Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_48h.class.cls #double_gel_8d_versus_double_gel_48h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_48h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | GLYCOLYSIS_AND_GLUCONEOGENESIS |
| Enrichment Score (ES) | 0.67067134 |
| Normalized Enrichment Score (NES) | 2.0609517 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.001924848 |
| FWER p-Value | 0.068 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 22 | 0.785 | 0.1271 | Yes |
| 2 | PFKP | PFKP Entrez, Source | phosphofructokinase, platelet | 29 | 0.753 | 0.2502 | Yes |
| 3 | PCK1 | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 35 | 0.711 | 0.3666 | Yes |
| 4 | G6PC | G6PC Entrez, Source | glucose-6-phosphatase, catalytic subunit | 57 | 0.628 | 0.4680 | Yes |
| 5 | GOT1 | GOT1 Entrez, Source | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 144 | 0.453 | 0.5358 | Yes |
| 6 | HK1 | HK1 Entrez, Source | hexokinase 1 | 251 | 0.342 | 0.5840 | Yes |
| 7 | PC | PC Entrez, Source | pyruvate carboxylase | 292 | 0.313 | 0.6324 | Yes |
| 8 | DLAT | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 444 | 0.246 | 0.6614 | Yes |
| 9 | FBP1 | FBP1 Entrez, Source | fructose-1,6-bisphosphatase 1 | 720 | 0.182 | 0.6707 | Yes |
| 10 | ALDOA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 1564 | 0.104 | 0.6244 | No |
| 11 | PFKL | PFKL Entrez, Source | phosphofructokinase, liver | 1624 | 0.101 | 0.6366 | No |
| 12 | ALDOC | ALDOC Entrez, Source | aldolase C, fructose-bisphosphate | 1980 | 0.086 | 0.6240 | No |
| 13 | HK2 | HK2 Entrez, Source | hexokinase 2 | 2661 | 0.063 | 0.5833 | No |
| 14 | PGAM2 | PGAM2 Entrez, Source | phosphoglycerate mutase 2 (muscle) | 3169 | 0.050 | 0.5534 | No |
| 15 | ALDOB | ALDOB Entrez, Source | aldolase B, fructose-bisphosphate | 3253 | 0.048 | 0.5551 | No |
| 16 | GPI | GPI Entrez, Source | glucose phosphate isomerase | 3287 | 0.048 | 0.5605 | No |
| 17 | PDHA1 | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 3365 | 0.046 | 0.5622 | No |
| 18 | PDHA2 | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 3467 | 0.044 | 0.5618 | No |
| 19 | LDHC | LDHC Entrez, Source | lactate dehydrogenase C | 3672 | 0.039 | 0.5529 | No |
| 20 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 3755 | 0.037 | 0.5529 | No |
| 21 | MDH1 | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 4125 | 0.030 | 0.5301 | No |
| 22 | FBP2 | FBP2 Entrez, Source | fructose-1,6-bisphosphatase 2 | 4805 | 0.018 | 0.4821 | No |
| 23 | GAPDH | GAPDH Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase | 5074 | 0.014 | 0.4643 | No |
| 24 | LDHA | LDHA Entrez, Source | lactate dehydrogenase A | 5536 | 0.007 | 0.4307 | No |
| 25 | PFKM | PFKM Entrez, Source | phosphofructokinase, muscle | 5738 | 0.004 | 0.4162 | No |
| 26 | ENO2 | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 6473 | -0.007 | 0.3622 | No |
| 27 | MDH2 | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 7022 | -0.015 | 0.3236 | No |
| 28 | GAPDHS | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 7146 | -0.017 | 0.3172 | No |
| 29 | PGAM1 | PGAM1 Entrez, Source | phosphoglycerate mutase 1 (brain) | 7875 | -0.029 | 0.2672 | No |
| 30 | ENO3 | ENO3 Entrez, Source | enolase 3 (beta, muscle) | 8467 | -0.038 | 0.2291 | No |
| 31 | GOT2 | GOT2 Entrez, Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 8497 | -0.039 | 0.2333 | No |
| 32 | DLD | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 9409 | -0.054 | 0.1737 | No |
| 33 | TPI1 | TPI1 Entrez, Source | triosephosphate isomerase 1 | 9804 | -0.062 | 0.1543 | No |
| 34 | PGK1 | PGK1 Entrez, Source | phosphoglycerate kinase 1 | 9880 | -0.064 | 0.1592 | No |
| 35 | LDHAL6B | LDHAL6B Entrez, Source | lactate dehydrogenase A-like 6B | 11134 | -0.094 | 0.0804 | No |
| 36 | PKLR | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 13114 | -0.257 | -0.0261 | No |
| 37 | GCK | GCK Entrez, Source | glucokinase (hexokinase 4, maturity onset diabetes of the young 2) | 13135 | -0.263 | 0.0156 | No |
