Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | BRCA_BRCA1_NEG |
| Enrichment Score (ES) | 0.52702177 |
| Normalized Enrichment Score (NES) | 1.8824444 |
| Nominal p-value | 0.0016949152 |
| FDR q-value | 0.014752431 |
| FWER p-Value | 0.697 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IGFBP7 | IGFBP7 Entrez, Source | insulin-like growth factor binding protein 7 | 2 | 1.254 | 0.1128 | Yes |
| 2 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 21 | 0.785 | 0.1822 | Yes |
| 3 | HMGCS2 | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 83 | 0.552 | 0.2274 | Yes |
| 4 | BEXL1 | BEXL1 Entrez, Source | brain expressed X-linked-like 1 | 110 | 0.489 | 0.2694 | Yes |
| 5 | GJA1 | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 173 | 0.414 | 0.3021 | Yes |
| 6 | DCI | DCI Entrez, Source | dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase) | 226 | 0.365 | 0.3311 | Yes |
| 7 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 230 | 0.365 | 0.3637 | Yes |
| 8 | AHNAK | AHNAK Entrez, Source | AHNAK nucleoprotein (desmoyokin) | 255 | 0.338 | 0.3923 | Yes |
| 9 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 316 | 0.294 | 0.4142 | Yes |
| 10 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 317 | 0.293 | 0.4407 | Yes |
| 11 | ACOX2 | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 379 | 0.269 | 0.4603 | Yes |
| 12 | HDGFRP3 | HDGFRP3 Entrez, Source | - | 724 | 0.182 | 0.4507 | Yes |
| 13 | RETSAT | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 730 | 0.181 | 0.4666 | Yes |
| 14 | EMP2 | EMP2 Entrez, Source | epithelial membrane protein 2 | 773 | 0.174 | 0.4791 | Yes |
| 15 | PPT1 | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 810 | 0.168 | 0.4915 | Yes |
| 16 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 870 | 0.160 | 0.5014 | Yes |
| 17 | PALMD | PALMD Entrez, Source | palmdelphin | 986 | 0.148 | 0.5060 | Yes |
| 18 | KLF9 | KLF9 Entrez, Source | Kruppel-like factor 9 | 998 | 0.147 | 0.5185 | Yes |
| 19 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 1054 | 0.141 | 0.5270 | Yes |
| 20 | TSPAN8 | TSPAN8 Entrez, Source | tetraspanin 8 | 1311 | 0.119 | 0.5184 | No |
| 21 | DUSP6 | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 1504 | 0.108 | 0.5137 | No |
| 22 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 1523 | 0.107 | 0.5220 | No |
| 23 | STXBP1 | STXBP1 Entrez, Source | syntaxin binding protein 1 | 1838 | 0.091 | 0.5065 | No |
| 24 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 1859 | 0.090 | 0.5131 | No |
| 25 | STK39 | STK39 Entrez, Source | serine threonine kinase 39 (STE20/SPS1 homolog, yeast) | 2034 | 0.084 | 0.5075 | No |
| 26 | CTSF | CTSF Entrez, Source | cathepsin F | 2228 | 0.076 | 0.4998 | No |
| 27 | STARD10 | STARD10 Entrez, Source | START domain containing 10 | 2321 | 0.073 | 0.4995 | No |
| 28 | ENC1 | ENC1 Entrez, Source | ectodermal-neural cortex (with BTB-like domain) | 2392 | 0.071 | 0.5006 | No |
| 29 | DUSP4 | DUSP4 Entrez, Source | dual specificity phosphatase 4 | 2400 | 0.071 | 0.5064 | No |
| 30 | INPP4B | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2455 | 0.069 | 0.5086 | No |
