Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | CORDERO_KRAS_KD_VS_CONTROL_UP |
| Enrichment Score (ES) | 0.75707376 |
| Normalized Enrichment Score (NES) | 2.3466768 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IGFBP7 | IGFBP7 Entrez, Source | insulin-like growth factor binding protein 7 | 2 | 1.254 | 0.1340 | Yes |
| 2 | MAP3K8 | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 12 | 0.878 | 0.2273 | Yes |
| 3 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 56 | 0.628 | 0.2912 | Yes |
| 4 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 58 | 0.625 | 0.3579 | Yes |
| 5 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 140 | 0.455 | 0.4006 | Yes |
| 6 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 145 | 0.452 | 0.4486 | Yes |
| 7 | HGD | HGD Entrez, Source | homogentisate 1,2-dioxygenase (homogentisate oxidase) | 146 | 0.449 | 0.4966 | Yes |
| 8 | SGK | SGK Entrez, Source | serum/glucocorticoid regulated kinase | 200 | 0.388 | 0.5341 | Yes |
| 9 | TAGLN | TAGLN Entrez, Source | transgelin | 250 | 0.344 | 0.5671 | Yes |
| 10 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 317 | 0.293 | 0.5935 | Yes |
| 11 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 329 | 0.291 | 0.6238 | Yes |
| 12 | SLC22A5 | SLC22A5 Entrez, Source | solute carrier family 22 (organic cation transporter), member 5 | 345 | 0.285 | 0.6531 | Yes |
| 13 | WASPIP | WASPIP Entrez, Source | Wiskott-Aldrich syndrome protein interacting protein | 427 | 0.251 | 0.6739 | Yes |
| 14 | CLDN4 | CLDN4 Entrez, Source | claudin 4 | 570 | 0.212 | 0.6859 | Yes |
| 15 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 571 | 0.212 | 0.7085 | Yes |
| 16 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 659 | 0.195 | 0.7228 | Yes |
| 17 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 673 | 0.190 | 0.7422 | Yes |
| 18 | JUNB | JUNB Entrez, Source | jun B proto-oncogene | 861 | 0.161 | 0.7454 | Yes |
| 19 | ECE1 | ECE1 Entrez, Source | endothelin converting enzyme 1 | 925 | 0.153 | 0.7571 | Yes |
| 20 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1210 | 0.127 | 0.7493 | No |
| 21 | IGSF4 | IGSF4 Entrez, Source | immunoglobulin superfamily, member 4 | 1345 | 0.117 | 0.7517 | No |
| 22 | LAMP2 | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 1744 | 0.095 | 0.7320 | No |
| 23 | GLIPR1 | GLIPR1 Entrez, Source | GLI pathogenesis-related 1 (glioma) | 2028 | 0.084 | 0.7197 | No |
| 24 | WISP2 | WISP2 Entrez, Source | WNT1 inducible signaling pathway protein 2 | 2285 | 0.074 | 0.7084 | No |
| 25 | INPP4B | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2455 | 0.069 | 0.7031 | No |
| 26 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 2660 | 0.063 | 0.6945 | No |
| 27 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 2686 | 0.063 | 0.6994 | No |
| 28 | CHST3 | CHST3 Entrez, Source | carbohydrate (chondroitin 6) sulfotransferase 3 | 2922 | 0.057 | 0.6878 | No |
| 29 | DKK3 | DKK3 Entrez, Source | dickkopf homolog 3 (Xenopus laevis) | 2975 | 0.055 | 0.6897 | No |
| 30 | JUN | JUN Entrez, Source | jun oncogene | 3104 | 0.052 | 0.6856 | No |
| 31 | SNAI1 | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 4250 | 0.028 | 0.6026 | No |
| 32 | BMP1 | BMP1 Entrez, Source | bone morphogenetic protein 1 | 4389 | 0.026 | 0.5949 | No |
| 33 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 5439 | 0.008 | 0.5169 | No |
| 34 | CALD1 | CALD1 Entrez, Source | caldesmon 1 | 5970 | 0.001 | 0.4771 | No |
| 35 | ADAM19 | ADAM19 Entrez, Source | ADAM metallopeptidase domain 19 (meltrin beta) | 6281 | -0.004 | 0.4543 | No |
| 36 | EVL | EVL Entrez, Source | Enah/Vasp-like | 6806 | -0.012 | 0.4162 | No |
| 37 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 7114 | -0.017 | 0.3949 | No |
| 38 | MGEA5 | MGEA5 Entrez, Source | meningioma expressed antigen 5 (hyaluronidase) | 8433 | -0.038 | 0.2999 | No |
| 39 | ATP2B4 | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 10001 | -0.066 | 0.1891 | No |
| 40 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 10057 | -0.068 | 0.1922 | No |
| 41 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 10575 | -0.079 | 0.1618 | No |
| 42 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 10960 | -0.089 | 0.1425 | No |
| 43 | GPR56 | GPR56 Entrez, Source | G protein-coupled receptor 56 | 12030 | -0.128 | 0.0758 | No |
| 44 | DICER1 | DICER1 Entrez, Source | Dicer1, Dcr-1 homolog (Drosophila) | 12970 | -0.213 | 0.0280 | No |
