Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | ET743_SARCOMA_DN |
| Enrichment Score (ES) | -0.33196202 |
| Normalized Enrichment Score (NES) | -1.3731918 |
| Nominal p-value | 0.018817205 |
| FDR q-value | 0.36302117 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 27 | 0.757 | 0.0632 | No |
| 2 | JAG1 | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 222 | 0.366 | 0.0801 | No |
| 3 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 523 | 0.222 | 0.0765 | No |
| 4 | SYNE1 | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 689 | 0.187 | 0.0801 | No |
| 5 | RNF14 | RNF14 Entrez, Source | ring finger protein 14 | 740 | 0.178 | 0.0917 | No |
| 6 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 778 | 0.173 | 0.1038 | No |
| 7 | SPRY2 | SPRY2 Entrez, Source | sprouty homolog 2 (Drosophila) | 784 | 0.172 | 0.1183 | No |
| 8 | CYHR1 | CYHR1 Entrez, Source | cysteine/histidine-rich 1 | 862 | 0.161 | 0.1263 | No |
| 9 | ACSL3 | ACSL3 Entrez, Source | acyl-CoA synthetase long-chain family member 3 | 1086 | 0.137 | 0.1213 | No |
| 10 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 1094 | 0.137 | 0.1325 | No |
| 11 | SLC2A1 | SLC2A1 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 1 | 1110 | 0.135 | 0.1431 | No |
| 12 | PLAG1 | PLAG1 Entrez, Source | pleiomorphic adenoma gene 1 | 1816 | 0.092 | 0.0976 | No |
| 13 | WNT5B | WNT5B Entrez, Source | wingless-type MMTV integration site family, member 5B | 2142 | 0.079 | 0.0799 | No |
| 14 | CDK5R1 | CDK5R1 Entrez, Source | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 2373 | 0.072 | 0.0686 | No |
| 15 | LRRC8C | LRRC8C Entrez, Source | leucine rich repeat containing 8 family, member C | 2453 | 0.069 | 0.0686 | No |
| 16 | BTG1 | BTG1 Entrez, Source | B-cell translocation gene 1, anti-proliferative | 2629 | 0.064 | 0.0609 | No |
| 17 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 3166 | 0.050 | 0.0247 | No |
| 18 | RAP1B | RAP1B Entrez, Source | RAP1B, member of RAS oncogene family | 3177 | 0.050 | 0.0282 | No |
| 19 | ELOVL6 | ELOVL6 Entrez, Source | ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) | 3278 | 0.048 | 0.0248 | No |
| 20 | HERC4 | HERC4 Entrez, Source | hect domain and RLD 4 | 3315 | 0.047 | 0.0261 | No |
| 21 | LUZP1 | LUZP1 Entrez, Source | leucine zipper protein 1 | 3481 | 0.043 | 0.0174 | No |
| 22 | PJA2 | PJA2 Entrez, Source | praja 2, RING-H2 motif containing | 3492 | 0.043 | 0.0203 | No |
| 23 | FZD1 | FZD1 Entrez, Source | frizzled homolog 1 (Drosophila) | 3493 | 0.043 | 0.0240 | No |
| 24 | NCOA6 | NCOA6 Entrez, Source | nuclear receptor coactivator 6 | 3527 | 0.042 | 0.0252 | No |
| 25 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 3662 | 0.040 | 0.0185 | No |
| 26 | GTF2B | GTF2B Entrez, Source | general transcription factor IIB | 4065 | 0.032 | -0.0093 | No |
| 27 | RAB5A | RAB5A Entrez, Source | RAB5A, member RAS oncogene family | 4218 | 0.029 | -0.0183 | No |
| 28 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 4225 | 0.029 | -0.0162 | No |
| 29 | CLCN7 | CLCN7 Entrez, Source | chloride channel 7 | 4535 | 0.023 | -0.0377 | No |
| 30 | STK17B | STK17B Entrez, Source | serine/threonine kinase 17b (apoptosis-inducing) | 4570 | 0.022 | -0.0384 | No |
| 31 | FNTA | FNTA Entrez, Source | farnesyltransferase, CAAX box, alpha | 4587 | 0.022 | -0.0377 | No |
| 32 | RAB1A | RAB1A Entrez, Source | RAB1A, member RAS oncogene family | 4611 | 0.021 | -0.0376 | No |