| 31 | TMEM98 | TMEM98 Entrez, Source | transmembrane protein 98 | 2645 | 0.064 | 0.5001 | No |
| 32 | GPC1 | GPC1 Entrez, Source | glypican 1 | 2672 | 0.063 | 0.5038 | No |
| 33 | PIB5PA | PIB5PA Entrez, Source | phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A | 2721 | 0.062 | 0.5058 | No |
| 34 | HTRA1 | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 2880 | 0.058 | 0.4991 | No |
| 35 | NPTN | NPTN Entrez, Source | neuroplastin | 3153 | 0.051 | 0.4831 | No |
| 36 | GREM1 | GREM1 Entrez, Source | gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) | 3429 | 0.044 | 0.4664 | No |
| 37 | PDLIM3 | PDLIM3 Entrez, Source | PDZ and LIM domain 3 | 3560 | 0.042 | 0.4603 | No |
| 38 | GOSR1 | GOSR1 Entrez, Source | golgi SNAP receptor complex member 1 | 3587 | 0.041 | 0.4620 | No |
| 39 | CHGA | CHGA Entrez, Source | chromogranin A (parathyroid secretory protein 1) | 3900 | 0.035 | 0.4416 | No |
| 40 | CXCR7 | CXCR7 Entrez, Source | chemokine (C-X-C motif) receptor 7 | 3953 | 0.034 | 0.4407 | No |
| 41 | RAB3B | RAB3B Entrez, Source | RAB3B, member RAS oncogene family | 4139 | 0.030 | 0.4295 | No |
| 42 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 4179 | 0.030 | 0.4292 | No |
| 43 | GALNT7 | GALNT7 Entrez, Source | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) | 4259 | 0.028 | 0.4258 | No |
| 44 | SCAMP1 | SCAMP1 Entrez, Source | secretory carrier membrane protein 1 | 4333 | 0.027 | 0.4227 | No |
| 45 | CPE | CPE Entrez, Source | carboxypeptidase E | 4444 | 0.025 | 0.4166 | No |
| 46 | DUSP13 | DUSP13 Entrez, Source | dual specificity phosphatase 13 | 4468 | 0.024 | 0.4170 | No |
| 47 | WT1 | WT1 Entrez, Source | Wilms tumor 1 | 4628 | 0.021 | 0.4069 | No |
| 48 | SERPINF1 | SERPINF1 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 4697 | 0.020 | 0.4036 | No |
| 49 | DNALI1 | DNALI1 Entrez, Source | dynein, axonemal, light intermediate chain 1 | 4823 | 0.018 | 0.3958 | No |
| 50 | DNAJA4 | DNAJA4 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 4 | 5030 | 0.015 | 0.3816 | No |
| 51 | GATA3 | GATA3 Entrez, Source | GATA binding protein 3 | 5124 | 0.013 | 0.3757 | No |
| 52 | LASP1 | LASP1 Entrez, Source | LIM and SH3 protein 1 | 5185 | 0.012 | 0.3723 | No |
| 53 | COL23A1 | COL23A1 Entrez, Source | collagen, type XXIII, alpha 1 | 5372 | 0.009 | 0.3590 | No |
| 54 | PNMT | PNMT Entrez, Source | phenylethanolamine N-methyltransferase | 5467 | 0.008 | 0.3526 | No |
| 55 | PARVA | PARVA Entrez, Source | parvin, alpha | 5605 | 0.006 | 0.3428 | No |
| 56 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 5723 | 0.004 | 0.3343 | No |
| 57 | GPRC5C | GPRC5C Entrez, Source | G protein-coupled receptor, family C, group 5, member C | 6046 | -0.001 | 0.3101 | No |
| 58 | SLC9A2 | SLC9A2 Entrez, Source | solute carrier family 9 (sodium/hydrogen exchanger), member 2 | 6191 | -0.003 | 0.2995 | No |
| 59 | GPC4 | GPC4 Entrez, Source | glypican 4 | 6215 | -0.003 | 0.2981 | No |
| 60 | SH3BP4 | SH3BP4 Entrez, Source | SH3-domain binding protein 4 | 6416 | -0.007 | 0.2835 | No |
| 61 | ETFB | ETFB Entrez, Source | electron-transfer-flavoprotein, beta polypeptide | 6510 | -0.008 | 0.2772 | No |
