Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | ELONGINA_KO_UP |
| Enrichment Score (ES) | 0.54078925 |
| Normalized Enrichment Score (NES) | 1.9485743 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0077563957 |
| FWER p-Value | 0.392 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 10 | 0.885 | 0.0701 | Yes |
| 2 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 58 | 0.625 | 0.1165 | Yes |
| 3 | CRYAB | CRYAB Entrez, Source | crystallin, alpha B | 106 | 0.494 | 0.1525 | Yes |
| 4 | SERPINH1 | SERPINH1 Entrez, Source | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 184 | 0.403 | 0.1789 | Yes |
| 5 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 230 | 0.365 | 0.2046 | Yes |
| 6 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 252 | 0.342 | 0.2304 | Yes |
| 7 | CITED2 | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 297 | 0.311 | 0.2519 | Yes |
| 8 | ENPEP | ENPEP Entrez, Source | glutamyl aminopeptidase (aminopeptidase A) | 298 | 0.310 | 0.2767 | Yes |
| 9 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 316 | 0.294 | 0.2989 | Yes |
| 10 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 317 | 0.293 | 0.3224 | Yes |
| 11 | TYRO3 | TYRO3 Entrez, Source | TYRO3 protein tyrosine kinase | 321 | 0.292 | 0.3455 | Yes |
| 12 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 329 | 0.291 | 0.3683 | Yes |
| 13 | DDAH1 | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 421 | 0.254 | 0.3817 | Yes |
| 14 | HERPUD1 | HERPUD1 Entrez, Source | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 448 | 0.245 | 0.3993 | Yes |
| 15 | THBD | THBD Entrez, Source | thrombomodulin | 474 | 0.236 | 0.4164 | Yes |
| 16 | EFEMP2 | EFEMP2 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 2 | 482 | 0.234 | 0.4345 | Yes |
| 17 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 600 | 0.206 | 0.4422 | Yes |
| 18 | SGCE | SGCE Entrez, Source | sarcoglycan, epsilon | 650 | 0.197 | 0.4543 | Yes |
| 19 | FUT8 | FUT8 Entrez, Source | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 793 | 0.170 | 0.4572 | Yes |
| 20 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 843 | 0.163 | 0.4666 | Yes |
| 21 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 943 | 0.152 | 0.4712 | Yes |
| 22 | NR4A1 | NR4A1 Entrez, Source | nuclear receptor subfamily 4, group A, member 1 | 1043 | 0.142 | 0.4751 | Yes |
| 23 | SLC38A1 | SLC38A1 Entrez, Source | solute carrier family 38, member 1 | 1109 | 0.135 | 0.4810 | Yes |
| 24 | TAX1BP3 | TAX1BP3 Entrez, Source | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 1166 | 0.131 | 0.4873 | Yes |
| 25 | CLIC1 | CLIC1 Entrez, Source | chloride intracellular channel 1 | 1263 | 0.123 | 0.4899 | Yes |
| 26 | CST3 | CST3 Entrez, Source | cystatin C (amyloid angiopathy and cerebral hemorrhage) | 1282 | 0.121 | 0.4982 | Yes |
| 27 | MESDC1 | MESDC1 Entrez, Source | mesoderm development candidate 1 | 1292 | 0.121 | 0.5072 | Yes |
| 28 | TTR | TTR Entrez, Source | transthyretin (prealbumin, amyloidosis type I) | 1318 | 0.119 | 0.5148 | Yes |
| 29 | EPAS1 | EPAS1 Entrez, Source | endothelial PAS domain protein 1 | 1321 | 0.118 | 0.5241 | Yes |
| 30 | VAMP8 | VAMP8 Entrez, Source | vesicle-associated membrane protein 8 (endobrevin) | 1336 | 0.117 | 0.5324 | Yes |
| 31 | NID2 | NID2 Entrez, Source | nidogen 2 (osteonidogen) | 1349 | 0.116 | 0.5408 | Yes |
| 32 | PLOD1 | PLOD1 Entrez, Source | procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | 1639 | 0.101 | 0.5270 | No |
