Notch homolog 2 (Drosophila)12769-0.180-0.0402No
148CD44CD44
Entrez,  Source
CD44 molecule (Indian blood group)12802-0.185-0.0331No
149EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)12857-0.193-0.0274No
150UGDHUGDH
Entrez,  Source
UDP-glucose dehydrogenase13081-0.242-0.0319No
151FMO1FMO1
Entrez,  Source
flavin containing monooxygenase 113123-0.259-0.0217No
152AOX1AOX1
Entrez,  Source
aldehyde oxidase 113251-0.347-0.0136No
153CES1CES1
Entrez,  Source
carboxylesterase 1 (monocyte/macrophage serine esterase 1)13281-0.3990.0046No
Table: GSEA details [plain text format]



Fig 2: BOQUEST_CD31PLUS_VS_CD31MINUS_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: BOQUEST_CD31PLUS_VS_CD31MINUS_DN: Random ES distribution   
Gene set null distribution of ES for BOQUEST_CD31PLUS_VS_CD31MINUS_DN