Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | CELLULAR_CATABOLIC_PROCESS |
| Enrichment Score (ES) | 0.52843577 |
| Normalized Enrichment Score (NES) | 1.9830484 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.005280528 |
| FWER p-Value | 0.25 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CPT1A | CPT1A Entrez, Source | carnitine palmitoyltransferase 1A (liver) | 47 | 0.660 | 0.0475 | Yes |
| 2 | HAO2 | HAO2 Entrez, Source | hydroxyacid oxidase 2 (long chain) | 54 | 0.630 | 0.0958 | Yes |
| 3 | PFKFB1 | PFKFB1 Entrez, Source | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 133 | 0.466 | 0.1260 | Yes |
| 4 | GOT1 | GOT1 Entrez, Source | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 144 | 0.453 | 0.1602 | Yes |
| 5 | HGD | HGD Entrez, Source | homogentisate 1,2-dioxygenase (homogentisate oxidase) | 146 | 0.449 | 0.1949 | Yes |
| 6 | AMPD3 | AMPD3 Entrez, Source | adenosine monophosphate deaminase (isoform E) | 167 | 0.426 | 0.2263 | Yes |
| 7 | MIOX | MIOX Entrez, Source | myo-inositol oxygenase | 178 | 0.406 | 0.2570 | Yes |
| 8 | ECH1 | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 181 | 0.405 | 0.2882 | Yes |
| 9 | GPX3 | GPX3 Entrez, Source | glutathione peroxidase 3 (plasma) | 199 | 0.391 | 0.3172 | Yes |
| 10 | HK1 | HK1 Entrez, Source | hexokinase 1 | 251 | 0.342 | 0.3398 | Yes |
| 11 | APOA4 | APOA4 Entrez, Source | apolipoprotein A-IV | 253 | 0.340 | 0.3660 | Yes |
| 12 | BCKDHA | BCKDHA Entrez, Source | branched chain keto acid dehydrogenase E1, alpha polypeptide | 272 | 0.326 | 0.3898 | Yes |
| 13 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 288 | 0.316 | 0.4132 | Yes |
| 14 | DDAH1 | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 421 | 0.254 | 0.4228 | Yes |
| 15 | DDAH2 | DDAH2 Entrez, Source | dimethylarginine dimethylaminohydrolase 2 | 501 | 0.227 | 0.4344 | Yes |
| 16 | ECHS1 | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 585 | 0.209 | 0.4443 | Yes |
| 17 | ARG1 | ARG1 Entrez, Source | arginase, liver | 704 | 0.185 | 0.4496 | Yes |
| 18 | PPT1 | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 810 | 0.168 | 0.4547 | Yes |
| 19 | HACL1 | HACL1 Entrez, Source | 2-hydroxyacyl-CoA lyase 1 | 839 | 0.164 | 0.4653 | Yes |
| 20 | COLQ | COLQ Entrez, Source | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 888 | 0.157 | 0.4738 | Yes |
| 21 | ACADS | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 1025 | 0.145 | 0.4747 | Yes |
| 22 | GUSB | GUSB Entrez, Source | glucuronidase, beta | 1047 | 0.142 | 0.4841 | Yes |
| 23 | LYPLA3 | LYPLA3 Entrez, Source | lysophospholipase 3 (lysosomal phospholipase A2) | 1075 | 0.138 | 0.4927 | Yes |
| 24 | APOA5 | APOA5 Entrez, Source | apolipoprotein A-V | 1126 | 0.134 | 0.4993 | Yes |
| 25 | RNASE6 | RNASE6 Entrez, Source | ribonuclease, RNase A family, k6 | 1246 | 0.124 | 0.4999 | Yes |
| 26 | BCKDHB | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 1252 | 0.124 | 0.5091 | Yes |
| 27 | ZFP36 | ZFP36 Entrez, Source | zinc finger protein 36, C3H type, homolog (mouse) | 1260 | 0.123 | 0.5181 | Yes |
| 28 | FAH | FAH Entrez, Source | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 1315 | 0.119 | 0.5232 | Yes |
| 29 | SMPD3 | SMPD3 Entrez, Source | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | 1478 | 0.109 | 0.5194 | Yes |
