Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | CHOLESTEROL_BIOSYNTHESIS |
| Enrichment Score (ES) | -0.71742904 |
| Normalized Enrichment Score (NES) | -1.8624715 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.03368093 |
| FWER p-Value | 0.657 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SQLE | SQLE Entrez, Source | squalene epoxidase | 3091 | 0.052 | -0.2001 | No |
| 2 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 3902 | 0.035 | -0.2396 | No |
| 3 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 5315 | 0.010 | -0.3395 | No |
| 4 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 7967 | -0.030 | -0.5198 | No |
| 5 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 9978 | -0.066 | -0.6302 | No |
| 6 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 11141 | -0.094 | -0.6597 | Yes |
| 7 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 11376 | -0.101 | -0.6153 | Yes |
| 8 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 11395 | -0.102 | -0.5541 | Yes |
| 9 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 11893 | -0.121 | -0.5171 | Yes |
| 10 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 11986 | -0.126 | -0.4470 | Yes |
| 11 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 12263 | -0.140 | -0.3818 | Yes |
| 12 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 12532 | -0.157 | -0.3056 | Yes |
| 13 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 12750 | -0.178 | -0.2130 | Yes |
| 14 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 12932 | -0.205 | -0.1011 | Yes |
| 15 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 12984 | -0.215 | 0.0269 | Yes |