| 33 | GNS | GNS Entrez, Source | glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) | 1850 | 0.091 | 0.5184 | No |
| 34 | LGMN | LGMN Entrez, Source | legumain | 1864 | 0.090 | 0.5246 | No |
| 35 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 1890 | 0.089 | 0.5298 | No |
| 36 | RAMP2 | RAMP2 Entrez, Source | receptor (calcitonin) activity modifying protein 2 | 1999 | 0.085 | 0.5285 | No |
| 37 | GHR | GHR Entrez, Source | growth hormone receptor | 2098 | 0.081 | 0.5276 | No |
| 38 | GNA12 | GNA12 Entrez, Source | guanine nucleotide binding protein (G protein) alpha 12 | 2156 | 0.079 | 0.5296 | No |
| 39 | HS3ST1 | HS3ST1 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 2172 | 0.078 | 0.5347 | No |
| 40 | STARD10 | STARD10 Entrez, Source | START domain containing 10 | 2321 | 0.073 | 0.5294 | No |
| 41 | ATP1B1 | ATP1B1 Entrez, Source | ATPase, Na+/K+ transporting, beta 1 polypeptide | 2395 | 0.071 | 0.5295 | No |
| 42 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 2524 | 0.067 | 0.5252 | No |
| 43 | PSAP | PSAP Entrez, Source | prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) | 2642 | 0.064 | 0.5215 | No |
| 44 | ZYX | ZYX Entrez, Source | zyxin | 2654 | 0.063 | 0.5257 | No |
| 45 | P4HA1 | P4HA1 Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I | 2948 | 0.056 | 0.5081 | No |
| 46 | MYL3 | MYL3 Entrez, Source | myosin, light chain 3, alkali; ventricular, skeletal, slow | 3152 | 0.051 | 0.4968 | No |
| 47 | CYBASC3 | CYBASC3 Entrez, Source | cytochrome b, ascorbate dependent 3 | 3583 | 0.041 | 0.4676 | No |
| 48 | CLU | CLU Entrez, Source | clusterin | 3739 | 0.038 | 0.4590 | No |
| 49 | JUND | JUND Entrez, Source | jun D proto-oncogene | 3846 | 0.036 | 0.4538 | No |
| 50 | GGTA1 | GGTA1 Entrez, Source | glycoprotein, alpha-galactosyltransferase 1 | 3898 | 0.035 | 0.4527 | No |
| 51 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 3949 | 0.034 | 0.4517 | No |
| 52 | GRINA | GRINA Entrez, Source | glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) | 3961 | 0.034 | 0.4535 | No |
| 53 | HSDL1 | HSDL1 Entrez, Source | hydroxysteroid dehydrogenase like 1 | 4052 | 0.032 | 0.4493 | No |
| 54 | FBLN2 | FBLN2 Entrez, Source | fibulin 2 | 4053 | 0.032 | 0.4518 | No |
| 55 | KDELR2 | KDELR2 Entrez, Source | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 4069 | 0.032 | 0.4532 | No |
| 56 | ARF4 | ARF4 Entrez, Source | ADP-ribosylation factor 4 | 4231 | 0.029 | 0.4433 | No |
| 57 | SNAI1 | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 4250 | 0.028 | 0.4442 | No |
| 58 | SPINK1 | SPINK1 Entrez, Source | serine peptidase inhibitor, Kazal type 1 | 4848 | 0.018 | 0.4006 | No |
| 59 | LRPAP1 | LRPAP1 Entrez, Source | low density lipoprotein receptor-related protein associated protein 1 | 5239 | 0.011 | 0.3720 | No |
| 60 | ATP6AP1 | ATP6AP1 Entrez, Source | ATPase, H+ transporting, lysosomal accessory protein 1 | 5443 | 0.008 | 0.3573 | No |
| 61 | NID1 | NID1 Entrez, Source | nidogen 1 | 5553 | 0.007 | 0.3496 | No |
| 62 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 5565 | 0.006 | 0.3493 | No |
| 63 | B2M | B2M Entrez, Source | beta-2-microglobulin | 5795 | 0.003 | 0.3322 | No |
| 64 | TXNDC4 | TXNDC4 Entrez, Source | thioredoxin domain containing 4 (endoplasmic reticulum) | 6328 | -0.005 | 0.2925 | No |
| 65 | SPOCK1 | SPOCK1 Entrez, Source | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 6415 | -0.006 | 0.2865 | No |
| 66 | PTPRM | PTPRM Entrez, Source | protein tyrosine phosphatase, receptor type, M | 6655 | -0.010 | 0.2692 | No |