| 30 | ALDOA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 1564 | 0.104 | 0.5211 | Yes |
| 31 | PFKL | PFKL Entrez, Source | phosphofructokinase, liver | 1624 | 0.101 | 0.5244 | Yes |
| 32 | ACO2 | ACO2 Entrez, Source | aconitase 2, mitochondrial | 1737 | 0.096 | 0.5234 | Yes |
| 33 | GNS | GNS Entrez, Source | glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) | 1850 | 0.091 | 0.5219 | Yes |
| 34 | GAA | GAA Entrez, Source | glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II) | 1940 | 0.087 | 0.5219 | Yes |
| 35 | GLUD1 | GLUD1 Entrez, Source | glutamate dehydrogenase 1 | 1962 | 0.087 | 0.5270 | Yes |
| 36 | UBE2B | UBE2B Entrez, Source | ubiquitin-conjugating enzyme E2B (RAD6 homolog) | 2086 | 0.081 | 0.5240 | Yes |
| 37 | MCCC2 | MCCC2 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | 2111 | 0.080 | 0.5284 | Yes |
| 38 | ALDH5A1 | ALDH5A1 Entrez, Source | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 2210 | 0.077 | 0.5270 | No |
| 39 | PYGB | PYGB Entrez, Source | phosphorylase, glycogen; brain | 2273 | 0.075 | 0.5281 | No |
| 40 | BNIP3 | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 2391 | 0.071 | 0.5247 | No |
| 41 | CEL | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 2522 | 0.067 | 0.5201 | No |
| 42 | CPT1B | CPT1B Entrez, Source | carnitine palmitoyltransferase 1B (muscle) | 2591 | 0.065 | 0.5200 | No |
| 43 | ANAPC2 | ANAPC2 Entrez, Source | anaphase promoting complex subunit 2 | 2963 | 0.056 | 0.4962 | No |
| 44 | ASL | ASL Entrez, Source | argininosuccinate lyase | 3041 | 0.053 | 0.4945 | No |
| 45 | NUDT3 | NUDT3 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | 3099 | 0.052 | 0.4942 | No |
| 46 | RNASEH2A | RNASEH2A Entrez, Source | ribonuclease H2, subunit A | 3157 | 0.051 | 0.4938 | No |
| 47 | ALDOB | ALDOB Entrez, Source | aldolase B, fructose-bisphosphate | 3253 | 0.048 | 0.4904 | No |
| 48 | TPP1 | TPP1 Entrez, Source | tripeptidyl peptidase I | 3294 | 0.047 | 0.4910 | No |
| 49 | SIAH2 | SIAH2 Entrez, Source | seven in absentia homolog 2 (Drosophila) | 3372 | 0.046 | 0.4887 | No |
| 50 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 3401 | 0.045 | 0.4901 | No |
| 51 | UBE4A | UBE4A Entrez, Source | ubiquitination factor E4A (UFD2 homolog, yeast) | 3642 | 0.040 | 0.4750 | No |
| 52 | ASPA | ASPA Entrez, Source | aspartoacylase (Canavan disease) | 3681 | 0.039 | 0.4752 | No |
| 53 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 3732 | 0.038 | 0.4743 | No |
| 54 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 3755 | 0.037 | 0.4756 | No |
| 55 | SDHD | SDHD Entrez, Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 3852 | 0.036 | 0.4711 | No |
| 56 | BCKDK | BCKDK Entrez, Source | branched chain ketoacid dehydrogenase kinase | 3853 | 0.036 | 0.4738 | No |
| 57 | DFFA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 3973 | 0.033 | 0.4674 | No |
| 58 | SDHC | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 4192 | 0.029 | 0.4532 | No |
| 59 | BTRC | BTRC Entrez, Source | beta-transducin repeat containing | 4396 | 0.025 | 0.4398 | No |
| 60 | ACADVL | ACADVL Entrez, Source | acyl-Coenzyme A dehydrogenase, very long chain | 4485 | 0.024 | 0.4350 | No |
