Details for gene set CARIES_PULP

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_48h_repos
Upregulated in class	double_gel_8d
GeneSet	CARIES_PULP_UP
Enrichment Score (ES)	0.5451689
Normalized Enrichment Score (NES)	2.036861
Nominal p-value	0.0
FDR q-value	0.0027893218
FWER p-Value	0.11

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	RGS2	RGS2 Entrez, Source	regulator of G-protein signalling 2, 24kDa	25	0.771	0.0466	Yes
2	MGP	MGP Entrez, Source	matrix Gla protein	52	0.634	0.0844	Yes
3	CYP1A1	CYP1A1 Entrez, Source	cytochrome P450, family 1, subfamily A, polypeptide 1	72	0.571	0.1188	Yes
4	RNASE1	RNASE1 Entrez, Source	ribonuclease, RNase A family, 1 (pancreatic)	94	0.529	0.1505	Yes
5	ADM	ADM Entrez, Source	adrenomedullin	96	0.523	0.1832	Yes
6	TNFAIP6	TNFAIP6 Entrez, Source	tumor necrosis factor, alpha-induced protein 6	116	0.483	0.2122	Yes
7	SERPINE2	SERPINE2 Entrez, Source	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	140	0.455	0.2390	Yes
8	CCL2	CCL2 Entrez, Source	chemokine (C-C motif) ligand 2	145	0.452	0.2671	Yes
9	APOC1	APOC1 Entrez, Source	apolipoprotein C-I	151	0.445	0.2947	Yes
10	F13A1	F13A1 Entrez, Source	coagulation factor XIII, A1 polypeptide	163	0.430	0.3209	Yes
11	BCL2A1	BCL2A1 Entrez, Source	BCL2-related protein A1	177	0.408	0.3455	Yes
12	CFD	CFD Entrez, Source	complement factor D (adipsin)	228	0.365	0.3647	Yes
13	CYBA	CYBA Entrez, Source	cytochrome b-245, alpha polypeptide	229	0.365	0.3876	Yes
14	CD48	CD48 Entrez, Source	CD48 molecule	352	0.281	0.3960	Yes
15	CCL3	CCL3 Entrez, Source	chemokine (C-C motif) ligand 3	353	0.281	0.4137	Yes
16	IER3	IER3 Entrez, Source	immediate early response 3	392	0.264	0.4273	Yes
17	UCP2	UCP2 Entrez, Source	uncoupling protein 2 (mitochondrial, proton carrier)	398	0.260	0.4433	Yes
18	PTGER4	PTGER4 Entrez, Source	prostaglandin E receptor 4 (subtype EP4)	402	0.258	0.4593	Yes
19	VCAM1	VCAM1 Entrez, Source	vascular cell adhesion molecule 1	516	0.223	0.4648	Yes
20	CCR1	CCR1 Entrez, Source	chemokine (C-C motif) receptor 1	564	0.213	0.4746	Yes
21	TYROBP	TYROBP Entrez, Source	TYRO protein tyrosine kinase binding protein	586	0.208	0.4861	Yes
22	RAB31	RAB31 Entrez, Source	RAB31, member RAS oncogene family	639	0.199	0.4947	Yes
23	TIMP1	TIMP1 Entrez, Source	TIMP metallopeptidase inhibitor 1	759	0.176	0.4968	Yes
24	LBP	LBP Entrez, Source	lipopolysaccharide binding protein	790	0.171	0.5053	Yes
25	ALOX5AP	ALOX5AP Entrez, Source	arachidonate 5-lipoxygenase-activating protein	834	0.165	0.5123	Yes
26	ARPC1B	ARPC1B Entrez, Source	actin related protein 2/3 complex, subunit 1B, 41kDa	924	0.153	0.5152	Yes
27	KYNU	KYNU Entrez, Source	kynureninase (L-kynurenine hydrolase)	934	0.153	0.5242	Yes
28	S100A8	S100A8 Entrez, Source	S100 calcium binding protein A8	960	0.151	0.5317	Yes
29	CXCL1	CXCL1 Entrez, Source	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	1041	0.142	0.5346	Yes
