Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | EXTRACELLULAR_MATRIX |
| Enrichment Score (ES) | 0.6543001 |
| Normalized Enrichment Score (NES) | 2.1350174 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.706423E-4 |
| FWER p-Value | 0.017 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 6 | 1.154 | 0.1339 | Yes |
| 2 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 21 | 0.785 | 0.2244 | Yes |
| 3 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 27 | 0.757 | 0.3121 | Yes |
| 4 | COL5A2 | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 34 | 0.714 | 0.3948 | Yes |
| 5 | MGP | MGP Entrez, Source | matrix Gla protein | 52 | 0.634 | 0.4673 | Yes |
| 6 | PRELP | PRELP Entrez, Source | proline/arginine-rich end leucine-rich repeat protein | 204 | 0.383 | 0.5006 | Yes |
| 7 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 252 | 0.342 | 0.5368 | Yes |
| 8 | LAMB2 | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 433 | 0.249 | 0.5523 | Yes |
| 9 | EFEMP2 | EFEMP2 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 2 | 482 | 0.234 | 0.5759 | Yes |
| 10 | SGCE | SGCE Entrez, Source | sarcoglycan, epsilon | 650 | 0.197 | 0.5863 | Yes |
| 11 | USH2A | USH2A Entrez, Source | Usher syndrome 2A (autosomal recessive, mild) | 684 | 0.187 | 0.6057 | Yes |
| 12 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 821 | 0.166 | 0.6148 | Yes |
| 13 | COLQ | COLQ Entrez, Source | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 888 | 0.157 | 0.6282 | Yes |
| 14 | ADAMTS5 | ADAMTS5 Entrez, Source | ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) | 1052 | 0.141 | 0.6323 | Yes |
| 15 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 1078 | 0.138 | 0.6465 | Yes |
| 16 | TFPI2 | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 1241 | 0.124 | 0.6488 | Yes |
| 17 | NID2 | NID2 Entrez, Source | nidogen 2 (osteonidogen) | 1349 | 0.116 | 0.6543 | Yes |
| 18 | FBN1 | FBN1 Entrez, Source | fibrillin 1 | 1643 | 0.100 | 0.6439 | No |
| 19 | COL11A1 | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 1749 | 0.095 | 0.6471 | No |
| 20 | COL4A4 | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 1802 | 0.093 | 0.6540 | No |
| 21 | COL18A1 | COL18A1 Entrez, Source | collagen, type XVIII, alpha 1 | 1942 | 0.087 | 0.6537 | No |
| 22 | IMPG1 | IMPG1 Entrez, Source | interphotoreceptor matrix proteoglycan 1 | 2202 | 0.077 | 0.6432 | No |
| 23 | TINAG | TINAG Entrez, Source | tubulointerstitial nephritis antigen | 2372 | 0.072 | 0.6388 | No |
| 24 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 2660 | 0.063 | 0.6246 | No |
| 25 | PRSS2 | PRSS2 Entrez, Source | protease, serine, 2 (trypsin 2) | 2794 | 0.060 | 0.6216 | No |
| 26 | SPG7 | SPG7 Entrez, Source | spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) | 2861 | 0.059 | 0.6235 | No |
| 27 | SGCG | SGCG Entrez, Source | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 2905 | 0.057 | 0.6269 | No |
| 28 | LTBP2 | LTBP2 Entrez, Source | latent transforming growth factor beta binding protein 2 | 3107 | 0.052 | 0.6178 | No |
| 29 | DSPP | DSPP Entrez, Source | dentin sialophosphoprotein | 3167 | 0.050 | 0.6192 | No |
| 30 | MEPE | MEPE Entrez, Source | matrix, extracellular phosphoglycoprotein with ASARM motif (bone) | 3410 | 0.045 | 0.6062 | No |
| 31 | COL9A1 | COL9A1 Entrez, Source | collagen, type IX, alpha 1 | 3413 | 0.045 | 0.6113 | No |
| 32 | COL16A1 | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 3530 | 0.042 | 0.6074 | No |
| 33 | ECM1 | ECM1 Entrez, Source | extracellular matrix protein 1 | 3867 | 0.035 | 0.5863 | No |
| 34 | FBLN2 | FBLN2 Entrez, Source | fibulin 2 | 4053 | 0.032 | 0.5760 | No |
| 35 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 4300 | 0.027 | 0.5607 | No |
| 36 | DMP1 | DMP1 Entrez, Source | dentin matrix acidic phosphoprotein | 4341 | 0.026 | 0.5608 | No |
| 37 | LUM | LUM Entrez, Source | lumican | 4533 | 0.023 | 0.5490 | No |
| 38 | MUC5AC | MUC5AC Entrez, Source | mucin 5AC, oligomeric mucus/gel-forming | 6169 | -0.003 | 0.4263 | No |
| 39 | MMP10 | MMP10 Entrez, Source | matrix metallopeptidase 10 (stromelysin 2) | 6646 | -0.010 | 0.3916 | No |
| 40 | CHI3L1 | CHI3L1 Entrez, Source | chitinase 3-like 1 (cartilage glycoprotein-39) | 6833 | -0.013 | 0.3790 | No |
| 41 | LTBP4 | LTBP4 Entrez, Source | latent transforming growth factor beta binding protein 4 | 7185 | -0.018 | 0.3547 | No |
| 42 | HAPLN1 | HAPLN1 Entrez, Source | hyaluronan and proteoglycan link protein 1 | 7300 | -0.020 | 0.3484 | No |
| 43 | MATN1 | MATN1 Entrez, Source | matrilin 1, cartilage matrix protein | 7327 | -0.020 | 0.3488 | No |
| 44 | FBN2 | FBN2 Entrez, Source | fibrillin 2 (congenital contractural arachnodactyly) | 7354 | -0.020 | 0.3492 | No |
| 45 | COL15A1 | COL15A1 Entrez, Source | collagen, type XV, alpha 1 | 7379 | -0.021 | 0.3498 | No |
| 46 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7545 | -0.023 | 0.3401 | No |
| 47 | FBLN5 | FBLN5 Entrez, Source | fibulin 5 | 8019 | -0.031 | 0.3081 | No |
| 48 | EFEMP1 | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 8124 | -0.033 | 0.3041 | No |
| 49 | COMP | COMP Entrez, Source | cartilage oligomeric matrix protein | 8125 | -0.033 | 0.3079 | No |
| 50 | FMOD | FMOD Entrez, Source | fibromodulin | 8247 | -0.035 | 0.3028 | No |
| 51 | THBS4 | THBS4 Entrez, Source | thrombospondin 4 | 8277 | -0.035 | 0.3048 | No |
| 52 | CHAD | CHAD Entrez, Source | chondroadherin | 9330 | -0.053 | 0.2318 | No |
| 53 | COL10A1 | COL10A1 Entrez, Source | collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) | 9784 | -0.062 | 0.2049 | No |
| 54 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 10069 | -0.068 | 0.1914 | No |
| 55 | IMPG2 | IMPG2 Entrez, Source | interphotoreceptor matrix proteoglycan 2 | 10421 | -0.075 | 0.1737 | No |
| 56 | CAV3 | CAV3 Entrez, Source | caveolin 3 | 10854 | -0.087 | 0.1513 | No |
| 57 | DMD | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 12470 | -0.153 | 0.0475 | No |
| 58 | COL5A3 | COL5A3 Entrez, Source | collagen, type V, alpha 3 | 12502 | -0.155 | 0.0632 | No |