| 61 | ALDH1L1 | ALDH1L1 Entrez, Source | aldehyde dehydrogenase 1 family, member L1 | 4510 | 0.023 | 0.4349 | No |
| 62 | PRDX6 | PRDX6 Entrez, Source | peroxiredoxin 6 | 4787 | 0.019 | 0.4155 | No |
| 63 | HPD | HPD Entrez, Source | 4-hydroxyphenylpyruvate dioxygenase | 4885 | 0.017 | 0.4095 | No |
| 64 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 4888 | 0.017 | 0.4106 | No |
| 65 | ACADM | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 4941 | 0.016 | 0.4080 | No |
| 66 | SDHA | SDHA Entrez, Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 4953 | 0.016 | 0.4084 | No |
| 67 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 5260 | 0.011 | 0.3860 | No |
| 68 | MPST | MPST Entrez, Source | mercaptopyruvate sulfurtransferase | 5279 | 0.010 | 0.3855 | No |
| 69 | GBA2 | GBA2 Entrez, Source | glucosidase, beta (bile acid) 2 | 5370 | 0.009 | 0.3794 | No |
| 70 | AMT | AMT Entrez, Source | aminomethyltransferase | 5396 | 0.009 | 0.3782 | No |
| 71 | PFKM | PFKM Entrez, Source | phosphofructokinase, muscle | 5738 | 0.004 | 0.3527 | No |
| 72 | NEU3 | NEU3 Entrez, Source | sialidase 3 (membrane sialidase) | 6050 | -0.001 | 0.3292 | No |
| 73 | SQSTM1 | SQSTM1 Entrez, Source | sequestosome 1 | 6184 | -0.003 | 0.3194 | No |
| 74 | NPLOC4 | NPLOC4 Entrez, Source | nuclear protein localization 4 homolog (S. cerevisiae) | 6354 | -0.006 | 0.3070 | No |
| 75 | HADHB | HADHB Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 6362 | -0.006 | 0.3069 | No |
| 76 | GCSH | GCSH Entrez, Source | glycine cleavage system protein H (aminomethyl carrier) | 6406 | -0.006 | 0.3042 | No |
| 77 | STUB1 | STUB1 Entrez, Source | STIP1 homology and U-box containing protein 1 | 6444 | -0.007 | 0.3019 | No |
| 78 | UBB | UBB Entrez, Source | ubiquitin B | 6484 | -0.007 | 0.2995 | No |
| 79 | YWHAH | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 6649 | -0.010 | 0.2878 | No |
| 80 | VCP | VCP Entrez, Source | valosin-containing protein | 7037 | -0.016 | 0.2598 | No |
| 81 | ERCC3 | ERCC3 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 7085 | -0.016 | 0.2575 | No |
| 82 | GAPDHS | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 7146 | -0.017 | 0.2543 | No |
| 83 | NEDD8 | NEDD8 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 8 | 7156 | -0.018 | 0.2550 | No |
| 84 | PARK2 | PARK2 Entrez, Source | Parkinson disease (autosomal recessive, juvenile) 2, parkin | 7304 | -0.020 | 0.2454 | No |
| 85 | UBE2N | UBE2N Entrez, Source | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 7534 | -0.023 | 0.2298 | No |
| 86 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7545 | -0.023 | 0.2309 | No |
| 87 | ACLY | ACLY Entrez, Source | ATP citrate lyase | 7774 | -0.027 | 0.2157 | No |
| 88 | TREH | TREH Entrez, Source | trehalase (brush-border membrane glycoprotein) | 7852 | -0.028 | 0.2121 | No |
| 89 | PSMC5 | PSMC5 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 7944 | -0.030 | 0.2075 | No |
| 90 | SYVN1 | SYVN1 Entrez, Source | synovial apoptosis inhibitor 1, synoviolin | 8081 | -0.032 | 0.1997 | No |
| 91 | DHPS | DHPS Entrez, Source | deoxyhypusine synthase | 8259 | -0.035 | 0.1890 | No |
| 92 | GOT2 | GOT2 Entrez, Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 8497 | -0.039 | 0.1741 | No |