30	IL1B	IL1B Entrez, Source	interleukin 1, beta	1197	0.128	0.5309	Yes
31	PTPRC	PTPRC Entrez, Source	protein tyrosine phosphatase, receptor type, C	1207	0.127	0.5382	Yes
32	PHLDA1	PHLDA1 Entrez, Source	pleckstrin homology-like domain, family A, member 1	1221	0.126	0.5452	Yes
33	VAMP8	VAMP8 Entrez, Source	vesicle-associated membrane protein 8 (endobrevin)	1336	0.117	0.5439	No
34	MAN2B1	MAN2B1 Entrez, Source	mannosidase, alpha, class 2B, member 1	1416	0.113	0.5450	No
35	CAPG	CAPG Entrez, Source	capping protein (actin filament), gelsolin-like	1684	0.098	0.5310	No
36	ARHGDIB	ARHGDIB Entrez, Source	Rho GDP dissociation inhibitor (GDI) beta	1774	0.094	0.5301	No
37	SPP1	SPP1 Entrez, Source	secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)	1776	0.094	0.5360	No
38	LCP2	LCP2 Entrez, Source	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	1958	0.087	0.5277	No
39	CEBPD	CEBPD Entrez, Source	CCAAT/enhancer binding protein (C/EBP), delta	1977	0.086	0.5317	No
40	APOE	APOE Entrez, Source	apolipoprotein E	2123	0.080	0.5258	No
41	ACSL1	ACSL1 Entrez, Source	acyl-CoA synthetase long-chain family member 1	2355	0.072	0.5129	No
42	CD53	CD53 Entrez, Source	CD53 molecule	2501	0.068	0.5062	No
43	SAMSN1	SAMSN1 Entrez, Source	SAM domain, SH3 domain and nuclear localisation signals, 1	2511	0.067	0.5097	No
44	CSF1R	CSF1R Entrez, Source	colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog	2552	0.066	0.5108	No
45	MNDA	MNDA Entrez, Source	myeloid cell nuclear differentiation antigen	2705	0.063	0.5033	No
46	CTSH	CTSH Entrez, Source	cathepsin H	2723	0.062	0.5059	No
47	C3AR1	C3AR1 Entrez, Source	complement component 3a receptor 1	2746	0.061	0.5081	No
48	LRRC15	LRRC15 Entrez, Source	leucine rich repeat containing 15	2764	0.061	0.5106	No
49	TRIB1	TRIB1 Entrez, Source	tribbles homolog 1 (Drosophila)	2792	0.060	0.5124	No
50	CCR2	CCR2 Entrez, Source	chemokine (C-C motif) receptor 2	2793	0.060	0.5161	No
51	LCP1	LCP1 Entrez, Source	lymphocyte cytosolic protein 1 (L-plastin)	2802	0.060	0.5193	No
52	BIRC3	BIRC3 Entrez, Source	baculoviral IAP repeat-containing 3	2803	0.060	0.5231	No
53	HBB	HBB Entrez, Source	hemoglobin, beta	2898	0.057	0.5196	No
54	PLAUR	PLAUR Entrez, Source	plasminogen activator, urokinase receptor	2983	0.055	0.5167	No
55	C1QB	C1QB Entrez, Source	complement component 1, q subcomponent, B chain	3017	0.054	0.5176	No
56	IL6	IL6 Entrez, Source	interleukin 6 (interferon, beta 2)	3854	0.036	0.4565	No
57	HCLS1	HCLS1 Entrez, Source	hematopoietic cell-specific Lyn substrate 1	4075	0.031	0.4419	No
58	IFI30	IFI30 Entrez, Source	interferon, gamma-inducible protein 30	4301	0.027	0.4266	No
59	ALOX5	ALOX5 Entrez, Source	arachidonate 5-lipoxygenase	4658	0.021	0.4009	No
60	RAB7L1	RAB7L1 Entrez, Source	RAB7, member RAS oncogene family-like 1	4790	0.019	0.3922	No