| 67 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 6774 | -0.012 | 0.2613 | No |
| 68 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 6856 | -0.013 | 0.2562 | No |
| 69 | PDE1B | PDE1B Entrez, Source | phosphodiesterase 1B, calmodulin-dependent | 6893 | -0.013 | 0.2545 | No |
| 70 | CCNC | CCNC Entrez, Source | cyclin C | 7174 | -0.018 | 0.2348 | No |
| 71 | LMBRD1 | LMBRD1 Entrez, Source | LMBR1 domain containing 1 | 7350 | -0.020 | 0.2232 | No |
| 72 | GATA6 | GATA6 Entrez, Source | GATA binding protein 6 | 7526 | -0.023 | 0.2119 | No |
| 73 | MID1 | MID1 Entrez, Source | midline 1 (Opitz/BBB syndrome) | 7656 | -0.025 | 0.2041 | No |
| 74 | CITED1 | CITED1 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 | 8127 | -0.033 | 0.1713 | No |
| 75 | SURF4 | SURF4 Entrez, Source | surfeit 4 | 8903 | -0.046 | 0.1164 | No |
| 76 | STRA6 | STRA6 Entrez, Source | stimulated by retinoic acid gene 6 homolog (mouse) | 8954 | -0.047 | 0.1163 | No |
| 77 | P4HB | P4HB Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | 9064 | -0.048 | 0.1120 | No |
| 78 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 9082 | -0.049 | 0.1146 | No |
| 79 | PTHR1 | PTHR1 Entrez, Source | parathyroid hormone receptor 1 | 9247 | -0.052 | 0.1063 | No |
| 80 | FKBP9 | FKBP9 Entrez, Source | FK506 binding protein 9, 63 kDa | 9467 | -0.055 | 0.0942 | No |
| 81 | TMED2 | TMED2 Entrez, Source | transmembrane emp24 domain trafficking protein 2 | 9762 | -0.061 | 0.0769 | No |
| 82 | PGA5 | PGA5 Entrez, Source | pepsinogen 5, group I (pepsinogen A) | 9935 | -0.065 | 0.0691 | No |
| 83 | CD38 | CD38 Entrez, Source | CD38 molecule | 9966 | -0.066 | 0.0721 | No |
| 84 | PRG1 | PRG1 Entrez, Source | proteoglycan 1, secretory granule | 10004 | -0.066 | 0.0746 | No |
| 85 | CALM1 | CALM1 Entrez, Source | calmodulin 1 (phosphorylase kinase, delta) | 10213 | -0.071 | 0.0646 | No |
| 86 | CREB3L1 | CREB3L1 Entrez, Source | cAMP responsive element binding protein 3-like 1 | 10480 | -0.077 | 0.0506 | No |
| 87 | TST | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 10520 | -0.078 | 0.0540 | No |
| 88 | PDIA3 | PDIA3 Entrez, Source | protein disulfide isomerase family A, member 3 | 10749 | -0.084 | 0.0435 | No |
| 89 | HSPA5 | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 10956 | -0.089 | 0.0351 | No |
| 90 | FDX1 | FDX1 Entrez, Source | ferredoxin 1 | 10969 | -0.090 | 0.0413 | No |
| 91 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 11386 | -0.102 | 0.0180 | No |
| 92 | AQP8 | AQP8 Entrez, Source | aquaporin 8 | 11422 | -0.103 | 0.0236 | No |
| 93 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 11445 | -0.104 | 0.0303 | No |
| 94 | CTSZ | CTSZ Entrez, Source | cathepsin Z | 11497 | -0.106 | 0.0349 | No |
| 95 | SRPRB | SRPRB Entrez, Source | signal recognition particle receptor, B subunit | 11877 | -0.121 | 0.0159 | No |
| 96 | GLUL | GLUL Entrez, Source | glutamate-ammonia ligase (glutamine synthetase) | 12268 | -0.141 | -0.0023 | No |
| 97 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 12592 | -0.163 | -0.0137 | No |
| 98 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 12777 | -0.181 | -0.0130 | No |
| 99 | SLC16A1 | SLC16A1 Entrez, Source | solute carrier family 16, member 1 (monocarboxylic acid transporter 1) | 12950 | -0.209 | -0.0093 | No |
| 100 | PSPH | PSPH Entrez, Source | phosphoserine phosphatase | 13062 | -0.238 | 0.0013 | No |
| 101 | CYP26A1 | CYP26A1 Entrez, Source | cytochrome P450, family 26, subfamily A, polypeptide 1 | 13087 | -0.247 | 0.0193 | No |