| 33 | NET1 | NET1 Entrez, Source | neuroepithelial cell transforming gene 1 | 5025 | 0.015 | -0.0676 | No |
| 34 | CMPK | CMPK Entrez, Source | cytidylate kinase | 5102 | 0.013 | -0.0722 | No |
| 35 | SPIN | SPIN Entrez, Source | spindlin | 5211 | 0.012 | -0.0794 | No |
| 36 | SON | SON Entrez, Source | SON DNA binding protein | 5330 | 0.010 | -0.0875 | No |
| 37 | CDC5L | CDC5L Entrez, Source | CDC5 cell division cycle 5-like (S. pombe) | 5412 | 0.009 | -0.0929 | No |
| 38 | MAPK14 | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 5554 | 0.007 | -0.1030 | No |
| 39 | NBN | NBN Entrez, Source | nibrin | 5580 | 0.006 | -0.1043 | No |
| 40 | CDK7 | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 5591 | 0.006 | -0.1046 | No |
| 41 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 5723 | 0.004 | -0.1142 | No |
| 42 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 5905 | 0.001 | -0.1277 | No |
| 43 | STAU1 | STAU1 Entrez, Source | staufen, RNA binding protein, homolog 1 (Drosophila) | 5908 | 0.001 | -0.1278 | No |
| 44 | TOP1 | TOP1 Entrez, Source | topoisomerase (DNA) I | 6078 | -0.001 | -0.1405 | No |
| 45 | HIST1H4B | HIST1H4B Entrez, Source | histone cluster 1, H4b | 6393 | -0.006 | -0.1637 | No |
| 46 | PSMB1 | PSMB1 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 1 | 6487 | -0.007 | -0.1701 | No |
| 47 | HSPA8 | HSPA8 Entrez, Source | heat shock 70kDa protein 8 | 6613 | -0.009 | -0.1788 | No |
| 48 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 6621 | -0.009 | -0.1785 | No |
| 49 | CXXC5 | CXXC5 Entrez, Source | CXXC finger 5 | 6698 | -0.011 | -0.1833 | No |
| 50 | MCTS1 | MCTS1 Entrez, Source | malignant T cell amplified sequence 1 | 6712 | -0.011 | -0.1834 | No |
| 51 | FAF1 | FAF1 Entrez, Source | Fas (TNFRSF6) associated factor 1 | 6848 | -0.013 | -0.1925 | No |
| 52 | RAB6A | RAB6A Entrez, Source | RAB6A, member RAS oncogene family | 6910 | -0.014 | -0.1959 | No |
| 53 | ERCC3 | ERCC3 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 7085 | -0.016 | -0.2077 | No |
| 54 | PPP2R1B | PPP2R1B Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform | 7092 | -0.017 | -0.2067 | No |
| 55 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 7101 | -0.017 | -0.2058 | No |
| 56 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 7199 | -0.018 | -0.2116 | No |
| 57 | SIRPA | SIRPA Entrez, Source | signal-regulatory protein alpha | 7460 | -0.022 | -0.2294 | No |
| 58 | SFRS9 | SFRS9 Entrez, Source | splicing factor, arginine/serine-rich 9 | 7495 | -0.022 | -0.2300 | No |
| 59 | EPS15 | EPS15 Entrez, Source | epidermal growth factor receptor pathway substrate 15 | 7677 | -0.026 | -0.2415 | No |
| 60 | PPP1CC | PPP1CC Entrez, Source | protein phosphatase 1, catalytic subunit, gamma isoform | 7701 | -0.026 | -0.2411 | No |
| 61 | GDI2 | GDI2 Entrez, Source | GDP dissociation inhibitor 2 | 7776 | -0.027 | -0.2443 | No |
| 62 | DNAJA2 | DNAJA2 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 2 | 8107 | -0.032 | -0.2665 | No |
| 63 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 8130 | -0.033 | -0.2654 | No |
| 64 | PSMC2 | PSMC2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 8346 | -0.037 | -0.2785 | No |
| 65 | THRAP3 | THRAP3 Entrez, Source | thyroid hormone receptor associated protein 3 | 8530 | -0.039 | -0.2889 | No |
| 66 | GGPS1 | GGPS1 Entrez, Source | geranylgeranyl diphosphate synthase 1 | 8601 | -0.041 | -0.2907 | No |
| 67 | PKN2 | PKN2 Entrez, Source | protein kinase N2 | 8737 | -0.043 | -0.2973 | No |