61	INHBA	INHBA Entrez, Source	inhibin, beta A (activin A, activin AB alpha polypeptide)	5081	0.014	0.3711	No
62	FGL2	FGL2 Entrez, Source	fibrinogen-like 2	5086	0.014	0.3717	No
63	IL10RA	IL10RA Entrez, Source	interleukin 10 receptor, alpha	5276	0.011	0.3580	No
64	CXCL12	CXCL12 Entrez, Source	chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)	5302	0.010	0.3568	No
65	C3	C3 Entrez, Source	complement component 3	5333	0.010	0.3551	No
66	ORM1	ORM1 Entrez, Source	orosomucoid 1	5348	0.009	0.3547	No
67	IRF8	IRF8 Entrez, Source	interferon regulatory factor 8	5398	0.009	0.3515	No
68	CXCL5	CXCL5 Entrez, Source	chemokine (C-X-C motif) ligand 5	5599	0.006	0.3367	No
69	C5AR1	C5AR1 Entrez, Source	complement component 5a receptor 1	5691	0.004	0.3301	No
70	CXCR4	CXCR4 Entrez, Source	chemokine (C-X-C motif) receptor 4	5981	0.000	0.3083	No
71	CD37	CD37 Entrez, Source	CD37 molecule	6038	-0.001	0.3041	No
72	SLC1A4	SLC1A4 Entrez, Source	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	6096	-0.002	0.2999	No
73	CFI	CFI Entrez, Source	complement factor I	6257	-0.004	0.2880	No
74	AQP3	AQP3 Entrez, Source	aquaporin 3 (Gill blood group)	6430	-0.007	0.2754	No
75	SERPINA1	SERPINA1 Entrez, Source	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	6493	-0.008	0.2712	No
76	GZMB	GZMB Entrez, Source	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	6537	-0.008	0.2685	No
77	LAPTM5	LAPTM5 Entrez, Source	lysosomal associated multispanning membrane protein 5	6572	-0.009	0.2664	No
78	NFIL3	NFIL3 Entrez, Source	nuclear factor, interleukin 3 regulated	6595	-0.009	0.2653	No
79	ANGPTL2	ANGPTL2 Entrez, Source	angiopoietin-like 2	6736	-0.011	0.2555	No
80	CHI3L1	CHI3L1 Entrez, Source	chitinase 3-like 1 (cartilage glycoprotein-39)	6833	-0.013	0.2490	No
81	ANPEP	ANPEP Entrez, Source	alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)	6961	-0.014	0.2403	No
82	IBSP	IBSP Entrez, Source	integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)	7019	-0.015	0.2369	No
83	SFRP4	SFRP4 Entrez, Source	secreted frizzled-related protein 4	7370	-0.021	0.2117	No
84	COL15A1	COL15A1 Entrez, Source	collagen, type XV, alpha 1	7379	-0.021	0.2124	No
85	RAC2	RAC2 Entrez, Source	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	7555	-0.023	0.2007	No
86	SLA	SLA Entrez, Source	Src-like-adaptor	7587	-0.024	0.1998	No
87	SERPINB2	SERPINB2 Entrez, Source	serpin peptidase inhibitor, clade B (ovalbumin), member 2	7731	-0.026	0.1907	No
88	SOCS3	SOCS3 Entrez, Source	suppressor of cytokine signaling 3	7799	-0.027	0.1873	No
89	KPNA2	KPNA2 Entrez, Source	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	7811	-0.028	0.1882	No
90	PLEK	PLEK Entrez, Source	pleckstrin	7997	-0.031	0.1762	No
91	UBD	UBD Entrez, Source	ubiquitin D	8096	-0.032	0.1708	No
92	CYBB	CYBB Entrez, Source	cytochrome b-245, beta polypeptide (chronic granulomatous disease)	8263	-0.035	0.1604	No