| 62 | CRYM | CRYM Entrez, Source | crystallin, mu | 6577 | -0.009 | 0.2730 | No |
| 63 | HAGH | HAGH Entrez, Source | hydroxyacylglutathione hydrolase | 6818 | -0.012 | 0.2560 | No |
| 64 | HSD11B2 | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 6935 | -0.014 | 0.2486 | No |
| 65 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 7101 | -0.017 | 0.2376 | No |
| 66 | UNC119 | UNC119 Entrez, Source | unc-119 homolog (C. elegans) | 7505 | -0.023 | 0.2092 | No |
| 67 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 8114 | -0.032 | 0.1663 | No |
| 68 | LRRC17 | LRRC17 Entrez, Source | leucine rich repeat containing 17 | 8238 | -0.035 | 0.1601 | No |
| 69 | FMOD | FMOD Entrez, Source | fibromodulin | 8247 | -0.035 | 0.1626 | No |
| 70 | NEO1 | NEO1 Entrez, Source | neogenin homolog 1 (chicken) | 9160 | -0.050 | 0.0983 | No |
| 71 | PDE8B | PDE8B Entrez, Source | phosphodiesterase 8B | 9248 | -0.052 | 0.0964 | No |
| 72 | TEGT | TEGT Entrez, Source | testis enhanced gene transcript (BAX inhibitor 1) | 9576 | -0.057 | 0.0768 | No |
| 73 | PLA2G10 | PLA2G10 Entrez, Source | phospholipase A2, group X | 9685 | -0.060 | 0.0741 | No |
| 74 | BRD8 | BRD8 Entrez, Source | bromodomain containing 8 | 9887 | -0.064 | 0.0647 | No |
| 75 | SPAG5 | SPAG5 Entrez, Source | sperm associated antigen 5 | 9912 | -0.065 | 0.0687 | No |
| 76 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 9946 | -0.065 | 0.0721 | No |
| 77 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 9978 | -0.066 | 0.0757 | No |
| 78 | MID1IP1 | MID1IP1 Entrez, Source | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | 10305 | -0.073 | 0.0576 | No |
| 79 | CAMK2N1 | CAMK2N1 Entrez, Source | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 10364 | -0.074 | 0.0599 | No |
| 80 | TXNDC13 | TXNDC13 Entrez, Source | thioredoxin domain containing 13 | 10415 | -0.075 | 0.0629 | No |
| 81 | GLI3 | GLI3 Entrez, Source | GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) | 10439 | -0.076 | 0.0680 | No |
| 82 | CLEC11A | CLEC11A Entrez, Source | C-type lectin domain family 11, member A | 10483 | -0.077 | 0.0717 | No |
| 83 | SYNJ2BP | SYNJ2BP Entrez, Source | synaptojanin 2 binding protein | 10964 | -0.089 | 0.0435 | No |
| 84 | SORD | SORD Entrez, Source | sorbitol dehydrogenase | 11046 | -0.092 | 0.0456 | No |
| 85 | PRKD1 | PRKD1 Entrez, Source | protein kinase D1 | 11594 | -0.109 | 0.0142 | No |
| 86 | MAP3K1 | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 11869 | -0.120 | 0.0044 | No |
| 87 | HEY1 | HEY1 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 1 | 11915 | -0.122 | 0.0120 | No |
| 88 | TAOK1 | TAOK1 Entrez, Source | TAO kinase 1 | 12009 | -0.127 | 0.0164 | No |
| 89 | CSNK1A1 | CSNK1A1 Entrez, Source | casein kinase 1, alpha 1 | 12054 | -0.129 | 0.0247 | No |
| 90 | TSPYL4 | TSPYL4 Entrez, Source | TSPY-like 4 | 12072 | -0.130 | 0.0351 | No |
| 91 | BMPR2 | BMPR2 Entrez, Source | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 12471 | -0.153 | 0.0189 | No |
| 92 | CA2 | CA2 Entrez, Source | carbonic anhydrase II | 12972 | -0.213 | 0.0003 | No |
| 93 | MPDZ | MPDZ Entrez, Source | multiple PDZ domain protein | 13206 | -0.306 | 0.0103 | No |