| 68 | YWHAE | YWHAE Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 8841 | -0.044 | -0.3012 | No |
| 69 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 8927 | -0.046 | -0.3037 | No |
| 70 | CSNK2A1 | CSNK2A1 Entrez, Source | casein kinase 2, alpha 1 polypeptide | 8931 | -0.046 | -0.3000 | No |
| 71 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 8991 | -0.047 | -0.3004 | No |
| 72 | PSMA4 | PSMA4 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 4 | 9027 | -0.048 | -0.2989 | No |
| 73 | EIF3S10 | EIF3S10 Entrez, Source | eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa | 9044 | -0.048 | -0.2960 | No |
| 74 | UBE2D2 | UBE2D2 Entrez, Source | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 9056 | -0.048 | -0.2927 | No |
| 75 | RAB2 | RAB2 Entrez, Source | RAB2, member RAS oncogene family | 9159 | -0.050 | -0.2961 | No |
| 76 | TMPO | TMPO Entrez, Source | thymopoietin | 9189 | -0.050 | -0.2940 | No |
| 77 | LRRC42 | LRRC42 Entrez, Source | leucine rich repeat containing 42 | 9233 | -0.051 | -0.2928 | No |
| 78 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 9367 | -0.054 | -0.2982 | No |
| 79 | CRLF3 | CRLF3 Entrez, Source | cytokine receptor-like factor 3 | 9382 | -0.054 | -0.2947 | No |
| 80 | XRCC5 | XRCC5 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) | 9405 | -0.054 | -0.2916 | No |
| 81 | ARPC5L | ARPC5L Entrez, Source | actin related protein 2/3 complex, subunit 5-like | 9654 | -0.059 | -0.3053 | No |
| 82 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 9690 | -0.060 | -0.3029 | No |
| 83 | RAD23B | RAD23B Entrez, Source | RAD23 homolog B (S. cerevisiae) | 9740 | -0.061 | -0.3013 | No |
| 84 | HSPE1 | HSPE1 Entrez, Source | heat shock 10kDa protein 1 (chaperonin 10) | 9837 | -0.063 | -0.3032 | No |
| 85 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 10056 | -0.067 | -0.3139 | No |
| 86 | JMJD1C | JMJD1C Entrez, Source | jumonji domain containing 1C | 10296 | -0.072 | -0.3257 | Yes |
| 87 | MID1IP1 | MID1IP1 Entrez, Source | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | 10305 | -0.073 | -0.3201 | Yes |
| 88 | BUB3 | BUB3 Entrez, Source | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | 10355 | -0.074 | -0.3174 | Yes |
| 89 | ATF1 | ATF1 Entrez, Source | activating transcription factor 1 | 10486 | -0.077 | -0.3206 | Yes |
| 90 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 10547 | -0.079 | -0.3183 | Yes |
| 91 | RABGGTB | RABGGTB Entrez, Source | Rab geranylgeranyltransferase, beta subunit | 10595 | -0.080 | -0.3150 | Yes |
| 92 | PSMC6 | PSMC6 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 10626 | -0.080 | -0.3104 | Yes |
| 93 | ARFGAP1 | ARFGAP1 Entrez, Source | ADP-ribosylation factor GTPase activating protein 1 | 10668 | -0.082 | -0.3064 | Yes |
| 94 | PSMA5 | PSMA5 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 5 | 10870 | -0.087 | -0.3141 | Yes |
| 95 | CCNH | CCNH Entrez, Source | cyclin H | 10928 | -0.089 | -0.3108 | Yes |
| 96 | FBXL3 | FBXL3 Entrez, Source | F-box and leucine-rich repeat protein 3 | 10974 | -0.090 | -0.3065 | Yes |
| 97 | PRIM2A | PRIM2A Entrez, Source | primase, polypeptide 2A, 58kDa | 10985 | -0.090 | -0.2995 | Yes |
| 98 | SUPV3L1 | SUPV3L1 Entrez, Source | suppressor of var1, 3-like 1 (S. cerevisiae) | 11025 | -0.091 | -0.2946 | Yes |
| 99 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 11066 | -0.092 | -0.2896 | Yes |
| 100 | SNIP1 | SNIP1 Entrez, Source | Smad nuclear interacting protein 1 | 11119 | -0.094 | -0.2855 | Yes |