93	THBS4	THBS4 Entrez, Source	thrombospondin 4	8277	-0.035	0.1617	No
94	CD14	CD14 Entrez, Source	CD14 molecule	8706	-0.042	0.1319	No
95	CCL5	CCL5 Entrez, Source	chemokine (C-C motif) ligand 5	8913	-0.046	0.1192	No
96	PTGS2	PTGS2 Entrez, Source	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	8937	-0.046	0.1204	No
97	LYN	LYN Entrez, Source	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	9007	-0.047	0.1181	No
98	IGFBP4	IGFBP4 Entrez, Source	insulin-like growth factor binding protein 4	9082	-0.049	0.1156	No
99	GPNMB	GPNMB Entrez, Source	glycoprotein (transmembrane) nmb	9192	-0.050	0.1105	No
100	CD93	CD93 Entrez, Source	CD93 molecule	9341	-0.053	0.1027	No
101	CTSC	CTSC Entrez, Source	cathepsin C	9429	-0.055	0.0995	No
102	SSR4	SSR4 Entrez, Source	signal sequence receptor, delta (translocon-associated protein delta)	9596	-0.058	0.0906	No
103	S100A9	S100A9 Entrez, Source	S100 calcium binding protein A9	9785	-0.062	0.0802	No
104	HCK	HCK Entrez, Source	hemopoietic cell kinase	9848	-0.063	0.0795	No
105	PRG1	PRG1 Entrez, Source	proteoglycan 1, secretory granule	10004	-0.066	0.0720	No
106	IL1RN	IL1RN Entrez, Source	interleukin 1 receptor antagonist	10398	-0.075	0.0469	No
107	ITGB2	ITGB2 Entrez, Source	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	10432	-0.076	0.0492	No
108	SELE	SELE Entrez, Source	selectin E (endothelial adhesion molecule 1)	10446	-0.076	0.0530	No
109	BLNK	BLNK Entrez, Source	B-cell linker	10728	-0.083	0.0370	No
110	ICAM1	ICAM1 Entrez, Source	intercellular adhesion molecule 1 (CD54), human rhinovirus receptor	10770	-0.085	0.0392	No
111	CTSB	CTSB Entrez, Source	cathepsin B	10843	-0.086	0.0392	No
112	PBEF1	PBEF1 Entrez, Source	pre-B-cell colony enhancing factor 1	11072	-0.092	0.0277	No
113	IL11	IL11 Entrez, Source	interleukin 11	11288	-0.098	0.0176	No
114	WARS	WARS Entrez, Source	tryptophanyl-tRNA synthetase	11445	-0.104	0.0123	No
115	LSP1	LSP1 Entrez, Source	lymphocyte-specific protein 1	11557	-0.108	0.0107	No
116	ABCA1	ABCA1 Entrez, Source	ATP-binding cassette, sub-family A (ABC1), member 1	11627	-0.110	0.0124	No
117	SOD2	SOD2 Entrez, Source	superoxide dismutase 2, mitochondrial	11710	-0.114	0.0134	No
118	PLAU	PLAU Entrez, Source	plasminogen activator, urokinase	11891	-0.121	0.0074	No
119	SKAP2	SKAP2 Entrez, Source	src kinase associated phosphoprotein 2	12042	-0.128	0.0041	No
120	MMP9	MMP9 Entrez, Source	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	12150	-0.134	0.0044	No
121	CD44	CD44 Entrez, Source	CD44 molecule (Indian blood group)	12802	-0.185	-0.0332	No
122	G0S2	G0S2 Entrez, Source	G0/G1switch 2	13137	-0.265	-0.0418	No
123	LTB	LTB Entrez, Source	lymphotoxin beta (TNF superfamily, member 3)	13186	-0.293	-0.0271	No
124	CD74	CD74 Entrez, Source	CD74 molecule, major histocompatibility complex, class II invariant chain	13325	-0.617	0.0013	No