| 93 | ASRGL1 | ASRGL1 Entrez, Source | asparaginase like 1 | 8649 | -0.041 | 0.1659 | No |
| 94 | UBE2I | UBE2I Entrez, Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 8725 | -0.043 | 0.1635 | No |
| 95 | FBXO7 | FBXO7 Entrez, Source | F-box protein 7 | 8758 | -0.043 | 0.1644 | No |
| 96 | ANAPC4 | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 8855 | -0.045 | 0.1606 | No |
| 97 | INDO | INDO Entrez, Source | indoleamine-pyrrole 2,3 dioxygenase | 8856 | -0.045 | 0.1641 | No |
| 98 | RNASEH1 | RNASEH1 Entrez, Source | ribonuclease H1 | 8861 | -0.045 | 0.1673 | No |
| 99 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 8991 | -0.047 | 0.1611 | No |
| 100 | UBE2D2 | UBE2D2 Entrez, Source | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 9056 | -0.048 | 0.1600 | No |
| 101 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 9075 | -0.048 | 0.1624 | No |
| 102 | USP33 | USP33 Entrez, Source | ubiquitin specific peptidase 33 | 9360 | -0.053 | 0.1451 | No |
| 103 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 9367 | -0.054 | 0.1488 | No |
| 104 | TSG101 | TSG101 Entrez, Source | tumor susceptibility gene 101 | 9444 | -0.055 | 0.1473 | No |
| 105 | UBE2G1 | UBE2G1 Entrez, Source | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) | 9631 | -0.058 | 0.1377 | No |
| 106 | FBXO22 | FBXO22 Entrez, Source | F-box protein 22 | 9993 | -0.066 | 0.1155 | No |
| 107 | UBE2A | UBE2A Entrez, Source | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 10509 | -0.078 | 0.0826 | No |
| 108 | TST | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 10520 | -0.078 | 0.0879 | No |
| 109 | GSPT1 | GSPT1 Entrez, Source | G1 to S phase transition 1 | 10533 | -0.079 | 0.0931 | No |
| 110 | BAX | BAX Entrez, Source | BCL2-associated X protein | 10615 | -0.080 | 0.0932 | No |
| 111 | DFFB | DFFB Entrez, Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 10724 | -0.083 | 0.0914 | No |
| 112 | BLVRA | BLVRA Entrez, Source | biliverdin reductase A | 11052 | -0.092 | 0.0738 | No |
| 113 | ABCE1 | ABCE1 Entrez, Source | ATP-binding cassette, sub-family E (OABP), member 1 | 11152 | -0.095 | 0.0736 | No |
| 114 | UFD1L | UFD1L Entrez, Source | ubiquitin fusion degradation 1 like (yeast) | 11173 | -0.095 | 0.0795 | No |
| 115 | GAD2 | GAD2 Entrez, Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 11228 | -0.096 | 0.0829 | No |
| 116 | GAD1 | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 11300 | -0.099 | 0.0851 | No |
| 117 | ARIH1 | ARIH1 Entrez, Source | ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) | 11547 | -0.107 | 0.0748 | No |
| 118 | PABPC4 | PABPC4 Entrez, Source | poly(A) binding protein, cytoplasmic 4 (inducible form) | 11571 | -0.108 | 0.0814 | No |
| 119 | HNRPD | HNRPD Entrez, Source | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 11613 | -0.110 | 0.0868 | No |
| 120 | UBE2V2 | UBE2V2 Entrez, Source | ubiquitin-conjugating enzyme E2 variant 2 | 12194 | -0.136 | 0.0535 | No |
| 121 | CDC20 | CDC20 Entrez, Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 12218 | -0.137 | 0.0624 | No |
| 122 | PPARA | PPARA Entrez, Source | peroxisome proliferative activated receptor, alpha | 12287 | -0.141 | 0.0682 | No |
| 123 | NUDT5 | NUDT5 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 5 | 12409 | -0.149 | 0.0706 | No |