| 101 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 11131 | -0.094 | -0.2782 | Yes |
| 102 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 11182 | -0.095 | -0.2738 | Yes |
| 103 | DKC1 | DKC1 Entrez, Source | dyskeratosis congenita 1, dyskerin | 11229 | -0.096 | -0.2690 | Yes |
| 104 | HSPH1 | HSPH1 Entrez, Source | heat shock 105kDa/110kDa protein 1 | 11297 | -0.099 | -0.2656 | Yes |
| 105 | CRSP6 | CRSP6 Entrez, Source | cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa | 11432 | -0.103 | -0.2668 | Yes |
| 106 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 11436 | -0.104 | -0.2581 | Yes |
| 107 | CCT4 | CCT4 Entrez, Source | chaperonin containing TCP1, subunit 4 (delta) | 11590 | -0.109 | -0.2603 | Yes |
| 108 | NMI | NMI Entrez, Source | N-myc (and STAT) interactor | 11644 | -0.111 | -0.2547 | Yes |
| 109 | RBM17 | RBM17 Entrez, Source | RNA binding motif protein 17 | 11745 | -0.115 | -0.2524 | Yes |
| 110 | OGT | OGT Entrez, Source | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | 11749 | -0.115 | -0.2428 | Yes |
| 111 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 11848 | -0.119 | -0.2399 | Yes |
| 112 | SERBP1 | SERBP1 Entrez, Source | SERPINE1 mRNA binding protein 1 | 11903 | -0.122 | -0.2335 | Yes |
| 113 | FOSL1 | FOSL1 Entrez, Source | FOS-like antigen 1 | 11938 | -0.123 | -0.2254 | Yes |
| 114 | PANX1 | PANX1 Entrez, Source | pannexin 1 | 12001 | -0.127 | -0.2192 | Yes |
| 115 | PTPRK | PTPRK Entrez, Source | protein tyrosine phosphatase, receptor type, K | 12109 | -0.132 | -0.2159 | Yes |
| 116 | XBP1 | XBP1 Entrez, Source | X-box binding protein 1 | 12147 | -0.134 | -0.2072 | Yes |
| 117 | TARDBP | TARDBP Entrez, Source | TAR DNA binding protein | 12292 | -0.142 | -0.2059 | Yes |
| 118 | NUFIP1 | NUFIP1 Entrez, Source | nuclear fragile X mental retardation protein interacting protein 1 | 12295 | -0.142 | -0.1938 | Yes |
| 119 | LBR | LBR Entrez, Source | lamin B receptor | 12381 | -0.148 | -0.1875 | Yes |
| 120 | DDX20 | DDX20 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 | 12437 | -0.150 | -0.1787 | Yes |
| 121 | EIF4B | EIF4B Entrez, Source | eukaryotic translation initiation factor 4B | 12447 | -0.151 | -0.1664 | Yes |
| 122 | PSME3 | PSME3 Entrez, Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 12468 | -0.152 | -0.1548 | Yes |
| 123 | CDC27 | CDC27 Entrez, Source | cell division cycle 27 | 12571 | -0.160 | -0.1487 | Yes |
| 124 | USP3 | USP3 Entrez, Source | ubiquitin specific peptidase 3 | 12588 | -0.162 | -0.1360 | Yes |
| 125 | MTIF2 | MTIF2 Entrez, Source | mitochondrial translational initiation factor 2 | 12601 | -0.163 | -0.1228 | Yes |
| 126 | AURKA | AURKA Entrez, Source | aurora kinase A | 12673 | -0.170 | -0.1135 | Yes |
| 127 | TXNRD1 | TXNRD1 Entrez, Source | thioredoxin reductase 1 | 12775 | -0.181 | -0.1055 | Yes |
| 128 | EP400 | EP400 Entrez, Source | E1A binding protein p400 | 12834 | -0.190 | -0.0935 | Yes |
| 129 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 12857 | -0.193 | -0.0786 | Yes |
| 130 | TDG | TDG Entrez, Source | thymine-DNA glycosylase | 12893 | -0.199 | -0.0641 | Yes |
| 131 | ARFGEF2 | ARFGEF2 Entrez, Source | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 13091 | -0.248 | -0.0577 | Yes |
| 132 | DCK | DCK Entrez, Source | deoxycytidine kinase | 13118 | -0.258 | -0.0374 | Yes |
| 133 | MAT2A | MAT2A Entrez, Source | methionine adenosyltransferase II, alpha | 13326 | -0.630 | 0.0012 | Yes |
